ACS Medicinal Chemistry Letters



[ASAP] Design of a Long-Acting and Selective MEG-Fatty Acid Stapled Prolactin-Releasing Peptide Analog (Mon, 22 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00182
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[ASAP] Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4) (Mon, 22 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00274
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[ASAP] Quick Building Blocks (QBB): An Innovative and Efficient Business Model To Speed Medicinal Chemistry Analog Synthesis (Thu, 18 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00205
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[ASAP] Identification of CB1 Receptor Allosteric Sites Using Force-Biased MMC Simulated Annealing and Validation by Structure–Activity Relationship Studies (Thu, 18 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00256
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[ASAP] In Praise of Remarkably Powerful Centamolecular Therapeutic Agents (Thu, 18 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00286
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[ASAP] Bis-benzoxaboroles: Design, Synthesis, and Biological Evaluation as Carbonic Anhydrase Inhibitors (Thu, 18 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00252
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[ASAP] Structure–Activity Relationship and Anticancer Profile of Second-Generation Anti-MRSA Synthetic Retinoids (Wed, 17 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00159
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[ASAP] PROTACs and Targeted Protein Degradation for Treating ALK-Mediated Cancers (Mon, 15 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00296
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[ASAP] Inhibition of ACSS2 for Treatment of Cancer and Neuropsychiatric Diseases (Mon, 15 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00295
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[ASAP] Effect of Linker Stereochemistry on the Activity of Indolinobenzodiazepine Containing Antibody–Drug Conjugates (ADCs) (Thu, 11 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00240
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[ASAP] Novel Small Molecule-Derived, Highly Selective Substrates for Fibroblast Activation Protein (FAP) (Wed, 10 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00191
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[ASAP] Treatment of Cancer and Alzheimer’s Disease by PROTAC Degradation of EGFR (Wed, 10 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00283
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[ASAP] Design, Synthesis, and Biological Evaluation of 2,4-Imidazolinedione Derivatives as HDAC6 Isoform-Selective Inhibitors (Tue, 09 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00084
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[ASAP] Correction to “Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3” (Tue, 09 Jul 2019)
ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00278
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[ASAP] DABMA: A Derivative of ABMA with Improved Broad-Spectrum Inhibitory Activity of Toxins and Viruses (Tue, 09 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00155
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[ASAP] Rotational Freedom, Steric Hindrance, and Protein Dynamics Explain BLU554 Selectivity for the Hinge Cysteine of FGFR4 (Tue, 09 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00196
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[ASAP] Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice (Mon, 08 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00171
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[ASAP] Successful Strategies for Mitigation of a Preclinical Signal for Phototoxicity in a DGAT1 Inhibitor (Fri, 05 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00117
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[ASAP] Evaluation of a Series of ß-Secretase 1 Inhibitors Containing Novel Heteroaryl-Fused-Piperazine Amidine Warheads (Fri, 05 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00181
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[ASAP] Cinnamonitrile Adjuvants Restore Susceptibility to ß-Lactams against Methicillin-Resistant <italic toggle="yes">Staphylococcus aureus</italic> (Fri, 05 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00169
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[ASAP] <italic toggle="yes">In Vitro</italic> Assessment of Putative PD-1/PD-L1 Inhibitors: Suggestions of an Alternative Mode of Action (Fri, 05 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00221
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[ASAP] Discovery of Selective, Orally Bioavailable Pyrazolopyridine Inhibitors of Protein Kinase C? (PKC?) That Ameliorate Symptoms of Experimental Autoimmune Encephalomyelitis (Wed, 03 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00134
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[ASAP] Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage (Wed, 08 May 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00065
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