Drugs targets                  
G protein-coupled receptors
Bioactive molecules (Binding DB site) Patents

CaSR

(calcium-sensing receptor)

44 hits

WO2010039911

WO2010039913

WO2010039922

WO2010065383

CB1

(Cannabinoid receptor type 1)

136 hits

WO2010012964

WO2010018328

WO2010018329

CB2

(Cannabinoid receptor type 2)

342 hits WO2010004215

CCR2

(Chemokine receptor type 2)

1059 hits

WO2010061329

WO2010008761

CCR3

(Chemokine receptor type 3)

992 hits WO2010013078

CCR5

(Chemokine receptor type 5)

1783 hits WO2010061329

CRF1

(Corticotropin releasing hormone receptor 1)

1429 hits

WO2010015655

WO2010015628

CRTH2

(Prostagladin D2 receptor)

658 hits

WO2010018112

WO2010018113

WO2010055004

WO2010055005

WO2010055006

CXCR2

(Interleukine 8 receptor)

496 hits WO2010015613

D3

(Dopamine-3 receptor)

2896 hits WO2010034656

GPBAR1

(G protein-coupled bile acid receptor)

6 hits
WO2010049303

GPR119

(G-protein-coupled receptor 119)

no hit

WO2010014593

WO2010006191

mGlu5

(Metabotropic glutamate receptor 5)

1636 hits

WO2010068172

WO2010049366

5-HT5A

(5-Hydroxytryptamine receptor 5A)

no hit
WO2010026110

5-HT6

(5-Hydroxytryptamine receptor 6)

  WO2010000456

H3

(Histamine H3 receptor)

2511 hits

WO2010062245

WO2010065798

WO2010065803

H4

(Histamine H4 receptor)

  WO2010002774

M1

(Muscarinic receptor) 

2311 hits

WO2010059773

WO2010037723

M3

(Muscarinic receptor)

1087 hits

WO2010007561

WO2010019097

WO2010067102

MC4

(Melacortin receptor) 

3584 hits WO2010015972

NK1

(Neurokinin 1)

50 hits               WO2010007032

NK3

(Tachykinin receptor 3)

no hit

WO2010040663

WO2010060703

NPS

(Neuropeptide S receptor)

no hit

WO2010056564

WO2010056567

P2Y12 

1005 hits

WO2010005385

EP2

(Prostaglandin E2 receptor)

144 hits               WO2010052625

S1P1

(Sphingosine-1-phosphate receptor 1)

32 hits               WO2010006704

SMO

(Smoothened)

190 hits  WO2010007120

SSTR5

(Somatostatin receptor subtype 5)

675 hits               WO2010056717

Y-2R

(Neuropeptide Y receptor type 2)

386 hits              

WO2010031707

Enzymes                 Patents

11-beta-HSD-1

(11-beta-hydrosteroid dehydrogenase type 1)

2 hits

WO2010022850

WO2010011917

WO2010049635

ACC

(Acetyl-CoA-carboxylate)

184 hits               WO2010003624

AKT

(protein kinase B (PKB))

1022 hits               WO2010045309

ALK

(Anaplastic lymphoma kinase)

no hit

WO2009158431

WO2010002655

BACE

(Beta secretase)

1700 hits              

WO2010058333

WO2010003976

WO2010056196

WO2010056195

WO2010056194

CDK1

(Cycline-dependent kinase 1)

1868 hits               WO2010020675

CDK2

(Cycline-dependent kinase 2)

1766 hits WO2010020675

CDK4

(Cycline-dependent kinase 4)

1043 hits WO2010020675

CHK-1

(Check point kinase)

1119 hits  WO2010016005

CK1

(Casein kinase 1)

21 hits 

WO2010018327

WO2010063929

WO2010070237

WO2010070238

c-Met

(hepatocyte growth factor receptor (HGFR))

522 hits 

WO2010036831

WO2010007316

WO2010007317

WO2010007318

DAAO

(Enzyme D-amino acid oxidase)

93 hits  WO2010058314

DGAT1

(Diacylglycerol acyl transferase 1)

34 hits 

WO2010056496

WO2010007046

DPP-4

(Dipeptidyl peptidase-IV enzyme)

70 hits  WO2010056708

ErbB

(Epidermal growth factor receptor (EGFR) family)

34 hits  WO2010061208

FAAH

(Fatty amide amide hydrolase)

