ACS Medicinal Chemistry Letters



[ASAP] Optimization of Indazole-Based GSK-3 Inhibitors with Mitigated hERG Issue and <italic toggle="yes">In Vivo</italic> Activity in a Mood Disorder Model (Fri, 27 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00633
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[ASAP] Phenolic Compounds from <italic toggle="yes">Morus nigra</italic> Regulate Viability and Apoptosis of Pancreatic ß-Cells Possibly via SERCA Activity (Thu, 26 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.0c00047
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[ASAP] Design of First-in-Class Dual EZH2/HDAC Inhibitor: Biochemical Activity and Biological Evaluation in Cancer Cells (Thu, 26 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.0c00014
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[ASAP] Multiple <italic toggle="yes">in Vitro</italic> Inhibition of HIV-1 Proteins by 2,6-Dipeptidyl-anthraquinone Conjugates Targeting the PBS RNA (Thu, 26 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00682
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[ASAP] Targeting Orthosteric and Allosteric Pockets of Aromatase via Dual-Mode Novel Azole Inhibitors (Thu, 26 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00591
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[ASAP] Inhibition of Human Immunodeficiency Virus-1 Integrase by ß-Diketo Acid Coated Gold Nanoparticles (Wed, 25 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00648
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[ASAP] Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy (Wed, 25 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.0c00058
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[ASAP] The Resurrection of Phenotypic Drug Discovery (Tue, 24 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.0c00006
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[ASAP] ProBiS H2O MD Approach for Identification of Conserved Water Sites in Protein Structures for Drug Design<xref rid="notes4" ref-type="statement">‡</xref> (Mon, 23 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00651
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[ASAP] 5,6-Dihydroxypyrimidine Scaffold to Target HIV-1 Nucleocapsid Protein (Mon, 23 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00608
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[ASAP] Pyridobenzothiazolones Exert Potent Anti-Dengue Activity by Hampering Multiple Functions of NS5 Polymerase (Mon, 23 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00619
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[ASAP] Benzofuran-Based Carboxylic Acids as Carbonic Anhydrase Inhibitors and Antiproliferative Agents against Breast Cancer (Fri, 20 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.0c00094
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[ASAP] Impact of Allosteric Modulation in Drug Discovery: Innovation in Emerging Chemical Modalities (Fri, 20 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00655
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[ASAP] Accelerated Discovery of Novel Ponatinib Analogs with Improved Properties for the Treatment of Parkinson’s Disease (Thu, 19 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00612
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[ASAP] Boron Accumulation in Brain Tumor Cells through Boc-Protected Tryptophan as a Carrier for Boron Neutron Capture Therapy (Thu, 19 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.0c00064
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[ASAP] Development of Selective Histone Deacetylase 6 (HDAC6) Degraders Recruiting Von Hippel–Lindau (VHL) E3 Ubiquitin Ligase (Wed, 18 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.0c00046
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[ASAP] Second Generation of Zafirlukast Derivatives with Improved Activity against the Oral Pathogen <italic toggle="yes">Porphyromonas gingivalis</italic> (Wed, 18 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00614
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[ASAP] Low-Molecular-Weight Branched Polyethylenimine Potentiates Ampicillin against MRSA Biofilms (Tue, 17 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00595
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[ASAP] Molecular Docking Studies of Royleanone Diterpenoids from <italic toggle="yes">Plectranthus</italic> spp. as P-Glycoprotein Inhibitors (Mon, 16 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00642
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[ASAP] Sulfonimide and Amide Derivatives as Novel PPARa Antagonists: Synthesis, Antiproliferative Activity, and Docking Studies (Mon, 16 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00666
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[ASAP] Identification of 2-(4-(Phenylsulfonyl)piperazine-1-yl)pyrimidine Analogues as Novel Inhibitors of Chikungunya Virus (Mon, 16 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00662
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[ASAP] Glycomimetic Based Approach toward Selective Carbonic Anhydrase Inhibitors (Mon, 16 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00590
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[ASAP] Strategic Incorporation of Polarity in Heme-Displacing Inhibitors of Indoleamine-2,3-dioxygenase-1 (IDO1) (Fri, 13 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.0c00010
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[ASAP] Discovery and Pharmacokinetics of Sulfamides and Guanidines as Potent Human Arginase 1 Inhibitors (Fri, 13 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00508
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[ASAP] Pyrrolyl Pyrazoles as Non-Diketo Acid Inhibitors of the HIV-1 Ribonuclease H Function of Reverse Transcriptase (Fri, 13 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00617
