MedChemComm



New N-phenyl-4,5-dibromopyrrolamides as DNA gyrase B inhibitors ()
Med. Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9MD00224C, Research Article Nace Zidar, Helena Macut, Tihomir Tomašič, Lucija Peterlin Mašič, JANEZ ILAŠ, Anamarija Zega, Päivi Tammela, Danijel Kikelj Due to the rapid development of antimicrobial resistance, the discovery of new antibacterials is essential in the fight against potentially lethal infections. The DNA gyrase B (GyrB) subunit of bacterial... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Prodrug strategies for targeted therapy triggered by reactive oxygen species ()
Med. Chem. Commun., 2019, Advance Article DOI: 10.1039/C9MD00169G, Review Article Jorge Peiró Cadahía, Viola Previtali, Nikolaj S. Troelsen, Mads H. Clausen A comprehensive review of ROS-activated produg strategies for targeted therapy, including state-of-the-art and future perspectives. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Fluoroquinolone-derived fluorescent probes for studies of bacterial penetration and efflux ()
Med. Chem. Commun., 2019, Advance Article DOI: 10.1039/C9MD00124G, Research Article Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. M. Rhia L. Stone, Muriel Masi, Wanida Phetsang, Jean-Marie Pagès, Matthew A. Cooper, Mark A. T. Blaskovich Fluorescent probes derived from the fluoroquinolone antibiotic ciprofloxacin were synthesised using a Cu(I)-catalysed azide–alkyne cycloaddition (CuAAC) to link a ciprofloxacin azide derivative with alkyne-substituted green and blue fluorophores. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Scaffold Hybridization Strategy towards potent hydroxamate-based inhibitors of Flaviviridae viruses and Trypanosoma species ()
Med. Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9MD00200F, Research Article Erofili Giannakopoulou, Vasiliki Pardali, Efseveia Frakolaki, Vasileiοs Siozos, Vassilios Myrianthopoulos, E. Mikros, Martin Taylor, John Kelly, Niki Vassilakic, Grigoris Zoidis Infections with Flaviviridae viruses, such as hepatitis C virus (HCV) and dengue virus (DENV) pose global health threats. Infected individuals are at risk of developing chronic liver failure or haemorrhagic... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Discovery of (aza)indole derivatives as novel respiratory syncytial virus fusion inhibitors ()
Med. Chem. Commun., 2019, Advance Article DOI: 10.1039/C9MD00178F, Research Article Xiufang Zheng, Chungen Liang, Lisha Wang, Kun Miao, Baoxia Wang, Weixing Zhang, Dongdong Chen, Guolong Wu, Wei Zhu, Lei Guo, Song Feng, Lu Gao, Hong C. Shen, Hongying Yun A new class of (aza)indole derivatives have been identified as potent RSV fusion inhibitors. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen ()
Med. Chem. Commun., 2019, Advance Article DOI: 10.1039/C9MD00096H, Research Article Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Benjamin N. Atkinson, David Steadman, Yuguang Zhao, James Sipthorp, Luca Vecchia, Reinis R. Ruza, Fiona Jeganathan, Georgie Lines, Sarah Frew, Amy Monaghan, Svend Kjær, Magda Bictash, E. Yvonne Jones, Paul V. Fish Optimization of fragment hit 3 identified isoquinoline 45 as a potent inhibitor of NOTUM with an unexpected flipped binding mode. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Revitalizing antifolates through understanding mechanisms that govern susceptibility and resistance ()
Med. Chem. Commun., 2019, Advance Article DOI: 10.1039/C9MD00078J, Review Article Shannon Lynn Kordus, Anthony David Baughn Mechanisms of antifolate resistance in bacterial and mammalian cells. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Novel antimycobacterial C-21 amide derivatives of the antibiotic fusidic acid: synthesis, pharmacological evaluation and rationalization of media-dependent activity using molecular docking studies in the binding site of human serum albumin ()
Med. Chem. Commun., 2019, Advance Article DOI: 10.1039/C9MD00161A, Research Article Godwin Akpeko Dziwornu, Stephanie Kamunya, Tando Ntsabo, Kelly Chibale Fusidic acid is a natural product antibiotic used clinically, primarily against staphylococcal infections. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Transition Metal Piano Stool Complexes with ActivityAgainst S. Aureus and MRSA: It is time to truly think outside of the box. ()
Med. Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9MD00140A, Research Article Christine DuChane, George Karpin, Joseph Falkinham, Marion Ehrich, Joseph S Merola A new class of piano-stool iridium complexes with 1,2-diaminoethane ligands are shown to beeffective and safe anti-microbials with activity againstS. Aureus, including various isolates of me-thicillin resistant strains (MRSA). Comparison... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Tailored therapeutics based on 1,2,3-1H-triazoles: A mini review ()
Med. Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9MD00218A, Review Article PARTEEK PRASHER, Mousmee Sharma The contemporary drug discovery approaches rely on library synthesis coupled with combinatorial methods and high-throughput screening to identify the leads. However, due to a multitude of the components involved, majority... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Fungal natural alkaloid Schizocommunin activates the aryl hydrocarbon receptor pathway ()
