ACS Chemical Biology



[ASAP] Remodeling of Cross-bridges Controls Peptidoglycan Cross-linking Levels in Bacterial Cell Walls (Fri, 03 Apr 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.0c00002
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[ASAP] Characterization of Tailoring Steps of Nargenicin A1 Biosynthesis Reveals a Novel Analogue with Anticancer Activities (Fri, 03 Apr 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.9b01034
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[ASAP] Fighting the Coronavirus Outbreak (Wed, 01 Apr 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.0c00175
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[ASAP] Development and Characterization of Mouse Monoclonal Antibodies Specific for <italic toggle="yes">Clostridiodes (Clostridium) difficile</italic> Lipoteichoic Acid (Wed, 01 Apr 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.0c00066
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[ASAP] A Fasciclin Protein Is Essential for Laccase-Mediated Selective Phenol Coupling in Sporandol Biosynthesis (Tue, 31 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.0c00025
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[ASAP] CanE, an Iron/2-Oxoglutarate-Dependent Lasso Peptide Hydroxylase from <italic toggle="yes">Streptomyces canus</italic> (Mon, 30 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.0c00109
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[ASAP] Circular Permutation of the Native Enzyme-Mediated Cyclization Position in Cyclotides (Mon, 30 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.9b00996
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[ASAP] Vancomycin Derivative Inactivates Carbapenem-Resistant <italic toggle="yes">Acinetobacter baumannii</italic> and Induces Autophagy (Fri, 27 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.0c00091
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[ASAP] Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase (Thu, 26 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.0c00032
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[ASAP] Stable Isotope-Assisted Metabolomics for Deciphering Xenobiotic Metabolism in Mammalian Cell Culture (Wed, 25 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.9b01016
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[ASAP] Development of Ratiometric Bioluminescent Sensors for <italic toggle="yes">in Vivo</italic> Detection of Bacterial Signaling (Wed, 25 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.9b00800
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[ASAP] A New Docking Domain Type in the Peptide-Antimicrobial-Xenorhabdus Peptide Producing Nonribosomal Peptide Synthetase from <italic toggle="yes">Xenorhabdus bovienii</italic> (Wed, 25 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.9b01022
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[ASAP] Revised Structure of Anthelvencin A and Characterization of the Anthelvencin Biosynthetic Gene Cluster (Mon, 23 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.9b00960
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[ASAP] Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites (Mon, 23 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.0c00058
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[ASAP] Biosynthetic Incorporation of Site-Specific Isotopes in ß-Lactam Antibiotics Enables Biophysical Studies (Fri, 20 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.9b01054
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[ASAP] A Highly Selective Chemical Probe for Activin Receptor-like Kinases ALK4 and ALK5 (Fri, 20 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.0c00076
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[ASAP] Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein–Protein Interaction (Fri, 20 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.0c00039
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[ASAP] Blockade of the Lysophosphatidylserine Lipase ABHD12 Potentiates Ferroptosis in Cancer Cells (Fri, 20 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.0c00086
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[ASAP] Designer Palmitoylation Motif-Based Self-Localizing Ligand for Sustained Control of Protein Localization in Living Cells and <italic toggle="yes">Caenorhabditis elegans</italic> (Fri, 20 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.0c00014
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[ASAP] 3-Oxo-ß-sultam as a Sulfonylating Chemotype for Inhibition of Serine Hydrolases and Activity-Based Protein Profiling (Fri, 20 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.0c00090
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[ASAP] Engineering Orthogonal, Plasma Membrane-Specific SLIPT Systems for Multiplexed Chemical Control of Signaling Pathways in Living Single Cells (Fri, 20 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.0c00024
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[ASAP] Harnessing ß-Lactam Antibiotics for Illumination of the Activity of Penicillin-Binding Proteins in <italic toggle="yes">Bacillus subtilis</italic> (Fri, 20 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.9b00977
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[ASAP] Cell-Based Ligand Discovery for the ENL YEATS Domain (Thu, 19 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.0c00124
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[ASAP] Precise Targeted Cleavage of a r(CUG) Repeat Expansion in Cells by Using a Small-Molecule–Deglycobleomycin Conjugate (Wed, 18 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.0c00036
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[ASAP] Covalent Modification of the Flavin in Proline Dehydrogenase by Thiazolidine-2-Carboxylate (Wed, 18 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.9b00935
