Journal of Medicinal Chemistry



[ASAP] Discovery of Balovaptan, a Vasopressin 1a Receptor Antagonist for the Treatment of Autism Spectrum Disorder (Fri, 17 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01478
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[ASAP] Systematic Investigation of Lipophilicity Modulation by Aliphatic Fluorination Motifs (Fri, 17 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01172
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[ASAP] Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist for Use in Central Nervous System Disease Models (Thu, 16 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01218
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[ASAP] The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-<italic toggle="yes">a</italic>]pyridin-6-yl)amino]-9-(tetrahydro-2<italic toggle="yes">H</italic>-pyran-4-yl)-7,9-dihydro-8<italic toggle="yes">H</italic>-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor (Wed, 15 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01684
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[ASAP] Computational Method for Structure-Based Analysis of SAR Transfer (Wed, 15 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01931
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[ASAP] Novel Class of Colony-Stimulating Factor 1 Receptor Kinase Inhibitors Based on an <italic toggle="yes">o</italic>-Aminopyridyl Alkynyl Scaffold as Potential Treatment for Inflammatory Disorders (Tue, 14 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01912
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[ASAP] Heterobifunctional Molecules Induce Dephosphorylation of Kinases–A Proof of Concept Study (Tue, 14 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01167
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[ASAP] Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders (Tue, 14 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01566
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[ASAP] Discovery of a Novel, Highly Potent, and Selective Thieno[3,2-<italic toggle="yes">d</italic>]pyrimidinone-Based Cdc7 Inhibitor with a Quinuclidine Moiety (TAK-931) as an Orally Active Investigational Antitumor Agent (Tue, 14 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01427
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[ASAP] Docking Finds GPCR Ligands in Dark Chemical Matter (Mon, 13 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01560
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[ASAP] Synthesis and Biological Evaluation of B-Cell Lymphoma 6 Inhibitors of <italic toggle="yes">N</italic>-Phenyl-4-pyrimidinamine Derivatives Bearing Potent Activities against Tumor Growth (Mon, 13 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01618
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[ASAP] Discovery of BAY-985, a Highly Selective TBK1/IKKe Inhibitor (Fri, 10 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01460
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[ASAP] Scaffold Hopping of Natural Product Evodiamine: Discovery of a Novel Antitumor Scaffold with Excellent Potency against Colon Cancer (Fri, 10 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01626
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[ASAP] Subtype-Selective Fluorescent Ligands as Pharmacological Research Tools for the Human Adenosine A<sub>2A</sub> Receptor (Thu, 09 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01856
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[ASAP] Binding Loop Substitutions in the Cyclic Peptide SFTI-1 Generate Potent and Selective Chymase Inhibitors (Thu, 09 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01811
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[ASAP] Identification of Selective Inhibitors of <italic toggle="yes">Plasmodium</italic> N-Myristoyltransferase by High-Throughput Screening (Wed, 08 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01343
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[ASAP] Optimization of Orally Bioavailable PI3Kd Inhibitors and Identification of Vps34 as a Key Selectivity Target (Wed, 08 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01585
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[ASAP] Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5-<italic toggle="yes">b</italic>]pyridazines for the Treatment of Human African Trypanosomiasis (Wed, 08 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01741
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[ASAP] Stepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2 (Tue, 07 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01582
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[ASAP] Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core (Tue, 07 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01608
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[ASAP] Potent Thiophene Antagonists of Human Complement C3a Receptor with Anti-Inflammatory Activity (Tue, 07 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b00927
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[ASAP] Synthesis and in Vitro and in Vivo Biological Evaluation of Tissue-Specific Bisthiazole Histone Deacetylase (HDAC) Inhibitors (Tue, 07 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01792
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[ASAP] Structure–Activity Relationship Study of Novel 6-Aryl-2-benzoyl-pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties (Tue, 07 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01815
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[ASAP] Structure–Activity Relationship in Pyrazolo[4,3-<italic toggle="yes">c</italic>]pyridines, First Inhibitors of PEX14–PEX5 Protein–Protein Interaction with Trypanocidal Activity (Mon, 06 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01876
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[ASAP] Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening (Mon, 06 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01670
