PROCESS FOR PREPARING 5-FLUORO-1-METHYL-3-DIFLUOROMETHYL-1H-PYRAZOLE-4-CARBALDEHYDE (Fri, 25 Jul 2014)
The present invention relates to a novel process for preparing 5-fluoro-1-methyl-3-difluoromethyl-1H-pyrazole-4-carbaldehyde, a useful intermediate in the manufacture of fungicides.
>> read more

DIFLUOROMETHYL-NICOTINIC- TETRAHYDRONAPHTYL CARBOXAMIDES (Fri, 27 Jun 2014)
The present invention relates to novel difluoromethyl-nicotinic tetrahydronaphtyl carboxamides of formula (I), to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof for the control of harmful microorganisms in crop protection.
>> read more

DIFLUOROMETHYL-NICOTINIC-INDANYL CARBOXAMIDES AS FUNGICIDES (Fri, 27 Jun 2014)
The present invention relates to novel difluoromethyl-nicotinic indanyl carboxamides of formula (I), to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials.
>> read more

TETRAHYDRONAPHTHYL(THIO) CARBOXAMIDES (Fri, 27 Jun 2014)
The present invention relates to novel tetrahydronaphthyl(thio) carboxamides, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials.
>> read more

SUBSTITUTED IMIDAZOPYRIDINES AND IMIDAZOPYRIDAZINES AND THE USE THEREOF (Fri, 20 Jun 2014)
<p id="p-0001" num="0000">The present application relates to novel substituted imidazopyridines and imidazopyridazines, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases and to their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.</p>
>> read more

NOVEL [F-18]-LABELLED L-GLUTAMIC ACID AND L-GLUTAMINE DERIVATIVES (I), THEIR USE AND PROCESSES FOR THEIR PREPARATION (Fri, 06 Jun 2014)
<p id="p-0001" num="0000">What is described are the compounds and the synthesis of [F-18]-labelled L-glutamic acid, [F-18]-labelled L-glutamate, their derivatives of the formula (I) and their use.</p>
>> read more

METHODS AND MEANS FOR THE MANUFACTURE OF HYALURONAN (Fri, 06 Jun 2014)
<p id="p-0001" num="0000">The present invention relates to plant cells and plants which synthesize hyaluronan and to methods for preparing such plants, and also to methods for preparing hyaluronan with the aid of these plant cells or plants. Furthermore, the present invention relates to the use of plants for preparing hyaluronan and to food or feed which comprises hyaluronan.</p>
>> read more

NOVEL SUBSTITUTED BIPYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE RECEPTOR LIGANDS (Fri, 06 Jun 2014)
<p id="p-0001" num="0000">The present invention relates to novel substituted 2,4′- and 3,4′-bipyridine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.</p>
>> read more

METHOD FOR PRODUCING POLYETHER POLYOLS (Fri, 06 Jun 2014)
<p id="p-0001" num="0000">The present invention relates to a process for the preparation of polyether carbonate polyols from one or more H-functional starter compounds, one or more alkylene oxides and carbon dioxide in the presence of a double metal cyanide catalyst, wherein (α) the H-functional starter substance or a mixture of at least two H-functional starter substances is initially introduced into the reaction vessel, (β) for the activation, a part amount (based on the total amount of the amount of alkylene oxides employed in steps (β) and (γ)) of one or more alkylene oxides is added to the mixture resulting from step (α), it also being possible for step (β) to be carried out several times for the activation, (γ) one or more alkylene oxides and carbon dioxide are metered continuously into the mixture resulting from step (β) (“copolymerization”), the alkylene oxides employed for the copolymerization being identical to or different from the alkylene oxides employed in step (β), characterized in that in step (γ) the carbon dioxide is passed into the mixture by (i) gassing the reaction mixture in the reactor from the bottom, (ii) using a hollow shaft stirrer, (iii) a combination of the metering operations according to (i) and (ii), and/or (iv) gassing over the surface of the liquid by using stirrer units configured in several stages.</p>
>> read more

CHIRAL SYNTHESIS OF N--1-[2,3-DIHYDROXY-PROPYL]CYCLOPROPANESULFONAMIDES (Fri, 06 Jun 2014)
<p id="p-0001" num="0000">The present invention relates to a novel enantioselective method of preparing (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-5 methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide.</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="99.23mm" wi="71.20mm" file="US20140155637A1-20140605-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p>
>> read more

HUMANIZED MONOCLONAL ANTIBODIES AGAINST ACTIVATED PROTEIN C AND USES THEREOF (Fri, 06 Jun 2014)
Provided are humanized antibodies that selectively bind to and inhibit activated protein C without binding to or inhibiting unactivated protein C. Methods of treatment employing these antibodies are described herein.
>> read more

(R) ENANTIOMERS OF CARBOXAMIDES FOR CONTROLLING OF HARMFUL MICROORGANISMS OR FOR ENHANCING PLANT HEALTH (Fri, 06 Jun 2014)
Use of (R) enantiomers of carboxamides for controlling of harmful microorganisms and for enhancing plant health The present invention relates to (R)-enantiomers of certain carboxamides, to compositions comprising these (R)-enantiomers, to a process for preparing these enantiomers and to the use for controlling of harmful microorganisms and for enhancing plant health in conventionally bred or transgenic plants of the Phaseoleae tribe, in particular conventionally bred or transgenic soybean.
>> read more

ACTIVE COMPOUND COMBINATIONS (Fri, 30 May 2014)
<p id="p-0001" num="0000">The present invention relates to active compound combinations, in particular within a fungicide composition, which comprises (A) a thiazolylisoxazoline of formula (I) and a further fungicidally active compound (B). Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi of plants or crops, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.</p>
>> read more

BICYCLIC AZA HETEROCYCLES, AND USE THEREOF (Fri, 30 May 2014)
<p id="p-0001" num="0000">The present application relates to novel bicyclic azaheterocycles, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.</p>
>> read more

Heterocyclic Compounds as Pesticides (Fri, 30 May 2014)
<p id="p-0001" num="0000">The present application relates to novel heterocyclic compounds, to the use thereof for controlling animal pests, which include arthropods and especially insects, and to processes for preparing the novel compounds.</p>
>> read more

PROCESS FOR PREPARING SODIUM SALTS OR POTASSIUM SALTS OF 4-HYDROXY-2-OXO-2,5-DIHYDROFURAN-3-CARBOXYLATE (Fri, 30 May 2014)
<p id="p-0001" num="0000">Process for preparing sodium or potassium salts of 4-hydroxy-2-oxo-2,5-dihydrofuran-3-carboxylic esters, comprising the reaction of a malonic ester with potassium hydroxide to give the corresponding malonic ester potassium salt of the formula (III)</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="13.12mm" wi="53.00mm" file="US20140148604A1-20140529-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0003" num="0000">which is then reacted further with a chloroacetic ester to give a compound of the formula (V)</p> <p id="p-0004" num="0000"><chemistry id="CHEM-US-00002" num="00002"> <img id="EMI-C00002" he="18.88mm" wi="60.45mm" file="US20140148604A1-20140529-C00002.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0005" num="0000">followed by a ring closure reaction in which the compound of the formula (V) is reacted with a sodium or potassium alkoxide of the formula ZOR<sup>1 </sup>where R<sup>1</sup>, R<sup>2</sup>, R<sup>3 </sup>and K are each as defined in the description.</p>
>> read more

METHOD FOR THE PRODUCTION OF 2-AMINO-5-CYANO-N,3-DIMETHYLBENZAMIDE (Fri, 30 May 2014)
<p id="p-0001" num="0000">The present invention relates to a process for preparing 2-amino-5-cyano-N,3-dimethylbenzamide of formula (1)</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="26.42mm" wi="55.88mm" file="US20140148611A1-20140529-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0003" num="0000">by reacting 2-amino-5-cyano-3-methylbenzoic esters or diesters with methylamine.</p>
>> read more

Multi-fluid medical injector system (Thu, 29 May 2014)
A multi-fluid injector system and methods of operation thereof are presented. One embodiment of such a fluid injector system includes a powered injector, a pressure jacket support, a syringe pressure jacket, and a syringe. The pressure jacket support includes a front plate and a rear plate. The rear plate is connected to the injector and the front plate is spaced from the rear plate and defines a slot. The syringe pressure jacket has a proximal end pivotally connected to the rear plate so that a distal end of the pressure jacket pivots relative to the front plate. The syringe has a syringe body with a distally extending discharge conduit. With the syringe disposed in a barrel of the pressure jacket, pivotal movement of the pressure jacket results in the distal end thereof pivoting toward the front plate to place the discharge conduit within the slot in the front plate.
>> read more

SUBSTITUTED 3-PHENYLPROPIONIC ACIDS AND THE USE THEREOF (Fri, 23 May 2014)
<p id="p-0001" num="0000">The present application relates to novel 3-phenylpropionic acid derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.</p>
>> read more

5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP (Fri, 23 May 2014)
The present invention relates to 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfoximine group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
>> read more

METHOD FOR THE PRODUCTION OF OXAZOLIDINONE COMPOUNDS (Fri, 23 May 2014)
The present invention relates to a method for the production of oxazolidinone compounds, comprising the step of slowly reacting an isocyanate compound with an epoxide compound in the presence of a Lewis acid catalyst. The invention further relates to an oxazolidinone compound, obtainable by a method according to the invention, with a colour as determined according to ASTM D1209 - 05 (2011) of ≤ 200 and a molar ratio of the oxazolidinone compound to isocyanurate by¬ product o/i of ≥ 85/15. Lastly, the invention relates to an oligomeric or polymeric oxazolidinone compound, obtainable by a method according to the invention using an isocyanate compound with two or more NCO groups per molecule and an epoxide compound with two or more epoxy groups per molecule, comprising at least two units derived from the isocyanate compound and at least two units derived from the epoxide compound, with a colour as determined according to ASTM D1209 - 05 (2011) of ≤ 200.
>> read more

4-(ORTHO)-FLUOROPHENYL-5-FLUOROPYRIMIDIN-2-YL AMINES CONTAINING A SULFOXIMINE GROUP (Fri, 23 May 2014)
The present invention relates to 4-(ortho)-fluorophenyl-5-fluoropyrimidin-2-yl amine derivatives containing a sulfoximine group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
>> read more

AMINOIMIDAZOPYRIDAZINES (Fri, 23 May 2014)
The present invention relates to amino-substituted imidazopyridazine compounds of general formula (I), in which A, R1, R2, R3, R4 and n are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper- proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
>> read more

N-(PYRIDIN-2-YL)PYRIMIDIN-4-AMINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP (Fri, 23 May 2014)
The present invention relates to disubstituted N-(pyridin-2-yl)pyrimidin-4-amine derivatives containing a sulfoximine group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/ or prophylaxis of disorders, in particular of hyper- proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
>> read more

Tungsten complexes with di-dentate ligands (Thu, 22 May 2014)
The present invention describes a new class of highly stable W 3 O 2 Clusters, a method for their preparation and their use as X-ray contrast agents.
>> read more

Novel Binder-Drug Conjugates (ADCs) and Use of Same (Fri, 09 May 2014)
<p id="p-0001" num="0000">The present patent application relates to novel binder-drug conjugates (ADCs) of N,N-dialkylauristatins directed against the target epidermal growth factor receptor (EGFR, gene ID 1956), effective metabolites of these ADCs, methods for producing these ADCs, use of these ADCs for treatment and or prevention of diseases as well as the use of these ADCs to produce pharmaceutical drugs for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic diseases such as cancer, for example. Such treatments may be administered as monotherapy or in combination with other pharmaceutical drugs or other therapeutic measures.</p>
>> read more

Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use (Fri, 09 May 2014)
<p id="p-0001" num="0000">The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.</p>
>> read more

Hydroxy-substituted imidazo[1,2-a]pyridinecarboxamides and their use (Fri, 09 May 2014)
<p id="p-0001" num="0000">The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.</p>
>> read more

Carboxy-substituted imidazo[1,2-a]pyridinecarboxamides and their use (Fri, 09 May 2014)
<p id="p-0001" num="0000">The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.</p>
>> read more

Hydroxy-substituted imidazo[1,2-a]-pyridinecarboxamides and their use (Fri, 09 May 2014)
<p id="p-0001" num="0000">The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.</p>
>> read more

PESTICIDAL DIARYL - HETEROCYCLYL DERIVATIVES (Fri, 09 May 2014)
<p id="p-0001" num="0000">To provide pesticidal allylAryl heterocycle derivatives that are useful as a pesticidal compound.</p> <p id="p-0002" num="0000">Pesticidal allylAryl heterocycle derivatives that are expressed by the Formula (I),</p> <p id="p-0003" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="23.45mm" wi="67.48mm" file="US20140128614A1-20140508-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0004" num="0000">and pesticides and an agent for controlling animal parasites which include the allylAryl heterocycle derivatives as an effective component.</p>
>> read more

BICYCLIC (THIO)CARBONYLAMIDINES (Fri, 25 Apr 2014)
<p id="p-0001" num="0000">Bicyclic (thio)carbonylamidines of the formula (I)</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="27.01mm" wi="53.59mm" file="US20140113824A1-20140424-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0003" num="0000">in which Q, B, Y, R<sup>1 </sup>and A are as defined in the description <br/> their preparation and their use for controlling plant pests and pests encountered in veterinary medicine. </p>
>> read more

IMIDAZOPYRIDAZINES AS AKT KINASE INHIBITORS (Fri, 25 Apr 2014)
<p id="p-0001" num="0000">Imidazopyridazines of formula (I) a process for their production and the use thereof.</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="45.21mm" wi="66.04mm" file="US20140113901A1-20140424-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p>
>> read more

SUBSTITUTED IMIDAZOPYRIDINES AND THE USE THEREOF (Fri, 25 Apr 2014)
<p id="p-0001" num="0000">The present application relates to novel substituted imidazopyridazines, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases and to their use for production of medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.</p>
>> read more

ARYLAMINOALCOHOL-SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINOLINES (Fri, 25 Apr 2014)
<p id="p-0001" num="0000">The present invention relates to substituted phenoxypyridine compounds of general formula (I); in which R<sup>1</sup>, R<sup>2 </sup>and R<sup>3 </sup>are as defined in the claims, to methods of preparing said compounds, to intermediates for the preparation of said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="29.97mm" wi="69.85mm" file="US20140113896A1-20140424-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p>
>> read more

N-(PYRIDIN-2-YL)PYRIMIDIN-4-AMINE DERIVATIVES CONTAINING A SULFONE GROUP (Fri, 25 Apr 2014)
The present invention relates to N-(pyridin-2-yl)pyrimidin-4-amine derivatives containing a sulfone group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
>> read more

ACTIVE COMPOUND COMBINATIONS COMPRISING CARBOXAMIDE DERIVATIVES AND A BIOLOGICAL CONTROL AGENT (Fri, 25 Apr 2014)
The present invention relates to active compound combinations, in particular within a composition, which comprises (A) ) a N-cyclopropyl-N-[substituted-benzyl]-3-(difluoromethyl)-5-fluoro-l-methyl- lH-pyrazole-4-carboxamide or thiocarboxamide derivative and (B) a biological control agent. Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi of plants or crops, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.
>> read more

METHOD OF PLANT GROWTH PROMOTION USING CARBOXAMIDE DERIVATIVES (Fri, 25 Apr 2014)
The present invention relates to a new method of plant treatment that is able to induce positive growth regulating responses by applying a non-phytotoxic, effective plant growth promoting amount of a compound having the formula (I).
>> read more

METHOD FOR TREATING PLANTS AGAINST FUNGI RESISTANT TO FUNGICIDES USING CARBOXAMIDE OR THIOCARBOXAMIDE DERIVATIVES (Fri, 25 Apr 2014)
The invention relates to the use of N-cyclopropyl-N-[substituted-benzyl]-3-(difluoromethyl)-5-fluoro-1- methyl-1H-pyrazole-4-carboxamide or thiocarboxamide derivatives and/or salts thereof for improving growth in crops, comprising preventively and/or curatively controlling resistant strains of fungi, particularly for controlling strains of fungi resistant to SDHI fungicides. The invention further relates to associated methods.
>> read more

ACTIVE COMPOUND COMBINATIONS COMPRISING CARBOXAMIDE DERIVATIVES (Fri, 25 Apr 2014)
The present invention relates to active compound combinations, in particular within a composition, which comprises (A) ) a N-cyclopropyl-N-[substituted-benzyl]-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide or thiocarboxamide derivative and (B) a further herbicidally active compound or (C) a plant growth regulator and/or (D) a safener for reducing phytotoxic actions of agrochemicals. Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi of plants or crops, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.
>> read more

4-(ORTHO)-FLUOROPHENYL-5-FLUOROPYRIMIDIN-2-YL AMINES CONTAINING A SULFONE GROUP (Fri, 25 Apr 2014)
The present invention relates to 4-(ortho)-fluorophenyl-5-fluoropyrimidin-2-yl amine derivatives of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
>> read more

METHOD FOR ENHANCING TOLERANCE TO ABIOTIC STRESS IN PLANTS USING CARBOXAMIDE OR THIOCARBOXAMIDE DERIVATIVES (Fri, 25 Apr 2014)
The invention relates to the use of a compound of formula (I) for enhancing tolerance in plants to abiotic stress and to the associated enhancement in plant growth and/or increase in plant yield, and to corresponding methods
>> read more

5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFONE GROUP (Fri, 25 Apr 2014)
The present invention relates to 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
>> read more

