WO2010018327 2-Alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo[1,2-IB]pyridazine derivatives, preparation thereof, and therapeutic application thereof

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Biological target:

Casein kinase 1: CK1

Activity:

Inhibitor

Steps Conditions Reactions
a 1-Benzyl-piperazine, 160oC, 1h SNAr
b n-butanol, 90oC, 1h40 Imidazopyridazine formation
c Ethyl chloroformate, pyridine, 0oC to room temperature
d ortho-chloranile, toluene Aromatisation
e Pd/C, HCOONH4, MeOH Hydrogenolysis, Secondary amine formation (Benzyl-deprotection)

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