Med. Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9MD00138G, Research Article Roxana Filip, Tyler Shaw, Atsushi Nishida, John Paul Pezacki Fungi, including mushrooms and mycelia, are a rich source for natural products with medicinal properties. In some cases, they can lead to opportunistic infections in humans and other mammals. In... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Druggability assessment of mammalian PAS domains using computational approaches ()
Med. Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9MD00148D, Research Article Joao de Souza, Sylvia Reznikov, Ruidi Zhu, Agnieszka K. Bronowska Per-Arnt-Sim (PAS) domains are key regions that occur in different regulatory proteins from all kingdoms of life. PAS domains show a remarkably conserved structural scaffold, despite a highly variable primary... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Aminopyrimidine-galactose hybrids are highly selective galectin-3 inhibitors ()
Med. Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9MD00183B, Research Article Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Alexander Dahlqvist, Fredrik Zetterberg, Hakon Leffler, Ulf J. Nilsson Galectins are a family of carbohydrate recognition proteins involved in, among other things, modulating cell signalling and cell-environment interactions, giving them roles in several pathologies like cancer and idiopathic lung... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

DIVERSIFICATION OF POLYKETIDE STRUCTURES VIA SYNTHASE ENGINEERING ()
Med. Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9MD00141G, Review Article Taylor Kornfuehrer, Alessandra Eustaquio Polyketide natural products possess diverse biological activities including antibiotic, anticancer, and immunosuppressive. Their equally varied and complex structures arise from head-to-tail condensation of simple, carboxyacyl monomers. Since the seminal discovery... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Synthesis and antitumor activity of aza-brazilan derivatives containing imidazolium salt pharmacophore ()
Med. Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9MD00112C, Research Article Mingqin Huang, Sheng-Zu Duan, Xueqiong Ma, Bicheng Cai, Dong-Mei Wu, Yan Li, Liang Li, Hongbin Zhang, Xiao-Dong Yang The synthesis of a series of novel aza-brazilan derivatives containing imidazolium salt pharmacophores is presented. Biological activity of such imidazolium salts was further evaluated in vitro against a panel of... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Synthesis, Molecular Docking, and Biological Evaluation of Novel 2-Pyrazoline Derivatives as Multifunctional Agents for the Treatment of Alzheimer's Disease ()
Med. Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9MD00030E, Research Article Oya Unsal Tan, Tuba Tüylü Küçükkılınç, Beyza Ayazgök, AYLA BALKAN, Keriman Ozadali Sari A novel series of 2-pyrazoline derivatives was designed, synthesized, and evaluated for cholinesterase (ChE) inhibitory, Aβ anti-aggregating and neuroprotective activities. Among these, 3d, 3e, 3g, and 3h were established as... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Construction of a hybrid gene cluster to reveal coupled ring formation–hydroxylation in the biosynthesis of HSAF and analogues from Lysobacter enzymogenes ()
Med. Chem. Commun., 2019, Advance Article DOI: 10.1039/C9MD00154A, Research Article Xue Li, Haoxin Wang, Yaoyao Li, Liangcheng Du HSAF and analogues are polycyclic tetramate macrolactams (PoTeMs) isolated from Lysobacter enzymogenes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Synthesis and Direct Comparison of the Anticancer Activities of Phomopsolides D/E and Two 7-Oxa-/7-Aza-analogues ()
Med. Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9MD00121B, Research Article Alhanouf Z Aljahdali, Seth Freedman, Jana Scott, Miaosheng Li, George A O'Doherty The synthesis of two stable phomopsolide natural products (D and E) and two analogues are presented. The cytotoxicity of these four compounds is surveyed and compared across a panel of... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Inhibiting bacterial secretion systems in the fight against antibiotic resistance ()
Med. Chem. Commun., 2019, Advance Article DOI: 10.1039/C9MD00076C, Review Article Elizabeth Boudaher, Carrie L. Shaffer The search for new ammunition to combat antibiotic resistance has uncovered diverse inhibitors of the bacterial type IV secretion system. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Synthetic small-molecule RNA ligands: future prospects as therapeutic agents ()
Med. Chem. Commun., 2019, Advance Article DOI: 10.1039/C9MD00195F, Review Article A. Di Giorgio, M. Duca RNA is one of the most intriguing and promising biological targets for the discovery of innovative drugs in many pathologies and various biologically relevant RNAs that could serve as drug targets have already been identified. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Using Drosophila as a platform for drug discovery from natural products in Parkinson's disease ()
