ACS Chemical Biology

[ASAP] Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors (Wed, 19 Sep 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00665
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[ASAP] <italic toggle="yes">In Situ</italic> Drug Delivery to Breast Cancer-Associated Extracellular Matrix (Tue, 18 Sep 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00396
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[ASAP] A Cyclic Peptide Inhibitor of the iNOS–SPSB Protein–Protein Interaction as a Potential Anti-Infective Agent (Tue, 18 Sep 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00561
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[ASAP] Rapid Discovery of Glycocins through Pathway Refactoring in <italic toggle="yes">Escherichia coli</italic> (Tue, 18 Sep 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00599
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[ASAP] Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach (Tue, 18 Sep 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00705
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[ASAP] Activation of the NLRP3 Inflammasome by Hyaboron, a New Asymmetric Boron-Containing Macrodiolide from the Myxobacterium <italic toggle="yes">Hyalangium minutum</italic> (Mon, 17 Sep 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00659
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[ASAP] Synthesis and Evaluation of a Mitochondria-Targeting Poly(ADP-ribose) Polymerase-1 Inhibitor (Fri, 14 Sep 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00423
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[ASAP] Embryonic Stem Cell Engineering with a Glycomimetic FGF2/BMP4 Co-Receptor Drives Mesodermal Differentiation in a Three-Dimensional Culture (Fri, 14 Sep 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00436
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[ASAP] Development of a Multiplexed Activity-Based Protein Profiling Assay to Evaluate Activity of Endocannabinoid Hydrolase Inhibitors (Wed, 12 Sep 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00534
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[ASAP] Molecular Basis for Olefin Rearrangement in the Gephyronic Acid Polyketide Synthase (Wed, 12 Sep 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00645
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[ASAP] Chemical Tools for Selective Activity Profiling of Endogenously Expressed MMP-14 in Multicellular Models (Tue, 11 Sep 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00562
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[ASAP] Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway (Mon, 10 Sep 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00673
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[ASAP] GLI1 Inhibitors Identified by Target Protein Oriented Natural Products Isolation (TPO-NAPI) with Hedgehog Inhibition (Fri, 07 Sep 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00492
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[ASAP] Rational Design of Potent Activators and Inhibitors of the <italic toggle="yes">Enterococcus faecalis</italic> Fsr Quorum Sensing Circuit (Fri, 07 Sep 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00610
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[ASAP] SNAP-Tagged Nanobodies Enable Reversible Optical Control of a G Protein-Coupled Receptor <italic toggle="yes">via</italic> a Remotely Tethered Photoswitchable Ligand (Fri, 07 Sep 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00628
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[ASAP] The Tetrazole Analogue of the Auxin Indole-3-acetic Acid Binds Preferentially to TIR1 and Not AFB5 (Thu, 06 Sep 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00527
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[ASAP] A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B) (Thu, 06 Sep 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00745
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[ASAP] Reprogramming a Deubiquitinase into a Transamidase (Thu, 06 Sep 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00759
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[ASAP] Genetic Code Expansion in Animals (Wed, 05 Sep 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00520
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[ASAP] Targeting Fluorescent Sensors to Endoplasmic Reticulum Membranes Enables Detection of Peroxynitrite During Cellular Phagocytosis (Wed, 05 Sep 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00535
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[ASAP] Homo-PROTACs for the Chemical Knockdown of Cereblon (Wed, 05 Sep 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00693
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[ASAP] Unexpected Bacterial Origin of the Antibiotic Icosalide: Two-Tailed Depsipeptide Assembly in Multifarious <italic toggle="yes">Burkholderia</italic> Symbionts (Tue, 04 Sep 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00600
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[ASAP] Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains (Fri, 31 Aug 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.7b00638
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[ASAP] Inhibiting Epidermal Growth Factor Receptor Dimerization and Signaling Through Targeted Delivery of a Juxtamembrane Domain Peptide Mimic (Fri, 31 Aug 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00555
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[ASAP] Structure–Function Analyses of the <italic toggle="yes">N</italic>-Butanoyl <sc>l</sc>-Homoserine Lactone Quorum-Sensing Signal Define Features Critical to Activity in RhlR (Fri, 31 Aug 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00577
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[ASAP] NRPS Protein MarQ Catalyzes Flexible Adenylation and Specific <italic toggle="yes">S</italic>-Methylation (Thu, 30 Aug 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00364