N-(1,2,5-OXADIAZOL-3-YL)-, N-(TETRAZOL-5-YL)- AND N-(TRIAZOL-5-YL)BICYCLOARYLCARBOXAMIDES AND THEIR USE AS HERBICIDES (Fri, 18 Apr 2014)
<p id="p-0001" num="0000">N-(1,2,5-Oxadiazol-3-yl)-, N-(tetrazol-5-yl)- and N-(triazol-5-yl)bicycloarylcarboxamides of the general formula (I) are described as herbicides.</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="27.77mm" wi="59.77mm" file="US20140106969A1-20140417-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0003" num="0000">In this formula (I), R<sup>3</sup>, R<sup>4 </sup>and R<sup>5 </sup>are each radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen. Q is a heterocycle. X and Y are each oxygen and sulfur.</p>
>> read more

METHOD FOR PRODUCING 2-CHLOROALLYL THIOCYANATE AND 2-CHLOROALLYL ISOTHIOCYANATE (Fri, 18 Apr 2014)
<p id="p-0001" num="0000">A process is described for producing 2-chloroallyl isothiocyanate from 2,3-dichloro-1-propene by reacting the 2,3-dichloro-1-propene with a thiocyanate in the presence of a phase transfer catalyst, without diluent or in the presence of up to 15 percent by weight based on 2,3-dichloropropene and simultaneously in the presence of an excess of from 10 to 200 mol percent of 2,3-dichloro-1-propene based on the thiocyanate. A process starting from 1,2,3-trichloropropane is also described.</p>
>> read more

NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS FOR PLANT DISEASE CONTROL (Fri, 04 Apr 2014)
The present invention relates to novel isoxazoline carboxamide derivatives, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials.
>> read more

SUBSTITUTED INDAZOL-PYRROLOPYRIMIDINES USEFUL IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES (Fri, 04 Apr 2014)
The present invention relates to substituted indazol-pyrrolopyrimidine compounds of general formula (I):in which R1a, R1b, R1c, R1d, R2a and R2b are as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
>> read more

PROCESS FOR THE PREPARATION OF OPTIONALLY SUBSTITUTED PHENYL AND PYRIDYL PYRROLIDINES (Fri, 04 Apr 2014)
The present invention relates to a method for the preparation of optionally substituted aryl and pyridyl pyrrolidines which are useful intermediates for the preparation of certain biologically active compounds.
>> read more

SUBSTITUTED INDAZOL-PYRROLOPYRIMIDINES USEFUL IN THE TREATMENT OF HYPERFOLIFERATIVE DISORDERS (Fri, 04 Apr 2014)
The present invention relates to substituted indazol-pyrrolopyrimidinecompounds of general formula I: in which R1a, R1b, R1c, R1d, R2a are as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
>> read more

SUBSTITUTED 4-CYAN-3-(2,6-DIFLUOROPHENYL)-4-PHENYLBUTANOATES, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF AS HERBICIDES AND PLANT GROWTH REGULATORS (Fri, 28 Mar 2014)
<p id="p-0001" num="0000">Compounds of the formula (I) or salts thereof,</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="35.98mm" wi="60.62mm" file="US20140087945A1-20140327-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0003" num="0000">in which <br/> R<sup>1 </sup>is H or a hydrolyzable radical, <br/> (R<sup>2</sup>)<sub>n </sub>is n substituents R<sup>2</sup>, <ul id="ul0001" list-style="none"> <li id="ul0001-0001" num="0000"> <ul id="ul0002" list-style="none"> <li id="ul0002-0001" num="0000">where R<sup>2 </sup>independently of the others is Hal, CN, NO<sub>2</sub>, (C<sub>1</sub>-C<sub>8</sub>)-alkyl, (C<sub>1</sub>-C<sub>8</sub>)-alkoxy, (C<sub>1</sub>-C<sub>8</sub>)-alkylthio, (C<sub>1</sub>-C<sub>8</sub>)-alkylsulfinyl, (C<sub>1</sub>-C<sub>8</sub>)-alkylsulfonyl, (C<sub>1</sub>-C<sub>6</sub>)-haloalkyl, (C<sub>1</sub>-C<sub>6</sub>)-haloalkoxy, (C<sub>1</sub>-C<sub>6</sub>)-haloalkylthio, (C<sub>1</sub>-C<sub>6</sub>)-haloalkylsulfinyl, (C<sub>1</sub>-C<sub>6</sub>)-haloalkylsulfonyl, (C<sub>2</sub>-C<sub>6</sub>)-alkenyl, (C<sub>2</sub>-C<sub>6</sub>)-alkynyl, tri-[(C<sub>1</sub>-C<sub>4</sub>)-alkyl]-silyl or tri-[(C<sub>1</sub>-C<sub>4</sub>)-alkyl]-silyl-(C<sub>1</sub>-C<sub>4</sub>)-alkyl</li> <li id="ul0002-0002" num="0000">or where in each case two groups R<sup>2 </sup>located ortho at the ring together are —Z<sup>1</sup>-A*-Z<sup>2</sup>, in which</li> <li id="ul0002-0003" num="0000">A* is (C<sub>1</sub>-C<sub>4</sub>)-alkylene, which is optionally substituted by radicals from the group consisting of halogen, (C<sub>1</sub>-C<sub>4</sub>)-alkyl, (C<sub>1</sub>-C<sub>4</sub>)-haloalkyl, (C<sub>1</sub>-C<sub>4</sub>)-alkoxy and (C<sub>1</sub>-C<sub>4</sub>)-haloalkoxy,</li> <li id="ul0002-0004" num="0000">Z<sup>1</sup>, Z<sup>2 </sup>are each a direct bond, O or S and</li> <li id="ul0002-0005" num="0000">where the group —Z<sup>1</sup>-A*-Z<sup>2 </sup>together with the carbon atoms, attached to the group, of the phenyl ring form a fused-on 5- or 6-membered ring, and <br/> n is 0, 1, 2, 3, 4 or 5, <br/> excluding the compound in which R<sup>1 </sup>is methyl and (R<sup>2</sup>)<sub>n </sub>is 3-fluoro (n=1), <br/> are suitable for use as herbicides and plant growth regulators and can be prepared by the process of claim <b>8. </b> </li> </ul> </li> </ul> </p>
>> read more

SUBSTITUTED 5-(CYCLOHEX-2-EN-1-YL)-PENTA-2,4-DIENES AND 5-(CYCLOHEX-2-EN-1-YL)-PENT-2-EN-4-INES AS ACTIVE AGENTS AGAINST ABIOTIC STRESS IN PLANTS (Fri, 28 Mar 2014)
<p id="p-0001" num="0000">The invention relates to substituted 5-(cyclohex-2-en-1-yl)penta-2,4-dienes and 5-(cyclohex-2-en-1-yl)pent-2-en-4-ines of the formula (I) and their salts</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="21.34mm" wi="54.86mm" file="US20140087949A1-20140327-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0003" num="0000">where the radicals R<sup>1</sup>, R<sup>2</sup>, R<sup>3</sup>, R<sup>4</sup>, [X—Y] and Q are each as defined in the description, to processes for preparation thereof and to the use thereof for enhancing stress tolerance in plants with respect to abiotic stress, and/or for increasing plant yield.</p>
>> read more

FUSED BICYCLIC IMIDAZOLES (Fri, 28 Mar 2014)
<p id="p-0001" num="0000">Compounds of formula (I)</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="32.85mm" wi="67.65mm" file="US20140088110A1-20140327-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0003" num="0000">a tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the imidazole to which it is fused, R4, R6 and R7 have the meanings as given in the description and the claims, are effective inhibitors of the Pi3K/Akt pathway.</p>
>> read more

N-(3-CARBAMOYLPHENLY)-1H-PYRAZOLE-5-CARBOXAMIDE DERIVATIVES AND THE USE THEREOF FOR CONTROLLING ANIMAL PESTS (Fri, 28 Mar 2014)
<p id="p-0001" num="0000">The invention relates to compounds of the general formula (I)</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="44.11mm" wi="69.85mm" file="US20140088153A1-20140327-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0003" num="0000">in which the radicals A<sub>1</sub>, A<sub>2</sub>, A<sub>3</sub>, A<sub>4</sub>, L, Q, R<sup>1</sup>, T and W have the meaning given in the description and to the use of the compounds for controlling animal pests. The invention furthermore relates to processes and intermediates for preparing the compounds of formula (I).</p>
>> read more

INDOLECARBOXAMIDES AND BENZIMIDAZOLECARBOXAMIDES AS INSECTICIDES AND ACARICIDES (Fri, 28 Mar 2014)
<p id="p-0001" num="0000">The present invention relates to compounds of the general formula (I)</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="24.21mm" wi="69.85mm" file="US20140088167A1-20140327-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> <ul id="ul0001" list-style="none"> <li id="ul0001-0001" num="0000"> <ul id="ul0002" list-style="none"> <li id="ul0002-0001" num="0000">in which R<sup>1 </sup>to R<sup>6</sup>, A, Y, X, G, n and m are each as defined in the description—and to a process for preparation thereof and to the use thereof as insecticides and acaricides.</li> </ul> </li> </ul> </p>
>> read more

SUBSTITUTED PYRROLOPYRIMIDINYLAMINO-BENZOTHIAZOLONES AS MKNK KINASE INHIBITORS (Fri, 28 Mar 2014)
The present invention relates to substituted pyrrolopyrimidinylamino-benzothiazolone compounds of general formula I as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
>> read more

1-ARYL-2-HETEROARYL BENZIMIDAZOLES FOR THE INDUCTION OF NEURONAL REGENERATION (Fri, 28 Mar 2014)
The invention relates to the use of 1-aryl-2-heteroaryl benzimidazole derivatives, for the production of pharmaceutical agents for treating and preventing diseases which benefit from therapeutic promotion of regenerative processes, e.g. remyelination and neurogenesis.
>> read more

N-(1,3,4-OXADIAZOL-2-YL)ARYLCARBOXAMIDES AND USE THEREOF AS HERBICIDES (Fri, 21 Mar 2014)
<p id="p-0001" num="0000">N-(1,3,4-Oxadiazol-2-yl)arylcarboxamides of the general formula (I) are described as herbicides.</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="23.79mm" wi="61.98mm" file="US20140080705A1-20140320-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0003" num="0000">In this formula (I) A is nitrogen or CY. R, X, Y and Z are each radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen.</p>
>> read more

O-CYCLOPROPYLCYCLOHEXYL-CARBOXANILIDES AND THEIR USE AS FUNGICIDES (Fri, 21 Mar 2014)
<p id="p-0001" num="0000">The present invention relates to O-CYCLOPROPYLCYCLOHEXYL-CARBOXANILIDES derivatives of formula (I); their process of preparation, their use as fungicide, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.</p>
>> read more

SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE SALTS (Fri, 14 Mar 2014)
<p id="p-0001" num="0000">The present invention relates:—to 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo-[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide dihydrochloride salt of formula (II): or a tautomer, solvate or hydrate thereof;—to methods of preparing said dihydrochloride salt;—to said dihydrochloride salt for the treatment and/or prophylaxis of a disease;—to the use of said dihydrochloride salt for the preparation of a medicament for the treatment and/or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, more particularly for the treatment or prophylaxis of a cancer, particularly lung cancer, in particular non-small cell lung carcinoma, colorectal cancer, melanoma, pancreatic cancer, hepatocyte carcinoma, pancreatic cancer, hepatocyte carcinoma or breast cancer;—to a pharmaceutical composition comprising said dihydrochloride salt; and to a pharmaceutical combination comprising said dihydrochloride salt in combination with one or more further pharmaceutical agents.</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="45.97mm" wi="69.85mm" file="US20140072529A1-20140313-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p>
>> read more

MEDICAL ADHESIVE FOR STEMMING BLEEDING (Fri, 07 Mar 2014)
<p id="p-0001" num="0000">The present invention relates to a polyurea system comprising as component A) isocyanate-functional prepolymers obtainable by reaction of aliphatic isocyanates A1) with polyols A2), which in particular can have a number-average molecular weight of ≧400 g/mol and a mean OH functionality of from 2 to 6, as component B) an amino-functional compound of the general formula (I) in which X is an organic radical containing a secondary amino function, Y is an organic radical that contains a tertiary amino group and does not contain Zerewitinoff-active hydrogen, R<sub>1 </sub>is a CH<sub>2</sub>—COOR<sub>3 </sub>radical in which R<sub>3 </sub>is an organic radical that does not contain Zerewitinoff-active hydrogen, a linear or branched C1- to C4-alkyl radical, a cyclopentyl radical, a cyclohexyl radical or H, R<sub>2 </sub>is an organic radical that does not contain Zerewitinoff-active hydrogen, a is 1 or 2, b is 1 or 2, and a+b=2 or 3, for stemming the escape of blood, and to a metering system for the polyurea system according to the invention.</p>
>> read more

N-(1,2,5-OXADIAZOL-3-YL)PYRIDINECARBOXAMIDES AND USE THEREOF AS HERBICIDES (Fri, 07 Mar 2014)
<p id="p-0001" num="0000">A description is given of N-(1,2,5-oxadiazol-3-yl)pyridinecarboxamides of the general formula (I) as herbicides. R in this formula (I) stands for radicals such as hydrogen, organic radicals, and other radicals such as halogen. W stands for a substituted pyridyl radical.</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="19.30mm" wi="52.07mm" file="US20140066301A1-20140306-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p>
>> read more

TISSUE ADHESIVE WITH ACCELERATED CURING (Fri, 07 Mar 2014)
<p id="p-0001" num="0000">The present invention relates to a polyurea system encompassing as component A) isocyanate-functional prepolymers obtainable by reaction of aliphatic isocyanates A1) with polyols A2), which can in particular have a number average molecular weight of ≧400 g/mol and an average OH functionality of 2 to 6, as component B) amino-functional compounds of general formula (I) in which X is an organic residue comprising a tertiary amino function, having no Zerewitinoff active hydrogen, R<sub>1 </sub>is a CH<sub>2</sub>—COOR<sub>3 </sub>residue, in which R<sub>3 </sub>is an organic residue having no Zerewitinoff active hydrogen, a linear or branched C1 to C4 alkyl residue, a cyclopentyl or cyclohexyl residue or H, R<sub>2 </sub>is an organic residue having no Zerewitinoff active hydrogen, n is an integer ≧2 or ≦3, in particular for closing, binding, bonding or covering cell tissue, and to a metering system for the polyurea system according to the invention.</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="18.29mm" wi="27.26mm" file="US20140066981A1-20140306-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p>
>> read more

Pyridinylcarboxylic acid derivatives as fungicides (Fri, 07 Mar 2014)
<p id="p-0001" num="0000">Pyridinylcarboxylic acid derivatives of the formula (I)</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="24.72mm" wi="69.85mm" file="US08748420-20140610-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> <br/> in which the symbols A, X, Y<sup>1</sup>, Y<sup>2</sup>, Y<sup>3</sup>, L<sup>1</sup>, L<sup>2</sup>, R<sup>G </sup>and R<sup>1 </sup>are each as defined in the description, and also salts, metal complexes and N-oxides of the compounds of the formula (I), and the use thereof for controlling phytopathogenic harmful fungi and processes for preparing compounds of the formula (I). </p>
>> read more

PROCEDURE FOR THE DECARBOXYLATION OF 3,5-BIS(HALOALKYL)-PYRAZOLE-4-CARBOXYLIC ACID DERIVATIVES (Fri, 07 Mar 2014)
A new process for the preparation of 3,5-bis(haloalkyl)-pyrazole derivatives of the general formula (I), is described, resulting from the reaction of 3,5-bis(haloalkyl)-pyrazole-4-carboxylic acid derivatives of the general formula (IIa) with a copper compound and a base at elevated temperature wherein R1 is selected from H, C1-12-alkyl, C3-8-cycloalkyl, C6-18-aryl, C7-19-arylalkyl or C7-19-alkylaryl, CH2CN, CH2CX3, CH2COOH, CH2COO(C1-12)-alkyl, and X is independently of each other F, Cl, Br, I; R2 and R3 are selected independently of each other from C1-C6-haloalkyl.
>> read more

BINDING PROTEINS TO INHIBITORS OF COAGULATION FACTORS (Fri, 21 Feb 2014)
<p id="p-0001" num="0000">The present invention relates to the identification and use of antigen-binding regions, antibodies, antigen-binding antibody fragments and antibody mimetics, neutralizing the anti-coagulant effect of an anticoagulant in vitro and/or in vivo. Antibodies and functional fragments of the invention and antibody mimetics can be used to specifically reverse the pharmacological effect of an anticoagulant e.g. a FXa inhibitor for therapeutic (antidote) and/or diagnostic purposes. The invention also provides nucleic acid sequences encoding foregoing molecules, vectors containing the same, pharmaceutical compositions and kits with instructions for use.</p>
>> read more

SUBSTITUTED 3-(BIPHENYL-3-YL)-8,8-DIFLUORO-4-HYDROXY-1-AZASPIRO[4.5]DEC-3-EN-2-ONES FOR THERAPY AND HALOGEN-SUBSTITUTED SPIROCYCLIC KETOENOLS (Fri, 14 Feb 2014)
<p id="p-0001" num="0000">The invention relates to novel compounds of the formula (I)</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="30.06mm" wi="69.85mm" file="US20140045696A1-20140213-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0003" num="0000">in which W, X, Y, Z, A, B, D and G have the meanings given above, <br/> to a plurality of processes and intermediates for their preparation, and to their use as pesticides and/or herbicides and/or fungicides. </p> <p id="p-0004" num="0000">The invention also relates to selective herbicidal compositions comprising, firstly, the halogen-substituted spirocyclic ketoenols and, secondly, a crop plant compatibility-improving compound.</p> <p id="p-0005" num="0000">The present invention furthermore relates to the boosting of the action of crop protection compositions comprising, in particular, halogen-substituted spirocyclic ketoenols, through the addition of ammonium salts or phosphonium salts and optionally penetrants, to the corresponding compositions, to processes for producing them and to their application in crop protection as pesticides and/or fungicides and/or for preventing unwanted plant growth.</p> <p id="p-0006" num="0000">The invention also relates to substituted 3-(biphenyl-3-yl)-8,8-difluoro-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-ones of the formula (Ia) for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and therapy of tumor disorders.</p>
>> read more

