MedChemComm

In depth analysis of kinase cross screening data to identify chemical starting points for inhibition of the Nek family of kinases ()
Med. Chem. Commun., 2018, Advance Article DOI: 10.1039/C7MD00510E, Review Article C. I. Wells, N. R. Kapadia, R. M. Counago, D. H. Drewry Potent, selective, and cell active small molecule kinase inhibitors are useful tools to help unravel the complexities of kinase signaling. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Recent development of lipoxygenase inhibitors as anti-inflammatory agents ()
Med. Chem. Commun., 2018, Advance Article DOI: 10.1039/C7MD00390K, Review Article Chaoyu Hu, Shutao Ma This review summarizes recent developments of LOX inhibitors. It also contains an introduction to their structures, biological activity, structure-activity relationships and molecular docking studies. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Applications and perspectives of nanomaterials in novel vaccine development ()
Med. Chem. Commun., 2018, Advance Article DOI: 10.1039/C7MD00158D, Review Article Yingbin Shen, Tianyao Hao, Shiyi Ou, Churan Hu, Long Chen Vaccines show great potential for both prophylactic and therapeutic use in infections, cancer, and other diseases. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Heterocyclic Schiff Base Transition Metal Complexes in Antimicrobial and Anticancer chemotherapy ()
Med. Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C7MD00526A, Review Article Manzoor Ahmad Malik, Ovas Ahmad Dar, PARVEEZ GULL, Mohmmad Younus Wani, Athar Adil HAshmi In recent years, the number of people suffering from cancer and multi-resistant infections has sharply increased, leaving the humanity without any choice but to search for new treatment options and... The content of this RSS Feed (c) The Royal Society of Chemistry
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Molecular modeling study, synthesis and biological evaluation of Combretastatin A-4 analogues as anticancer agents and tubulin inhibitors ()
Med. Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C7MD00416H, Research Article Yang Ping Quan, Li Ping Cheng, Tian Chi Wang, Wan Pang, Fan Hong Wu, Jin Wen Huang As the major structural component of microtubules, tubulin is an interesting target for the development of anticancer agents. In this study, 64 tubulin polymerization inhibitors of five-membered heterocycle-based combretastatin A-4... The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and in vitro evaluation of substituted 3-Cinnamoyl-4-hydroxy-pyran-2-one (CHP) in pursuit of new potential antituberculosis agents ()
Med. Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C7MD00366H, Research Article Zubair Shanib Bhat, Hafiz Ul Lahc, Muzafar Ahmad Ahmad Rather, Mubashir Maqbool, Tabassum Ara, syed khalid Yousuf, Zahoor Ahmad Parry Tuberculosis is an ever evolving infectious disease that demands urgent need for new drugs. In search for new antituberculosis agents, a library of 3-Cinnamoyl-4-hydroxy-6-methyl-2H-pyran-2-ones (CHPs) (2a-2y) was synthesised and evaluated... The content of this RSS Feed (c) The Royal Society of Chemistry
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Polyphenols from Ilex latifolia Thunb. (a Chinese bitter tea) exerts anti-atherosclerotic activity through suppressing NF-[small kappa]B activation and phosphorylation of ERK1/2 in macrophages ()
Med. Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C7MD00477J, Research Article Tiantian Zhang, Chaoyang Zheng, Ting Hu, Jian-Guo Jiang, Jingwen Zhao, Wei Zhu Ilex latifolia Thunb is a kind of herbal tea and widely consumed as a functional tea beverage in Asia countries. In this study, polyphenols was extracted from I. latifolia and... The content of this RSS Feed (c) The Royal Society of Chemistry
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Hepatocellular Targeted [small alpha]-Tocopherol based pH sensitive Galactosylated Lipid: Design, Synthesis and Transfection Studies ()
