ACS Medicinal Chemistry Letters



[ASAP] Peptides Mimicking the ß7/ß8 Loop of HIV-1 Reverse Transcriptase p51 as “Hotspot-Targeted” Dimerization Inhibitors (Tue, 28 Jan 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00623
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[ASAP] Discovery of Hydroxyamidine Based Inhibitors of IDO1 for Cancer Immunotherapy with Reduced Potential for Glucuronidation (Mon, 27 Jan 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00572
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[ASAP] BRM Targeting Compounds for the Potential Treatment of Cancer (Fri, 24 Jan 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.0c00007
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[ASAP] Structure–Bioactivity Relationships of Lapatinib Derived Analogs against <italic toggle="yes">Schistosoma mansoni</italic> (Wed, 22 Jan 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00455
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[ASAP] Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors (Wed, 22 Jan 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00453
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[ASAP] Do We Build Similar Molecules for Comorbid Diseases? <italic toggle="yes">Tevarud</italic> in Drug Design, an Analysis for Depression and Inflammation (Wed, 22 Jan 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00519
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[ASAP] Discovery of Zika Virus NS2B/NS3 Inhibitors That Prevent Mice from Life-Threatening Infection and Brain Damage (Tue, 21 Jan 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00405
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[ASAP] Structural and in Vivo Characterization of Tubastatin A, a Widely Used Histone Deacetylase 6 Inhibitor (Tue, 21 Jan 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00560
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[ASAP] Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8<italic toggle="yes">S</italic> Configuration (Tue, 21 Jan 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00302
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[ASAP] Drug Synergism: Studies of Combination of RK-52 and Curcumin against Rhodesain of <italic toggle="yes">Trypanosoma brucei rhodesiense</italic> (Fri, 17 Jan 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00635
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[ASAP] Discovery of a New Sulfonamide Hepatitis B Capsid Assembly Modulator (Wed, 15 Jan 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00550
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[ASAP] Discovery of <italic toggle="yes">N</italic>-(Indazol-3-yl)piperidine-4-carboxylic Acids as ROR?t Allosteric Inhibitors for Autoimmune Diseases (Tue, 14 Jan 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00431
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[ASAP] New Chemical Modalities and Strategic Thinking in Early Drug Discovery (Tue, 14 Jan 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00582
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[ASAP] Structure–Functional–Selectivity Relationship Studies of Novel Apomorphine Analogs to Develop D1R/D2R Biased Ligands (Mon, 13 Jan 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00575
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[ASAP] Developing Cyclic Opioid Analogues: Fluorescently Labeled Bioconjugates of Biphalin (Fri, 10 Jan 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00569
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[ASAP] Functionalized Naphthalimide-4-aminoquinoline Conjugates as Promising Antiplasmodials, with Mechanistic Insights (Fri, 10 Jan 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00521
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[ASAP] Toward Orally Absorbed Prodrugs of the Antibiotic Aztreonam. Design of Novel Prodrugs of Sulfate Containing Drugs. Part 2 (Fri, 10 Jan 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00534
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[ASAP] Methyl Scanning and Revised Binding Mode of 2-Pralidoxime, an Antidote for Nerve Agent Poisoning (Fri, 10 Jan 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00586
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[ASAP] Design and Optimization of 3'-(Imidazo[1,2-<italic toggle="yes">a</italic>]pyrazin-3-yl)-[1,1'-biphenyl]-3-carboxamides as Selective DDR1 Inhibitors (Thu, 09 Jan 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00495
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[ASAP] Structure-Guided Optimization of Replication Protein A (RPA)–DNA Interaction Inhibitors (Thu, 09 Jan 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00440
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[ASAP] Structure–Activity Relationships of Radioiodinated 6,5,6-Tricyclic Compounds for the Development of Tau Imaging Probes (Thu, 09 Jan 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00456
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[ASAP] Design and Catalyzed Activation of Tak-242 Prodrugs for Localized Inhibition of TLR4-Induced Inflammation (Wed, 08 Jan 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00518
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[ASAP] Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors (Mon, 06 Jan 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00493
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[ASAP] Missing Selectivity of Targeted 4ß-Phorbol Prodrugs Expected to be Potential Chemotherapeutics (Fri, 27 Dec 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00554
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[ASAP] Improving the Potency of <italic toggle="yes">N</italic>-Aryl-2,5-dimethylpyrroles against Multidrug-Resistant and Intracellular Mycobacteria (Mon, 23 Dec 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00515
