WO 2010102958: 4-Oxadiazol-2-yl-Indazoles as Inhibitors of PI3 Kinases

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Biological target:

Phosphatidylinositol 3-kinases-beta: PI3K-beta

Activity:

Inhibitor

Steps Conditions Reactions
a NaH, DMF N-acylation
b Trimethylsilyl azide, Dibutyltin oxide, toluene, microwaves 110oC, 1h
c Chloroacetyl chloride, microwaves 130oC, 20min
d Morpholine, CH3CN, microwaves 80oC, 45min Nucleophilic substitution
e Pd(dppf)Cl2, K3PO4, dioxane, microwaves 100oC, 30min Suzuki cross coupling reaction