Med. Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C7MD00503B, Research Article Srilakshmi V Patri, Venkanna Muripiti, Brijesh Lohchania, Srujan Kumar Marepally Receptor mediated gene delivery to liver offers advantages in treating genetic disorders such as hemophilia, hereditary tyrosinemia type I (HTI). Prior findings demonstrated that tethering D-Galactose head group to cationic... The content of this RSS Feed (c) The Royal Society of Chemistry
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Strigolactones: A plant phytohormone as novel anti-inflammatory agents ()
Med. Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C7MD00461C, Research Article JunXia Zheng, YuShui Han, JinCai Wang, Hui Yang, Hao Kong, KangJia Liu, SiYu Chen, YiRui Chen, YiQun Chang, Wei-Min Chen, Jialiang Guo, Ping-Hua Sun Strigolactones (SLs) are a novel class of plant hormones with enormous potential in the prevention and treatment of inflammation. To further investigate the anti-inflammatory activities of SLs, a representative SL,... The content of this RSS Feed (c) The Royal Society of Chemistry
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Novel cell-penetrating-amyloid peptide conjugates preferentially kill cancer cells ()
Med. Chem. Commun., 2018, Advance Article DOI: 10.1039/C7MD00321H, Research Article John R. Veloria, Luxi Chen, Lin Li, Gail A. M. Breen, Jiyong Lee, Warren J. Goux The goal of this study was to develop a peptide which could use the toxic effects of amyloid, a substance which is the hallmark of over 25 known human diseases, to selectively kill cancer cells. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and biological evaluation of rapamycin-derived, next generation small molecules ()
Med. Chem. Commun., 2018, Advance Article DOI: 10.1039/C7MD00474E, Review Article Shiva Krishna Reddy Guduru, Prabhat Arya This review describes mammalian target of rapamycin (mTOR) structure with key role in biological system and selected case studies related to the synthesis of rapamycin-derived and hybrid molecules to explore their biological properties. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Design, synthesis and antibacterial evaluation of a polycationic calix[4]arene derivative alone and in combination with antibiotics ()
Med. Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C7MD00527J, Research Article Grazia Maria Letizia Consoli, Giuseppe Granata, Roberta Picciotto, Anna Rita Blanco, Corrada Geraci, Andreana Marino, A. Nostro The growing antibiotic resistance phenomenon continues to stimulate the search of new compounds and strategies to combat bacterial infections. In this study, we designed and synthesized a new polycationic macrocyclic... The content of this RSS Feed (c) The Royal Society of Chemistry
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Design, Synthesis and Biological Evaluation of Tacrine 1,2,3-Triazole Derivatives as Potent Cholinesterase Inhibitors ()
Med. Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C7MD00457E, Research Article Gaochan Wu, yun gao, Dongwei Kang, Boshi Huang, zhipeng Huo, Huiqing Liu, Vasanthanathan Poongavanam, Peng Zhan, Xinyong Liu We report herein the design and synthesis of a series of 11 novel tacrine-1,2,3-triazole derivatives via Cu(I)-catalyzed, alkyne-azide 1,3-dipolar cycloaddition (CuAAC) reaction. The newly synthesized compounds were evaluated for their... The content of this RSS Feed (c) The Royal Society of Chemistry
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Rise of the biologics ()
Med. Chem. Commun., 2018, Advance Article DOI: 10.1039/C7MD90046E, In the Pipeline Antibodies, RNA and gene therapy don't necessarily compete with small molecule drugs - and they all rely on chemistry. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Identification of non-substrate-like glycosyltransferase inhibitors from library screening: pitfalls & hits ()
Med. Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C7MD00550D, Research Article Gerd Wagner, Masaki Ema, Yong Xu, Sebastian Gehrke Bacterial glycosyltransferases are potential targets for the development of novel antibiotics and anti-virulence agents. Most existing glycosyltransferase inhibitors are substrate analogues with limited potential for drug development. The identification of... The content of this RSS Feed (c) The Royal Society of Chemistry
