MedChemComm

Extraction of antioxidant and antiproliferative ingredients from Fruits of Rubus chingii Hu by active tracking guidance ()
Med. Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C7MD00240H, Research Article Tiantian Zhang, Yajun Liu, Li Yang, Jian-Guo Jiang, Jingwen Zhao, Wei Zhu Rubus chingii Hu., namely "Fu-pen-zi" in Chinese, has been used as a functional food in China for a long time. This study was aimed to identify the bioactive constituents with... The content of this RSS Feed (c) The Royal Society of Chemistry
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Polyhydroxyalkanoates as biomaterials ()
Med. Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C7MD00252A, Review Article Bhagyashri Thorat Gadgil, Naresh Killi, Rathna VN Gundloori Polyhydroxyalkanoates (PHAs) are biopolymers synthesized by bacteria during unbalanced growth conditions. These biopolymers are considered as potential biomaterials for future applications because they are biocompatible, biodegradable, easy to produce and... The content of this RSS Feed (c) The Royal Society of Chemistry
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Biscarbene gold(I) complexes: Structure-activity-relationships regarding antibacterial effects, cytotoxicity, TrxR inhibition and cellular bioavailability ()
Med. Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C7MD00269F, Research Article Claudia Schmidt, Bianka Karge, Rainer Misgeld, Aram Prokop, Mark Bronstrup, Ingo Ott A series of gold(I) complexes with two N-heterocyclic carbene ligands (biscarbene gold complexes) was prepared and evaluated for effects against cancer cells and pathogenic bacteria. Proliferation inhibition was observed in... The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and chemical characterization of several perfluorinated sialic acid glycals and evaluation of their in vitro antiviral activity against Newcastle disease virus ()
Med. Chem. Commun., 2017, Advance Article DOI: 10.1039/C7MD00072C, Research Article P. Rota, N. Papini, P. La Rocca, M. Montefiori, F. Cirillo, M. Piccoli, R. Scurati, L. Olsen, P. Allevi, L. Anastasia Synthesis and biological evaluation of some C-5 modified sialic acid glycals, epimerized or not at the C-4 position, as HN inhibitors of Newcastle Disease Virus (NDV). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Bitopic Fluorescent Antagonists of the A2A Adenosine Receptor Based on Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine Functionalized Congeners ()
Med. Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C7MD00247E, Research Article Romain Duroux, A. Ciancetta, Philip Mannes, Jinha Yu, Shireesha Boyapati, Elizabeth Gizewski, Said Yous, Francisco Ciruela, John Auchampach, Zhan-Guo Gao, Kenneth Jacobson A pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine antagonist of the A2A adenosine receptor (AR) was functionalized as amine congeners, fluorescent conjugates and a sulfonate, and A2AAR binding modes were predicted computationally. The optimal n-butyl spacer... The content of this RSS Feed (c) The Royal Society of Chemistry
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Design, synthesis, and biological evaluation of new thiazolo[5,4-d]pyrimidine derivatives as potent antiproliferative agents ()
Med. Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C7MD00165G, Research Article Bin Yu, Hong-Min Liu, Zhonghua Li, XueQi Liu, PengFei Geng, Jin-Lian Ma, TaoQian Zhao, HaoMing Wei A series of thiazolo[5,4-d]pyrimidine derivatives were synthesized and evaluated for their antiproliferative activities against several human cancer cell lines. The structure-activity relationship studies were carried out, showing that most of... The content of this RSS Feed (c) The Royal Society of Chemistry
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Correction: Design, synthesis, crystal structure and fungicidal activity of (E)-5-(methoxyimino)-3,5-dihydrobenzo[e][1,2]oxazepin-4(1H)-one analogues ()