4-(4-CYANO-2-THIOARYL)DIHYDROPYRIMIDINONES AND THEIR USE (Fri, 14 Feb 2014)
<p id="p-0001" num="0000">The present invention relates to novel 4-(4-cyano-2-thioaryl)dihydropyrimidin-2-one derivatives, to processes for their preparation, to their use alone or in combination for the treatment and/or prevention of diseases and also to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of disorders of the lung and the cardiovascular system.</p>
>> read more

SUBSTITUTED 4-ARYL-N-PHENYL-1,3,5-TRIAZIN-2-AMINES (Fri, 14 Feb 2014)
<p id="p-0001" num="0000">The present invention relates to substituted 4-Aryl-N-phenyl-1,3,5-triazin-2-amines of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).</p>
>> read more

PESTICIDAL ARYLPYRROLIDINES (Fri, 14 Feb 2014)
<p id="p-0001" num="0000">Arylpyrrolidines of Formula (I): wherein each substituent is as defined in the specification, and use thereof as pesticides and animal paracite-controlling agents.</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="30.06mm" wi="64.35mm" file="US20140046069A1-20140213-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p>
>> read more

METHOD FOR THE PREPARATION OF PERFLUOROALKYL CONTAINING PYRAZOLES CARBOXYLATES (Fri, 14 Feb 2014)
The present invention pertains to a novel process for the preparation of Fluoroalkylpyrazole- or Bisperfluoroalkypyrazole carboxylates (I) comprising a cyclization of PerfluoroalkyI ketoesters (II) with hydrazines (lll).
>> read more

USE OF SUBSTITUTED SPIROCYCLIC SULFONAMIDOCARBOXYLIC ACIDS, CARBOXYLIC ESTERS THEREOF, CARBOXAMIDES THEREOF AND CARBONITRILES THEREOF OR SALTS THEREOF FOR ENHANCEMENT OF STRESS TOLERANCE IN PLANTS (Fri, 07 Feb 2014)
<p id="p-0001" num="0000">Use of substituted spirocyclic sulfonamidocarboxylic acids, -carboxylic esters, -carboxamides and -carbonitriles or salts thereof for enhancement of stress tolerance in plants.</p> <p id="p-0002" num="0000">The invention relates to the use of spirocyclic sulfonamidocarboxylic acids, -carboxylic esters, -carboxamides and -carbonitriles or salts thereof of the formula (I)</p> <p id="p-0003" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="22.10mm" wi="55.46mm" file="US20140038822A1-20140206-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0004" num="0000">in which the respective substituents have the meanings given in the description, for increasing stress tolerance in plants with respect to abiotic stress, and also for increasing plant growth and/or for increasing plant yield.</p>
>> read more

Use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc). (Fri, 07 Feb 2014)
<p id="p-0001" num="0000">The use of sGC stimulators, sGC activators alone, or in combination with PDE5 inhibitors for the prevention and treatment of fibrotic diseases, such as systemic sclerosis, scleroderma, and the concomitant fibrosis of internal organs.</p>
>> read more

Substituted dihydropyrazolones and their use (Fri, 07 Feb 2014)
<p id="p-0001" num="0000">The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and haematological diseases and kidney diseases, and for promoting wound healing.</p>
>> read more

TRIAZOLO AND TETRAZOLO PYRIMIDINE DERIVATIVES AS HNE INHIBITORS FOR TREATING COPD (Fri, 07 Feb 2014)
<p id="p-0001" num="0000">The present invention relates to novel heterocyclically fused diaryldihydropyrimidine derivatives, to processes for their preparation, to their use alone or in combination for the treatment and/or prevention of diseases and also to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of disorders of the lung and the cardiovascular system.</p>
>> read more

COMBINATIONS FOR THE TREATMENT OF CANCER (Fri, 07 Feb 2014)
The present invention relates to combinations of at least two compounds A and B, compound A being an inhibitor of Mps-1 kinase, and compound B being an inhibitor of an anti-apoptotic protein of the Bcl-2 family. Another aspect of the present invention relates to the use of such combinations as described supra for the preparation of a medicament for the treatment or prophylaxis of a disease, particularly for the treatment of cancer. Another aspect of the present invention relates to the use of an anti- apoptotic protein from the Bcl-2 family as a sensitizer of cells to Mps-1 inhibitors. Another aspect of the present invention relates to the use of the ratio of pro-apoptotic and anti-apoptotic proteins from the Bcl-2 family in a biological sample as a biomarker for a Mps-1 kinase inhibitor treatment.
>> read more

SUBSTITUTED DIHYDROPYRAZOLONES FOR TREATING CARDIOVASCULAR AND HEMATOLOGICAL DISEASES (Fri, 31 Jan 2014)
<p id="p-0001" num="0000">The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.</p>
>> read more

Novel 5-aminotetrahydroquinoline-2-carboxylic acids and their use (Fri, 31 Jan 2014)
<p id="p-0001" num="0000">The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders.</p>
>> read more

Thiazol-4-Carboxylic Acid Esters and Thioesters as Plant Protection Agents (Fri, 31 Jan 2014)
<p id="p-0001" num="0000">The use of thiazole-4-carboxylic esters and thioesters of the formula (I)</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="33.44mm" wi="75.27mm" file="US20140031553A1-20140130-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0003" num="0000">in which <ul id="ul0001" list-style="none"> <li id="ul0001-0001" num="0000">R<sup>1</sup>, R<sup>2</sup>, R<sup>3</sup>, R<sup>4</sup>, R<sup>5</sup>, R<sup>6</sup>, R<sup>7</sup>, Y<sup>1</sup>, Y<sup>2</sup>, Y<sup>3</sup>, W, X and G have the meanings given in the description, and also of agrochemically active salts thereof, as fungicides.</li> </ul> </p>
>> read more

Haloalkylmethyleneoxyphenyl-Substituted Ketoenols (Fri, 31 Jan 2014)
<p id="p-0001" num="0000">The invention relates to novel compounds of the formula (I),</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="24.30mm" wi="51.22mm" file="US20140031577A1-20140130-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0003" num="0000">in which W, X, Y, Z and CKE are each as defined above,</p> <p id="p-0004" num="0000">to several methods and intermediates for preparation thereof and to the use thereof as pesticides and/or herbicides.</p> <p id="p-0005" num="0000">The invention also relates to selective herbicidal compositions which comprise firstly haloalkylmethyleneoxyphenyl-substituted ketoenols and secondly a compound which improves crop plant compatibility.</p> <p id="p-0006" num="0000">The present invention further relates to the enhancement of the action of crop protection compositions comprising especially haloalkylmethyleneoxyphenyl-substituted ketoenols, by the addition of ammonium or phosphonium salts and optionally penetration enhancers, to the corresponding compositions, to methods for production thereof and to the use thereof in crop protection as insecticides and/or acaricides and/or for preventing undesired plant growth.</p>
>> read more

Method for producing 2-(triazinylcarbonyl) sulfonanilides (Fri, 24 Jan 2014)
<p id="p-0001" num="0000">The present application relates to a process based on the oxidative ring opening of a compound with oxindole structure for preparation of substituted 2-(triazinylcarbonyl)sulfonanilides of the formula (1-1) proceeding from N-sulfonyl-substituted 3-triazinyloxindole of the formula (2-1), and to the 2-(triazinylcarbonyl)sulfonanilides of the formula (1-1) thus prepared, and to the use thereof as intermediates for the synthesis of fine chemicals and of active ingredients in the agricultural sector.</p> <p id="p-0002" num="0000">The invention also relates to a multistage process for preparation of N-alkyl-N-[2-(1,3,5-triazin-2-ylcarbonyl)phenyl]alkanesulfonamides of the formula (4-1), proceeding from a 3-(alkylsulfanyl)-1,3-dihydro-2H-indol-2-one of the formula (7-1), wherein the multistage process also comprises, as a component step, the oxidative ring opening mentioned, and to the 2-(triazinylcarbonyl)sulfonanilides of the formula (1-1) which are obtained by the oxidative ring opening and are used as intermediates in the multistage process.</p>
>> read more

PROCESS FOR THE PREPARATION OF 5-FLUORO-1H-PYRAZOLES (Fri, 24 Jan 2014)
A new process for the preparation of 5-fluoro-1H-pyrazoles of the general formula (I), is described, resulting from the reaction of an olefin of the general formula (II) with hydrazines of the formula (III) R1-NH-NH2 (III), wherein R1 is selected from C1-C6 alkyl, C5-C10 aryl; R2 is a trihalomethyl moiety with at least one fluorine atom; and R3 is selected from C1-C5 haloalkyl, CF3, C2F5, C3F7, CF2CF2CI, CFCICF3, in the presence of water and a base.
>> read more

PESTICIDAL MIXTURES (Fri, 17 Jan 2014)
<p id="p-0001" num="0000">The present invention relates to a pesticidal mixture comprising, as active I) at least one active compound I selected from the group consisting of the <i>Streptomyces galbus </i>strain having accession number NRRL 30232, the <i>Streptomyces galbus </i>strain having accession number NRRL 50334, a mutant of said strains, a variant of said strains, a metabolite produced by said strains, a supernatant obtained from the whole broth culture of said strains and a solvent extract of said supernatants, wherein said mutant and variant have the identifying characteristics substantially identical to those of said strains, and 2) at least one active compound II selected from the groups A.I to A.27 as defined in the description, in synergistically effective amounts</p>
>> read more

METHOD FOR PRODUCING POLYCARBONATE POLYOLS BY THE IMMORTAL POLYMERIZATION OF CYCLIC CARBONATES (Fri, 17 Jan 2014)
<p id="p-0001" num="0000">The invention relates to a process for the preparation of polycarbonate polyols, characterised in that cyclic carbonates are polymerised in the presence of DMC catalysts and chain-transfer agents consisting of polyether carbonate polyols.</p>
>> read more

METHOD FOR PREPARING SUBSTITUTED TRIAZOLOPYRIDINES (Fri, 17 Jan 2014)
The present invention relates to methods of preparing substituted triazolopyridine compounds of general formula (I) as described and defined herein, as well as to intermediate compounds useful in the preparation of said compounds.
>> read more

COATING METHOD AND HARDENER FOR POLYURETHANE PAINT (Fri, 17 Jan 2014)
[Problem] In a coating method of a two-coat one-bake system where a clear coat paint is coated after a base coat paint is coated, then these two coated layers are simultaneously hardened, adhesive strength between the two coated layers is to increase in comparison with the conventional method. [Solution] Provided is a coating method; A specific hardener is used in the clear co at paint. The hardener is one containing a polyisocyanate derived from 1, 6-hexamethylene diisocyanate, satisfying all the following conditions: 1 ) Hardener does not virtually include diisocyanate monomer, 2) Viscosity of hardener is not more than 1000 mPa-s/23°C, 3) Content of HDI trimer in hardener is not less than 60 weight %, and 4) Content of HDI dimer in hardener is less than 10 weight %.
>> read more

USE OF OPEN-CHAIN CARBOXYLIC ACIDS, CARBONIC ESTERS, CARBOXAMIDES AND CARBONITRILES OF ARYL, HETEROARYL AND BENZYLSULFONAMIDE OR THE SALTS THEREOF FOR IMPROVING THE STRESS TOLERANCE IN PLANTS (Fri, 10 Jan 2014)
<p id="p-0001" num="0000">The invention relates to the use of open-chain aryl-, heteroaryl- and benzylsulfonamidocarboxylic acids, -carboxylic esters, -carboxamides and -carbonitriles or salts thereof of the formula (I)</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="22.10mm" wi="55.20mm" file="US20140011682A1-20140109-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0003" num="0000">in which the respective substituents have the meanings given in the description, for increasing stress tolerance in plants with respect to abiotic stress, and also for increasing plant growth and/or for increasing plant yield.</p>
>> read more

SUBSTITUTED 3-(BIPHENYL-3-YL)-8,8-DIFLUORO-4-HYDROXY-1-AZASPIRO[4.5]DEC-3-EN-2-ONES FOR THERAPY (Fri, 10 Jan 2014)
<p id="p-0001" num="0000">The invention relates to substituted 3-(biphenyl-3-yl)-8,8-difluoro-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-ones of the formula (Ia) for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and therapy of tumour disorders.</p> <p id="p-0002" num="0000">The invention also relates to novel compounds of the formula (I)</p> <p id="p-0003" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="29.46mm" wi="69.85mm" file="US20140011853A1-20140109-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0004" num="0000">in which W, X, Y, Z, A, B, D and G have the meanings given above, <br/> to a plurality of processes and intermediates for their preparation, and to their use as pesticides and/or herbicides and/or fungicides. </p> <p id="p-0005" num="0000">The invention also relates to selectively herbicidal compositions comprising, firstly, the halogen-substituted spirocyclic ketoenols and, secondly, a crop plant compatibility-improving compound.</p> <p id="p-0006" num="0000">The present invention furthermore relates to the boosting of the action of crop protection compositions comprising, in particular, halogen-substituted spirocyclic ketoenols, through the addition of ammonium salts or phosphonium salts and optionally penetrants, to the corresponding compositions, to processes for producing them and to their application in crop protection as pesticides and/or fungicides and/or for preventing unwanted plant growth.</p>
>> read more

N-[4-(Quinolin-4-yloxy)cyclohexyl(methyl)](hetero)arylcarboxamides as androgen receptor antagonists, production and use thereof as medicinal products (Sat, 04 Jan 2014)
The invention relates to N-[4-(quinolin-4-yloxy)cyclohexyl(methyl)](hetero)arylcarboxamides, intermediates and methods for their production, use thereof for treating and/or preventing diseases and use thereof for producing medicinal products and use thereof for treating and/or preventing diseases, especially of hyperproliferative diseases.
>> read more

HETEROARYL PIPERIDINE AND HETEROARYL PIPERAZINE DERIVATIVES AS FUNGICIDES (Fri, 03 Jan 2014)
<p id="p-0001" num="0000">Heteroarylpiperidine and -piperazine derivatives of the formula (I)</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="19.47mm" wi="64.69mm" file="US20140005224A1-20140102-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0003" num="0000">in which the symbols A, X, Y, L<sup>1</sup>, L<sup>2</sup>, G, Q, p, R<sup>1</sup>, R<sup>2 </sup>and R<sup>10 </sup>are each as defined in the description, and salts, metal complexes and N-oxides of the compounds of the formula (I), and the use thereof for controlling phytopathogenic harmful fungi and processes for preparing compounds of the formula (I).</p>
>> read more

METHOD FOR PRODUCING N-SULFONYL-SUBSTITUTED OXINDOLES (Fri, 03 Jan 2014)
<p id="p-0001" num="0000">Process for the selective N-sulfonylation of oxindoles, in particular process for the N-sulfonylation of 3-triazinyloxindoles, and also N-sulfonyl-substituted 3-triazinyloxindoles and the use of N-sulfonyl-substituted oxindoles and of N-sulfonyl-substituted 3-triazinyloxindoles as intermediates for the synthesis of fine chemicals and of active ingredients in the field of pharmacy and agriculture, and also the use of these compounds as active ingredients in the field of agriculture.</p>
>> read more

ALKOXY-SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINES (Fri, 13 Dec 2013)
<p id="p-0001" num="0000">The present invention relates to alkoxy-substituted 2,3-dihydroimidazo[1,2-c]quinazoline compounds of general formula (I) in which R1, R2 and R3 are as defined in the claims, to methods of preparing said compounds, to intermediates for the preparation of said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="29.97mm" wi="69.85mm" file="US20130330327A1-20131212-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p>
>> read more

GLUCOSE TRANSPORT INHIBITORS (Fri, 13 Dec 2013)
The present invention relates to chemical compounds of general formula (I): in which RA, RB, RC, RD, m, and n are as given in the description and in the claims, and which effectively and selectively inhibit glucose transporter 1 (GLUT1), to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.
>> read more

ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS (Fri, 06 Dec 2013)
<p id="p-0001" num="0000">The present invention relates to new insecticides of the formula (I)</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="41.83mm" wi="62.57mm" file="US20130324560A1-20131205-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0003" num="0000">in which R<sup>1</sup>, R<sup>2</sup>, R<sup>3</sup>, R<sup>4</sup>, R<sup>5</sup>, R<sup>6</sup>, A, Q and n can have the definitions stated in the description, to a number of processes for preparing them and to their use as active compounds, more particularly to their use as pest control compositions.</p>
>> read more

TISSUE ADHESIVE BASED ON NITROGEN-MODIFIED ASPARTATES (Fri, 06 Dec 2013)
<p id="p-0001" num="0000">The invention relates to a polyurea system comprising as component A) isocyanate-functional prepolymers which can be obtained by reacting aliphatic isocyanates A1) with polyols A2) that can have a number-average molecular weight of =400 g/mol and an average OH functionality of 2 to 6 in particular; and as component B) amino-functional aspartic acid esters of the general formula (I) in which X is an organic group containing a secondary amino function, R1, R2 are the same or different organic groups that do not have Zerewitinoff-active hydrogen, and n is a whole number of at least 2, in particular for sealing, bonding, gluing, or covering cell tissue. The invention also relates to a metering system for the polyurea system according to the invention.</p>
>> read more