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[ASAP] Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AgRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-<sc>d</sc>Pro] Decreases Melanocortin-4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin-5 Receptor Antagonists (Mon, 06 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b00860
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[ASAP] <italic toggle="yes">In Vivo Veritas</italic>: <sup>18</sup>F-Radiolabeled Glycomimetics Allow Insights into the Pharmacological Fate of Galectin-3 Inhibitors (Fri, 03 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01692
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[ASAP] Application of Fluorine- and Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators (Fri, 03 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01142
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[ASAP] Correction to Novel Ligustrazine-Based Analogs of Piperlongumine Potently Suppress Proliferation and Metastasis of Colorectal Cancer Cells in Vitro and in Vivo (Fri, 03 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b02072
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[ASAP] Discovery and Characterization of 1<italic toggle="yes">H</italic>-1,2,3-Triazole Derivatives as Novel Prostanoid EP4 Receptor Antagonists for Cancer Immunotherapy (Thu, 02 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01269
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[ASAP] Design of Bimodal Ligands of Neurotensin Receptor 1 for Positron Emission Tomography Imaging and Fluorescence-Guided Surgery of Pancreatic Cancer (Thu, 02 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01407
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[ASAP] Potent, Orally Bioavailable, and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups (Thu, 02 Jan 2020)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01768
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[ASAP] Potent, Efficacious, and Stable Cyclic Opioid Peptides with Long Lasting Antinociceptive Effect after Peripheral Administration (Fri, 27 Dec 2019)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01963
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[ASAP] Utilizing Stimulated Raman Scattering Microscopy To Study Intracellular Distribution of Label-Free Ponatinib in Live Cells (Fri, 27 Dec 2019)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01546
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[ASAP] Benzothiazole-Based LRRK2 Inhibitors as Wnt Enhancers and Promoters of Oligodendrocytic Fate (Thu, 26 Dec 2019)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01752
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[ASAP] Heterotrimeric G Proteins as Therapeutic Targets in Drug Discovery (Thu, 26 Dec 2019)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01452
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[ASAP] Kinetic Target-Guided Synthesis: Reaching the Age of Maturity<subtitle>Miniperspective</subtitle> (Tue, 24 Dec 2019)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01183
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[ASAP] Targeting Stimulator of Interferon Genes (STING): A Medicinal Chemistry Perspective (Fri, 20 Dec 2019)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01039
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[ASAP] The Druggability of Solute Carriers (Thu, 19 Dec 2019)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01237
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[ASAP] Structural Refinement of Glucagon for Therapeutic Use (Wed, 18 Dec 2019)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01493
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[ASAP] New Therapeutic Targets for Brain Function and Disease (Tue, 17 Dec 2019)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01947
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[ASAP] Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-ß-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections (Mon, 16 Dec 2019)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01518
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[ASAP] A Novel Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA<sub>1</sub>), UCM-05194, Shows Efficacy in Neuropathic Pain Amelioration (Mon, 16 Dec 2019)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01287
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[ASAP] Distorted Gold(I)–Phosphine Complexes as Antifungal Agents (Mon, 16 Dec 2019)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01436
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[ASAP] Drug Metabolism by the Mitochondrial Amidoxime Reducing Component (mARC): Rapid Assay and Identification of New Substrates (Mon, 16 Dec 2019)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01483
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[ASAP] Porphyrinoid–Cyclodextrin Assemblies in Biomedical Research: An Update (Fri, 06 Dec 2019)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01069
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[ASAP] Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of a7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure–Activity Relationship and Preclinical Characterization (Fri, 06 Dec 2019)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01569
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[ASAP] Subtype Selective ?-Aminobutyric Acid Type A Receptor (GABA<sub>A</sub>R) Modulators Acting at the Benzodiazepine Binding Site: An Update (Thu, 05 Dec 2019)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01312
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[ASAP] 4-Aryl-1-oxa-4,9-diazaspiro[5.5]undecane Derivatives as Dual µ-Opioid Receptor Agonists and s<sub>1</sub> Receptor Antagonists for the Treatment of Pain (Thu, 05 Dec 2019)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01256
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[ASAP] Structure-Based Optimization of Coumarin hA<sub>3</sub> Adenosine Receptor Antagonists (Wed, 04 Dec 2019)
TOC Graphic Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.9b01572
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