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[ASAP] Synthesis, Cytotoxicity Evaluation, and Computational Insights of Novel 1,4-Diazepane-Based Sigma Ligands (Thu, 19 Dec 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00524
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[ASAP] Discovery and Evaluation of Pyrazolo[3,4-<italic toggle="yes">d</italic>]pyridazinone as a Potent and Orally Active Irreversible BTK Inhibitor (Mon, 16 Dec 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00395
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[ASAP] Design of Dual Inhibitors of Soluble Epoxide Hydrolase and LTA<sub>4</sub> Hydrolase (Tue, 26 Nov 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00330
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[ASAP] Development of a Versatile and Sensitive Direct Ligand Binding Assay for Human NR5A Nuclear Receptors (Tue, 26 Nov 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00442
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[ASAP] Inhibition of Macrophage Migration Inhibitory Factor by a Chimera of Two Allosteric Binders (Mon, 25 Nov 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00351
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[ASAP] Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity (Tue, 19 Nov 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00380
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[ASAP] Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation (Tue, 19 Nov 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00420
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[ASAP] Optimization of Small Molecules That Sensitize HIV-1 Infected Cells to Antibody-Dependent Cellular Cytotoxicity (Fri, 15 Nov 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00445
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[ASAP] Discovery of New 1,1'-Biphenyl-4-sulfonamides as Selective Subnanomolar Human Carbonic Anhydrase II Inhibitors (Tue, 12 Nov 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00437
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[ASAP] Reactive Oxygen Species (ROS)-Activatable Prodrug for Selective Activation of ATF6 after Ischemia/Reperfusion Injury (Fri, 08 Nov 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00299
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[ASAP] Structure–Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors (Thu, 07 Nov 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00402
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[ASAP] Structure–Activity Relationship Evaluation of Wasp Toxin ß-PMTX Leads to Analogs with Superior Activity for Human Neuronal Sodium Channels (Fri, 01 Nov 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00415
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[ASAP] Design, Synthesis, and Evaluation of Highly Potent FAK-Targeting PROTACs (Tue, 29 Oct 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00372
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[ASAP] SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K (Tue, 29 Oct 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00399
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[ASAP] Regioisomeric Family of Novel Fluorescent Substrates for SHIP2 (Tue, 22 Oct 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00368
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[ASAP] Spiro-oxindole Piperidines and 3-(Azetidin-3-yl)-1<italic toggle="yes">H</italic>-benzimidazol-2-ones as mGlu<sub>2</sub> Receptor PAMs (Wed, 16 Oct 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00350
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[ASAP] Structure–Activity Relationship for the Oxadiazole Class of Antibacterials (Thu, 10 Oct 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00379
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[ASAP] An Alkyne-functionalized Arginine for Solid-Phase Synthesis Enabling “Bioorthogonal” Peptide Conjugation (Fri, 04 Oct 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00388
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[ASAP] Codrug Approach for the Potential Treatment of EML4-ALK Positive Lung Cancer (Tue, 01 Oct 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00378
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[ASAP] Discovery of Potent <italic toggle="yes">N</italic>-Ethylurea Pyrazole Derivatives as Dual Inhibitors of <italic toggle="yes">Trypanosoma brucei</italic> and <italic toggle="yes">Trypanosoma cruzi</italic> (Wed, 11 Sep 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00218
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[ASAP] Targeting an Artificial Metal Nuclease to DNA by a Simple Chemical Modification and Its Drastic Effect on Catalysis (Wed, 14 Aug 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00289
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[ASAP] Targeted Detection of Cyclooxygenase-1 in Ovarian Cancer (Fri, 26 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00280
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[ASAP] Single Nucleotide Polymorphisms in the Melanocortin His-Phe-Arg-Trp Sequences Decrease Tetrapeptide Potency and Efficacy (Wed, 24 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00198
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[ASAP] Structure–Activity Relationship and Anticancer Profile of Second-Generation Anti-MRSA Synthetic Retinoids (Wed, 17 Jul 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00159
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[ASAP] Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage (Wed, 08 May 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00065
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