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[ASAP] AuNP Pyrazolo[3,4-<italic toggle="yes">d</italic>]pyrimidine Nanosystem in Combination with Radiotherapy against Glioblastoma (Thu, 12 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00538
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[ASAP] Brain Permeable Tafamidis Amide Analogs for Stabilizing TTR and Reducing APP Cleavage (Thu, 12 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00688
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[ASAP] Highly Promising Antitumor Agent of a Novel Platinum(II) Complex Bearing a Tetradentate Chelating Ligand (Thu, 12 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00676
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[ASAP] Screen of Unfocused Libraries Identified Compounds with Direct or Synergistic Antibacterial Activity (Wed, 11 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00674
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[ASAP] Targeting YAP Degradation by a Novel 1,2,4-Oxadiazole Derivative via Restoration of the Function of the Hippo Pathway (Wed, 11 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00501
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[ASAP] Targeting mPGES-1 by a Combinatorial Approach: Identification of the Aminobenzothiazole Scaffold to Suppress PGE<sub>2</sub> Levels (Tue, 10 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00618
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[ASAP] Bifunctional Pyrimidines as Modulators of Focal Adhesion Kinase (Mon, 09 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.0c00096
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[ASAP] Discovery of Small-Molecule Stabilizers of 14-3-3 Protein–Protein Interactions via Dynamic Combinatorial Chemistry (Mon, 09 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00541
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[ASAP] Catching a Moving Target: Comparative Modeling of Flaviviral NS2B-NS3 Reveals Small Molecule Zika Protease Inhibitors (Mon, 09 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00629
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[ASAP] Looking toward the Rim of the Active Site Cavity of Druggable Human Carbonic Anhydrase Isoforms (Mon, 09 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.0c00062
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[ASAP] Selective Estrogen Receptor Degraders for the Potential Treatment of Cancer (Mon, 09 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.0c00107
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[ASAP] GPBAR1 Activation by C6-Substituted Hyodeoxycholane Analogues Protect against Colitis (Fri, 06 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00636
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[ASAP] Importance of Quantifying Drug-Target Engagement in Cells (Fri, 06 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00570
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[ASAP] Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors (Fri, 06 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.0c00004
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[ASAP] Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RET<sup>V804M</sup> Kinase (Fri, 06 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00615
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[ASAP] Factor H-Inspired Design of Peptide Biomarkers of the Complement C3d Protein (Thu, 05 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00663
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[ASAP] Deuterium-Enabled Chiral Switching (DECS) Yields Chirally Pure Drugs from Chemically Interconverting Racemates (Thu, 05 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.0c00052
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[ASAP] Natural Product Evodiamine with Borate Trigger Unit: Discovery of Potent Antitumor Agents against Colon Cancer (Wed, 04 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00513
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[ASAP] New Class of Betulinic Acid-Based Nanoassemblies of Cabazitaxel, Podophyllotoxin, and Thiocolchicine (Wed, 04 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00668
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[ASAP] Ahp-Cyclodepsipeptide Inhibitors of Elastase: Lyngbyastatin 7 Stability, Scalable Synthesis, and Focused Library Analysis (Wed, 04 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00473
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[ASAP] Discovery of [1,2,4]Triazolo[1,5-<italic toggle="yes">a</italic>]pyridine Derivatives as Potent and Orally Bioavailable ROR?t Inverse Agonists (Tue, 03 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00649
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[ASAP] Molecular Imaging of Inflammation in Osteoarthritis Using a Water-Soluble Fluorocoxib (Tue, 03 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00512
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[ASAP] Design, Synthesis, and X-ray Studies of Potent HIV-1 Protease Inhibitors with P2-Carboxamide Functionalities (Tue, 03 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00670
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[ASAP] Exception That Proves the Rule: Investigation of Privileged Stereochemistry in Designing Dopamine D<sub>3</sub>R Bitopic Agonists (Tue, 03 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00660
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[ASAP] Supramolecular Hyaluronic Assembly with Aggregation-Induced Emission Mediated in Two Stages for Targeting Cell Imaging (Tue, 03 Mar 2020)
TOC Graphic ACS Medicinal Chemistry Letters DOI: 10.1021/acsmedchemlett.9b00559
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