ACS Medicinal Chemistry Letters

[ASAP] Discovery of a First-in-Class Gut-Restricted RET Kinase Inhibitor as a Clinical Candidate for the Treatment of IBS (Thu, 24 May 2018)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00035
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[ASAP] Chemical Proteomic Characterization of a Covalent KRASG12C Inhibitor (Wed, 23 May 2018)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00110
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[ASAP] Using Tumor Explants for Imaging Mass Spectrometry Visualization of Unlabeled Peptides and Small Molecules (Tue, 22 May 2018)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00091
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[ASAP] Quinoxaline-Based Linear HCV NS3/4A Protease Inhibitors Exhibit Potent Activity against Drug Resistant Variants (Tue, 22 May 2018)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00150
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[ASAP] ROR(GMMA)T Modulating Activity for the Treatment of Cancers (Tue, 22 May 2018)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00216
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[ASAP] Design, Synthesis, and Biological Evaluation of Allosteric Effectors That Enhance CO Release from Carboxyhemoglobin (Mon, 21 May 2018)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00166
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[ASAP] Covalent Inhibitors of the TEC Family of Kinases and Their Methods of Use (Mon, 14 May 2018)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00178
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[ASAP] Profiling and Application of Photoredox C(sp<sup>3</sup>)–C(sp<sup>2</sup>) Cross-Coupling in Medicinal Chemistry (Fri, 11 May 2018)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00183
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[ASAP] Plasmin-Binding Tripeptide-Decorated Liposomes Loading Pyrazolo[3,4-<italic toggle="yes">d</italic>]pyrimidines for Targeting Hepatocellular Carcinoma (Thu, 10 May 2018)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00062
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[ASAP] Novel Aminoquinoline Derivatives Significantly Reduce Parasite Load in <italic toggle="yes">Leishmania infantum</italic> Infected Mice (Wed, 09 May 2018)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00053
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[ASAP] Synthesis and Evaluation of a <sup>18</sup>F-Labeled Triazinediamine Analogue for Imaging Mutant IDH1 Expression in Gliomas by PET (Tue, 08 May 2018)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.7b00478
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[ASAP] LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity (Fri, 04 May 2018)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00014
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[ASAP] MK-7622: A First-in-Class M<sub>1</sub> Positive Allosteric Modulator Development Candidate (Fri, 04 May 2018)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00095
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[ASAP] Why Decreasing Lipophilicity Alone Is Often Not a Reliable Strategy for Extending IV Half-life (Fri, 20 Apr 2018)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00047
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[ASAP] Homogeneous Assay for Target Engagement Utilizing Bioluminescent Thermal Shift (Thu, 19 Apr 2018)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00081
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[ASAP] Strategy for Extending Half-life in Drug Design and Its Significance (Wed, 04 Apr 2018)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00018
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[ASAP] Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8 (Wed, 21 Mar 2018)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00011
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[ASAP] Azithromycin-Induced Changes to Bacterial Membrane Properties Monitored <italic toggle="yes">in Vitro</italic> by Second-Harmonic Light Scattering (Fri, 16 Mar 2018)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.7b00499
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[ASAP] Synthesis of Thymoquinone–Artemisinin Hybrids: New Potent Antileukemia, Antiviral, and Antimalarial Agents (Fri, 05 Jan 2018)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.7b00412
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