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[ASAP] Förster Resonance Energy Transfer Based Biosensor for Targeting the hNTH1–YB1 Interface as a Potential Anticancer Drug Target (Tue, 17 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.9b01023
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[ASAP] Selective Fluorogenic ß-Glucocerebrosidase Substrates for Convenient Analysis of Enzyme Activity in Cell and Tissue Homogenates (Mon, 16 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.9b01044
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[ASAP] Perfluoro-<italic toggle="yes">tert</italic>-Butyl Hydroxyprolines as Sensitive, Conformationally Responsive Molecular Probes: Detection of Protein Kinase Activity by <sup>19</sup>F NMR (Mon, 16 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.0c00131
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[ASAP] Covalent Immune Recruiters: Tools to Gain Chemical Control Over Immune Recognition (Fri, 13 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.0c00112
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[ASAP] 2'-Fluorinated Hydantoins as Chemical Biology Tools for Base Excision Repair Glycosylases (Fri, 13 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.9b00923
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[ASAP] Engineering Caveolae-Targeted Lipid Nanoparticles To Deliver mRNA to the Lungs (Fri, 13 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.0c00003
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[ASAP] Yeast Tripartite Biosensors Sensitive to Protein Stability and Aggregation Propensity (Tue, 10 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.0c00083
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[ASAP] Engineering a Proximity-Directed O-GlcNAc Transferase for Selective Protein O-GlcNAcylation in Cells (Mon, 02 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.0c00074
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[ASAP] Translation of Microbiota Short-Chain Fatty Acid Mechanisms Affords Anti-infective Acyl-Salicylic Acid Derivatives (Mon, 02 Mar 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.9b01009
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[ASAP] A Fluorescent Teixobactin Analogue (Wed, 26 Feb 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.9b00908
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[ASAP] Mechanistic Studies of Bioorthogonal ATP Analogues for Assessment of Histidine Kinase Autophosphorylation (Mon, 24 Feb 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.9b01024
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[ASAP] Fluorescence Assessment of the AmpR-Signaling Network of <italic toggle="yes">Pseudomonas aeruginosa</italic> to Exposure to ß-Lactam Antibiotics (Mon, 10 Feb 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.9b00875
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[ASAP] The Kinetic and Molecular Basis for the Interaction of LexA and Activated RecA Revealed by a Fluorescent Amino Acid Probe (Wed, 05 Feb 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.9b00886
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[ASAP] Identification of Interferon Receptor IFNAR2 As a Novel HCV Entry Factor by Using Chemical Probes (Mon, 03 Feb 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.9b00912
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[ASAP] An Inactive Dispersin B Probe for Monitoring PNAG Production in Biofilm Formation (Tue, 21 Jan 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.9b00907
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[ASAP] Small Molecule Inhibitor Screen Reveals Calcium Channel Signaling as a Mechanistic Mediator of <italic toggle="yes">Clostridium difficile</italic> TcdB-Induced Necrosis (Tue, 14 Jan 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.9b00906
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[ASAP] Chemical Mechanisms of Colonization Resistance by the Gut Microbial Metabolome (Tue, 14 Jan 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.9b00813
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[ASAP] Site-Specific Siderocalin Binding to Ferric and Ferric-Free Enterobactin As Revealed by Mass Spectrometry (Mon, 13 Jan 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.9b00741
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[ASAP] Discovery of the Biosynthetic Machinery for Stravidins, Biotin Antimetabolites (Thu, 09 Jan 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.9b00890
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[ASAP] Thailandenes, Cryptic Polyene Natural Products Isolated from <italic toggle="yes">Burkholderia thailandensis</italic> Using Phenotype-Guided Transposon Mutagenesis (Thu, 02 Jan 2020)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.9b00883
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[ASAP] Genome Mining and Heterologous Expression Reveal Two Distinct Families of Lasso Peptides Highly Conserved in Endofungal Bacteria (Wed, 18 Dec 2019)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.9b00805
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[ASAP] Heterologous Biosynthesis of Type II Polyketide Products Using <italic toggle="yes">E. coli</italic> (Mon, 16 Dec 2019)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.9b00827
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[ASAP] End-Binding E3 Ubiquitin Ligases Enable Protease Signaling (Wed, 20 Nov 2019)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.9b00621
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[ASAP] Identification and Mobilization of a Cryptic Antibiotic Biosynthesis Gene Locus from a Human-Pathogenic <italic toggle="yes">Nocardia</italic> Isolate (Thu, 14 Nov 2019)
TOC Graphic ACS Chemical Biology DOI: 10.1021/acschembio.9b00763
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