ACS Medicinal Chemistry Letters



[ASAP] Pyridinylimidazoles as GSK3ß Inhibitors: The Impact of Tautomerism on Compound Activity via Water Networks (Wed, 18 Sep 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00177
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[ASAP] Dual Inhibition of TAF1 and BET Bromodomains from the BI-2536 Kinase Inhibitor Scaffold (Wed, 18 Sep 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00243
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[ASAP] Biocatalysis in Medicinal Chemistry: Challenges to Access and Drivers for Adoption (Mon, 16 Sep 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00410
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[ASAP] <italic toggle="yes">N</italic>-Trifluoromethylthiolated Sulfonimidamides and Sulfoximines: Anti-microbial, Anti-mycobacterial, and Cytotoxic Activity (Mon, 16 Sep 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00285
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[ASAP] A Bioreductive Prodrug of Cucurbitacin B Significantly Inhibits Tumor Growth in the 4T1 Xenograft Mice Model (Fri, 13 Sep 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00161
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[ASAP] Chalcone-Thiazole Hybrids: Rational Design, Synthesis, and Lead Identification against 5-Lipoxygenase (Fri, 13 Sep 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00193
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[ASAP] Design of Potent and Selective Covalent Inhibitors of Bruton’s Tyrosine Kinase Targeting an Inactive Conformation (Thu, 12 Sep 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00317
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[ASAP] Discovery of Potent <italic toggle="yes">N</italic>-Ethylurea Pyrazole Derivatives as Dual Inhibitors of <italic toggle="yes">Trypanosoma brucei</italic> and <italic toggle="yes">Trypanosoma cruzi</italic> (Wed, 11 Sep 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00218
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[ASAP] Preclinical Development of PQR514, a Highly Potent PI3K Inhibitor Bearing a Difluoromethyl–Pyrimidine Moiety (Wed, 11 Sep 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00333
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[ASAP] Synthesis and Evaluation of Camptothecin Antibody–Drug Conjugates (Mon, 09 Sep 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00301
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[ASAP] PROTAC-Mediated Degradation of Estrogen Receptor in the Treatment of Cancer (Mon, 09 Sep 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00397
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[ASAP] Development of Kinase Inactive PD173955 Analogues for Reducing Production of Aß Peptides (Fri, 06 Sep 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00213
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[ASAP] Deuteration of BTZ043 Extends the Lifetime of Meisenheimer Intermediates to the Antituberculosis Nitroso Oxidation State (Wed, 04 Sep 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00308
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[ASAP] Targeting an Artificial Metal Nuclease to DNA by a Simple Chemical Modification and Its Drastic Effect on Catalysis (Wed, 14 Aug 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00289
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[ASAP] Targeted Detection of Cyclooxygenase-1 in Ovarian Cancer (Fri, 26 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00280
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[ASAP] Single Nucleotide Polymorphisms in the Melanocortin His-Phe-Arg-Trp Sequences Decrease Tetrapeptide Potency and Efficacy (Wed, 24 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00198
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[ASAP] Structure–Activity Relationship and Anticancer Profile of Second-Generation Anti-MRSA Synthetic Retinoids (Wed, 17 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00159
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[ASAP] Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage (Wed, 08 May 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00065
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