WO2010052625 Pyrrolidines

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Scaffold: pyrrolidine

Biological target:

Prostaglandin E2 receptor: EP2

Activity:

Antagonist

Steps Conditions Reactions
a 4-methoxy-benzoyl chloride / Et3N / THF Amide synthesis
b LiHMDS / ethyl chloroformate / THF Ester synthesis
c Savinase 16T Type W enzyme / H3PO4 /  ACN Carboxylic acid synthesis (Ester hydrolysis)
d LiBH4 / isopropanol Ester reduction
e AcCl / EtOH Ester synthesis (esterification)
f 4-Toluenesulfonyl chloride / Trimethylamine / Triethylamine / DCM Tosyl synthesis
Steps Conditions Reactions
a K2CO3 / DMSO Ether synthesis (Nucleophilic substitution)