WO 2010102958: 4-Oxadiazol-2-yl-Indazoles as Inhibitors of PI3 Kinases

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Biological target:

Phosphatidylinositol 3-kinases-beta: PI3K-beta

Activity:

Inhibitor

Steps	Conditions	Reactions
a	NaH, DMF	N-acylation
b	Trimethylsilyl azide, Dibutyltin oxide, toluene, microwaves 110^oC, 1h
c	Chloroacetyl chloride, microwaves 130^oC, 20min
d	Morpholine, CH₃CN, microwaves 80^oC, 45min	Nucleophilic substitution
e	Pd(dppf)Cl₂, K₃PO₄, dioxane, microwaves 100^oC, 30min	Suzuki cross coupling reaction