Med. Chem. Commun., 2017, 8,1366-1366 DOI: 10.1039/C7MD90022H, Correction Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Dongyan Yang, Chuan Wan, MengMeng He, Chuanliang Che, Yumei Xiao, Bin Fu, Zhaohai Qin The content of this RSS Feed (c) The Royal Society of Chemistry
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Succinct synthesis of saturated hydroxy fatty acids and in vitro evaluation of all hydroxylauric acids on FFA1, FFA4 and GPR84 ()
Med. Chem. Commun., 2017, 8,1360-1365 DOI: 10.1039/C7MD00130D, Research Article Mads Holmgaard Kaspersen, Laura Jenkins, Julia Dunlop, Graeme Milligan, Trond Ulven A concise synthetic protocol enables rapid receptor screening of hydroxy fatty acid. The content of this RSS Feed (c) The Royal Society of Chemistry
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Dichloro-naphthoquinone as a non-classical inhibitor of the mycobacterial carbonic anhydrase Rv3588c ()
Med. Chem. Commun., 2017, 8,1318-1321 DOI: 10.1039/C7MD00090A, Research Article M. A. Dallaston, S. Rajan, J. Chekaiban, M. Wibowo, M. Cross, M. J. Coster, R. A. Davis, A. Hofmann This study reports the most active non-sulfonamide mycobacterial CA inhibitor to date. The content of this RSS Feed (c) The Royal Society of Chemistry
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Facilitating the presentation of antigen peptides on dendritic cells for cancer immunotherapy using a polymer-based synthetic receptor ()
Med. Chem. Commun., 2017, 8,1207-1212 DOI: 10.1039/C7MD00188F, Research Article Cuicui Li, Masafumi Takeo, Masayoshi Matsuda, Hiroko Nagai, Sun Xizheng, Wataru Hatanaka, Akihiro Kishimura, Hiroyuki Inoue, Kenzaburo Tani, Takeshi Mori, Yoshiki Katayama A synthetic receptor modified on DCs successfully facilitated cancer immunotherapy. The content of this RSS Feed (c) The Royal Society of Chemistry
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Maltodextrin modified liposomes for drug delivery through the blood-brain barrier ()
Med. Chem. Commun., 2017, 8,1337-1345 DOI: 10.1039/C7MD00045F, Research Article Zeynep Gurturk, Aysen Tezcaner, Ali Deniz Dalgic, Seval Korkmaz, Dilek Keskin Maltodextrin conjugated and glutathione co-loaded liposomes can improve brain targeting of levodopa by enhancing blood-brain barrier targeting and transport. The content of this RSS Feed (c) The Royal Society of Chemistry
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Ring-opened aminothienopyridazines as novel tau aggregation inhibitors ()
Med. Chem. Commun., 2017, 8,1275-1282 DOI: 10.1039/C6MD00306K, Research Article M. Moir, S. W. Chua, T. Reekie, A. D. Martin, A. Ittner, L. M. Ittner, M. Kassiou Simplified aminothienopyridazine analogues were synthesised and their inhibition of tau protein aggregation assessed. The content of this RSS Feed (c) The Royal Society of Chemistry
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Benzylsulfanyl benzo-heterocycle amides and hydrazones as new agents against drug-susceptible and resistant Mycobacterium tuberculosis ()
Med. Chem. Commun., 2017, 8,1303-1306 DOI: 10.1039/C7MD00146K, Research Article Xiaoyun Lu, Xianglong Hu, Zhiyong Liu, Tianyu Zhang, Ruibing Wang, Baojie Wan, Scott G. Franzblau, Qidong You A series of benzylsulfanyl benzo-heterocycle amides and hydrazones were synthesized and evaluated for anti-tubercular activities. The content of this RSS Feed (c) The Royal Society of Chemistry
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5-Methyl-N-(8-(5,6,7,8-tetrahydroacridin-9-ylamino)octyl)-5H-indolo[2,3-b]quinolin-11-amine: a highly potent human cholinesterase inhibitor ()
