ACS Medicinal Chemistry Letters



[ASAP] Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity (Fri, 22 Mar 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00631
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[ASAP] Discovery of CDK5 Inhibitors through Structure-Guided Approach (Fri, 22 Mar 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00029
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[ASAP] Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor (Wed, 20 Mar 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00027
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[ASAP] Hybridization of Fluoro-amodiaquine (FAQ) with Pyrimidines: Synthesis and Antimalarial Efficacy of FAQ–Pyrimidines (Tue, 19 Mar 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00496
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[ASAP] Discovery of Stereospecific PARP-1 Inhibitor Isoindolinone NMS-P515 (Fri, 15 Mar 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00569
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[ASAP] Selective Inhibitors of T Cell Receptor Recognition of Antigen–MHC Complexes for Rheumatoid Arthritis (Fri, 15 Mar 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00601
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[ASAP] Novel Cyclic Biphalin Analogues by Ruthenium-Catalyzed Ring Closing Metathesis: <italic toggle="yes">in Vivo</italic> and <italic toggle="yes">in Vitro</italic> Biological Profile (Wed, 13 Mar 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00495
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[ASAP] Contract Research Organizations Are Seeking Transformation in the Pharmaceutical Value Chain (Wed, 13 Mar 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00046
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[ASAP] Treatment of Alzheimer’s by PROTAC-Tau Protein Degradation (Tue, 12 Mar 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00083
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[ASAP] Chalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T-cell Acute Lymphoblastic Leukemia (Mon, 04 Mar 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00608
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[ASAP] Identification of the 2-Benzoxazol-2-yl-phenol Scaffold as New Hit for JMJD3 Inhibition (Fri, 01 Mar 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00589
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[ASAP] Novel Phenyldiazenyl Fibrate Analogues as PPAR a/?/d Pan-Agonists for the Amelioration of Metabolic Syndrome (Thu, 28 Feb 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00574
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[ASAP] Polycyclic Maleimide-based Scaffold as New Privileged Structure for Navigating the Cannabinoid System Opportunities (Wed, 27 Feb 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00594
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[ASAP] Coupling Supervised Molecular Dynamics (SuMD) with Entropy Estimations To Shine Light on the Stability of Multiple Binding Sites (Mon, 25 Feb 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00490
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[ASAP] Covalent Inhibitors of <italic toggle="yes">Plasmodium falciparum</italic> Glyceraldehyde 3-Phosphate Dehydrogenase with Antimalarial Activity in Vitro (Mon, 25 Feb 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00592
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[ASAP] Mechanisms of Metabolite Amyloid Formation: Computational Studies for Drug Design against Metabolic Disorders (Mon, 25 Feb 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00024
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[ASAP] High-Resolution Crystal Structure of Endoplasmic Reticulum Aminopeptidase 1 with Bound Phosphinic Transition-State Analogue Inhibitor (Sun, 24 Feb 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00002
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[ASAP] First-of-its-kind STARD<sub>3</sub> Inhibitor: <italic toggle="yes">In Silico</italic> Identification and Biological Evaluation as Anticancer Agent (Fri, 22 Feb 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00509
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[ASAP] Discovery of 1,4-Naphthoquinones as a New Class of Antiproliferative Agents Targeting GPR55 (Thu, 21 Feb 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00333
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[ASAP] a,?-Diketocarboxylic Acids and Their Esters Act as Carbonic Anhydrase IX and XII Selective Inhibitors (Thu, 21 Feb 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00023
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[ASAP] Behind the Mirror: Chirality Tunes the Reactivity and Cytotoxicity of Chloropiperidines as Potential Anticancer Agents (Tue, 19 Feb 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00580
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[ASAP] Identification of Isoform 2 Acid-Sensing Ion Channel Inhibitors as Tool Compounds for Target Validation Studies in CNS (Mon, 18 Feb 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00591
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[ASAP] Prediction of UGT-mediated Metabolism Using the Manually Curated MetaQSAR Database (Mon, 18 Feb 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00603
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[ASAP] Deciphering the Nonsense Readthrough Mechanism of Action of Ataluren: An <italic toggle="yes">in Silico</italic> Compared Study (Wed, 13 Feb 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00558
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[ASAP] Stereoselective Synthesis of C-2 Alkylated Trihydroxypiperidines: Novel Pharmacological Chaperones for Gaucher Disease (Wed, 13 Feb 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00602
