WO2010037760 Compounds which potentiate AMPA receptor and uses thereof in medecine

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Biological target:

AMPA

Activity:

Positive Allosteric Modulators

Steps Conditions Reactions
a Bis(pinacolato)diboron / Pd(dppf)Cl2 / AcOK / DMSO Boronic ester synthesis
b Hydrogen peroxide / MeOH Phenol synthesis
c

2-(R)-tetrahydro-2-furanylmethanol / DIAD / PPh3 / DCM

Ether synthesis (Mitsunobu synthesis)