1620 hits 

WO2010049841

WO2010010288

WO2010055267

FAK

(Focal adhesion kinase)

no hit
WO2010062578

Flt3

(fms-like tyrosine kinase receptor-3)

no hit

WO2010004197

WO2010004198

FPPS

(Farnesyl pyrophosphate synthase)

12 hits  WO2010043584
Glucokinase enzyme 389 hits 

WO2010013161

WO2010015849

Gamma secretase 98 hits 

WO2010040661

WO2010055348

WO2010132015

GlyT1

(Glycine transporter 1)

563 hits 

WO2010020548

WO2010010133

GlyT2

(Glycine transporter 2)

381 hits  WO2010020548

HDAC

(Histone deacetylase)

29 hits  WO2010031708
HIF propyl-hydroxylase  56 hits 

WO2010022307

WO2010022308

WO2010025087

WO2010059555

WO2010059552

WO2010059549

HIV integrase 2374 hits  WO2010068262
HIV reverse transcriptase 2262 hits 

WO2010026075

WO2010011818

IGF-1

(Insulin-like Growth Factor 1)

180 hits 

WO2010049731

WO2009158431

WO2010002655

WO2010045451

JAK

(Janus kinase)

no hit

WO2010063634

WO2010010184

WO2010020810

WO2010038060

WO2010010186

WO2010010187

WO2010010189

WO2010149769

JNK1

(c-Jun N-terminal kinases)

582 hits  WO2010046273

JNK2

(c-Jun N-terminal kinases)

314 hits  WO2010046273

MAPK11

(P38 mitogen-activated protein kinases)

166 hits  WO2010039079

mTOR

(Mammalian target of rapamycin protein kinase)

373 hits 

WO2010038165

WO2010126895

WO2010132589

MMP13

(Collagenase 3)

187 hits  WO2010007027

MPO 

(Myeloperoxidase)

5 hits  WO2010068171

NPP2 or ENPP2

(Autotaxin or ectonucleotide pyrophosphatase/phosphodiesterase 2)

74 hits  WO2010063352

PDE10A

(Phosphodiesterase 10A)

64 hits  WO2010063610

PDGF

(Platelet-derived growth factor)

151 hits  WO2010004197

PDK1

(Phosphoinositide dependent kinase 1)

234 hits 

WO2010065384

WO2010019637

WO2010059658

PI3-K alpha

(Phosphoinositide 3-kinase alpha)

142 hits 

WO2010038165

WO2010029082

WO2010108074

WO2010126895

WO2010132589

PI3-K beta

(Phosphoinositide 3-kinase Beta)

136 hits

WO2010135504

WO2010102658

WO2010108074

WO2010126895

WO2010132589

Pim-1

(serine/threonine-protein kinase-1)

275 hits 

WO2010001169

WO2010026122

WO2010026121

WO2010026124

Pim-2

(serine/threonine-protein kinase-2)

58 hits 

WO2010001169

WO2010026124

Pim-3 

(seine/threonine-protein kinase-3)

2 hits
WO2010026124

SCD

(Stearoyl-CoA-desaturase-1)

no hit
WO2010028761

sEH

(Soluble epoxide hydrolase)

no hit
WO2010011917

sGC

(Soluble guanylase cyclase)

no hit

WO2010015653

WO2010015652

Syk

(Spleen tyrosine kinase)

no hit
WO2010065571
Tryptase 54 hits  WO2010022196
Ligand-gated ion channels    Patents
AMPA receptor  46 hits 

WO2010038167

WO2010037760

alpha-7

(Nicotinic acetylcholine receptor)

no hit  WO2010043515

TRPV4

(Transient receptor potential cation channel subfamily V member 4)

10 hits  WO2010011914
Voltages-gated ion channels   Patents
Nav1.5
  WO2010035166

NHE3

(Sodium-hydrogen antiporter 3)

5 hits  WO2010025856
Cav2.2  

WO2010007074

WO2010007072

WO2010007073

Nuclear hormone receptors   Patents

PR

(Progesterone receptor or NRC3)

2078 hits  WO2010032200

PPAR delta PPAR alpha

(Peroxisome proliferator-activated receptor)

 281 hits  WO2010000353

FXR

(Farnesoid-X-receptor)

518 hits 

WO2010043513

WO2010028981

WO2010034649

WO2010034657

GR

(Glucocorticoid receptor)

1867 hits  WO2010049073

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