6-(2-Aminophenyl)picolinates and their use as herbicides (Fri, 06 Dec 2013)
<p id="p-0001" num="0000">The present invention relates to novel herbicidally active 6-(2-aminophenyl)picoline derivatives and to processes for preparation thereof. The present invention further provides for the use thereof as a herbicide, especially as a herbicide for selective control of weed plants in useful plant crops, and as a plant growth regulator alone or in combination with safeners and/or in a mixture with other herbicides.</p>
>> read more

BIOMARKERS FOR DETERMINING EFFECTIVE RESPONSE OF TREATMENTS OF HEPATOCELLULAR CARCINOMA (HCC) PATIENTS (Fri, 06 Dec 2013)
This invention is directed to the use of one or more biomarkers defined as KRAS or NRAS gene for predicting the pharmaceutical efficacy or clinical response of MEK protein kinase inhibitor and/or Sorafenib or Regorafenib to be administred to a Hepatocellular carcinoma (HCC) patient. Futher the invention is directed to in-vitro methods for identifying mutated-type KRAS or NRAS gene in HCC patient and kits thereof.
>> read more

SUBSTITUTED PYRROLOPYRIMIDINES (Fri, 29 Nov 2013)
The present invention relates to substituted pyrrolopyrimidine compounds general formula I : in which A, X, R1, R2, m and n are as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
>> read more

THIENOPYRIMIDINES (Fri, 29 Nov 2013)
The present invention relates to substituted thienopyrimidine compounds of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and /or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
>> read more

SUBSTITUTED BENZOTHIENOPYRIMIDINES (Fri, 29 Nov 2013)
The present invention relates to substituted benzothienopyrimidine compounds of general formula I: in which R1a, R1b, R2a, R2b, and R2c are as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
>> read more

BIS AZAINOSITOL HEAVY METAL COMPLEXES FOR X-RAY IMAGING (Fri, 22 Nov 2013)
The present invention describes a new class of trinuclear heavy metal complexes comprising two hexadentate azainositol tricarboxylic acid ligands, a method for their preparation and their use as X-ray contrast agents.
>> read more

IMIDAZOPYRAZINES FOR USE AS MPS-1 AND TKK INHIBITORS IN THE TREATMENT HYPERPROLIFERATIVE DISORDERS (Fri, 15 Nov 2013)
<p id="p-0001" num="0000">The present invention relates to substituted imidazopyrazine compounds of general formula (I): in which R<sup>1</sup>, R<sup>2</sup>, R<sup>3</sup>, R<sup>4 </sup>and R<sup>5 </sup>are as defined in the claims, to methods of and intermediates for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="30.56mm" wi="69.85mm" file="US20130303532A1-20131114-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p>
>> read more

BENZIMIDAZOLE AND PYRAZOLOPYRIDINE DERIVATIVES FOR TREATING AND/OR PREVENTING CARDIOVASCULAR DISEASES (Fri, 15 Nov 2013)
<p id="p-0001" num="0000">The present application relates to novel fused, heteroatom-bridged pyrazole and imidazole derivatives, to processes for their preparation, to their use, alone or in combination, for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.</p>
>> read more

SUBSTITUTED CYCLOALKENOPYRAZOLES AS BUB1 INHIBITORS FOR THE TREATMENT OF CANCER (Fri, 15 Nov 2013)
Compounds of formula (I), processes for their production and their use as Bubl kinase inhibitors for the treatment of hyperproliferative diseases and/or disorders responsive to induction of cell death.
>> read more

PYRAZOLE INDANYL CARBOXAMIDES (Fri, 15 Nov 2013)
The present invention relates to novel 1-methyl-pyrazole(thio)indanyl carboxamides, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials.
>> read more

PYRAZOLE INDANYL CARBOXAMIDES (Fri, 15 Nov 2013)
The present invention relates to novel l-methyl-pyrazole(thio)indanyl carboxamides, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials.
>> read more

5-HALOGENOPYRAZOLE BENZOFURANYL CARBOXAMIDES (Fri, 15 Nov 2013)
The present invention relates to novel 1-methyl-3-dihalogenomethyl-5-halogenopyrazole(thio)benzofurany carboxamides, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials.
>> read more

PYRAZOLE TETRAHYDRONAPHTHYL CARBOXAMIDES (Fri, 15 Nov 2013)
The present invention relates to novel pyrazole(thio) tetrahydronaphthyl carboxamides, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials.
>> read more

5-HALOGENOPYRAZOLE BIPHENYLCARBOXAMIDES (Fri, 15 Nov 2013)
The present invention relates to novel l-methyl-3- dihalogenomehtyl-5-halogenopyrazole(thio)biphenyl carboxamides, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials.
>> read more

5-HALOGENOPYRAZOLE INDANYL CARBOXAMIDES (Fri, 15 Nov 2013)
The present invention relates to novel 1-methyl-3- dihalogenomethyl-5-halogenopyrazole(thio)indanyl carboxamides, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials.
>> read more

HERBICIDE TRIAZOLYLPYRIDINE KETONES (Fri, 08 Nov 2013)
<p id="p-0001" num="0000">Triazolylpyridine ketones expressed by the following formula (1) and use thereof as herbicides.</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="29.55mm" wi="69.85mm" file="US20130296168A1-20131107-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p>
>> read more

HETEROARYLPIPERIDINE AND -PIPERAZINE DERIVATIVES AS FUNGICIDES (Fri, 08 Nov 2013)
<p id="p-0001" num="0000">Heteroarylpiperidine and -piperazine derivatives of the formula (I)</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="19.56mm" wi="64.69mm" file="US20130296272A1-20131107-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0003" num="0000">in which the symbols A, X, Y, L<sup>1</sup>, L<sup>2</sup>, G, Q, p, R<sup>1</sup>, R<sup>2 </sup>and R<sup>10 </sup>are each as defined in the description, and salts, metal complexes and N-oxides of the compounds of the formula (I), and the use thereof for controlling phytopathogenic harmful fungi and processes for preparing compounds of the formula (I).</p>
>> read more

5-Halogenopyrazolecarboxamides (Fri, 08 Nov 2013)
<p id="p-0001" num="0000">The present invention relates to novel 5-halogenopyrazole(thio)carboxamides, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.</p>
>> read more

SUBSTITUTED IMIDAZO- AND TRIAZOLOPYRIMIDINES, IMIDAZO- AND PYRAZOLOPYRAZINES AND IMIDAZOTRIAZINES (Fri, 08 Nov 2013)
<p id="p-0001" num="0000">The invention relates to substituted imidazo- and triazolopyrimidines, imidazo- and pyrazolopyrazines and imidazotriazines and processes for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of hematological disorders, preferably of leukopenias and neutropenias.</p>
>> read more

DECAHYDRO-1,4-METHANONAPHTHALEN CARBOXAMIDES (Fri, 08 Nov 2013)
<p id="p-0001" num="0000">The present invention relates to decahydro-1,4-methanonaphthalen carboxamide derivatives of formula (Ia) or (Ib); their process of preparation, their use as fungicide, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.</p>
>> read more

Cyanoenamines and their use as fungicides (Fri, 08 Nov 2013)
<p id="p-0001" num="0000">The present invention relates to cyanoenamine derivatives, their process of preparation, intermediate compounds, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants and in material protection, using these compounds or compositions.</p>
>> read more

Cyanoenamines and Their use as Fungicides (Fri, 08 Nov 2013)
<p id="p-0001" num="0000">The present invention relates to cyanoenamine derivatives, their process of preparation, intermediate compounds, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants and in material protection, using these compounds or compositions.</p>
>> read more

PROCESS FOR PREPARING N-(5-CHLORO-2-ISOPROPYLBENZYL)CYCLOPROPANAMINE (Fri, 01 Nov 2013)
The present invention relates to a process for preparing N-(5-chloro-2-isopropylbenzyl)cyclopropanamine by hydrogenation of N-[(5-chloro-2-isopropylphenyl)methylene]cyclopropanamine over specific platinum catalysts.
>> read more

6-THIO-SUBSTITUTED IMIDAZOPYRAZINES FOR USE AS MPS-1 AND TKK INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS (Fri, 25 Oct 2013)
<p id="p-0001" num="0000">The present invention relates to substituted imidazopyrazine compounds of general formula (I): (I) in which R<sup>1</sup>, R<sup>2</sup>, R<sup>3</sup>, R<sup>4 </sup>and R<sup>5 </sup>are as defined in the claims, to methods of and intermediates for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="29.97mm" wi="69.85mm" file="US20130281460A1-20131024-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p>
>> read more

Phenylpyri(mi)dinylazoles (Fri, 25 Oct 2013)
<p id="p-0001" num="0000">Phenylpyri(mi)dinylazoles of the formula [I-a] and [I-b],</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="73.41mm" wi="59.61mm" file="US20130281455A1-20131024-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0003" num="0000">wherein the symbols have the meanings stated in the description, and agrochemically active salts thereof and the use thereof for the control of undesired microorganisms in the protection of plants and materials and for the reduction of mycotoxins in plants and plant parts and methods for the production of compounds of the formula [I-a] and [I-b].</p>
>> read more

N-CYCLOALKYL-N-[(TRISUBSTITUTEDSILYLPHENYL)METHYLENE]-(THIO)CARBOXAMIDE DERIVATIVES (Fri, 25 Oct 2013)
The present invention relates to fungicidal N-cycloalkyl-N-[(trisubstitutedsilylphenyl)methylene] carboxamide derivatives and their thiocarbonyl derivatives, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
>> read more

N-CYCLOALKYL-N-[(HETEROCYCLYLPHENYL)METHYLENE]-(THIO)CARBOXAMIDE DERIVATIVES (Fri, 25 Oct 2013)
The present invention relates to fungicidal N-cycloalkyl-N-[(heterocyclylphenyl)methylene] carboxamide derivatives and their thiocarbonyl derivatives, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
>> read more

Ketoheteroarylpiperdine and -Piperazine Derivatives as Fungicides (Fri, 18 Oct 2013)
<p id="p-0001" num="0000">Ketoheteroarylpiperidine and -piperazine derivatives of the formula (I),</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="14.99mm" wi="69.85mm" file="US20130274292A1-20131017-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0003" num="0000">in which the symbols A, L<sup>1</sup>, G, X, Y, T and R<sup>1 </sup>have the meanings given in the description and agrochemically active salts thereof and their use for controlling phytopathogenic harmful fungi and also processes for preparing compounds of the formula (I).</p>
>> read more

N-ACYL- 2 - (CYCLO) ALKYLPYRROLIDINES AND PIPERIDINES USEFUL AS FUNGICIDES (Fri, 18 Oct 2013)
The present invention relates to fungicidal 1-(pyrazolylcarbonyl)piperidines or pyrrolidines, and their thiocarbonyl derivatives, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
>> read more

SUBSTITUTED 6-IMIDAZOPYRAZINES FOR USE AS MPS-1 AND TKK INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS (Fri, 11 Oct 2013)
<p id="p-0001" num="0000">The present invention relates to substituted imidazopyrazine compounds of general formula (I), in which R<sup>1</sup>, R<sup>2</sup>, R<sup>3</sup>, R<sup>4 </sup>and R<sup>5 </sup>are as defined in the claims, to methods of and intermediates for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="30.65mm" wi="69.85mm" file="US20130267527A1-20131010-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p>
>> read more

SUBSTITUTED 6-FLUORO-1H-PYRAZOLO[4,3-B]PYRIDINES AND USE THEREOF (Fri, 11 Oct 2013)
<p id="p-0001" num="0000">The present application relates to novel substituted 6-fluoro-1H-pyrazolo[4,3-b]pyridines, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases and to the use thereof for preparing Medicaments for the treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.</p>
>> read more

ALKYLAMINE-SUBSTITUTED DICYANOPYRIDINE AND AMINO ACID ESTER PRODRUGS THEREOF (Fri, 11 Oct 2013)
<p id="p-0001" num="0000">The present application relates to novel 6-alkylamino-substituted dicyanopyridines, to their amino acid ester prodrugs, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.</p>
>> read more

AMINO-SUBSTITUTED IMIDAZOPYRIDAZINES (Fri, 11 Oct 2013)
The present invention relates to amino-substituted imidazopyridazine compounds of general formula (I); in which A, R1, R2, R3, R4, R5 and n are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper- proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
>> read more

HIGH PRESSURE SENSOR FOR USE WITH A FLUID DELIVERY SYSTEM (Fri, 11 Oct 2013)
A pressure sensor for use with a fluid delivery system having good sensitivity at low pressure, but also configured to remain in operating condition after being exposed to high pressures is disclosed herein. In one variation, the pressure sensor includes a fluid path set, a deformable element associated with the fluid path set and configured to deform in response to an external pressure, and a pressure transducer for monitoring deformation of the deformable element. In certain embodiments, the pressure sensor is configured to measure fluid pressure within the range of between about 0 mm Hg to about 300 mm Hg. However, the sensor pressure is also be configured to remain functional after being exposed to pressure in excess of about 60,000 mm Hg.
>> read more

N-CARBOXYALKYL-AURISTATIN AND THE USE THEREOF (Fri, 04 Oct 2013)
<p id="p-0001" num="0000">The present application relates to new derivatives of monomethylauristatin F, substituted on the N terminus by a carboxyalkyl group, processes for preparing these derivatives, their use for the treatment and/or prevention of diseases and to produce medication for the treatment and/or prevention of diseases, particularly hyperproliferative and/or angiogenic disorders such as cancer disorders, for example. Such treatments can occur as monotherapies or in combination with other medication or further therapeutic measures.</p>
>> read more

IMIDAZO-, PYRAZOLOPYRAZINES AND IMIDAZOTRIAZINES AND THEIR USE (Fri, 04 Oct 2013)
<p id="p-0001" num="0000">The invention relates to substituted imidazo-, pyrazolopyrazines and imidazotriazines and processes for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of hematological disorders, preferably of leukopenias and neutropenias.</p>
>> read more

SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS (Fri, 04 Oct 2013)
<p id="p-0001" num="0000">This invention relates to novel 2,3-dihydroimidazo[1,2-c]quinazoline compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for phosphotidylinositol-3-kinase (PI3K) inhibition and treating diseases associated with phosphotidylinositol-3-kinase (PI3K) activity, in particular treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.</p>
>> read more

NOVEL HETEROCYCLIC COMPOUNDS AS PESTICIDES (Fri, 04 Oct 2013)
<p id="p-0001" num="0000">The present application relates to novel heterocyclic compounds, to processes for preparation thereof and to the use thereof for controlling animal pests, which also include arthropods and especially insects.</p>
>> read more

FUNGICIDE N-CYCLOALKYL-N-BICYCLICMETHYLENE-CARBOXAMIDE DERIVATIVES (Fri, 04 Oct 2013)
The present invention relates to N-cycloalkyl-N-bicyclicmethylene-carboxamide or thiocarboxamide derivatives, their process of preparation, preparation of intermediate compounds, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.
>> read more

AMINO-SUBSTITUTED IMIDAZOPYRIDAZINES (Fri, 04 Oct 2013)
The present invention relates to amino-substituted imidazopyridazine compounds of general formula (I), in which A, R1, R2, R3, R4, R5 and n are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper- proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
>> read more

N-CYCLOALKYL-N-[(CYCLOALKENYLPHENYL)METHYLENE]-(THIO)CARBOXAMIDE DERIVATIVES (Fri, 04 Oct 2013)
The present invention relates to fungicidal N-cycloalkyl-N-[(cycloalkenylphenyl)methylene] carboxamide derivatives and their thiocarbonyl derivatives, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
>> read more

DIFUNCTIONAL (METH)ACRYLATE WRITING MONOMERS (Fri, 27 Sep 2013)
<p id="p-0001" num="0000">The invention relates to compounds, of formula (I) in which X is CH<sub>3 </sub>or hydrogen, Z is a linear or branched C2 to C4 alky radical, R is a linear or branched, optionally heteroatom-substituted aliphatic, aromatic or araliphatic radical, Y in each occurrence is independently hydrogen, methyl, ethyl, propyl, n-butyl, tert-butyl, chlorine, bromine, iodine, methylthio, phenyl or phenylthio, n is from 0 to 4 and m is from 0 to 5. The invention further relates to the use of such a compound as writing monomer in a photopolymer formulation. In addition, a photopolymer formulation comprising as least a polyisocyanate component, a polyol component, a photoinitiator and a compound of formula (I) as writing monomer, and also the use of the photopolymer formulation for producing holographic media, are likewise subjects of the invention.</p>
>> read more

6,7-DIHYDRO-5H-BENZO[7]ANNULENE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, PHARMACEUTICAL PREPARATIONS COMPRISING THEM, AND THE USE THEREOF FOR PRODUCTION OF MEDICAMENTS (Fri, 27 Sep 2013)
<p id="p-0001" num="0000">The invention relates to selective oestrogen receptor modulators (SERM) and methods of production thereof, use thereof for the treatment and/or prophylaxis of diseases and use thereof for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular of bleeding disorders, osteoporosis, endometriosis, myomata, hormone-dependent tumours, for hormone replacement therapy and for contraception.</p>
>> read more

SUBSTITUTED PHENOXYPYRIDINES (Fri, 27 Sep 2013)
<p id="p-0001" num="0000">The present invention relates to substituted phenoxypyridine compounds of general formula (I) in which R1, R2 and R3 are as defined in the claims, to methods of preparing said compounds, to intermediates for the preparation of said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="30.06mm" wi="63.58mm" file="US20130252922A1-20130926-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p>
>> read more