Med. Chem. Commun., 2017, 8,1307-1317 DOI: 10.1039/C7MD00143F, Research Article Li Wang, Ignacio Moraleda, Isabel Iriepa, Alejandro Romero, Francisco Lopez-Munoz, Mourad Chioua, Tsutomu Inokuchi, Manuela Bartolini, Jose Marco-Contelles 5-Methyl-N-(8-(5,6,7,8-tetrahydroacridin-9-ylamino)octyl)-5H-indolo[2,3-b]quinolin-11-amine is a very potent human ChE inhibitor [IC50 (hAChE) = 0.95 +/- 0.04 nM]. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of thioether andrographolide derivatives and their inhibitory effect against cancer cells ()
Med. Chem. Commun., 2017, 8,1268-1274 DOI: 10.1039/C7MD00169J, Research Article Yi Liu, Ren-Ming Liang, Qing-Ping Ma, Kai Xu, Xin-Yong Liang, Wei Huang, Robert Sutton, Jie Ding, Paul M. O'Neil, Chun-Ru Cheng Novel thioether andrographolide derivatives were designed and synthesized and some of them exhibited excellent anticancer activity. The content of this RSS Feed (c) The Royal Society of Chemistry
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A structurally guided dissection-then-evolution strategy for ligand optimization of smoothened receptor ()
Med. Chem. Commun., 2017, 8,1332-1336 DOI: 10.1039/C7MD00104E, Research Article Lintao Ye, Kang Ding, Fei Zhao, Xiaoyan Liu, Yiran Wu, Yang Liu, Dongxiang Xue, Fang Zhou, Xianjun Zhang, Raymond C. Stevens, Fei Xu, Suwen Zhao, Houchao Tao We present herein a novel dissection-then-evolution strategy for ligand optimization. The content of this RSS Feed (c) The Royal Society of Chemistry
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The discovery of a potent Nav1.3 inhibitor with good oral pharmacokinetics ()
Med. Chem. Commun., 2017, 8,1255-1267 DOI: 10.1039/C7MD00131B, Research Article D. C. Pryde, N. A. Swain, P. A. Stupple, C. W. West, B. Marron, C. J. Markworth, D. Printzenhoff, Z. Lin, P. J. Cox, R. Suzuki, S. McMurray, G. J. Waldron, C. E. Payne, J. S. Warmus, M. L. Chapman An aryl ether series of potent and selective Nav1.3 inhibitors is described, starting from a series of diphenymethyl amides. The content of this RSS Feed (c) The Royal Society of Chemistry
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Interaction of indomethacin with calf thymus DNA: a multi-spectroscopic, thermodynamic and molecular modelling approach ()
Med. Chem. Commun., 2017, 8,1283-1296 DOI: 10.1039/C7MD00094D, Research Article Mohammed Amir Husain, Hassan Mubarak Ishqi, Tarique Sarwar, Sayeed Ur Rehman, Mohammad Tabish Indomethacin belongs to the acetic acid derivative class of non-steroidal anti-inflammatory drugs with diverse pharmacological and biological activities. The content of this RSS Feed (c) The Royal Society of Chemistry
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High throughput methods to measure the propensity of compounds to form intramolecular hydrogen bonding ()
Med. Chem. Commun., 2017, 8,1143-1151 DOI: 10.1039/C7MD00101K, Review Article Giulia Caron, Maura Vallaro, Giuseppe Ermondi Implementation of IMHB considerations in drug discovery needs robust and validated descriptors to experimentally verify the propensity of compounds to exhibit IMHBs. The content of this RSS Feed (c) The Royal Society of Chemistry
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Novel bipharmacophoric inhibitors of the cholinesterases with affinity to the muscarinic receptors M1 and M2 ()
Med. Chem. Commun., 2017, 8,1346-1359 DOI: 10.1039/C7MD00149E, Research Article Regina Messerer, Clelia Dallanoce, Carlo Matera, Sarah Wehle, Lisa Flammini, Brian Chirinda, Andreas Bock, Matthias Irmen, Christian Trankle, Elisabetta Barocelli, Michael Decker, Christoph Sotriffer, Marco De Amici, Ulrike Holzgrabe Hybrids of allosteric modulators of the muscarinic receptor and the AChE inhibitor tacrine and the orthosteric muscarinic agonists iperoxo and isox were synthesized. The content of this RSS Feed (c) The Royal Society of Chemistry
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Development of 2-aminooxazoline 3-azaxanthene [small beta]-amyloid cleaving enzyme (BACE) inhibitors with improved selectivity against Cathepsin D ()
