Journal of Medicinal Chemistry

Activation of the γ-Aminobutyric Acid Type B (GABAB) Receptor by Agonists and Positive Allosteric Modulators (Fri, 24 Apr 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5018913
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Discovery of Potent Indenoisoquinoline Topoisomerase I Poisons Lacking the 3-Nitro Toxicophore (Fri, 24 Apr 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00303
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HM30181 Derivatives as Novel Potent and Selective Inhibitors of the Breast Cancer Resistance Protein (BCRP/ABCG2) (Fri, 24 Apr 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00188
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6-Substituted Sulfocoumarins Are Selective Carbonic Anhdydrase IX and XII Inhibitors with Significant Cytotoxicity against Colorectal Cancer Cells (Thu, 23 Apr 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00523
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Correction to Discovery of Potent and Selective 8-Fluorotriazolopyridine c-Met Inhibitors (Wed, 22 Apr 2015)
Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00591
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Structure–Activity Relationship in a Purine-Scaffold Compound Series with Selectivity for the Endoplasmic Reticulum Hsp90 Paralog Grp94 (Wed, 22 Apr 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00197
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Lathyrol Diterpenes as Modulators of P-Glycoprotein Dependent Multidrug Resistance: Structure–Activity Relationship Studies on Euphorbia Factor L3 Derivatives (Wed, 22 Apr 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00058
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pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures (Wed, 22 Apr 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00104
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ent-Kaurane Diterpenoids from Chinese Liverworts and Their Antitumor Activities through Michael Addition As Detected in Situ by a Fluorescence Probe (Tue, 21 Apr 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00208
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A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein–Basic Protein 1 (PA-PB1) Subunits (Mon, 20 Apr 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00012
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Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved Pharmacokinetics (Mon, 20 Apr 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00413
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Structure-Related Mode-of-Action Differences of Anticancer Organoruthenium Complexes with β-Diketonates (Fri, 17 Apr 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00288
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Discovery of Tricyclic Indoles That Potently Inhibit Mcl-1 Using Fragment-Based Methods and Structure-Based Design (Fri, 17 Apr 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501984f
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Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo (Thu, 16 Apr 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501998m
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Short Hydrophobic Peptides with Cyclic Constraints Are Potent Glucagon-like Peptide-1 Receptor (GLP-1R) Agonists (Thu, 16 Apr 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00166
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Design, Synthesis, and Structure–Activity Relationship Studies of 3-(Phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Derivatives as a New Class of Src Inhibitors with Potent Activities in Models of Triple Negative Breast Cancer (Thu, 16 Apr 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00270
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Progress Toward the Development of Noscapine and Derivatives as Anticancer Agents (Thu, 16 Apr 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501180v
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Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep) (Wed, 15 Apr 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00132
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Correction to GPR103 Antagonists Demonstrating Anorexigenic Activity in Vivo: Design and Development of Pyrrolo[2,3-c]pyridines That Mimic the C-Terminal Arg-Phe Motif of QRFP26 (Wed, 15 Apr 2015)
Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00479
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Identification of Novel ROS Inducers: Quinone Derivatives Tethered to Long Hydrocarbon Chains (Wed, 15 Apr 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501846y
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Poly(amidoamine) Dendrimers with Carbonic Anhydrase Inhibitory Activity and Antiglaucoma Action (Wed, 15 Apr 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00383
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Discovery of Small Molecules for Up-Regulating the Translation of Antiamyloidogenic Secretase, a Disintegrin and Metalloproteinase 10 (ADAM10), by Binding to the G-Quadruplex-Forming Sequence in the 5′ Untranslated Region (UTR) of Its mRNA (Wed, 15 Apr 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00139
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Peroxisome Proliferator-Activated Receptor γ (PPARγ) and Ligand Choreography: Newcomers Take the Stage (Thu, 09 Apr 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501155f
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Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B (Mon, 06 Apr 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00209
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Volume of Distribution in Drug Design (Wed, 01 Apr 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00201
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Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis (Tue, 31 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501512b
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Clostridium difficile Drug Pipeline: Challenges in Discovery and Development of New Agents (Mon, 30 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5016846
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Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases (Tue, 17 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00127
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Fighting Malaria: Structure-Guided Discovery of Nonpeptidomimetic Plasmepsin Inhibitors (Tue, 17 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5014133
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Origins of the Quinolone Class of Antibacterials: An Expanded “Discovery Story” (Thu, 12 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501881c
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The Hippo Pathway and YAP/TAZ–TEAD Protein–Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment (Wed, 11 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501615v
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A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design (Tue, 03 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501853m
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Tau Positron Emission Tomography (PET) Imaging: Past, Present, and Future (Wed, 25 Feb 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5017544
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Synthetic Nucleic Acid Delivery Systems: Present and Perspectives (Fri, 20 Feb 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500330k
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Bronchodilating Drugs for Chronic Obstructive Pulmonary Disease: Current Status and Future Trends (Mon, 09 Feb 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5013227
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Antitumor Sulfonylhydrazines: Design, Structure–Activity Relationships, Resistance Mechanisms, and Strategies for Improving Therapeutic Utility (Mon, 09 Feb 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501459c
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Progress in Discovery of KIF5B-RET Kinase Inhibitors for the Treatment of Non-Small-Cell Lung Cancer (Wed, 04 Feb 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501464c
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