Med. Chem. Commun., 2019, Advance Article DOI: 10.1039/C9MD00099B, Review Article Urmila Maitra, Lukasz Ciesla The review provides an overview of discovery of new drug leads from natural extracts using Drosophila as a screening platform to evaluate the therapeutic potential of phytochemicals against Parkinson's disease. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

3-Ketoacyl-ACP synthase (KAS) III homologues and their roles in natural product biosynthesis ()
Med. Chem. Commun., 2019, Advance Article DOI: 10.1039/C9MD00162J, Review Article Risa Nofiani, Benjamin Philmus, Yosi Nindita, Taifo Mahmud KAS III-like enzymes play a significant role in natural product biosynthesis through C–C, C–O, and/or C–N bond formation. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Synthesis, ribosomal selectivity, and antibacterial activity of netilmicin 4′-derivatives ()
Med. Chem. Commun., 2019, Advance Article DOI: 10.1039/C9MD00153K, Research Article Amr Sonousi, Dimitri Shcherbakov, Andrea Vasella, Erik C. Böttger, David Crich We describe the synthesis and evaluation of 4′-subsituted netilmicin derivatives by selective functionalization at the 4′-position of the endocyclic enolether function. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Stereoselective semi-synthesis of the neuroprotective natural product, serofendic acid ()
Med. Chem. Commun., 2019, Advance Article DOI: 10.1039/C9MD00145J, Research Article Dimitri Perusse, Michael J. Smanski Our synthesis of neuroprotectant serofendic acid from biosourced ent-atis-16-en-19-oic acid represents the best route to date. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Anthranilic amide and imidazobenzothiadiazole compounds disrupt Mycobacterium tuberculosis membrane potential ()
Med. Chem. Commun., 2019, Advance Article DOI: 10.1039/C9MD00088G, Research Article Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Jake Smith, Heather Wescott, Julie Early, Steven Mullen, Junitta Guzman, Joshua Odingo, Jason Lamar, Tanya Parish Compounds 1 and 2 disrupt M. tuberculosis membrane potential and demonstrate bactericidal activity against non-replicating M. tuberculosis in pH 4.5 buffer. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Inhibitors of Inosine 5´-monophosphate dehydrogenase as emerging new age antimicrobial agents ()
Med. Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9MD00179D, Review Article sivapriya kirubakaran, Kapil Juvale , Althaf Shaik Inosine 5´-monophosphate dehydrogenase (IMPDH) is a vital enzyme involved in the de-novo synthesis of guanine nucleotides. IMPDH catalyses a crucial step of converting IMP into XMP that is further converted... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Synthesis and initial evaluation of radioactive 5-I-α-methyl-tryptophan: a Trp based agent targeting IDO-1 ()
Med. Chem. Commun., 2019, Advance Article DOI: 10.1039/C9MD00082H, Research Article Benjamin C. Giglio, Hui Wang, Xuefeng Yan, Zibo Li A synthetic approach is established to achieve radioactive 5-I-α-methyl-tryptophan (5-I-AMT). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

3D QSAR-based design and liquid phase combinatorial synthesis of 1,2-disubstituted benzimidazole-5-carboxylic acid and 3-substituted-5H-benzimidazo[1,2-d][1,4]benzodiazepin-6(7H)-one derivatives as anti-mycobacterial agents ()
Med. Chem. Commun., 2019, Advance Article DOI: 10.1039/C9MD00006B, Research Article Nikum D. Sitwala, Vivek K. Vyas, Piyush Gedia, Kinjal Patel, Rania Bouzeyen, Saqib Kidwai, Ramandeep Singh, Manjunath D. Ghate Novel benzimidazole-5-carboxylic acid and benzodiazepin-6(7H)-one derivatives as anti-mycobacterial agents. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Recent advances in the genome mining of Aspergillus secondary metabolites (covering 2012–2018) ()
Med. Chem. Commun., 2019, Advance Article DOI: 10.1039/C9MD00054B, Review Article Jillian Romsdahl, Clay C. C. Wang This review covers advances made in genome mining SMs produced by Aspergillus nidulans, Aspergillus fumigatus, Aspergillus niger, and Aspergillus terreus in the past six years (2012–2018). Genetic identification and molecular characterization of SM biosynthetic gene clusters, along with proposed biosynthetic pathways, is discussed in depth. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2-c]pyrazole tethered carbohydrazide hybrids: exploring their in silico ADMET, ergosterol inhibition and ROS inducing potential ()
Med. Chem. Commun., 2019, Advance Article DOI: 10.1039/C9MD00155G, Research Article Mohd Adil Shareef, K. Sirisha, Irfan Khan, Ibrahim Bin Sayeed, Surender Singh Jadav, Gopathi Ramu, C. Ganesh Kumar, Ahmed Kamal, Bathini Nagendra Babu Non-toxic compounds with antifungal activity, ergosterol inhibition and ROS inducing potential. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Leveraging synthetic biology for producing bioactive polyketides and non-ribosomal peptides in bacterial heterologous hosts ()
Med. Chem. Commun., 2019, Advance Article DOI: 10.1039/C9MD00055K, Review Article Taylor B. Cook, Brian F. Pfleger A review discussing the role of heterologous expression in the discovery and engineered production of bioactive polyketides and non-ribosomal peptides from bacteria. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More