Substituted piperidines (Fri, 27 Sep 2013)
<p id="p-0001" num="0000">The invention relates to novel substituted piperidines, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular diseases and tumour diseases.</p>
>> read more

COMPOSITIONS COMPRISING A STRIGOLACTAME COMPOUND FOR ENHANCED PLANT GROWTH AND YIELD (Fri, 27 Sep 2013)
The present invention relates to strigolactame derivatives of formula (I) that are active oh plants and to compositions comprising said derivatives. The present invention also relates to the use of said derivatives or compositions for enhancing the plant growth, yield, vigor and/or mycchorization and to corresponding methods.
>> read more

PROCESS FOR PREPARING PAN-CDK INHIBITORS OF THE FORMULA (I), AND INTERMEDIATES IN THE PREPARATION (Fri, 20 Sep 2013)
<p id="p-0001" num="0000">The invention relates to a novel process for the preparation of pan-CDK inhibitors of the formula (I), and intermediates of the preparation.</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="49.11mm" wi="56.05mm" file="US20130245261A1-20130919-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p>
>> read more

SUBSTITUTED IMIDAZOPYRIDAZINES (Fri, 20 Sep 2013)
The present invention relates to substituted imidazopyridazine compounds of general formula I in which R3, R5 and A are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
>> read more

PESTICIDAL ARYLPYRROLIDINES (Fri, 20 Sep 2013)
Arylpyrrolidines of formula (I) wherein each substituent is as defined in the specification, and use thereof as pesticides and animal parasite-controlling agents.
>> read more

N-ARYL PYRAZOLE(THIO)CARBOXAMIDES (Fri, 13 Sep 2013)
<p id="p-0001" num="0000">The present invention relates to novel (thio)carboxamides, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.</p>
>> read more

Substituted 5-fluoro-1H-pyrazolopyridines and their use (Fri, 13 Sep 2013)
<p id="p-0001" num="0000">The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.</p>
>> read more

PEPTIDES BASED TARGETING OF THE PLATELET DERIVED GROWTH FACTOR RECEPTOR BETA (PDGFRβ) AND CD276 (Fri, 13 Sep 2013)
The present invention concerns novel peptides and pentamer binding to PDGFRβ and CD276 proteins that are up regulated in cancer. Novel peptides and pentamer are radiolabeled for imaging of cancer and/or for radiotherapy. Method for imaging and treatment as well as method for obtaining radiopharmaceutical agent and medicament is disclosed.
>> read more

SUBSTITUTED PHENYLACETATE AND PHENYLPROPANE AMIDES AND USE THEREOF (Fri, 06 Sep 2013)
<p id="p-0001" num="0000">The present application relates to novel substituted phenylacetamides and phenylpropanamides, to processes for preparing them, to their use alone or in combinations for the treatment and/or prevention of diseases and also to their use for the production of medicaments for the treatment and/or prevention of diseases, more particularly for the treatment and/or prevention of cardiovascular disorders.</p>
>> read more

5-HALOGENOPYRAZOLE(THIO)CARBOXAMIDES (Fri, 06 Sep 2013)
<p id="p-0001" num="0000">The present invention relates to novel 5-halogenopyrazole(thio)carboxamides, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.</p>
>> read more

SUBSTITUTED BENZOTHIENYL-PYRROLOTRIAZINES AND USES THEREOF (Fri, 30 Aug 2013)
This invention relates to novel substituted 5-(1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.
>> read more

1-(heterocyclic carbonyl)-2-substituted pyrrolidines (Fri, 23 Aug 2013)
<p id="p-0001" num="0000">The present invention relates to fungicidal 1-(heterocyclic carbonyl)-2-substituted pyrrolidines and their thiocarbonyl derivatives, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.</p>
>> read more

ALKALINE EARTH METAL-COMPLEXED METAL BISAMIDES (Fri, 23 Aug 2013)
The present invention relates to alkaline earth metal-complexed metal bisamides of the formula (I), to a process for preparation thereof and to the use thereof for metallation of aromatics, heteroaromatics, alkenes, alkynes and other organic compounds having activated C-H bonds.
>> read more

CF3O-containing enaminoketones and their utilization for the preparation of CF3O-containing pyrazoles (Fri, 23 Aug 2013)
The present invention pertains to novel enaminoketones containing a CF3O-group, novel pyrazole-derivatives containing a CF3O group as well as to a novel process for their preparation comprising aminoformylation of CF30-ketones and cyclization of the obtained CF30-enaminoketones with hydrazines to trifluoromethoxy pyrazoles.
>> read more

SUBSTITUTED DICYANOPYRIDINES AND USE THEREOF (Fri, 16 Aug 2013)
<p id="p-0001" num="0000">The present application relates to novel substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prophylaxis of cardiovascular disorders.</p>
>> read more

SUBSTITUTED IMIDAZOPYRAZINES (Fri, 16 Aug 2013)
<p id="p-0001" num="0000">The present invention relates to substituted imidazopyrazine compounds of general formula (I) in which A, R<sup>1</sup>, R<sup>3 </sup>and R<sup>5 </sup>are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="36.15mm" wi="69.85mm" file="US20130210815A1-20130815-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p>
>> read more

SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINES (Fri, 16 Aug 2013)
<p id="p-0001" num="0000">The invention relates to imidazo[1,2-b]pyridazines of general formula (I) a process for their manufacuture and their use for the treatment of benign and malignant neoplasia.</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="38.02mm" wi="69.85mm" file="US20130210825A1-20130815-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p>
>> read more

Substituted fused imidazoles and pyrazoles and use thereof (Fri, 16 Aug 2013)
<p id="p-0001" num="0000">The present application relates to novel substituted fused imidazoles and pyrazoles, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases and to the use thereof producing medicaments for the treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.</p>
>> read more

METHOD FOR THE PRODUCTION OF 5-FLUORO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBONITRILE (Fri, 16 Aug 2013)
<p id="p-0001" num="0000">The present invention relates to a process for preparing 5-fluoro-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile of the formula (I)</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="35.05mm" wi="59.18mm" file="US20130211090A1-20130815-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0003" num="0000">which serves as a synthesis intermediate for production of medicaments, especially for production of medicaments for treatment and/or prophylaxis of cardiovascular disorders.</p>
>> read more

PROCESS FOR THE PREPARATION OF N-HYDROXY-1-(1-ALKYL-1H-TETRAZOL-5-YL)-1-PHENYLMETHANIMINE DERIVATIVES (Fri, 16 Aug 2013)
The present invention relates to a process for the preparation of N-hydroxy-l-(l-alkyl-lH-tetrazol-5-yl)-l-phenylmethanimine derivatives of the general formula (I)
>> read more

Substituted 8-alkoxy-2-aminotetralin derivatives, and use thereof (Fri, 09 Aug 2013)
<p id="p-0001" num="0000">The present application relates to novel substituted 8-alkoxy-2-aminotetraline derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.</p>
>> read more

IMIDAZOPYRAZINES (Fri, 02 Aug 2013)
<p id="p-0001" num="0000">The present invention relates to imidazopyrazine compounds of general Formula (I): in which X, R<sup>1</sup>, R<sup>2</sup>, R<sup>3a</sup>, R<sup>3b</sup>, R<sup>4a</sup>, R<sup>4b</sup>, R<sup>4C</sup>, and R<sup>4D </sup>are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="45.04mm" wi="58.59mm" file="US20130195848A1-20130801-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p>
>> read more

HETEROCYCLICALLY SUBSTITUTED ARYL COMPOUNDS AS HIF INHIBITORS (Fri, 02 Aug 2013)
<p id="p-0001" num="0000">The present application relates to novel aryl compounds with heterocyclic substituents, processes for their preparation, their use for treatment and/or prevention of diseases and their use for the preparation of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be carried out as monotherapy or also in combination with other medicaments or further therapeutic measures.</p>
>> read more

Novel Heterocyclic Alkanol Derivatives (Fri, 02 Aug 2013)
<p id="p-0001" num="0000">The present invention relates to novel heterocyclic alkanol derivatives, to processes for preparing these compounds, to compositions comprising these compounds and to their use as biologically active compounds, in particular for controlling harmful microorganisms in crop protection and in the protection of materials and as plant growth regulators.</p>
>> read more

Method for the regioselective synthesis of 1-Alkyl-3-haloalkyl-pyrazole-4-carboxylic acid derivatives (Fri, 02 Aug 2013)
<p id="p-0001" num="0000">The present invention relates to a process for the regioselective synthesis of 1-alkyl-3-halo-alkylpyrazole-4-carboxylic acid derivatives by cyclization of 2,3-disubstituted acrylic acid derivatives, and to the hydrazones formed as intermediates in the process.</p>
>> read more

Phenyl and benzodioxinyl substituted indazole derivatives (Thu, 01 Aug 2013)
A compound of formula Ia : The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments
>> read more

Substituted phenylimidazopyrazoles and their use (Fri, 26 Jul 2013)
<p id="p-0001" num="0000">The present application relates to novel 1-phenyl-1H-imidazo[1,2-b]pyrazole derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular angiogenic disorders and hyperproliferative disorders, where neovascularization plays a role, such as, for example, neoplastic disorders and tumour disorders. Such treatments can be carried out as monotherapy or else in combination with other medicaments or further therapeutic measures.</p>
>> read more

Substituted Imidazo[1,2-a]pyrimidines and -pyridines (Fri, 26 Jul 2013)
<p id="p-0001" num="0000">Compounds of formula (I) which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="46.57mm" wi="65.28mm" file="US20130190332A1-20130725-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p>
>> read more

BISARYL-BONDED ARYLTRIAZOLONES AND USE THEREOF (Fri, 26 Jul 2013)
<p id="p-0001" num="0000">The present application relates to novel bisaryl-linked 5-aryl-1,2,4-triazolone derivatives, to processes for preparing them, to their use alone or in combinations for the treatment and/or prevention of diseases and also to their use for the production of medicaments for the treatment and/or prevention of diseases, more particularly for the treatment and/or prevention of cardiovascular disorders.</p>
>> read more

SPIROINDOLINE DERIVATIVES AS GONADOTROPIN- RELEASING HORMONE RECEPTOR ANTAGONISTS (Fri, 26 Jul 2013)
Spiroindoline derivatives, process for their preparation and pharmaceutical compositions thereof, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially sex-hormone-related diseases in both men and women, in particularly those selded from the group of endometriosis, uterine fibroids, polycystic ovarian disease, hirsutism, precocious puberty, gonadal steroid-dependent neoplasia such as cancers of the prostate, breast and ovary, gonadotrope pituitary adenomas, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hypertrophy, contraception and infertility (e.g., assisted reprodudive therapy such as in vitro fertilization). The present application relates in particular to spiroindoline derivatives as gonadotropin-releasing hormone (GnRH) receptor antagonists.
>> read more

DRUG COMBINATIONS WITH FLUORO-SUBSTITUTED OMEGA-CARBOXYARYL DIPHENYL UREA FOR THE TREATMENT AND PREVENTION OF DISEASES AND CONDITIONS (Fri, 19 Jul 2013)
<p id="p-0001" num="0000">The present invention relates to drug combinations and pharmaceutical compositions for treating hyperproliferative disorders such as cancer including non-small cell lung carcinoma, said drug combination comprising (1) a fluoro-substituted-diaryl urea of Formula (I), (2) at least one antifolate and optionally (3) at least one platinum complex antineoplastic nucleic acid binding agent, where any of these components can be present in the form of a pharmaceutically acceptable salt or other derivative thereof.</p>
>> read more

BICYCLIC PYRIMIDINES (Fri, 19 Jul 2013)
<p id="p-0001" num="0000">Compounds of formula (I), which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="38.10mm" wi="70.10mm" file="US20130184273A1-20130718-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p>
>> read more

PROCESS FOR THE PREPARATION OF POLYETHER CARBONATE POLYOLS (Fri, 19 Jul 2013)
<p id="p-0001" num="0000">The present invention relates to a process for the preparation of polyether carbonate polyols from one or more alkylene oxides, carbon dioxide and optionally from one or more H-functional starter substances in the presence of at least one double metal cyanide catalyst, wherein the double metal cyanide catalyst comprises an unsaturated alcohol as a complexing ligand.</p>
>> read more

SUBSTITUTED IMIDAZOPYRAZINES AS AKT KINASE INHIBITORS (Fri, 19 Jul 2013)
Compounds of formula (I) which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
>> read more

SUBSTITUTED PYRAZOLOPYRIMIDINES AS AKT KINASE INHIBITORS (Fri, 19 Jul 2013)
Compounds of formula (I) which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
>> read more

Substituted heterocyclyl benzyl pyrazoles, and use thereof (Fri, 05 Jul 2013)
<p id="p-0001" num="0000">The present application relates to novel substituted 1-[3-(heterocyclyl)benzyl]-1H-pyrazole derivatives, to processes for preparation thereof, to use thereof for treatment and/or prevention of diseases and to use thereof for production of medicaments for treatment and/or prevention of diseases, more particularly for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be effected in the form of monotherapy or else in combination with other medicaments or further therapeutic measures.</p>
>> read more

Haloalky -substituted amides as insecticides and acaricides (Fri, 05 Jul 2013)
<p id="p-0001" num="0000">The present invention relates to halogen-substituted amide derivatives of the general formula (I)</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="24.47mm" wi="67.73mm" file="US08710242-20140429-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> <ul id="ul0001" list-style="none"> <li id="ul0001-0001" num="0000"> <ul id="ul0002" list-style="none"> <li id="ul0002-0001" num="0000">in which R<sup>1 </sup>to R<sup>6</sup>, Q<sup>1 </sup>to Q<sup>8</sup>, A, V, W, X, Y, n and m are each defined as described in the description—and to a process for preparation thereof and to the use thereof as insecticides and acaricides.</li> </ul> </li> </ul> </p>
>> read more

Process for preparing chiral 3-triazolyl sulphoxide derivatives (Fri, 05 Jul 2013)
<p id="p-0001" num="0000">The present invention relates to a catalytic process for preparing 3-triazolyl sulphoxide derivatives in enantiomerically pure or enantiomerically enriched form.</p>
>> read more

Ring-fused 4-aminopyrimidines and use thereof as stimulators of soluable guanylate cyclases (Fri, 05 Jul 2013)
<p id="p-0001" num="0000">The present application relates to novel fused 4-aminopyrimidines, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for the treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.</p>
>> read more

FUNGICIDAL 3-[(PYRIDIN-2-YLMETHOXYIMINO)(PHENYL)METHYL]-2-SUBSTITUTED-1,2,4-OXADIAZOL-5(2H)-ONE DERIVATIVES (Fri, 05 Jul 2013)
The present invention relates to 3-[(pyridin-2-ylmethoxyimino)(phenyl)methyl]-2-substituted-1,2,4-oxadiazol-5(2H)-one derivatives of formula (I), their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.
>> read more

FUNGICIDAL 3-[(1,3-THIAZOL-4-YLMETHOXYIMINO)(PHENYL)METHYL]-2-SUBSTITUTED-1,2,4-OXADIAZOL-5(2H)-ONE DERIVATIVES (Fri, 05 Jul 2013)
The present invention relates to 3-[(1,3-thiazol-4-ylmethoxyimino)(phenyl)methyl]-2-substituted- 1,2,4-oxadiazol-5(2H)-one derivatives of formula (I), their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.
>> read more

Preparing 5-fluoro-1-alkyl-3-fluoroalkyl-1H-pyrazole-4-carbaldehydes (Fri, 28 Jun 2013)
<p id="p-0001" num="0000">The present invention relates to a novel process for preparing 5-fluoro-1-alkyl-3-fluoroalkyl-1H-pyrazole-4-carbonyl chlorides, a useful intermediate in the manufacture of fungicides.</p>
>> read more

SUBSTITUTED BENZYLPYRAZOLES (Fri, 28 Jun 2013)
Compounds of formula (I) and their use as pharmaceutical.
>> read more

Compounds with nematicidal activity (Thu, 27 Jun 2013)
The present invention relates to the use of predominantly known pyridyl carboxamide derivatives as nematicides, compositions containing such compounds and methods for the control of nematodes.
>> read more

Compounds with nematicidal activity (Thu, 27 Jun 2013)
The present invention relates to the use of predominantly known pyridyl carboxamide derivatives as nematicides, compositions containing such compounds and methods for the control of nematodes.
>> read more

Substituted Triazolopyridines (Fri, 21 Jun 2013)
<p id="p-0001" num="0000">The present invention relates to substituted triazolopyridine compounds of general formula (I): in which R<sup>1</sup>, R<sup>2</sup>, R<sup>3</sup>, R<sup>4</sup>, and R<sup>5 </sup>are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease of uncontrolled cell growth, proliferation and/or survival as well as to the use of intermediate compounds for the preparation of said compounds.</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="27.77mm" wi="69.85mm" file="US20130156756A1-20130620-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p>
>> read more

USE OF STIMULATORS AND ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE FOR TREATING SICKLE-CELL ANEMIA AND CONSERVING BLOOD SUBSTITUTES (Fri, 21 Jun 2013)
<p id="p-0001" num="0000">The present invention relates to the novel use of stimulators and activators of soluble guanylate cyclase for the treatment of sickle cell anemia and for the preservation of blood substitutes. The present invention furthermore relates to the use of stimulators and activators of soluble guanylate cyclase in combination with PDE5 inhibitors for the treatment of sickle cell anemia and for the preservation of blood substitutes.</p>
>> read more

