Journal of Medicinal Chemistry

Synthesis and Bioactivity of β-Substituted Fosmidomycin Analogues Targeting 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase (Tue, 31 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5014264
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Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis (Tue, 31 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501512b
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Novel Multitarget-Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT4R) Agonist Activities As Potential Agents against Alzheimer’s Disease: The Design of Donecopride (Tue, 31 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00115
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DUPA Conjugation of a Cytotoxic Indenoisoquinoline Topoisomerase I Inhibitor for Selective Prostate Cancer Cell Targeting (Mon, 30 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5018384
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Clostridium difficile Drug Pipeline: Challenges in Discovery and Development of New Agents (Mon, 30 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5016846
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Perturbation of the c-Myc–Max Protein–Protein Interaction via Synthetic α-Helix Mimetics (Mon, 30 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501440q
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Synthesis of Improved Lysomotropic Autophagy Inhibitors (Fri, 27 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501586m
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Ensemble-Based Virtual Screening for Cannabinoid-Like Potentiators of the Human Glycine Receptor α1 for the Treatment of Pain (Fri, 27 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501873p
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Synthesis and Structure–Activity Relationships for Extended Side Chain Analogues of the Antitubercular Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824) (Fri, 27 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501608q
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Design, Synthesis, in Vitro, and in Vivo Anticancer and Antiangiogenic Activity of Novel 3-Arylaminobenzofuran Derivatives Targeting the Colchicine Site on Tubulin (Thu, 26 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00155
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Synthesis and Biological Evaluation of Nitrated 7-, 8-, 9-, and 10-Hydroxyindenoisoquinolines as Potential Dual Topoisomerase I (Top1)–Tyrosyl-DNA Phosphodiesterase I (TDP1) Inhibitors (Thu, 26 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00136
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Design, Synthesis, and Biological Evaluation of Novel 2-((2-(4-(Substituted)phenylpiperazin-1-yl)ethyl)amino)-5′-N-ethylcarboxamidoadenosines as Potent and Selective Agonists of the A2A Adenosine Receptor (Wed, 25 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00215
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N-Benzoyl-1,5-benzothiazepine and Its S-Oxide as Vasopressin Receptor Ligands: Insight into the Active Stereochemistry around the Seven-Membered Ring (Tue, 24 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00289
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X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein (Mon, 23 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00050
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10-Iodo-11H-indolo[3,2-c]quinoline-6-carboxylic Acids Are Selective Inhibitors of DYRK1A (Mon, 23 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501994d
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Design of a Potent Antibiotic Peptide Based on the Active Region of Human Defensin 5 (Fri, 20 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501824a
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3′-Functionalized Adamantyl Cannabinoid Receptor Probes (Fri, 20 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501960u
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Lead Optimization toward Proof-of-Concept Tools for Huntington’s Disease within a 4-(1H-Pyrazol-4-yl)pyrimidine Class of Pan-JNK Inhibitors (Thu, 19 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5013598
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Structure-Guided Design and Optimization of Dipeptidyl Inhibitors of Norovirus 3CL Protease. Structure–Activity Relationships and Biochemical, X-ray Crystallographic, Cell-Based, and In Vivo Studies (Thu, 19 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5019934
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Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT): Cocrystal Structures of Pyrazolopyrans with Potent Blood- and Liver-Stage Activities (Wed, 18 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501987h
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Discovery and Optimization of Novel Antagonists to the Human Neurokinin-3 Receptor for the Treatment of Sex-Hormone Disorders (Part I) (Wed, 18 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5017413
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Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases (Tue, 17 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b00127
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Fighting Malaria: Structure-Guided Discovery of Nonpeptidomimetic Plasmepsin Inhibitors (Tue, 17 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5014133
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Origins of the Quinolone Class of Antibacterials: An Expanded “Discovery Story” (Thu, 12 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501881c
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The Hippo Pathway and YAP/TAZ–TEAD Protein–Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment (Wed, 11 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501615v
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Niraparib: A Poly(ADP-ribose) Polymerase (PARP) Inhibitor for the Treatment of Tumors with Defective Homologous Recombination (Wed, 11 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5018237
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A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design (Tue, 03 Mar 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501853m
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Discovery and Safety Profiling of a Potent Preclinical Candidate, (4-[4-[[(3R)-3-(Hydroxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenoxy]-N-methylbenzamide) (CM-352), for the Prevention and Treatment of Hemorrhage (Wed, 25 Feb 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501939z
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Tau Positron Emission Tomography (PET) Imaging: Past, Present, and Future (Wed, 25 Feb 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5017544
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Synthetic Nucleic Acid Delivery Systems: Present and Perspectives (Fri, 20 Feb 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500330k
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Bronchodilating Drugs for Chronic Obstructive Pulmonary Disease: Current Status and Future Trends (Mon, 09 Feb 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5013227
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Antitumor Sulfonylhydrazines: Design, Structure–Activity Relationships, Resistance Mechanisms, and Strategies for Improving Therapeutic Utility (Mon, 09 Feb 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501459c
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Progress in Discovery of KIF5B-RET Kinase Inhibitors for the Treatment of Non-Small-Cell Lung Cancer (Wed, 04 Feb 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501464c
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(Dis)similar Analogues of Riboswitch Metabolites as Antibacterial Lead Compounds (Tue, 03 Feb 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500868e
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Small Molecule Discoidin Domain Receptor Kinase Inhibitors and Potential Medical Applications (Wed, 21 Jan 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5012319
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Stemistry: The Control of Stem Cells in Situ Using Chemistry (Thu, 15 Jan 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500838d
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Organic Carbamates in Drug Design and Medicinal Chemistry (Wed, 07 Jan 2015)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501371s
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