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MyD88 in antigen-presenting cells is not required for CD4+ T-cell responses during peptide nanofiber vaccination ()
Med. Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C7MD00367F, Research Article Youhui Si, Yi Wen, Jianjun Chen, Rebecca R. Pompano, Huifang Han, Joel H. Collier, Anita S Chong Self-assembled peptide nanofibers raise significant antibody and T cell responses without adjuvants, but the mechanism by which they achieve this has not been fully elucidated. Myeloid differentiation primary response gene... The content of this RSS Feed (c) The Royal Society of Chemistry
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Antitumor effect of sikokianin C, a selective cystathionine [small beta]-synthase inhibitor, against human colon cancer in vitro and in vivo ()
Med. Chem. Commun., 2018, Advance Article DOI: 10.1039/C7MD00484B, Research Article Weining Niu, Fei Chen, Jun Wang, Jing Qian, Shasha Yan A natural biflavonoid compound, sikokianin C, which is a selective, competitive inhibitor of cystathionine [small beta]-synthase, inhibits the proliferation and growth of colon cancer cells in vitro and in vivo. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of Biologically Active Boron-Containing Compounds ()
Med. Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C7MD00552K, Review Article Fei Yang, Mingyan Zhu, Jinyi Zhang, Huchen Zhou Boron-containing compounds which possess unique and attractive properties have received increasing attention from pharmaceutical industry and academia recently. They have shown interesting and useful biological activities, including antibacterial, antifungal, antiparasitic,... The content of this RSS Feed (c) The Royal Society of Chemistry
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Highly efficient antibody purification with controlled orientation of protein A on magnetic nanoparticles ()
Med. Chem. Commun., 2018, Advance Article DOI: 10.1039/C7MD00468K, Research Article Sunghyun Kim, Daekyung Sung, Jeong Ho Chang In this study, we prepared protein A grafted magnetic nanoparticles for industrial large-scale purification of antibodies with enhancement of binding capacity and immobilization by controlled orientation with chlorophenylsilane (CPTMS) on the surface. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A [small beta]-carboline derivative-based nickel(II) complex as a potential antitumor agent: synthesis, characterization, and cytotoxicity ()
Med. Chem. Commun., 2018, Advance Article DOI: 10.1039/C7MD00428A, Research Article Jing-Mei Yang, Yan-Hong Zhu, Sheng Chen, Xing Lu, Yi-Ming Wu, Feng-E Ma, Liang-Ping Li, Yang Yang, Zhen-Hao Shi, Kun-Yuan Huang, Xue Hong, Ping Jiang, Yan Peng A novel nickel(II) complex was synthesized and characterized. It significantly induced cell cycle arrest at S phase, and caused the down-regulation of p-AKT, cyclin E, cyclin A and CDK2 and the up-regulation of p27. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Phenylethynyl-substituted heterocycles inhibit cyclin D1 and induce the expression of cyclin-dependent kinase inhibitor p21Wif1/Cip1 in colorectal cancer cells ()
Med. Chem. Commun., 2018, Advance Article DOI: 10.1039/C7MD00393E, Research Article Vitaliy M. Sviripa, Liliia M. Kril, Wen Zhang, Yanqi Xie, Przemyslaw Wyrebek, Larissa Ponomareva, Xifu Liu, Yaxia Yuan, Chang-Guo Zhan, David S. Watt, Chunming Liu Fluorinated phenylethynyl-substituted heterocycles inhibit cyclin D1, induce cyclin-dependent kinase inhibitor-1 and block the proliferation of colorectal cancer cells. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Studies on enantioselectivity of chiral 4-acetylamino-6-alkyloxy-2-alkylthiopyrimidines acting as antagonists of the human A3 adenosine receptor ()
Med. Chem. Commun., 2018, Advance Article DOI: 10.1039/C7MD00375G, Research Article Barbara Cosimelli, Giovanni Greco, Sonia Laneri, Ettore Novellino, Antonia Sacchi, Simona Collina, Daniela Rossi, Sandro Cosconati, Elisabetta Barresi, Sabrina Taliani, Maria Letizia Trincavelli, Claudia Martini Chiral pyrimidines were identified as potent and selective hA3 AR antagonists. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Correction: Development of highly active anti-Pneumocystis bisbenzamidines: insight into the influence of selected substituents on the in vitro activity ()