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[ASAP] EC18 as a Tool To Understand the Role of HCN4 Channels in Mediating Hyperpolarization-Activated Current in Tissues (Tue, 12 Feb 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00587
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[ASAP] Cannabinoids from <italic toggle="yes">Cannabis sativa</italic> L.: A New Tool Based on HPLC–DAD–MS/MS for a Rational Use in Medicinal Chemistry (Mon, 11 Feb 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00571
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[ASAP] Replacement of the Thiosugar of Auranofin with Iodide Enhances the Anticancer Potency in a Mouse Model of Ovarian Cancer (Fri, 08 Feb 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00007
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[ASAP] Discovery of the First-in-Class GSK-3ß/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer’s Disease (Thu, 07 Feb 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00507
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[ASAP] Bioisosteres of Indomethacin as Inhibitors of Aldo-Keto Reductase 1C3 (Wed, 06 Feb 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00484
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[ASAP] Proof-of-Concept Multistage Biomimetic Liposomal DNA Origami Nanosystem for the Remote Loading of Doxorubicin (Wed, 06 Feb 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00557
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[ASAP] SAR Studies and Biological Characterization of a Chromen-4-one Derivative as an Anti-<italic toggle="yes">Trypanosoma brucei</italic> Agent (Wed, 06 Feb 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00565
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[ASAP] Role of the NMDA Receptor in the Antitumor Activity of Chiral 1,4-Dioxane Ligands in MCF-7 and SKBR3 Breast Cancer Cells (Thu, 31 Jan 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00536
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[ASAP] Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication (Thu, 24 Jan 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00583
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[ASAP] Novel Compounds Targeting the RNA-Binding Protein HuR. Structure-Based Design, Synthesis, and Interaction Studies (Thu, 24 Jan 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00600
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[ASAP] Discovery of Pyrido[3',2':5,6]thiopyrano[4,3-<italic toggle="yes">d</italic>]pyrimidine-Based Antiproliferative Multikinase Inhibitors (Wed, 23 Jan 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00499
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[ASAP] L-DOPA-quinone Mediated Recovery from GIRK Channel Firing Inhibition in Dopaminergic Neurons (Fri, 18 Jan 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00477
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[ASAP] Drug Design and Synthesis of First in Class PDZ1 Targeting NHERF1 Inhibitors as Anticancer Agents (Fri, 18 Jan 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00532
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[ASAP] Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists (Tue, 15 Jan 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00534
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[ASAP] Mass Spectrometry-based Label-free Quantitative Proteomics To Study the Effect of 3PO Drug at Cellular Level (Tue, 15 Jan 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00593
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[ASAP] Self-assembling Releasable Thiocolchicine–Diphenylbutenylaniline Conjugates (Fri, 11 Jan 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00605
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[ASAP] Inhibition Mechanism of Urease by Au(III) Compounds Unveiled by X-ray Diffraction Analysis (Wed, 09 Jan 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00585
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[ASAP] Identification of a Strigoterpenoid with Dual Nrf2 and Nf-?B Modulatory Activity (Wed, 09 Jan 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00604
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[ASAP] Exploiting Chemical Toolboxes for the Expedited Generation of Tetracyclic Quinolines as a Novel Class of PXR Agonists (Tue, 08 Jan 2019)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00459
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[ASAP] Investigation on 2',3'-<italic toggle="yes">O</italic>-Substituted ATP Derivatives and Analogs as Novel P2X3 Receptor Antagonists (Fri, 28 Dec 2018)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00524
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[ASAP] Synthesis and Anti-HIV Profile of a Novel Tetrahydroindazolylbenzamide Derivative Obtained by Oxazolone Chemistry (Mon, 24 Dec 2018)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00511
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[ASAP] Investigating the Anticancer Activity of Isatin/Dihydropyrazole Hybrids (Fri, 21 Dec 2018)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00596
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[ASAP] Discovering New Casein Kinase 1d Inhibitors with an Innovative Molecular Dynamics Enabled Virtual Screening Workflow (Tue, 18 Dec 2018)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00523
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[ASAP] Synthesis and Evaluation of Bifunctional Aminothiazoles as Antiretrovirals Targeting the HIV-1 Nucleocapsid Protein (Thu, 13 Dec 2018)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00506
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[ASAP] Novel Isoxazole Derivatives with Potent FXR Agonistic Activity Prevent Acetaminophen-Induced Liver Injury (Wed, 12 Dec 2018)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.8b00423
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