ACS Medicinal Chemistry Letters



[ASAP] Discovery of New 1,1'-Biphenyl-4-sulfonamides as Selective Subnanomolar Human Carbonic Anhydrase II Inhibitors (Tue, 12 Nov 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00437
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[ASAP] Eighteen 5,7-Dihalo-8-quinolinol and 2,2'-Bipyridine Co(II) Complexes as a New Class of Promising Anticancer Agents (Sat, 09 Nov 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00356
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[ASAP] Modulation of Tropomyosin Receptor Kinase for the Treatment of Neurotrophin Diseases: Alzheimer’s, Huntington’s and Parkinson’s (Fri, 08 Nov 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00506
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[ASAP] Approaches for Prevention and Treatment of Neurodegenerative Diseases: ALS and Alzheimer’s (Fri, 08 Nov 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00504
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[ASAP] Reactive Oxygen Species (ROS)-Activatable Prodrug for Selective Activation of ATF6 after Ischemia/Reperfusion Injury (Fri, 08 Nov 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00299
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[ASAP] Novel Quinoline-based Ir(III) Complexes Exhibit High Antitumor Activity <italic toggle="yes">in Vitro</italic> and <italic toggle="yes">in Vivo</italic> (Fri, 08 Nov 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00337
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[ASAP] Structure–Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors (Thu, 07 Nov 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00402
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[ASAP] Structure–Activity Relationship Evaluation of Wasp Toxin ß-PMTX Leads to Analogs with Superior Activity for Human Neuronal Sodium Channels (Fri, 01 Nov 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00415
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[ASAP] Discovery of ABBV/GLPG-3221, a Potent Corrector of CFTR for the Treatment of Cystic Fibrosis (Thu, 31 Oct 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00377
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[ASAP] SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K (Tue, 29 Oct 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00399
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[ASAP] Discovery of a Potent and Selective TRPC5 Inhibitor, Efficacious in a Focal Segmental Glomerulosclerosis Model (Tue, 29 Oct 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00430
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[ASAP] Design, Synthesis, and Evaluation of Highly Potent FAK-Targeting PROTACs (Tue, 29 Oct 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00372
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[ASAP] Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors (Mon, 28 Oct 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00381
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[ASAP] Synthesis and Evaluation of Bicyclic Hydroxypyridones as Inhibitors of Catechol <italic toggle="yes">O</italic>-Methyltransferase (Fri, 25 Oct 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00345
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[ASAP] Escaping from Flatland: [2 + 2] Photocycloaddition; Conformationally Constrained sp<sup>3</sup>-rich Scaffolds for Lead Generation (Thu, 24 Oct 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00409
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[ASAP] INCB050465 (Parsaclisib), a Novel Next-Generation Inhibitor of Phosphoinositide 3-Kinase Delta (PI3Kd) (Thu, 24 Oct 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00334
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[ASAP] Optimization of PDE3A Modulators for SLFN12-Dependent Cancer Cell Killing (Wed, 23 Oct 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00360
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[ASAP] Regioisomeric Family of Novel Fluorescent Substrates for SHIP2 (Tue, 22 Oct 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00368
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[ASAP] Scaffold Morphing Identifies 3-Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT) (Thu, 17 Oct 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00325
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[ASAP] Synthesis and µ-Opioid Activity of the Primary Metabolites of Carfentanil (Wed, 16 Oct 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00404
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[ASAP] Spiro-oxindole Piperidines and 3-(Azetidin-3-yl)-1<italic toggle="yes">H</italic>-benzimidazol-2-ones as mGlu<sub>2</sub> Receptor PAMs (Wed, 16 Oct 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00350
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[ASAP] Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors (Fri, 11 Oct 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00141
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[ASAP] Structure–Activity Relationship for the Oxadiazole Class of Antibacterials (Thu, 10 Oct 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00379
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[ASAP] Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors (Tue, 08 Oct 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00401
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[ASAP] An Alkyne-functionalized Arginine for Solid-Phase Synthesis Enabling “Bioorthogonal” Peptide Conjugation (Fri, 04 Oct 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00388
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[ASAP] Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy (Wed, 02 Oct 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00344
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[ASAP] Codrug Approach for the Potential Treatment of EML4-ALK Positive Lung Cancer (Tue, 01 Oct 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00378
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[ASAP] Discovery of Potent <italic toggle="yes">N</italic>-Ethylurea Pyrazole Derivatives as Dual Inhibitors of <italic toggle="yes">Trypanosoma brucei</italic> and <italic toggle="yes">Trypanosoma cruzi</italic> (Wed, 11 Sep 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00218
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[ASAP] Targeting an Artificial Metal Nuclease to DNA by a Simple Chemical Modification and Its Drastic Effect on Catalysis (Wed, 14 Aug 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00289
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[ASAP] Targeted Detection of Cyclooxygenase-1 in Ovarian Cancer (Fri, 26 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00280
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[ASAP] Single Nucleotide Polymorphisms in the Melanocortin His-Phe-Arg-Trp Sequences Decrease Tetrapeptide Potency and Efficacy (Wed, 24 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00198
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[ASAP] Structure–Activity Relationship and Anticancer Profile of Second-Generation Anti-MRSA Synthetic Retinoids (Wed, 17 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00159
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[ASAP] Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage (Wed, 08 May 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00065
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