Med. Chem. Commun., 2017, 8,2164-2164 DOI: 10.1039/C7MD90042B, Correction Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. D. Maciejewska, J. Zabinski, M. Rezler, P. Kazmierczak, M. S. Collins, L. Ficker, M. T. Cushion The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and pharmaceutical characterization of site specific mycophenolic acid-modified Xenopus glucagon-like peptide-1 analogs ()
Med. Chem. Commun., 2018, Advance Article DOI: 10.1039/C7MD00471K, Research Article Jing Han, Junjie Fu, Lidan Sun, Yue Han, Qiuyi Mao, Fang Liao, Xinshi Zheng, Ke Zhu A novel means for half-life extension of peptide drugs. 3d has potential to be developed as a therapeutic agent for T2DM. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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New N-(2-phenyl-4-oxo-1,3-thiazolidin-3-yl)-1,2-benzothiazole-3-carboxamides and acetamides as antimicrobial agents ()
Med. Chem. Commun., 2017, 8,2142-2154 DOI: 10.1039/C7MD00334J, Research Article Matteo Incerti, Paola Vicini, Athina Geronikaki, Phaedra Eleftheriou, Athanasios Tsagkadouras, Panagiotis Zoumpoulakis, Charalmpos Fotakis, Ana Ciric, Jasmina Glamoclija, Marina Sokovic 21 novel N-(2-phenyl-4-oxo-1,3-thiazolidin-3-yl)-1,2-benzothiazole-3-carboxamides and acetamides have been synthesized and evaluated for their antimicrobial activity. The content of this RSS Feed (c) The Royal Society of Chemistry
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Alkyne-azide cycloaddition analogues of dehydrozingerone as potential anti-prostate cancer inhibitors via the PI3K/Akt/NF-kB pathway ()
Med. Chem. Commun., 2017, 8,2115-2124 DOI: 10.1039/C7MD00267J, Research Article Chetan Kumar, Reyaz Ur Rasool, Zainab Iqra, Yedukondalu Nalli, Prabhu Dutt, Naresh K. Satti, Neha Sharma, Sumit G. Gandhi, Anindya Goswami, Asif Ali Alkyne-azide cycloaddition derivatives of DHZ (1) were synthesized and screened for cytotoxic potential in which the derivatives, 3, 6, 7, 8, 9 and 15 displayed most potent with IC50 value ranging from 1.8-3.0 [small mu ]M. The content of this RSS Feed (c) The Royal Society of Chemistry
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Benzisoxazole: a privileged scaffold for medicinal chemistry ()
Med. Chem. Commun., 2017, 8,2023-2039 DOI: 10.1039/C7MD00449D, Review Article K. P. Rakesh, C. S. Shantharam, M. B. Sridhara, H. M. Manukumar, Hua-Li Qin The benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds. The content of this RSS Feed (c) The Royal Society of Chemistry
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Dark chemical matter in public screening assays and derivation of target hypotheses ()
Med. Chem. Commun., 2017, 8,2100-2104 DOI: 10.1039/C7MD00426E, Research Article Swarit Jasial, Jurgen Bajorath Inactive and active analogs, shown is a dark chemical matter (DCM) compound with statistics for primary and confirmatory assays and a bioactive analog with target annotation. The content of this RSS Feed (c) The Royal Society of Chemistry
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Triazolopyrimidines identified as reversible myeloperoxidase inhibitors ()
Med. Chem. Commun., 2017, 8,2093-2099 DOI: 10.1039/C7MD00268H, Research Article Franck Duclos, Lynn M. Abell, David G. Harden, Kristen Pike, Kimberly Nowak, Gregory A. Locke, Gerald J. Duke, Xiaoqin Liu, Gayani Fernando, Scott A. Shaw, Benjamin P. Vokits, Nicholas R. Wurtz, Andrew Viet, Meriah N. Valente, Sylwia Stachura, Paul Sleph, Javed A. Khan, Ji Gao, Ashok R. Dongre, Lei Zhao, Ruth R. Wexler, David A. Gordon, Ellen K. Kick A novel myeloperoxidase inhibitor, 7-benzylether triazolopyrimidine was discovered which reversibly inhibits enzyme activity and shows pharmacodynamic effects in mouse models. The content of this RSS Feed (c) The Royal Society of Chemistry
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Antiproliferative activities of alkaloid-like compounds ()
