WO2010020548 GLYT1 receptor antagonists

WO2010020548.pdf
Adobe Acrobat Document [1.9 MB]
Download

Scaffold: oxetane

Biological target:

Glycine transporter 1: GlyT-1

Glycine transporter 2: GlyT-2

Activity:

Inhibitor

Steps Conditions Reactions
a AcOH Strecker reaction
b Phenyllithium 2M / THF Nucleophilic substitution
c HATU / DIEA / DMF Amide synthesis (HATU coupling)
Steps Conditions Reactions
a sec-Butyllithium / N,N,N',N'-tetramethylethylendiamine / dimethyl disulfide / THF Thioether synthesis

Site Search