Process for Preparing Crystalline 3,6,9-triaza-3,6,9-tris(carboxymethyl)-4-(4-ethoxybenzyl)undecanedioic Acid and Use for Production of Primovist® (Fri, 21 Jun 2013)
<p id="p-0001" num="0000">The invention relates to a method for producing crystalline 3,6,9-triaza-3,6,9-tris(carboxymethyl)-4-(4-ethoxybenzyl)undecanedioic acid of the formula I</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="49.11mm" wi="64.77mm" file="US20130158241A1-20130620-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0003" num="0000">by saponifying 3,6,9-triaza-3,6,9-tris(tert-butoxycarbonylmethyl)-4-(4-ethoxybenzyl)-undecanedioic acid di-tert-butyl ester of the formula II in an aqueous alkali metal hydroxide solution and using 3,6,9-triaza-3,6,9-tris(carboxymethyl)-4-(4-ethoxybenzyl)undecanedioic acid of the formula I for producing the gadolinium complex of 3,6,9-triaza-3,6,9-tris(carboxymethyl)-4-(4-ethoxybenzyl)undecanedioic acid [(Gd-EOB-DTPA)=Primovist®].</p>
>> read more

AMINO-SUBSTITUTED IMIDAZOPYRIDAZINES (Fri, 21 Jun 2013)
The present invention relates to amino-substituted imidazopyndazine compounds of general formula (I) : in which A, R1, R2, R3, R4 and n are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
>> read more

SUBSTITUTED BENZOTHIENYL - PYRROLOTRIAZINES AND USES THEREOF IN THE TREATMENT CANCER (Fri, 21 Jun 2013)
This invention relates to novel substituted 5-(l-benzothiophen-2-yl)pyrrolo[2,l-fJ[l,2,4]triazin-4-amine derivatives having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.
>> read more

DISUBSTITUTED BENZOTHIENYL-PYRROLOTRIAZINES AND THEIR USE AS FGFR KINASE INHIBITORS (Fri, 21 Jun 2013)
This invention relates to novel substituted 5-(1-benzothiophen-2-yl) pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives of formula (I) wherein R1 is hydrogen, chloro, methyl or methoxy, R2 is hydrogen or methoxy, with the proviso that at least one of R1 and R2 is other than hydrogen, G1 represents chloro, (C1-C4)-alkyl, (C1-C4)-alkoxycarbonyl, 5-membered aza-heteroaryl, or the group -CH2-OR3, -CH2-NR4R5 or -C(=0)- NR4R6, and G2 represents chloro, cyano, (C1-C4)-alkyl, or the group - CR8AR8B-OH, -CH2-NR9R10, -C(=0)-NR11R12 or -CH2-OR15, having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.
>> read more

SUBSTITUTED TRIAZOLOPYRIDINES AND THEIR USE AS TTK INHIBITORS (Fri, 21 Jun 2013)
The present invention relates to substituted triazolopyndine compounds of general formula (I) : in which R1, R2, R3, R4, and R5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.
>> read more

METHOD FOR PRODUCTION OF F-18 LABELED GLUTAMIC ACID DERIVATIVES (Fri, 14 Jun 2013)
<p id="p-0001" num="0000">This invention relates to methods, which provide access to F-18 labeled glutamic acid derivatives.</p>
>> read more

3-(Fluorovinyl)pyrazoles and their use (Fri, 14 Jun 2013)
<p id="p-0001" num="0000">The present application relates to novel 3-(fluorovinyl)pyrazole derivatives, to processes for their preparation, to their use for treatment and/or prevention of diseases and to their use for the preparation of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be carried out as monotherapy or also in combination with other medicaments or further therapeutic measures.</p>
>> read more

Process for preparing substituted 5-fluoro-1H-pyrazolopyridines (Fri, 07 Jun 2013)
<p id="p-0001" num="0000">The present application relates to a novel and efficient process for preparing novel substituted 5-fluoro-1H-pyrazolopyridines of the formula (VI)</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="35.05mm" wi="59.52mm" file="US20130143900A1-20130606-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0003" num="0000">which are suitable as an intermediate for production of medicaments and for production of medicaments for treatment and/or prophylaxis of cardiovascular disorders. More particularly, the 5-fluoro-1H-pyrazolopyridines of the formula (VI) are suitable for preparation of the compound of the formula (I)</p> <p id="p-0004" num="0000"><chemistry id="CHEM-US-00002" num="00002"> <img id="EMI-C00002" he="66.04mm" wi="58.67mm" file="US20130143900A1-20130606-C00002.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0005" num="0000">which serves for production of medicaments, for production of medicaments for treatment and/or prophylaxis of cardiovascular disorders.</p>
>> read more

HETEROARYL CARBOXAMIDES (Fri, 07 Jun 2013)
<p id="p-0001" num="0000">The invention relates to novel heteroaryl carboxamides, a process for their preparation, and pharmaceutical compositions containing them. These materials are useful for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory.</p>
>> read more

NOVEL 2H-INDAZOLES AS EP2 RECEPTOR ANTAGONISTS (Fri, 07 Jun 2013)
The present invention relates to novel 2H-indazoles of the general formula (I), methods for the preparation thereof and the use thereof for the production of pharmaceutical agents for the treatment of diseases and indications which are linked with the EP2- receptor.
>> read more

FUNGICIDAL N- BICYCLOALKYL AND N-TRICYCLOALKYL PYRAZOLE - 4 - (THIO) CARBOXAMIDE DERIVATIVES (Fri, 07 Jun 2013)
The present invention relates to fungicidal N-bicycloalkyl and N-tricycloalkyl pyrazole-4-(thio)carboxamide derivatives of formula (I), wherein • T represents 0 or S; • n represents 0 or 1; and • B represents where the bond marked by * is attached to the (CZ2Z3)n-N amide moiety, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
>> read more

ANTIBACTERIAL TYLOSIN DERIVATIVES AND METHODS FOR THEIR PREPARATION (Fri, 31 May 2013)
The present invention relates to new macrolide derivatives, in particular new tylosin derivatives of the formula (I); a pharmaceutical or veterinary composition comprising the derivatives; a method for preparation thereof; a method for treating and/or preventing bacterial infections in an animal, wherein the method comprises administering the derivatives or the composition; and a use of the derivatives for the manufacture of medicaments for treating and/or preventing bacterial infections in an animal.
>> read more

FUNGICIDE N-[(TRISUBSTITUTEDSILYL)METHYL]-CARBOXAMIDE DERIVATIVES (Fri, 31 May 2013)
The present invention relates to fungicidal N-[(trisubstitutedsilyl)methyl]carboxamide or its thiocarboxamide derivative, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
>> read more

Fluro substituted Omega-Carboxyaryl Diphenyl Urea for the Treatment and Prevention of Diseases and Conditions (Fri, 24 May 2013)
<p id="p-0001" num="0000">A compound of Formula (I):</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="26.84mm" wi="75.86mm" file="US20130131122A1-20130523-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0003" num="0000">salts thereof, prodrugs thereof, metabolites thereof, pharmaceutical compositions containing such a compound, and use of such compound and compositions to treat diseases mediated by raf, VEGFR, PDGFR, p38 and flt-3.</p>
>> read more

Process for Preparing Pyridyl-Substituted Pyrazoles (Fri, 24 May 2013)
<p id="p-0001" num="0000">The present invention relates to a process for preparing 1-pyridyl-substituted pyrazoles, comprising the reaction of acetyleneketones with pyridylhydrazine derivatives to give 1-pyridyl-substituted dihydro-1H-pyrazoles, the further reaction thereof with elimination of water to give 1-pyridyl-substituted trihalomethylpyrazoles, and the further processing thereof.</p>
>> read more

Furopyridinyl-substituted 1,4-dihydropyridine derivatives and methods of use thereof (Fri, 24 May 2013)
<p id="p-0001" num="0000">This invention relates to novel 4-(furo[3,2-c]pyridin-2-yl)-1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders.</p>
>> read more

O-cyclopropylcyclohexyl-carboxanilides and their use as fungicides (Fri, 24 May 2013)
<p id="p-0001" num="0000">The present invention relates to O-CYCLOPROPYLCYCLOHEXYL-CARBOXANILIDES derivatives of formula (I); their process of preparation, their use as fungicide, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.</p>
>> read more

TRIAZOLOPYRIDINE DERIVATIVES (Fri, 17 May 2013)
<p id="p-0001" num="0000">The present invention relates to triazolopyridine compounds of general formula (I) which are Monopolar Spindle 1 kinase (Mps-1 or TTK) inhibitors in which R<sup>1</sup>, R<sup>2</sup>, R<sup>3</sup>, R<sup>4</sup>, and R<sup>5 </sup>are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of proliferative diseases, as well as to intermediate compounds useful in the preparation of said compounds.</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="27.77mm" wi="69.85mm" file="US20130121994A1-20130516-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p>
>> read more

NEW BINDER-DRUG CONJUGATES (ADCS) AND USE THEREOF (Fri, 17 May 2013)
<p id="p-0001" num="0000">The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target mesothelin, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures.</p>
>> read more

Substituted enaminocarbonyl compounds (Fri, 17 May 2013)
<p id="p-0001" num="0000">The present invention relates to novel substituted enaminocarbonyl compounds, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in particular insects.</p>
>> read more

TYROSINE BASED LINKERS FOR THE RELEASABLE CONNECTION OF PEPTIDES (Sat, 11 May 2013)
The invention relates to novel tyrosine based linkers that allow the releasable connection of peptides or proteins with other molecular entities, e.g. polyethylene glycol, to processes for their preparation and their use for preparing medicaments for the treatment and/or prophylaxis of diseases.
>> read more

COMPOUNDS WITH NEMATICIDAL ACTIVITY (Sat, 11 May 2013)
The present invention relates to the use of known pyridyl carboxamide derivatives and novel pyridyl carboxamide derivatives as nematicides, compositions containing such compounds and methods for the control of nematodes.
>> read more

COMPOUNDS WITH NEMATICIDAL ACTIVITY (Sat, 11 May 2013)
The present invention relates to the use of predominantly known pyridyl carboxamide derivatives as nematicides, compositions containing such compounds and methods for the control of nematodes.
>> read more

POLYETHYLENE GLYCOL BASED PRODRUG OF ADRENOMEDULLIN AND USE THEREOF (Sat, 11 May 2013)
The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders.
>> read more

METHOD FOR PRODUCING SUBSTITUTED PYRIDIN-2-ONE (Fri, 10 May 2013)
<p id="p-0001" num="0000">The present invention relates to a process for the preparation of substituted 3-(2-hydroxyethyl)-1-[4-nitrophenyl]pyridin-2(1H)-ones which serve as important intermediate compounds for producing drugs.</p>
>> read more

Process for the preparation of 4-{4[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy}-<i>N</i>-methylpyridine-2-carboxamide, its salts and monohydrate (Fri, 10 May 2013)
<p id="p-0001" num="0000">The present invention relates to a process for preparing 4-{4-[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide, its salts and monohydrate.</p>
>> read more

New binder-drug conjugates (ADCs) and use thereof (Fri, 19 Apr 2013)
<p id="p-0001" num="0000">The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target C4.4a, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures.</p>
>> read more

PROCESS FOR THE PREPARATION OF LOW-VISCOSITY, WATER-DILUTABLE URETHANE (METH)ACRYLATES (Fri, 19 Apr 2013)
<p id="p-0001" num="0000">The present invention relates to a process for the preparation of highly reactive, low-viscosity and water-dilutable polyisocyanate reaction products which contain activated groups which react, by polymerization, with ethylenically unsaturated compounds under the action of actinic radiation. The present invention furthermore relates to a process for the preparation of such products and their use.</p>
>> read more

PROCESS FOR THE PREPARATION OF LOW-VISCOSITY, WATER-EMULSIFIABLE ALLOPHANATES WITH RADIATION-CURABLE GROUPS (Fri, 19 Apr 2013)
<p id="p-0001" num="0000">The present invention relates to a process for the preparation of low-viscosity polyisocyanate reaction products which contain allophanate groups, can be readily emulsified in water and contain activated groups which react, by polymerization, with ethylenically unsaturated compounds under the action of actinic radiation. The present invention furthermore relates to the products which can be prepared by the process according to the invention and their use.</p>
>> read more

PLANTS WITH DECREASED ACTIVITY OF A STARCH DEPHOSPHORYLATING ENZYME (Fri, 19 Apr 2013)
The present invention relates to plant cells and plants that are genetically modified, whereby the genetic modification leads to a decreasein the activity of a starch dephosphorylating LSF-2 proteinand a starch dephosphorylating SEX4 proteinin comparison to corresponding wild type plant cells or wild type plants that have not been genetically modified. The present invention also relates to means and methods for the manufacture of such plant cells and plants. These types of plant cells and plants synthesise a modified starch. Therefore, the present invention also concerns the starch synthesised from the plant cells and plants according to the invention, methods for the manufacture of this starch, and the manufacture of starch derivatives of this modified starch, as well as flours containing starches according to the invention. In addition, the present invention relates to vectorscomprising nucleic acids encoding a starch dephosphorylating LSF-2 proteinstarch dephosphorylating SEX4 protein, host cells such asplant cells, and plants containing such chimeric genes.
>> read more

PLANTS WITH DECREASED ACTIVITY OF A STARCH DEPHOSPHORYLATING ENZYME (Fri, 19 Apr 2013)
The present invention relates to plant cells and plants that are genetically modified, whereby the genetic modification leads to a decrease in the activity of a starch dephosphorylating LSF-2 protein in comparison to corresponding wild type plant cells or wild type plants that have not been genetically modified. The present invention also relates to means and methods for the manufacture of such plant cells and plants. These types of plant cells and plants synthesise a modified starch. Therefore,the present invention also concerns the starch synthesised from the plant cells and plants according to the invention, methods for the manufacture of this starch, and the manufacture of starch derivatives of this modified starch, as well as flours containing starches according to the invention. In addition, the present invention relates to chimeric genes comprising nucleic acids encoding a starch dephosphorylating LSF-2 protein, vectors, host cells such as plant cells, and plants containing such chimeric genes.
>> read more

Thiazolylpiperidine Derivatives as Fungicides (Fri, 12 Apr 2013)
<p id="p-0001" num="0000">Thiazolylpiperidine derivatives of the formula (I),</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="16.51mm" wi="67.90mm" file="US20130090477A1-20130411-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0003" num="0000">in which the symbols A, G, Y, n, R<sup>1</sup>, R<sup>2</sup>, R<sup>3</sup>, R<sup>4 </sup>and R<sup>5 </sup>have the meanings given in the description, and also agrochemically active salts thereof, and their use for controlling phytopathogenic harmful fungi, and also processes for preparing compounds of the formula (I).</p>
>> read more

Thiazolylpiperidine Derivatives as Fungicides (Fri, 12 Apr 2013)
<p id="p-0001" num="0000">Thiazolylpiperidine derivatives of the formula (I),</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="16.43mm" wi="67.90mm" file="US20130090476A1-20130411-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p> <p id="p-0003" num="0000">in which the symbols A, G, Y, n, R<sup>1</sup>, R<sup>2</sup>, R<sup>3</sup>, R<sup>4 </sup>and R<sup>5 </sup>have the meanings given in the description, and also agrochemically active salts thereof, and their use for controlling phytopathogenic harmful fungi, and also processes for preparing compounds of the formula (I).</p>
>> read more

SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES. (Fri, 12 Apr 2013)
Compounds of formula (I) which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.
>> read more

HETEROCYCLYLPYRI(MI)DINYLPYRAZOLE (Fri, 12 Apr 2013)
Heterocyclylpyri(mi)dinylpyrazole of the formula (I), in which R1 to R5, X1, U, Q, W, a, b and n have the meanings given in the description, and agrochemically active salts, to their use and to methods and compositions for controlling phytopathogenic harmful fungi in and/or on plants or in and/or on seed of plants and for reducing mycotoxins in plants and parts of the plants, to processes for preparing such compounds and compositions and treated seed and also to their use for controlling phytopathogenic harmful fungi in agriculture, horticulture, forestry, in animal husbandry, in the protection of materials, in the domestic and hygiene field and for the reduction of mycotoxins in plants and parts of the plants.
>> read more

HETEROCYCLYLPYRI (MI) DINYLPYRAZOLE AS FUNGICIDALS (Fri, 12 Apr 2013)
Heterocyclylpyri(mi)dinylpyrazole of the formula (I) in which R1 to R5, X1, U, Q, W, Y, n, a, b have the meanings given in the description, and agrochemically active salts, to their use and to methods and compositions for controlling phytopathogenic harmful fungi in and/or on plants or in and/or on seed of plants and for reducing mycotoxins in plants and parts of the plants, to processes for preparing such compounds and compositions and treated seed and also to their use for controlling phytopathogenic harmful fungi in agriculture, horticulture, forestry, in animal husbandry, in the protection of materials, in the domestic and hygiene field and for the reduction of mycotoxins in plants and parts of the plants.
>> read more

IDENTIFICATION OF INSECT ATTRACTANT, ARRESTING, AND/OR AGGREGATION COMPOUNDS AND METHODS THEREOF (Thu, 11 Apr 2013)
Compounds, compositions, kits, devices, and methods of attracting, detecting, eradicating, controlling, or killing an insect, such as a bed bug, by utilizing insect attractant, arresting, and/or aggregation compounds and compositions is provided. Insect attractant, arresting, and/or aggregation compounds identified from insect fecal extract by an analytical technique, such as gas chromatography, nuclear magnetic resonance (NMR), Carbon-13 NMR, mass spectroscopy, LC-MS, GC-MS, high performance liquid chromatography (HPLC), or combinations thereof are provided. A bed bug attractant, arresting, and/or aggregation compound identified from bed bug feces and exhibiting a Carbon-13 NMR peak at about δ 159.453 ppm is also provided.
>> read more