Med. Chem. Commun., 2017, 8,1196-1206 DOI: 10.1039/C7MD00106A, Research Article Jonathan D. Low, Michael D. Bartberger, Kui Chen, Yuan Cheng, Mark R. Fielden, Vijay Gore, Dean Hickman, Qingyian Liu, E. Allen Sickmier, Hugo M. Vargas, Jonathan Werner, Ryan D. White, Douglas A. Whittington, Stephen Wood, Ana E. Minatti We report the discovery of an orally efficacious 3-aza-aminooxazoline-BACE1 inhibitor with 1 800 000[times] fold selectivity against CatD and no retinal effects in an early screening rat toxicology study. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis, structure-activity relationship and binding mode analysis of 4-thiazolidinone derivatives as novel inhibitors of human dihydroorotate dehydrogenase ()
Med. Chem. Commun., 2017, 8,1297-1302 DOI: 10.1039/C7MD00081B, Research Article Fanxun Zeng, Tiantian Qi, Chunyan Li, Tingfang Li, Honglin Li, Shiliang Li, Lili Zhu, Xiaoyong Xu A series of 4-thiazolidinone derivatives were synthesized and evaluated as novel human dihydroorotate dehydrogenase (hDHODH) inhibitors. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of benzo[d]thiazole-hydrazone analogues: molecular docking and SAR studies of potential H+/K+ ATPase inhibitors and anti-inflammatory agents ()
Med. Chem. Commun., 2017, 8,1173-1189 DOI: 10.1039/C7MD00111H, Research Article Shi-Meng Wang, Gao-Feng Zha, K. P. Rakesh, N. Darshini, T. Shubhavathi, H. K. Vivek, N. Mallesha, Hua-Li Qin A series of new benzo[d]thiazole-hydrazones were synthesized and characterized by analytical and spectroscopic techniques. The content of this RSS Feed (c) The Royal Society of Chemistry
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Pyrazolo[3,4-d]pyrimidines as sigma-1 receptor ligands for the treatment of pain. Part 2: Introduction of cyclic substituents in position 4 ()
Med. Chem. Commun., 2017, 8,1246-1254 DOI: 10.1039/C7MD00078B, Research Article Jose Luis Diaz, Jordi Corbera, Daniel Martinez, Magda Bordas, Cristina Sicre, Rosalia Pascual, M[a] Jose Pretel, Ana Paz Marin, Ana Montero, Albert Dordal, Ines Alvarez, Carmen Almansa A SAR study identified the 4-(1-methylpyrazol-5-yl) derivative, 12f, as a selective [sigma]1R antagonist with a good ADMET profile and potent antinociception. The content of this RSS Feed (c) The Royal Society of Chemistry
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Pyrazolo[3,4-d]pyrimidines as sigma-1 receptor ligands for the treatment of pain. Part 1: 4-acylamino derivatives ()
Med. Chem. Commun., 2017, 8,1235-1245 DOI: 10.1039/C7MD00077D, Research Article Jose Luis Diaz, Jordi Corbera, Rosa Cuberes, Montserrat Contijoch, Raquel Enrech, Sandra Yeste, Ana Montero, Albert Dordal, Xavier Monroy, Carmen Almansa The 4-acylaminopyrazolo[3,4-d]pyrimidine 9a was identified as a highly selective [sigma]1R antagonist, showing as well substantial antinociceptive properties. The content of this RSS Feed (c) The Royal Society of Chemistry
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PAIN-less identification and evaluation of small molecule inhibitors against protein tyrosine phosphatase 1B ()
Med. Chem. Commun., 2017, 8,1220-1224 DOI: 10.1039/C7MD00126F, Research Article Hamid R. Nasiri, Philipp Mracek, Steffen K. Grimm, Janine Gastaldello, Adrian Kolodzik, Dirk Ullmann A miniaturized assay was set up to test a set of natural products against protein tyrosine phosphatase 1B (PTP1B). By using several read-out and counter assays, berberine and palmatine were identified as PAINS (pan-assay interference compounds) and [small alpha]-TOS as a novel inhibitor of PTP1B. The content of this RSS Feed (c) The Royal Society of Chemistry
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Design of a ligand for cancer imaging with long blood circulation and an enhanced accumulation ability in tumors ()
