Journal of Medicinal Chemistry

Studies Examining the Relationship between the Chemical Structure of Protoxin II and Its Activity on Voltage Gated Sodium Channels (Thu, 24 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500687u
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Discovery and Optimization of 1,3,5-Trisubstituted Pyrazolines as Potent and Highly Selective Allosteric Inhibitors of Protein Kinase C-ζ (Thu, 24 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500521n
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Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2 (Thu, 24 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5007275
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Correction to 4-Amino-1-hydroxy-2-oxo-1,8-naphthyridine-Containing Compounds Having High Potency against Raltegravir-Resistant Integrase Mutants of HIV-1 (Wed, 23 Jul 2014)
Journal of Medicinal Chemistry DOI: 10.1021/jm501059k
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Discovery of Glycine Sulfonamides as Dual Inhibitors of sn-1-Diacylglycerol Lipase α and α/β-Hydrolase Domain 6 (Wed, 23 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500681z
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[111In-DOTA]LTT-SS28, a First Pansomatostatin Radioligand for in Vivo Targeting of Somatostatin Receptor-Positive Tumors (Wed, 23 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500581d
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N-Tetradecylcarbamyl Lipopeptides as Novel Agonists for Toll-like Receptor 2 (Wed, 23 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500722p
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Optimization of Potent DFG-in Inhibitors of Platelet Derived Growth Factor Receptorβ (PDGF-Rβ) Guided by Water Thermodynamics (Mon, 21 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500373x
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N-Aryl-2-aminobenzimidazoles: Novel, Efficacious, Antimalarial Lead Compounds (Mon, 21 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500715u
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Modification and Biological Evaluation of Thiazole Derivatives as Novel Inhibitors of Metastatic Cancer Cell Migration and Invasion (Fri, 18 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500724x
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Discovery of Selective Hexapeptide Agonists to Human Neuromedin U Receptors Types 1 and 2 (Fri, 18 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500599s
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Putative Kappa Opioid Heteromers As Targets for Developing Analgesics Free of Adverse Effects (Fri, 18 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500159d
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Pyridyl Benzamides as a Novel Class of Potent Inhibitors for the Kinetoplastid Trypanosoma brucei (Thu, 17 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500191u
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Method for the Evaluation of Structure–Activity Relationship Information Associated with Coordinated Activity Cliffs (Thu, 17 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500577n
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Indazole- and Indole-5-carboxamides: Selective and Reversible Monoamine Oxidase B Inhibitors with Subnanomolar Potency (Wed, 16 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500729a
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Development and Biological Evaluation of Potent and Selective c-KITD816V Inhibitors (Wed, 16 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500413g
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Diarylthiazole: An Antimycobacterial Scaffold Potentially Targeting PrrB-PrrA Two-Component System (Wed, 16 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500833f
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Development of First Lead Structures for Phosphoinositide 3-Kinase-C2γ Inhibitors (Mon, 14 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5006034
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Toward Fluorescent Probes for G-Protein-Coupled Receptors (GPCRs) (Thu, 10 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm401823z
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Ado-trastuzumab Emtansine (T-DM1): An Antibody–Drug Conjugate (ADC) for HER2-Positive Breast Cancer (Thu, 10 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500766w
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Discovery of a Small Molecule MDM2 Inhibitor (AMG 232) for Treating Cancer (Wed, 09 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500627s
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Targeting the Androgen Receptor with Steroid Conjugates (Tue, 08 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500101h
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Discovery of Selective and Orally Bioavailable Protein Kinase Cθ (PKCθ) Inhibitors from a Fragment Hit (Mon, 07 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500669m
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Recent Developments in Novel Antidepressants Targeting α4β2-Nicotinic Acetylcholine Receptors (Wed, 02 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm401937a
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Polypharmacology: Challenges and Opportunities in Drug Discovery (Wed, 25 Jun 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5006463
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Calcitonin Gene-Related Peptide Receptor Antagonists: New Therapeutic Agents for Migraine (Tue, 24 Jun 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500364u
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The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1R,2S)-2-(3-((E)-4-(((cis)-2,6-Dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent (Tue, 24 Jun 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5005336
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Development of Synthetic Lethality Anticancer Therapeutics (Fri, 13 Jun 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500415t
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Elements and Modulation of Functional Dynamics (Tue, 10 Jun 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500325k
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Physicochemical Descriptors of Aromatic Character and Their Use in Drug Discovery (Tue, 03 Jun 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500515d
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Serotonin 5-HT6 Receptor Antagonists for the Treatment of Cognitive Deficiency in Alzheimer’s Disease (Tue, 03 Jun 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5003952
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From Chemical Tools to Clinical Medicines: Nonimmunosuppressive Cyclophilin Inhibitors Derived from the Cyclosporin and Sanglifehrin Scaffolds (Tue, 03 Jun 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500223x
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The Medicinal Chemistry of Liver X Receptor (LXR) Modulators (Wed, 28 May 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500442z
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Small Molecule Inhibitors Targeting Activator Protein 1 (AP-1) (Tue, 27 May 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5004733
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Discovery of Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent Inhibitory Activities against Both Wild-type and Mutant ALK Kinases (Thu, 08 May 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5005144
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Structural Basis for Isoform Selectivity in a Class of Benzothiazole Inhibitors of Phosphoinositide 3-Kinase γ (Fri, 02 May 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500362j
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Biased Ligand Modulation of Seven Transmembrane Receptors (7TMRs): Functional Implications for Drug Discovery (Tue, 29 Apr 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm401677g
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Successes and Challenges in Phenotype-Based Lead Discovery for Prion Diseases (Thu, 24 Apr 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5001425
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Nucleotide-Binding Oligomerization Domain (NOD) Inhibitors: A Rational Approach toward Inhibition of NOD Signaling Pathway (Tue, 22 Apr 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm401841p
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Motor Neuron Disease: A Chemical Perspective (Thu, 17 Apr 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5001584
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Structure-Based Drug Design of RN486, a Potent and Selective Bruton’s Tyrosine Kinase (BTK) Inhibitor, for the Treatment of Rheumatoid Arthritis (Wed, 16 Apr 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500305p
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Functional Probes of Drug–Receptor Interactions Implicated by Structural Studies: Cys-Loop Receptors Provide a Fertile Testing Ground (Mon, 10 Mar 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500023m
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Strategies To Inhibit Tumor Associated Integrin Receptors: Rationale for Dual and Multi-Antagonists (Fri, 07 Mar 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5000547
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Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress (Thu, 06 Mar 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm4011675
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