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[ASAP] Quantitative Live-Cell Kinetic Degradation and Mechanistic Profiling of PROTAC Mode of Action (Thu, 30 Aug 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00692
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[ASAP] Investigation of Anti-SOD1 Antibodies Yields New Structural Insight into SOD1 Misfolding and Surprising Behavior of the Antibodies Themselves (Thu, 30 Aug 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00729
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[ASAP] Cell-Specific Chemical Delivery Using a Selective Nitroreductase–Nitroaryl Pair (Wed, 29 Aug 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00524
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[ASAP] Structure-Based Design of Novel EphA2 Agonistic Agents with Nanomolar Affinity <italic toggle="yes">in Vitro</italic> and in Cell (Wed, 29 Aug 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00556
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[ASAP] Mycobacterial MenJ: An Oxidoreductase Involved in Menaquinone Biosynthesis (Mon, 27 Aug 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00402
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[ASAP] The Recognition of Unrelated Ligands by Identical Proteins (Mon, 27 Aug 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00443
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[ASAP] Evaluation of APOBEC3B Recognition Motifs by NMR Reveals Preferred Substrates (Mon, 27 Aug 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00639
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[ASAP] Furamidine Rescues Myotonic Dystrophy Type I Associated Mis-Splicing through Multiple Mechanisms (Mon, 27 Aug 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00646
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[ASAP] Tackling <italic toggle="yes">Pseudomonas aeruginosa</italic> Virulence by a Hydroxamic Acid-Based LasB Inhibitor (Fri, 24 Aug 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00257
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[ASAP] A Commensal Dipeptidyl Aminopeptidase with Specificity for N-Terminal Glycine Degrades Human-Produced Antimicrobial Peptides <italic toggle="yes">in Vitro</italic> (Thu, 23 Aug 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00420
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[ASAP] A Key Role for the Periplasmic PfeE Esterase in Iron Acquisition <italic toggle="yes">via</italic> the Siderophore Enterobactin in <italic toggle="yes">Pseudomonas aeruginosa</italic> (Wed, 22 Aug 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00543
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[ASAP] Protein–Lipid Interfaces Can Drive the Functions of Membrane-Embedded Protein–Protein Complexes (Wed, 22 Aug 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00644
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[ASAP] Amyloidogenicity, Cytotoxicity, and Receptor Activity of Bovine Amylin: Implications for Xenobiotic Transplantation and the Design of Nontoxic Amylin Variants (Wed, 22 Aug 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00690
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[ASAP] Fluorinated Analogues of Desferrioxamine B from Precursor-Directed Biosynthesis Provide New Insight into the Capacity of DesBCD (Mon, 20 Aug 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00340
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[ASAP] Enzymatic Synthesis of the C-Glycosidic Moiety of Nogalamycin R (Mon, 20 Aug 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00658
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[ASAP] Reconstitution of Enzymatic Carbon–Sulfur Bond Formation Reveals Detoxification-Like Strategy in Fungal Toxin Biosynthesis (Fri, 17 Aug 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00413
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[ASAP] Discovery of an Antibacterial Isoindolinone-Containing Tetracyclic Polyketide by Cryptic Gene Activation and Characterization of Its Biosynthetic Gene Cluster (Fri, 17 Aug 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00553
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[ASAP] GAS41 Recognizes Diacetylated Histone H3 through a Bivalent Binding Mode (Fri, 17 Aug 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00674
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[ASAP] Facile Solid-Phase Synthesis and Assessment of Nucleoside Analogs as Inhibitors of Bacterial UDP-Sugar Processing Enzymes (Thu, 16 Aug 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00477
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[ASAP] Paramagnetic Tag for Glycosylation Sites in Glycoproteins: Structural Constraints on Heparan Sulfate Binding to Robo1 (Thu, 16 Aug 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00511
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[ASAP] The <italic toggle="yes">RAD17</italic> Promoter Sequence Contains a Potential Tail-Dependent G-Quadruplex That Downregulates Gene Expression upon Oxidative Modification (Wed, 15 Aug 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00522
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[ASAP] Syntheses and Activities of the Functional Structures of a Glycolipid Essential for Membrane Protein Integration (Wed, 15 Aug 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00654
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[ASAP] Discovery and Optimization of Inhibitors of the Parkinson’s Disease Associated Protein DJ-1 (Wed, 15 Aug 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00701
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[ASAP] Circularly Permuted Fluorogenic Proteins for the Design of Modular Biosensors (Tue, 14 Aug 2018)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.8b00417
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