Med. Chem. Commun., 2017, 8,1190-1195 DOI: 10.1039/C7MD00102A, Research Article Elnaz Nakhaei, Chan Woo Kim, Daiki Funamoto, Hikari Sato, Yuta Nakamura, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama Palmitoyl modification on a folate-fluorophore conjugate can induce long blood circulation through non-covalent binding to serum albumin. The content of this RSS Feed (c) The Royal Society of Chemistry
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Design, synthesis and pharmacological evaluation of new 2-oxo-quinoline derivatives containing [small alpha]-aminophosphonates as potential antitumor agents ()
Med. Chem. Commun., 2017, 8,1158-1172 DOI: 10.1039/C7MD00098G, Research Article Yan-Cheng Yu, Wen-Bin Kuang, Ri-Zhen Huang, Yi-Lin Fang, Ye Zhang, Zhen-Feng Chen, Xian-Li Ma Novel 2-oxo-quinoline derivatives containing [small alpha]-aminophosphonates were synthesized as antitumor agents. Compound 5b blocked HepG2 cell cycle at G2/M phase and induced apoptosis in mitochondrial pathway. The content of this RSS Feed (c) The Royal Society of Chemistry
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In silico prediction of chemical subcellular localization via multi-classification methods ()
Med. Chem. Commun., 2017, 8,1225-1234 DOI: 10.1039/C7MD00074J, Research Article Hongbin Yang, Xiao Li, Yingchun Cai, Qin Wang, Weihua Li, Guixia Liu, Yun Tang Multi-classification models were developed for prediction of subcellular localization of small molecules by machine learning methods. The content of this RSS Feed (c) The Royal Society of Chemistry
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Development of novel [small beta]-carboline-based hydroxamate derivatives as HDAC inhibitors with DNA damage and apoptosis inducing abilities ()
Med. Chem. Commun., 2017, 8,1213-1219 DOI: 10.1039/C6MD00681G, Research Article Ji Liu, Tingting Wang, Xinyang Wang, Lin Luo, Jing Guo, Yanfu Peng, Qibing Xu, Jiefei Miao, Yanan Zhang, Yong Ling A series of novel [small beta]-carboline-based hydroxamate derivatives (8a-n) as HDAC inhibitors have been designed and synthesized. The content of this RSS Feed (c) The Royal Society of Chemistry
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Identification of steroid-like natural products as antiplasmodial agents by 2D and 3D similarity-based virtual screening ()
Med. Chem. Commun., 2017, 8,1152-1157 DOI: 10.1039/C7MD00063D, Research Article Elumalai Pavadai, Gurminder Kaur, Sergio Wittlin, Kelly Chibale The emergence of drug resistance in Plasmodium falciparum to available antimalarial drugs has challenged current antimalarial treatments. The content of this RSS Feed (c) The Royal Society of Chemistry
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Discovery of novel trimethoxy-ring BRD4 bromodomain inhibitors: AlphaScreen assay, crystallography and cell-based assay ()
Med. Chem. Commun., 2017, 8,1322-1331 DOI: 10.1039/C7MD00083A, Research Article Zhifeng Chen, Hao Zhang, Shien Liu, Yiqian Xie, Hao Jiang, Wenchao Lu, Heng Xu, Liyan Yue, Yuanyuan Zhang, Hong Ding, Mingyue Zheng, Kunqian Yu, Kaixian Chen, Hualiang Jiang, Cheng Luo A novel category of BRD4 bromodomain inhibitors was discovered through AlphaScreen assay, and the binding mode was revealed by a crystallographic method. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and evaluation of oxindoles as promising inhibitors to the immunosuppressive enzyme indoleamine 2,3-Dioxygenase 1 ()
Med. Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C7MD00226B, Research Article Saurav Paul, Ashalata Roy, Suman Jyoti Deka, Subhankar Panda, Gopal Narayan Srivastava, Vishal Trivedi, Debasis Manna Indoleamine 2,3-dioxygenase 1 (IDO1) is considered as an important therapeutic target for the treatment of cancer, chronic infections and other diseases that are associated with immune suppression. Recent developments in... The content of this RSS Feed (c) The Royal Society of Chemistry
