Heck reaction

The Heck reaction (also called the Mizoroki-Heck reaction) is the chemical reaction of an unsaturated halide (or triflate) with an alkene and a strong base and palladium catalyst to form a substituted alkene.Together with the other palladium-catalyzed cross-coupling reactions, this reaction is of great importance, as it allows to do substitution reactions on planar centers. 

Patents references

Step Conditions Patent
a tri(o-tolyl)phosphine / Et3N / Pd(OAc)2 / ACN WO2010026110 (Roche)
Step Conditions Patent
a  tri(o-tolyl)phosphine / Et3N / Pd(OAc)2 / DMF WO2010026110 (Roche)

References

 

Palladium-Triarylphosphine Complexes as Catalysts for Vinylic Halide Reactions
Advances in Chemistry1982196, Ch.12, pp 213-230.

 

Palladium-catalyzed reactions of organic halides with olefins
Acc. Chem. Res.197912(4), pp 146-151

 

Acylation, methylation, and carboxyalkylation of olefins by Group VIII metal derivatives
J. Am. Chem. Soc.196890(20), pp 5518-5526

 

Palladium-catalyzed vinylic hydrogen substitution reactions with aryl, benzyl, and styryl halides
J. Org. Chem.197237(14), pp 2320-2322

 

Palladium-catalyzed annulation of aryl iodides with diphenylacetylene
Organometallics19876(9), pp 1941-1946

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