MEDICAMENTS CONTAINING VARDENAFIL HYDROCHLORIDE TRIHYDRATE (Fri, 29 Mar 2013)
<p id="p-0001" num="0000">The invention relates to a method for producing medicaments that contain vardenafil hydrochloride, essentially as trihydrate in solid form, and to medicaments that can be obtained according to this method</p>
>> read more

PHARMACEUTICALLY ACTIVE DISUBSTITUTED TRIAZINE DERIVATIVES (Fri, 29 Mar 2013)
<p id="p-0001" num="0000">The present invention relates to disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said disubstituted triazine derivatives as inhibitors for a protein kinase.</p>
>> read more

Branched 3-phenylpropionic acid derivatives and their use (Fri, 29 Mar 2013)
<p id="p-0001" num="0000">The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.</p>
>> read more

SUBSTITUTED IMIDAZOPYRIDAZINES (Fri, 29 Mar 2013)
The present invention relates to substituted imidazopyridazine compounds of general formula(I): in which A, Q, R1, R3,R4 and n are as defined in the claims, to methods of preparing said compounds,to intermediate compounds useful for preparing said compounds,to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/ or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
>> read more

PROGESTERONE RECEPTOR ANTAGONISTS (Fri, 22 Mar 2013)
<p id="p-0001" num="0000">The invention relates to 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl derivatives of formula I with progesterone-antagonizing action and methods of production thereof, use thereof for the treatment and/or prevention of diseases and use thereof for producing medicinal products for the treatment and/or prevention of diseases, in particular uterine fibroids (myomata, uterine leiomyomata), endometriosis, heavy menstrual bleeding, meningiomata, hormone-dependent breast cancers and menopause-associated complaints or for fertility control and emergency contraception.</p>
>> read more

FUNGICIDAL 4-SUBSTITUTED-3-{PHENYL[(HETEROCYCLYLMETHOXY)IMINO]METHYL}-1,2,4-OXADIZOL-5(4H)-ONE DERIVATIVES (Fri, 22 Mar 2013)
The present invention provides fungicidal 4-substituted-3-{phenyl[(heterocyclylmethoxy)imino]methyl}-1,2,4-oxadiazol-5(4H)-one derivatives of formula (I) wherein A represents a pyridyl or thiazole group and X1, Y1 to Y5 represent independently different substituents.
>> read more

DISUBSTITUTED 5-FLUORO-PYRIMIDINES (Fri, 22 Mar 2013)
The present invention relates to disubstituted 5-fluoro-pyrimidines of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
>> read more

DISUBSTITUTED 5-FLUORO PYRIMIDINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP (Fri, 22 Mar 2013)
The present invention relates to disubstituted 5-fluoro pyrimidine derivatives containing a sulfoximine group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
>> read more

NEW BINDER-DRUG CONJUGATES (ADCS) AND USE THEREOF (Fri, 15 Mar 2013)
<p id="p-0001" num="0000">The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target C4.4a, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures.</p>
>> read more

MULTI-AMINE FUNCTIONAL OLIGOMERS AND METHOD FOR PRODUCING THE SAME BY THE REDUCTION OF CORRESPONDING OXIMES (Fri, 15 Mar 2013)
<p id="p-0001" num="0000">The invention relates to multi-amine functional oligomers and multi-oxime functional oligomers in addition to a method for producing the same by means of the co-polymerisation of carbonyl carriers such as olefins or dienes, reaction with hydroxylamine and a subsequent selective catalytic hydrogenation.</p>
>> read more

POLYCARBONATE POLYOLS (Fri, 15 Mar 2013)
A mixture comprises a polycarbonate polyol with a decomposition temperature of ≥ 180 °C at ≥ 0.1 mbar to ≤ 1 mbar which is based on at least two different diols selected from the group consisting of C4, C5 and C6 diols, the mixture having an altogether low amount of amines and/or ammonium ions, alkali metal atoms and/or ions, earth alkali metal atoms and/or ions, metals and/or ions of the 13th through 15th Group of the Periodic Table of the Elements (i.e. metals from Boron, Carbon and Nitrogen Group), and transition metal atoms and/or ions of the 4th through 12th Group of the Periodic Table of the Elements in relation to the total weight of the polycarbonate polyol. Furthermore, the pH value of the 10 weight-% slurry of this mixture in water lies in the range from ≥ 5.0 to ≤ 8.0. The present invention also relates to the use of these polyols for the production of polyurethanes, in particular dispersions and thermoplastic polymers.
>> read more

AMINO-SUBSTITUTED IMIDAZOPYRIDAZINES (Fri, 15 Mar 2013)
The present invention relates to amino-substituted imidazopyridazine compounds of general formula(I): in which A, R1, R3 and n are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
>> read more

GENETICALLY MODIFIED PLANTS WHICH SYNTHESIZE A LOW AMYLOSE STARCH WITH INCREASED SWELLING POWER (Fri, 08 Mar 2013)
<p id="p-0001" num="0000">The present invention relates to genetically modified monocotyledonous plant cells and plants whose starch has an apparent amylose content of less than 5% by weight and an increased activity of a protein with the activity of a starch synthase II and an increased activity of a protein with the activity of a glucan, water dikinase. Such plants synthesize starch with an increased hot-water swelling power. Methods and processes for the generation/preparation of these plant cells, plants, starches and flours are likewise subject matter of the present invention.</p>
>> read more

AZABICYCLIC CARBAMATES AND THEIR USE AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS (Fri, 08 Mar 2013)
<p id="p-0001" num="0000">The invention relates to novel benzothiophene-, benzofuran-, and indole ureas and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning, and/or memory.</p>
>> read more

FUNGICIDE HYDROXIMOYL-TETRAZOLE DERIVATIVES (Fri, 01 Mar 2013)
The present invention relates to hydroximoyl-tetrazole derivatives of formula (I), their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions wherein A represents a tetrazolyl group, Het represents a pyridyl group or a thiazolyl group and X represents various substituents.
>> read more

POLYNUCLEOTIDE, POLYPEPTIDE, ANIMAL MODEL AND METHOD FOR THE DEVELOPMENT OF COMPLEMENT SYSTEM MODULATORS (Fri, 15 Feb 2013)
The present invention is in the field of molecular biology, more particularly, the present invention relates to nucleic acid sequences and amino acid sequences of a hamster C5aR1 and the use of hamster as an animal model for the characterization of complement system modulators within drug discovery.
>> read more

Aryl-substituted pyrazoles (Fri, 18 Jan 2013)
<p id="p-0001" num="0000">The present invention relates to a process for preparing 1-aryl-substituted pyrazoles, comprising the reaction of alkoxy enones and enamino ketones with arylhydrazine derivatives to give 1-aryl-substituted dihydro-1H-pyrazoles, the further reaction thereof with elimination of water to give 1-aryl-substituted trihalomethylpyrazoles, and the further processing thereof.</p>
>> read more

Spiroheterocyclic tetronic acid derivatives (Fri, 11 Jan 2013)
<p id="p-0001" num="0000">The present invention relates to novel compounds of the formula (I),</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="28.28mm" wi="69.85mm" file="US08592610-20131126-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> <br/> in which W, X, Y, Z, G, A and t have the meanings given above, <br/> to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides. </p> <p id="p-0003" num="0000">Moreover, the invention relates to selective herbicidal compositions comprising, firstly, the spiroheterocyclic tetronic acid derivates and, secondly, a crop plant compatibility-improving compound.</p> <p id="p-0004" num="0000">The present invention furthermore relates to increasing the activity of crop protection compositions comprising in particular phenyl-substituted bicyclooctane-1,3-dione derivates by adding ammonium salts or phosphonium salts and, if appropriate, penetrants, to the corresponding compositions, to processes for their preparation and to their use in crop protection as insecticides and/or acaricides and/or for preventing unwanted plant growth.</p>
>> read more

HYDROXYMETHYLARYL-SUBSTITUTED PYRROLOTRIAZINES AS ALK1 INHIBITORS (Fri, 11 Jan 2013)
This invention relates to novel 5-[(hydroxymethyl)aryl] -substituted pyrrolo[2, 1-f][1, 2, 4] triazin-4-amines of formula (I), to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating angiogenesis-related disorders, in particular angiogenesis-related ocular disorders.
>> read more

Substituted oxazolidinones and their use in the field of blood coagulation (Fri, 04 Jan 2013)
<p id="p-0001" num="0000">The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I)</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="38.10mm" wi="69.85mm" file="US08530505-20130910-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> <br/> processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described. </p>
>> read more

BIS TRIDENTATE W3O2 CLUSTERS FOR X-RAY IMAGING (Fri, 04 Jan 2013)
The present invention describes a new class of highly stable W3O2 Clusters, a method for their preparation, their use as X-ray contrast agents and the intermediates tri- or tetracarboxylic acids as desired tridentate ligand resources.
>> read more

CRYSTALLINE FORM OF INDAZOLYL AMIDE DERIVATIVES FOR THE TREATMENT GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS (Fri, 04 Jan 2013)
Crystalline forms of 2,2,2-trifluoro-N-[(lR,2S)-l-[l-(4-fluorophenyl)in- dazol-5-yl]oxy-l-(3-methoxyphenyl)propan-2-yl]acetamide, processes for obtaining them, pharmaceutical intermediates used in their manu¬ facture, pharmaceutical compositions containing them, and their use in medical treatment.
>> read more

Substituted triazolopyridines (Fri, 28 Dec 2012)
<p id="p-0001" num="0000">The present invention relates to triazolopyridine compounds of general formula (I) which are Monopolar Spindle 1 kinase (Mps-1 or TTK) inhibitors: Formula (I), in which R<sup>1</sup>, R<sup>2</sup>, R<sup>3</sup>, R<sup>4</sup>, and R<sup>5 </sup>are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis proliferative of diseases, as well as to intermediate compounds useful in the preparation of said compounds.</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="27.77mm" wi="69.85mm" file="US08551980-20131008-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> </p>
>> read more

THIENYLPYRI(MI)DINYLPYRAZOLE (Fri, 28 Dec 2012)
Thienylpyri(mi)dinylpyrazole of the formula (I) in which R1 to R8 and X1 have the meanings given in the description, and agrochemically active salts, to their use and to methods and compositions for controlling phytopathogenic harmful fungi in and/or on plants or in and/or on seed of plants and for reducing mycotoxins in plants and parts of the plants, to processes for preparing such compounds and compositions and treated seed and also to their use for controlling phytopathogenic harmful fungi in agriculture, horticulture, forestry, in animal husbandry, in the protection of materials, in the domestic and hygiene field and for the reduction of mycotoxins in plants and parts of the plants
>> read more

PYRIDINONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF (Fri, 28 Dec 2012)
The present application relates to imidazopyridinone derivatives of the formula (I) as gonadotropin-releasing hormone (GnRH) receptor antagonists. Further aspects of the invention are a process for their preparation and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially sex-hormone-related conditions in both men and women. For example, such conditions include endometriosis, uterine fibroids, polycystic ovarian disease, hirsutism, precocious puberty, gonadal steroid-dependent neoplasia such as cancers of the prostate, breast and ovary, gonadotrope pituitary adenomas, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hypertrophy, contraception and infertility (e.g., assisted reproductive therapy such as in vitro fertilization).
>> read more

HETEROCYCLYL AMINOIMIDAZOPYRIDAZINES (Fri, 28 Dec 2012)
The present invention relates to heterocyclyl aminoimidazopyridazine compounds of general formula (I) : in which A, R1, R2, R3 and R4 are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper- proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
>> read more

Pesticidal arylpyrrolidines (Fri, 21 Dec 2012)
<p id="p-0001" num="0000">The present invention relates to novel pesticidal arylpyrrolidine compounds (arylpyrrolidines) having the general formula (I)</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="28.28mm" wi="72.14mm" file="US08536201-20130917-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> <ul id="ul0001" list-style="none"> <li id="ul0001-0001" num="0000"> <ul id="ul0002" list-style="none"> <li id="ul0002-0001" num="0000">wherein A, X<sup>1</sup>, X<sup>2</sup>, X<sup>3</sup>, X<sup>4</sup>, R<sup>1</sup>, R<sup>2</sup>, R<sup>3</sup>, R<sup>4</sup>, and G are as defined in the application and their use as pesticide, in particular for combating animal pests which occur in the agricultural and/or the veterinary field, as well as to a preparation methods for preparing such compounds.</li> </ul> </li> </ul> </p>
>> read more

ACTIVE COMPOUND COMBINATIONS (Fri, 14 Dec 2012)
The present invention relates to active compound combinations, in particular within a fungicide composition, which comprises (A) a thiazolylisoxazoline of formula (I) and a further fungicidally active compound (B). Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi of plants or crops, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.
>> read more

SUBSTITUTED AMINOIMIDAZOPYRIDAZINES (Fri, 07 Dec 2012)
The present invention relates to substituted aminoimidazopyridazine compounds of general formula (I) : in which A, R1, R2, R3 and R4 are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper- proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
>> read more

CHIRAL SYNTHESIS OF N-{3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]-6-METHOXYPHENYL}-1-[2,3-DIHYDROXY-PROPYL]CYCLOPROPANESULFONAMIDES (Fri, 07 Dec 2012)
The present invention relates to a novel enantioselective method of preparing (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-5 methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2- fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[2,3-dihydroxy- propyl]cyclopropanesulfonamide.
>> read more

SUBSTITUTED TRIAZOLOPYRIDINES (Fri, 30 Nov 2012)
The present invention relates to substituted triazolopyridine compounds of general formula (I) : in which R1, R2, R3, R4, and R5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease such as tumours and proliferative diseases, as well as to intermediate compounds useful in the preparation of said compounds.
>> read more

4-ARYL-N-PHENYL-1,3,5-TRIAZIN-2-AMINES CONTAINING A SULFOXIMINE GROUP (Fri, 30 Nov 2012)
The present invention relates to 4-aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group of general formula (I) or (Ia) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I) or (Ia).
>> read more

AMINO-SUBSTITUTED IMIDAZOPYRIDAZINES AS MKNK1 KINASE INHIBITORS (Fri, 23 Nov 2012)
The present invention relates to amino imidazopyridazine compounds of general formula (I) : in which A, R1, R2, R3 and R4 are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said 10 compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper- proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
>> read more

PESTICIDAL ARYLPYRROLIDINES (Thu, 08 Nov 2012)
The present invention relates to novel pesticidal arylpyrrolidine compounds (arylpyrrolidines) having the general formula (I) wherein A, X<sp>1</sp>, X<sp>2</sp>, X<sp>3</sp>, X<sp>4</sp>, R<sp>1</sp>, R<sp>2</sp>, R<sp>3</sp>, R<sp>4</sp>, and G are as defined in the application and their use as pesticide, in particular for combating animal pests which occur in the agricultural and / or the veterinary field, as well as to a preparation methods for preparing such compounds.
>> read more

PESTICIDAL DIARYL - HETEROCYCLYL DERIVATIVES (Fri, 02 Nov 2012)
To provide pesticidal allylAryl heterocycle derivatives that are useful as a pesticidal compound. Pesticidal allylAryl heterocycle derivatives that are expressed by the Formula (I) and pesticides and an agent for controlling animal parasites which include the allylAryl heterocycle derivatives as an effective component.
>> read more

TRIAZOLOPYRIDINES (Sat, 27 Oct 2012)
The present invention relates to triazolopyridine compounds of general formula (I) : in which R1, R2, R3, R4, and R5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.
>> read more

SUBSTITUTED 4-ARYL-N-PHENYL-1,3,5-TRIAZIN-2-AMINES (Sat, 27 Oct 2012)
The present invention relates to substituted 4-Aryl-N-phenyl-1,3,5-triazin-2-amines of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
>> read more

Substituted dihydropyrazolones and use thereof as HIF-prolyl-4-hydroxylase inhibitors (Fri, 19 Oct 2012)
<p id="p-0001" num="0000">The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.</p>
>> read more

Propenoates as fungicides (Thu, 18 Oct 2012)
The present invention relates to propenoate derivatives, their process of preparation, intermediate compounds, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants and in material protecion, using these compounds or compositions. in which R represents one of the following groups R A or R B
>> read more

SUBSTITUTED IMIDAZOPYRIDINES AND INTERMEDIATES THEREOF (Fri, 12 Oct 2012)
The present invention relates to substituted imidazopyridine compounds of general formula (I) in which R3, R5 and A are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
>> read more

SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE SALTS (Fri, 12 Oct 2012)
The present invention relates : - to 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo- [1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide dihydrochloride salt of formula (II) : or a tautomer, solvate or hydrate thereof; - to methods of preparing said dihydrochloride salt; - to said dihydrochloride salt for the treatment and/or prophylaxis of a disease; - to the use of said dihydrochloride salt for the preparation of a medicament for the treatment and/or prophylaxis of a disease, in particular of a hyper- proliferative and/or angiogenesis disorder, more particularly for the treatment or prophylaxis of a cancer, particularly lung cancer, in particular non-small cell lung carcinoma, colorectal cancer, melanoma, pancreatic cancer, hepatocyte carcinoma, pancreatic cancer, hepatocyte carcinoma or breast cancer; - to a pharmaceutical composition comprising said dihydrochloride salt; and - to a pharmaceutical combination comprising said dihydrochloride salt in combination with one or more further pharmaceutical agents.
>> read more