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18[small alpha]-Glycyrrhetinic acid monoglucuronide as an anti-inflammatory agent through suppression of the NF-[small kappa]B and MAPK signaling pathway ()
Med. Chem. Commun., 2017, Advance Article DOI: 10.1039/C7MD00210F, Research Article Bo Li, Yongan Yang, Liuzeng Chen, Shichao Chen, Jing Zhang, Wenjian Tang 18[small alpha]-GAMG exhibited strong anti-inflammatory activity through inhibiting the expression of iNOS, COX-2, and MAPKs, as well as activation of NF-[small kappa]B. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Discovery of potential antifungal triazoles: Design, synthesis, biological evaluation, and preliminary antifungal mechanism exploration ()
Med. Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C7MD00112F, Research Article Yuan Zhang, Guri L V Damu, Shengfeng Cui, Jiali Mi, Vijai Kumar Reddy Tangadanchu, Cheng-He Zhou A series of triazoles as miconazole analogues were designed, synthesized and characterized by IR, NMR, MS and HRMS spectra. All the newly prepared compounds were screened for their antifungal activities... The content of this RSS Feed (c) The Royal Society of Chemistry
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Rational design and optimization of selenophenes with basic side chains as novel potent selective estrogen receptor modulators (SERMs) for breast cancer therapy ()
Med. Chem. Commun., 2017, Advance Article DOI: 10.1039/C7MD00163K, Research Article Junjie Luo, Zhiye Hu, Yuan Xiao, Tongxin Yang, Chune Dong, Jian Huang, Hai-Bing Zhou Selenophenes with basic side chains showed excellent antagonist activity for ERs and increased antiproliferative activity than that of 4OHT in MCF-7 cells. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Characterization and lymphocytes proliferation activity of an oligosaccharide degradated from Astragalus polysaccharide ()
Med. Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C7MD00148G, Research Article ZY Zhu, Jinyu Zhang, Fei Liu, Ling Chen, Lijing Chen, Yun Tang An Astragalus oligosaccharide (AOS) degraded from the Astragalus polysaccharide (APS) and purified by membrane dialysis and silicon gel chromatography was studied in this paper. The structural features of AOS were... The content of this RSS Feed (c) The Royal Society of Chemistry
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Identification of Potent Cholecystokinin-B Receptor Antagonists: Synthesis, Molecular Modeling and anti-cancer activity against Pancreatic Cancer Cells. ()
Med. Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C7MD00171A, Research Article Saroj Kumari, Joyita Chowdhary, Manisha Sikka, Priyanka Verma, Prakash Jha, Anil Kumar Mishra, Daman Saluja, Madhu Chopra Advanced malignant stage of pancreatic cancer has poor prognosis and very few treatment strategies are available. Pancreatic cancer is known to possess unique growth-related receptors that when activated stimulate tumour... The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis, Molecular Modeling and Biological Evaluation of Aza-flavanones as [small alpha]-Glucosidase Inhibitors ()
Med. Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C7MD00162B, Research Article Shivaprasad Kasturi, Sujatha Surarapu, Chandra Chary Bathoju, Srinivas Uppalanchi, Shubham Dwivedi, Yogeswari Perumal , Dilep Kumar Sigalapalli , Nagendra Babu Bathini, Kishna S Ethiraj, Jayashree Anireddy An efficient acid catalyzed methodology has been employed to synthesize a variety of aza-flavanones and their [small alpha]-glucosidase inhibitory activity is evaluated using Acarbose, Miglitol and Voglibose as reference standards. And... The content of this RSS Feed (c) The Royal Society of Chemistry
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Developments of bioorthogonal handle-containing photo-crosslinkers for photoaffinity labeling ()
