Journal of Medicinal Chemistry

Progress in the Discovery and Development of Heat Shock Protein 90 (Hsp90) Inhibitors (Fri, 29 Aug 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500823a
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Modular Assembly of Purine-like Bisphosphonates as Inhibitors of HIV-1 Reverse Transcriptase (Fri, 29 Aug 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501010f
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Synthetic ω-3 Epoxyfatty Acids As Antiproliferative and Pro-apoptotic Agents in Human Breast Cancer Cells (Fri, 29 Aug 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501083y
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Small Molecule Adenosine 5′-Monophosphate Activated Protein Kinase (AMPK) Modulators and Human Diseases (Thu, 28 Aug 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm401994c
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A New Avenue toward Androgen Receptor Pan-antagonists: C2 Sterically Hindered Substitution of Hydroxy-propanamides (Thu, 28 Aug 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5005122
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Small-Molecule Suppression of β-Lactam Resistance in Multidrug-Resistant Gram-Negative Pathogens (Thu, 28 Aug 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm501050e
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Propylene Cross-Bridged Macrocyclic Bifunctional Chelator: A New Design for Facile Bioconjugation and Robust 64Cu Complex Stability (Tue, 26 Aug 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500348z
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3-Alkoxy-pyrrolo[1,2-b]pyrazolines as Selective Androgen Receptor Modulators with Ideal Physicochemical Properties for Transdermal Administration (Tue, 26 Aug 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5009049
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Identification of N-[(5-{[(4-Methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a Neurotensin-like Nonpeptide Compound Selective for the Neurotensin Receptor Type 2 (Tue, 26 Aug 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500857r
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Design, Synthesis, and Biological Evaluation of Stable Colchicine Binding Site Tubulin Inhibitors as Potential Anticancer Agents (Tue, 26 Aug 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500764v
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Design, Synthesis, and Biological Evaluation of 3-(1-Aryl-1H-indol-5-yl)propanoic Acids as New Indole-Based Cytosolic Phospholipase A2α Inhibitors (Tue, 26 Aug 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500494y
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Synthesis, Characterization, and Biological Evaluation of New Ru(II) Polypyridyl Photosensitizers for Photodynamic Therapy (Tue, 26 Aug 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500566f
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Discovery of Carbohybrid-Based 2-Aminopyrimidine Analogues As a New Class of Rapid-Acting Antimalarial Agents Using Image-Based Cytological Profiling Assay (Tue, 26 Aug 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5009693
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Conjugation of a Nonspecific Antiviral Sapogenin with a Specific HIV Fusion Inhibitor: A Promising Strategy for Discovering New Antiviral Therapeutics (Tue, 26 Aug 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500763m
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The Identification of Perillyl Alcohol Glycosides with Improved Antiproliferative Activity (Mon, 25 Aug 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500870u
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N-[6-(4-Butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a Novel Intravenous and Oral, Reversible, and Directly Acting P2Y12 Antagonist (Mon, 25 Aug 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500588w
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Design, Synthesis, and Biological Evaluation of (3R)-1,2,3,4-Tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide (JDTic) Analogues: In Vitro Pharmacology and ADME Profile (Mon, 25 Aug 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5008177
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Synthesis and Structure–Activity Relationships of Pteridine Dione and Trione Monocarboxylate Transporter 1 Inhibitors (Fri, 22 Aug 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500640x
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Discovery of (R)-1-(7-Chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): A Temperature-Neutral Transient Receptor Potential Vanilloid-1 (TRPV1) Antagonist with Analgesic Efficacy (Thu, 21 Aug 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500916t
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Water-Soluble and Cleavable Quercetin–Amino Acid Conjugates as Safe Modulators for P-Glycoprotein-Based Multidrug Resistance (Wed, 20 Aug 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500290c
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Human Toll-Like Receptor 8-Selective Agonistic Activities in 1-Alkyl-1H-benzimidazol-2-amines (Wed, 20 Aug 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500701q
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Rational Use of Plasma Protein and Tissue Binding Data in Drug Design (Wed, 06 Aug 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5007935
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Small Molecule Ghrelin Receptor Inverse Agonists and Antagonists (Wed, 06 Aug 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5003183
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Comprehensive Analysis of Three-Dimensional Activity Cliffs Formed by Kinase Inhibitors with Different Binding Modes and Cliff Mapping of Structural Analogues (Thu, 31 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5009264
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Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) (Wed, 30 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500480k
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Current Compound Coverage of the Kinome (Wed, 30 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5008159
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Optimization of Potent DFG-in Inhibitors of Platelet Derived Growth Factor Receptorβ (PDGF-Rβ) Guided by Water Thermodynamics (Mon, 21 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500373x
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Development of First Lead Structures for Phosphoinositide 3-Kinase-C2γ Inhibitors (Mon, 14 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5006034
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Toward Fluorescent Probes for G-Protein-Coupled Receptors (GPCRs) (Thu, 10 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm401823z
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Targeting the Androgen Receptor with Steroid Conjugates (Tue, 08 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500101h
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Discovery of Selective and Orally Bioavailable Protein Kinase Cθ (PKCθ) Inhibitors from a Fragment Hit (Mon, 07 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500669m
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Recent Developments in Novel Antidepressants Targeting α4β2-Nicotinic Acetylcholine Receptors (Wed, 02 Jul 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm401937a
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Polypharmacology: Challenges and Opportunities in Drug Discovery (Wed, 25 Jun 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5006463
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Calcitonin Gene-Related Peptide Receptor Antagonists: New Therapeutic Agents for Migraine (Tue, 24 Jun 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500364u
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The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1R,2S)-2-(3-((E)-4-(((cis)-2,6-Dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent (Tue, 24 Jun 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5005336
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Development of Synthetic Lethality Anticancer Therapeutics (Fri, 13 Jun 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500415t
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Elements and Modulation of Functional Dynamics (Tue, 10 Jun 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500325k
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Physicochemical Descriptors of Aromatic Character and Their Use in Drug Discovery (Tue, 03 Jun 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500515d
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Serotonin 5-HT6 Receptor Antagonists for the Treatment of Cognitive Deficiency in Alzheimer’s Disease (Tue, 03 Jun 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5003952
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From Chemical Tools to Clinical Medicines: Nonimmunosuppressive Cyclophilin Inhibitors Derived from the Cyclosporin and Sanglifehrin Scaffolds (Tue, 03 Jun 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500223x
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The Medicinal Chemistry of Liver X Receptor (LXR) Modulators (Wed, 28 May 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500442z
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Discovery of Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent Inhibitory Activities against Both Wild-type and Mutant ALK Kinases (Thu, 08 May 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm5005144
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Structural Basis for Isoform Selectivity in a Class of Benzothiazole Inhibitors of Phosphoinositide 3-Kinase γ (Fri, 02 May 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500362j
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Structure-Based Drug Design of RN486, a Potent and Selective Bruton’s Tyrosine Kinase (BTK) Inhibitor, for the Treatment of Rheumatoid Arthritis (Wed, 16 Apr 2014)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/jm500305p
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