IMIDAZOPYRIDAZINES AS AKT KINASE INHIBITORS (Fri, 12 Oct 2012)
Imidazopyridazines of formula (I) a process for their production and the use thereof.
>> read more

USE OF SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINES (Fri, 12 Oct 2012)
The present invention relates to: - use of a 2,3-dihydroimidazo[1,2-c]quinazoline compound, or of a pharmaceutical composition containing same, as a sole active agent, or of a combination of a) said compound or a pharmaceutical composition containing said compound and b) one or more further active agents, for the preparation of a medicament for the treatment or prophylaxis of cancer; - combinations of a) said compound and b) one or more further active agents; - a pharmaceutical composition comprising said compound as a sole active agent for the treatment of breast cancer; - a pharmaceutical composition comprising a combination of a) said compound and b) one or more further active agents; - use of biomarkers involved in the modification of Bel expression, HER family expression and/or activation, PIK3CA signaling and / or loss of PTEN for predicting the sensitivity and /or resistance of a cancer patient to said compound and providing a rationale-based synergistic combination as defined herein to increase sensitivity and/or to overcome resistance; and - a method of determining the level of a component of one or more of Bcl expression, HER family expression and/or activation, PIK3CA signaling and / or loss of PTEN.
>> read more

FUNGICIDE HYDROXIMOYL-TETRAZOLE DERIVATIVES (Fri, 12 Oct 2012)
The present invention relates to hydroximoyl-tetrazole derivatives of formula (I), their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions. Formula (I) wherein A represents a tetrazoyl group, Het represents a pyridyl group or a thiazolyl group and X represents various substituents.
>> read more

Substituted triazolopyridines (Thu, 11 Oct 2012)
The present invention relates to triazolopyridine compounds of general formula (I) which are Monopolar Spindle 1 kinase (Mps-1 or TTK) inhibitors: Formula (I), in which R<sp>1</sp>, R<sp>2</sp>, R<sp>3</sp>, R<sp>4</sp>, and R<sp>5</sp> are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis proliferative of diseases, as well as to intermediate compounds useful in the preparation of said compounds.
>> read more

SUBSTITUTED BENZIMIDAZOLES (Fri, 05 Oct 2012)
The present invention relates to substituted benzimidazole compounds of general formula (I) in which R3, R5 and A are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
>> read more

Furopyridinyl-substituted 1,4-dihydropyridine derivatives and methods of use thereof (Thu, 27 Sep 2012)
This inventionrelates to novel 4-(furo[3,2-c]pyridin-2-yl)-1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders.
>> read more

FUNGICIDE HYDROXIMOYL-TETRAZOLE DERIVATIVES (Fri, 21 Sep 2012)
The present invention relates to hydroximoyl-tetrazole derivatives of formula (I), their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions, wherein A represents a tetrazoyi group, Het represents a pyridyl group or a thiazolyl group and X represents various substituents.
>> read more

INDOLECARBOXAMIDES AND BENZIMIDAZOLECARBOXAMIDES AS INSECTICIDES AND ACARICIDES (Fri, 14 Sep 2012)
The present invention relates to compounds of the general formula (I), where R1 to R6, A, Y, X, G, n and m have the meanings given in the description, and also a process for the preparation thereof and the use thereof as insecticides and acaricides.</p>
>> read more

PHARMACEUTICALLY ACTIVE DISUBSTITUTED PYRIDINE DERIVATIVES (Sat, 08 Sep 2012)
The present invention relates to disubstituted pyridine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said disubstituted pyridine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said disubstituted pyridine derivatives as inhibitors for a protein kinase.
>> read more

PHARMACEUTICALLY ACTIVE DISUBSTITUTED TRIAZINE DERIVATIVES (Sat, 08 Sep 2012)
The present invention relates to disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said disubstituted triazine derivatives as inhibitors for a protein kinase.
>> read more

Dithiinetetra(thio)carboximides (Fri, 07 Sep 2012)
<p id="p-0001" num="0000">The present invention relates to novel dithiinetetra(thio)carboximides, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials and as plant growth regulators.</p>
>> read more

Glycopegylation Methods and Proteins/Peptides Produced by the Methods (Fri, 31 Aug 2012)
<p id="p-0001" num="0000">The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.</p>
>> read more

FLAME RETARDANT, THERMOPLASTIC POLYCARBONATE MOLDING COMPOSITIONS (Fri, 17 Aug 2012)
A flame-retardant thermoplastic molding composition is disclosed. The composition contains aromatic polycarbonate resin, about 0.01 to 0.15 wt.-% of a salt, wherein the salt is an alkali metal or alkaline earth metal salt of perfluoroalkane sulfonic acid, aromatic sulfimide, ar aromatic sulfonic acid, and about 0.5 to 10 wt.-% of poly- and/or oligo-aryloxysiloxane (herein after referred as aryloxysiloxane) as flame-retardant synergist. The inventive composition is characterized in that its flammability rating is better than that of aromatic polycarbonate resin containing only inorganic salt of a derivative from aliphatic or aromatic sulfonic acid, sulphonamide or sulfonimide in accordance with UL-94 V standard, while mechanical and optical properties of the compositions are maintained.
>> read more

FLUORO-SUBSTITUTED 3,5-DICYANO-4-(1H-INDAZOL-5-YL)-2,6-DIMETHYL-1,4-DIHYDROPYRIDINE DERIVATIVES AND METHODS OF USE THEREOF (Thu, 16 Aug 2012)
The present invention relates to novel fluoro-substituted 3,5-dicyano-4-(1<i>H</i>-indazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders.
>> read more

Method for the determination of intra- and intermolecular interactions in aqueous solution (Fri, 10 Aug 2012)
<p id="p-0001" num="0000">The present invention relates to the determination of intra- or intermolecular interaction between molecules in aqueous solution, the method comprising the steps of: (a) determining the dehydration of all atoms in the intermolecular interface, (b) adding the vacuum hydrogen bond energy, and (c) further adding the change in the free enthalpy of the interacting partners upon their interaction. The obtained results can be used for the prediction if and to what extent two molecules of various origin fit to each other.</p>
>> read more

DERIVATIZATION OF RADIOPHARMACEUTICALS (Fri, 10 Aug 2012)
This invention relates to methods for analyzing radiopharmaceuticals wherein the radiopharmaceutical is derivatized beforehand. This method is suitable for compounds labeled with radioisotope or with cold counterpart e.g. 18F or 19F, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for analyzing radiopharmaceuticals. wherein R1 is C(=0)OR6; R2 is C(=0)OR7; R3 is,19F or 18F R4 is hydrogen, Methyl, Ethyl, Propyl. Butyl, t-Butyl or Benzyl; R5 is hydrogen. Methyl, Ethyl, Propyl. Butyl, t-Butyl or Benzyl; R6 is hydrogen, Methyl, Ethyl, Propyl, Butyl, t-Butyl or Benzyl; R7 is hydrogen, Methyl, Ethyl, Propyl. Butyl, t-Butyl or Benzyl; with the proviso that at least one of R4, R5, R6, and R7 is hydrogen
>> read more

Process for the preparation of cis-1-ammonium-4-alkoxycyclohexanecarbonitrile salts (Fri, 03 Aug 2012)
<p id="p-0001" num="0000">The present invention relates to a novel process for the preparation of cis-1-ammonium-4-alkoxycyclohexanecarbonitrile salts and to novel intermediates or starting compounds which are passed through or used in the process according to the invention.</p>
>> read more

Process for the preparation of 2,2-difluoroethylamine (Fri, 27 Jul 2012)
<p id="p-0001" num="0000">A process for the preparation of 2,2-difluoroethylamine, comprising the reaction of 2,2-difluoro-1-chloroethane with an imide of the formula (II)</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="23.62mm" wi="69.85mm" file="US08580973-20131112-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> <br/> in the presence of an acid scavenger, to give a compound of the formula (III) </p> <p id="p-0003" num="0000"><chemistry id="CHEM-US-00002" num="00002"> <img id="EMI-C00002" he="24.64mm" wi="69.85mm" file="US08580973-20131112-C00002.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> <br/> in which, in the compounds of the formulae (II) and (III), R<sup>1 </sup>and R<sup>2 </sup>are, each independently of one another, hydrogen or C<sub>1</sub>-C<sub>6</sub>-alkyl or R<sup>1 </sup>and R<sup>2 </sup>form, together with the carbon atoms to which they are bonded, a six-membered aromatic ring which is optionally substituted; and the cleavage of 2,2-difluoroethylamine by reaction of the compound of the formula (III) with acid, base or hydrazine. </p>
>> read more

BINDING PROTEINS TO INHIBITORS OF COAGULATION FACTORS (Fri, 27 Jul 2012)
The present invention relates to the identification and use of antigen-binding regions, antibodies, antigen-binding antibody fragments and antibody mimetics, neutralizing the anti-coagulant effect of an anticoagulant in vitro and/or in vivo. Antibodies and functional fragments of the invention and antibody mimetics can be used to specifically reverse the pharmacological effect of an anticoagulant e.g. a FX a inhibitor for therapeutic (antidote) and/or diagnostic purposes. The invention also provides nucleic acid sequences encoding foregoing molecules, vectors containing the same, pharmaceutical compositions and kits with instructions for use.
>> read more

Process for preparing 2,2-difluoroethylamine from 2,2-difluoro-1-chloroethane and ammonia (Fri, 20 Jul 2012)
<p id="p-0001" num="0000">Process for preparing 2,2-difluoroethylamine, comprising the following steps: <ul id="ul0001" list-style="none"> <li id="ul0001-0001" num="0000"> <ul id="ul0002" list-style="none"> <li id="ul0002-0001" num="0000">(i) mixing 2,2-difluoro-1-chloroethane and gaseous, liquid or supercritical ammonia in a pressure-stable, closed reaction vessel under a pressure in the range from 10 to 180 bar;</li> <li id="ul0002-0002" num="0000">(ii) reacting the reaction mixture at a reaction temperature in the range from 80° C. to 200° C.;</li> <li id="ul0002-0003" num="0000">(iii) letting down the reaction mixture and isolating 2,2-difluoroethylamine.</li> </ul> </li> </ul> </p>
>> read more

Method for preparing a <i>Centella asiatica </i>extract rich in madecassoside and in terminoloside (Fri, 13 Jul 2012)
<p id="p-0001" num="0000">The invention concerns an extract of <i>Centella asiatica </i>comprising more than 75 wt. % of a mixture of madecassoside, terminoloside and asiaticoside, relative to the extract total weight, an extract of <i>Centella asiatica </i>comprising more than 95 wt. % of a mixture of madecassoside and terminoloside relative to the extract total weight and their use for regulating inflammatory mechanisms.</p>
>> read more

FUNGICIDE HYDROXIMOYL-TETRAZOLE DERIVATIVES (Fri, 06 Jul 2012)
The present invention relates to hydroximoyl-heterocycle derivatives of formula (I) wherein X represents various substituents, A represents a tetrazoyl group, and Het represents a pyridyl group of formula (II). The present invention relates to their use as fungicide active agents, particularly in the form of fungicide compositions and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.
>> read more

Heterocyclic compounds as pesticides (Fri, 29 Jun 2012)
<p id="p-0001" num="0000">The present application relates to novel heterocyclic compounds, to the use thereof for controlling animal pests, which include arthropods and especially insects, and to processes for preparing the novel compounds.</p>
>> read more

Substituted enaminocarbonyl compounds (Fri, 22 Jun 2012)
<p id="p-0001" num="0000">The present invention relates to novel substituted enaminocarbonyl compounds, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in particular insects.</p>
>> read more

N-biarylamides (Fri, 22 Jun 2012)
<p id="p-0001" num="0000">The invention relates to N-biarylamides useful for the prophylaxis and/or treatment of impairments of perception, concentration, learning and/or memory, and to processes for preparing them, and pharmaceutical compositions containing them.</p>
>> read more

6-THIO-SUBSTITUTED IMIDAZOPYRAZINES FOR USE AS MPS-1 AND TKK INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS (Fri, 22 Jun 2012)
The present invention relates to substituted imidazopyrazine compounds of general formula (I) : (I) in which R1, R2, R3, R4 and R5 are as defined in the claims, to methods of and intermediates for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
>> read more

2-SUBSTITUTED IMIDAZOPYRAZINES FOR USE AS MPS-1 AND TKK INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS (Fri, 22 Jun 2012)
The present invention relates to substituted imidazopyrizine compounds of general formual (I): in which R1, R2, R3, R4 and R5 are as defined in the claims, to methods of and intermediates for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
>> read more

SUBSTITUTED PYRIMIDO[1,2-B]INDAZOLES AND THEIR USE AS MODULATORS OF THE PI3K/AKT PATHWAY (Fri, 22 Jun 2012)
Compounds of Formula (I), which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals. The compounds of formula (I) a: useful for the treatment of cancer.
>> read more

SUBSTITUTED 6-IMIDAZOPYRAZINES FOR USE AS MPS-1 AND TKK INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS (Fri, 22 Jun 2012)
The present invention relates to substituted imidazopyrazine compounds of general formula (I), in which R1, R2, R3, R4 and R5 are as defined in the claims, to methods of and intermediates for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
>> read more

6 SUBSTITUTED IMIDAZOPYRAZINES FOR USE AS MPS-1 AND TKK INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS (Fri, 22 Jun 2012)
The present invention relates to substituted imidazopyrazine compounds of general formula (I) in which R1, R2, R3, R4 and R5 are as defined in the claims, to methods of and intermediates for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
>> read more

IMIDAZOPYRAZINES FOR USE AS MPS-1 AND TKK INHIBITORS IN THE TREATMENT HYPERPROLIFERATIVE DISORDERS (Fri, 22 Jun 2012)
The present invention relates to substituted imidazopyrazine compounds of general formula (I) : in which R1, R2, R3, R4 and R5 are as defined in the claims, to methods of and intermediates for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
>> read more

6-SUBSTITUTED IMIDAZOPYRAZINES FOR USE AS MPS-1 AND TKK INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS (Fri, 22 Jun 2012)
The present invention relates to substituted imidazopyrazine compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined in the claims, to methods of and intermediates for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
>> read more

Process for the preparation of 2,2-difluoroethylamine starting from prop-2-en-1-amine (Fri, 08 Jun 2012)
<p id="p-0001" num="0000">A process for the preparation of 2,2-difluoroethylamine of the formula (I) <br/> <?in-line-formulae description="In-line Formulae" end="lead"?>CHF<sub>2</sub>CH<sub>2</sub>NH<sub>2</sub>  (I)<?in-line-formulae description="In-line Formulae" end="tail"?> <br/> comprising the stages (i) and (ii): <br/> stage (i): reaction of 2,2-difluoro-1-haloethane of the formula (II) <br/> <?in-line-formulae description="In-line Formulae" end="lead"?>CHF<sub>2</sub>—CH<sub>2</sub>Hal  (II)<?in-line-formulae description="In-line Formulae" end="tail"?> <br/> in which Hal is chlorine, bromine or iodine, <br/> with prop-2-en-1-amine of the formula (III) </p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"> <img id="EMI-C00001" he="7.28mm" wi="69.85mm" file="US08766012-20140701-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> <br/> to give N-(2,2-difluoroethyl)prop-2-en-1-amine of the formula (IV) </p> <p id="p-0003" num="0000"><chemistry id="CHEM-US-00002" num="00002"> <img id="EMI-C00002" he="13.04mm" wi="69.85mm" file="US08766012-20140701-C00002.TIF" alt="embedded image" img-content="chem" img-format="tif"/> </chemistry> <br/> preferably in the presence of an acid scavenger, <br/> and <br/> stage (ii): removal of the allyl group from the N-(2,2-difluoroethyl)prop-2-en-1-amine of the formula (IV) obtained in stage (i) to give 2,2-difluoroethylamine of the formula (I) or a salt thereof. </p>
>> read more

Substituted piperidines (Fri, 01 Jun 2012)
<p id="p-0001" num="0000">The invention relates to novel substituted piperidines, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular diseases and tumour diseases.</p>
>> read more

Multi-fluid medical injector system (Thu, 31 May 2012)
A multi-fluid injector system and methods of operation thereof are presented. One embodiment of such a fluid injector system includes a powered injector, a pressure jacket support, a syringe pressure jacket, and a syringe. The pressure jacket support includes a front plate and a rear plate. The rear plate is connected to the injector and the front plate is spaced from the rear plate and defines a slot. The syringe pressure jacket has a proximal end pivotally connected to the rear plate so that a distal end of the pressure jacket pivots relative to the front plate. The syringe has a syringe body with a distally extending discharge conduit. With the syringe disposed in a barrel of the pressure jacket, pivotal movement of the pressure jacket results in the distal end thereof pivoting toward the front plate to place the discharge conduit within the slot in the front plate.
>> read more

Substituted sodium 1H-pyrazol-5-olate (Fri, 25 May 2012)
<p id="p-0001" num="0000">The present application relates to sodium 1-[6-(morpholin-4-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-5-olate, to processes for its preparation, to its use for the treatment and/or prophylaxis of diseases and to its use for the preparation of medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and haematological diseases and kidney diseases, and for promoting wound healing.</p>
>> read more

DECAHYDRO-1,4-METHANONAPHTHALEN CARBOXAMIDES (Fri, 25 May 2012)
The present invention relates to decahydro-1,4-methanonaphthalen carboxamide derivatives of formula (Ia) or (Ib); their process of preparation, their use as fungicide, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.
>> read more

Site Search