Med. Chem. Commun., 2017, 8,2105-2114 DOI: 10.1039/C7MD00435D, Research Article Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. XiXi Xu, Tristan Rawling, Ariane Roseblade, Roger Bishop, Alison T. Ung Tricyclic alkaloid-like compounds were synthesised in a few steps, via the bridging Ritter reaction. The content of this RSS Feed (c) The Royal Society of Chemistry
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Development of NMR and thermal shift assays for the evaluation of Mycobacterium tuberculosis isocitrate lyase inhibitors ()
Med. Chem. Commun., 2017, 8,2155-2163 DOI: 10.1039/C7MD00456G, Research Article Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Ram Prasad Bhusal, Krunal Patel, Brooke X. C. Kwai, Anne Swartjes, Ghader Bashiri, Johannes Reynisson, Jonathan Sperry, Ivanhoe K. H. Leung The enzymes isocitrate lyase (ICL) isoforms 1 and 2 are essential for Mycobacterium tuberculosis survival within macrophages during latent tuberculosis (TB). Herein we report the development of a combined NMR spectroscopy and thermal shift assay for the screening and evaluation of ICL inhibitors. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and antifungal activity of novel oxazolidin-2-one-linked 1,2,3-triazole derivatives ()
Med. Chem. Commun., 2017, Advance Article DOI: 10.1039/C7MD00442G, Research Article Alejandra Ramirez-Villalva, Davir Gonzalez-Calderon, Roxana I. Rojas-Garcia, Carlos Gonzalez-Romero, Joaquin Tamariz-Mascarua, Macario Morales-Rodriguez, Nieves Zavala-Segovia, Aydee Fuentes-Benites Novel oxazolidin-2-one-linked 1,2,3-triazole derivatives (4a-k) were synthesized by straightforward and versatile azide-enolate (3 + 2) cycloaddition. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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The synthesis, biological evaluation and structure-activity relationship of 2-phenylaminomethylene-cyclohexane-1,3-diones as specific anti-tuberculosis agents ()
Med. Chem. Commun., 2017, 8,2133-2141 DOI: 10.1039/C7MD00350A, Research Article Muzafar Ahmad Rather, Ali Mohd Lone, Bisma Teli, Zubair Shanib Bhat, Paramjeet Singh, Mubashir Maqbool, Bashir Ahmad Shairgojray, Mohd Jamal Dar, Shajrul Amin, Syed Khalid Yousuf, Bilal A. Bhat, Zahoor Ahmad Synthetic interventions on previously identified hits; structure 39 was identified as the best lead against Mycobacterium tuberculosis H37Rv and was evaluated further. The content of this RSS Feed (c) The Royal Society of Chemistry
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Design, synthesis and structure-activity relationships of (+/-)-isochaihulactone derivatives ()
Med. Chem. Commun., 2017, 8,2040-2049 DOI: 10.1039/C7MD00310B, Research Article Yu Zhao, Po-Yen Liu, Kan-Yen Hsieh, Pei-Ling Hsu, Masuo Goto, Susan L. Morris-Natschke, Horng-Jyh Harn, Kuo-Hsiung Lee Seventeen new derivatives of (+/-)-isochaihulactone were synthesized. SAR conclusions were first established for isochaihulactone-type compounds. The content of this RSS Feed (c) The Royal Society of Chemistry
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The use of matched molecular series networks for cross target structure activity relationship translation and potency prediction ()
Med. Chem. Commun., 2017, 8,2067-2078 DOI: 10.1039/C7MD00465F, Research Article Christopher E. Keefer, George Chang Matched molecular series (MMS) network for PDE2A, DGAT1, and HCV showing the relationships between shared MMS/target combinations. The content of this RSS Feed (c) The Royal Society of Chemistry
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Orthoester functionalized N-guanidino derivatives of 1,5-dideoxy-1,5-imino-D-xylitol as pH-responsive inhibitors of [small beta]-glucocerebrosidase ()
Med. Chem. Commun., 2017, 8,2050-2054 DOI: 10.1039/C7MD00480J, Research Article Alen Sevsek, Javier Sastre Torano, Linda Quarles van Ufford, Ed E. Moret, Roland J. Pieters, Nathaniel I. Martin Alkylated guanidinium iminosugar derivatives bearing a pH sensitive orthoester moiety are potent and selective [small beta]-glucosidase inhibitors. The content of this RSS Feed (c) The Royal Society of Chemistry
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Cu(II), Ga(III) and In(III) complexes of 2-acetylpyridine N(4)-phenylthiosemicarbazone: synthesis, spectral characterization and biological activities ()
Med. Chem. Commun., 2017, 8,2125-2132 DOI: 10.1039/C7MD00415J, Research Article Yu-Ting Wang, Yan Fang, Meng Zhao, Ming-Xue Li, Yu-Mei Ji, Qiu-Xia Han The complexes possess effective antibacterial activity and considerable cytotoxicity against HepG2 cells. In addition, the indium(III) complex exhibits excellent photoluminescence properties. The content of this RSS Feed (c) The Royal Society of Chemistry
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Cancer nanomedicine: from PDGF targeted drug delivery ()
Med. Chem. Commun., 2017, 8,2055-2059 DOI: 10.1039/C7MD00391A, Research Article Chandrababu Rejeeth, Raju Vivek, Varukattu NipunBabu, Alok Sharma, Xianting Ding, Kun Qian An innovative approach for the distinctively efficient action of smart targeted drug delivery to a specific cell type is obtained through the modification of the surface of nanoparticles. The content of this RSS Feed (c) The Royal Society of Chemistry
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Study on the interaction between the 1,4,5,8-naphthalene diimide-spermine conjugate (NDIS) and DNA using a spectroscopic approach and molecular docking ()
Med. Chem. Commun., 2017, 8,2079-2092 DOI: 10.1039/C7MD00389G, Research Article Zhiyong Tian, Hailong Cui, He Liu, Jun Dong, Huanyang Dong, Luyao Zhao, Xueting Li, Yan Zhang, Yingying Huang, Lina Song, Longxiang Bian, Yuxia Wang, Xuejun Xu, Chaojie Wang NDIS has obvious differences from NIS in the process of its binding to DNA. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synergism of fused bicyclic 2-aminothiazolyl compounds with polymyxin B against Klebsiella pneumoniae ()
Med. Chem. Commun., 2017, 8,2060-2066 DOI: 10.1039/C7MD00354D, Research Article Rong Wang, Shuang Hou, Xiaojing Dong, Daijie Chen, Lei Shao, Liujia Qian, Zhong Li, Xiaoyong Xu A series of fused bicyclic 2-aminothiazolyl compounds were synthesized and evaluated for their synergistic effects with polymyxin B (PB) against Klebsiella pneumoniae (SIPI-KPN-1712). The content of this RSS Feed (c) The Royal Society of Chemistry
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Deciphering the role of hydrophobic and hydrophilic bile acids in angiogenesis using in vitro and in vivo model systems ()
Med. Chem. Commun., 2017, Advance Article DOI: 10.1039/C7MD00475C, Research Article Somanath Kundu, Sandhya Bansal, Kalai Mangai Muthukumarasamy, Chetana Sachidanandan, Rajender K. Motiani, Avinash Bajaj SAR studies revealed the pro-angiogenic properties of chenodeoxycholic acid in a zebrafish model. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Artificial macrocycles as IL-17A/IL-17RA antagonists ()
Med. Chem. Commun., 2018, Advance Article DOI: 10.1039/C7MD00464H, Review Article Wenjia Wang, Matthew R. Groves, Alexander Domling Interleukin 17(A) is a pro-inflammatory cytokine involved in several auto-immune and inflammatory diseases. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Novel T-C@AgNPs mediated biocidal mechanism against biofilm associated methicillin-resistant Staphylococcus aureus (Bap-MRSA) 090, cytotoxicity and its molecular docking studies ()
Med. Chem. Commun., 2017, Advance Article DOI: 10.1039/C7MD00486A, Research Article H. M. Manukumar, B. Chandrasekhar, K. P. Rakesh, A. P. Ananda, M. Nandhini, P. Lalitha, S. Sumathi, Hua-Li Qin, S. Umesha Staphylococcus aureus is a commonly found pathogen cause life threatening infections and can be controlled by nanoparticles as antibiofilm candidates. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Narrow-spectrum antibacterial agents ()
Med. Chem. Commun., 2018, Advance Article DOI: 10.1039/C7MD00528H, Review Article Roberta J. Melander, Daniel V. Zurawski, Christian Melander Narrow-spectrum antibiotics have the potential to limit selection for and spread of resistance, and to elicit a lesser detrimental effect upon the host microbiome. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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