Med. Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C7MD00217C, Review Article Zhengqiu Li, Haijun Guo Photoaffinity labeling (PAL) has been widely applied in various research areas such as medicinal chemistry, chemical biology and structural biology, owing to its capability of interrogating non-covalent ligand-protein interactions under... The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis, [small alpha]-glucosidase inhibition and molecular docking studies of novel thiazolidine-2,4-dione or rhodanine derivatives ()
Med. Chem. Commun., 2017, Advance Article DOI: 10.1039/C7MD00173H, Research Article Guang-cheng Wang, Ya-ping Peng, Zhen-zhen Xie, Jing Wang, Ming Chen A series of novel thiazolidine-2,4-dione or rhodanine derivatives (5a-5k, 6a-6k) were synthesized and evaluated for their [small alpha]-glucosidase inhibitory activity. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of novel inhibitors of [small alpha]-amylase based on the thiazolidine-4-one skeleton containing a pyrazole moiety and their configurational studies ()
Med. Chem. Commun., 2017, Advance Article DOI: 10.1039/C7MD00080D, Research Article Parvin Kumar, Meenakshi Duhan, Kulbir Kadyan, Jayant Sindhu, Sunil Kumar, Hitender Sharma The results showed that some of the synthesized compounds exhibited significant inhibitory activities. Compound 5a at 100 [small mu ]g mL-1 concentration showed a remarkable inhibition of 90.04%. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and pharmacological evaluation of multi-functional homoisoflavonoid derivatives as potent inhibitors of monoamine oxidase B and cholinesterase for the treatment of Alzheimer's disease ()
Med. Chem. Commun., 2017, Advance Article DOI: 10.1039/C7MD00199A, Research Article Qiao-Hong Liu, Jia-Jia Wu, Fan Li, Pei Cai, Xue-Lian Yang, Ling-Yi Kong, Xiao-Bing Wang Homoisoflavonoid derivatives were synthesized and evaluated as multi-functional anti-Alzheimer's agents. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Recent progress in the development of metal complexes as [small beta]-amyloid imaging probes in the brain ()
Med. Chem. Commun., 2017, Advance Article DOI: 10.1039/C7MD00064B, Review Article Kaihua Chen, Mengchao Cui In this review, we have focused on the recent progress in metal complexes that are able to bind to [small beta]-amyloid (A[small beta]) species. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Advances in indoleamine 2,3-dioxygenase 1 medicinal chemistry ()
Med. Chem. Commun., 2017, Advance Article DOI: 10.1039/C7MD00109F, Review Article Alice Coletti, Francesco Antonio Greco, Daniela Dolciami, Emidio Camaioni, Roccaldo Sardella, Maria Teresa Pallotta, Claudia Volpi, Ciriana Orabona, Ursula Grohmann, Antonio Macchiarulo Structure-function relationships of IDO1 and structure-activity relationships of inhibitors are discussed with an outlook on next generation IDO1 ligand. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Deciphering the origins of molecular toxicity for combretastatin A4 and its glycoconjugates: Interactions with major drug transporters and their safety profiles in vitro and in vivo ()
Med. Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C7MD00246G, Research Article Zhenhua Huang, Gentao Li, Xue Wang, Hu Xu, Youcai Zhang, Qingzhi Gao Cellular uptake and transport mechanism directly correlate with drug-like profiles of a lead compound. To decipher the molecular origin of the toxicity of combretastatin A4 (CA4), an important microtubule targeting... The content of this RSS Feed (c) The Royal Society of Chemistry
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Approaches to selective fibroblast growth factor receptor 4 inhibition through targeting the ATP-pocket middle-hinge region ()
Med. Chem. Commun., 2017, Advance Article DOI: 10.1039/C7MD00213K, Research Article Robin A. Fairhurst, Thomas Knoepfel, Catherine Leblanc, Nicole Buschmann, Christoph Gaul, Jutta Blank, Inga Galuba, Jorg Trappe, Chao Zou, Johannes Voshol, Christine Genick, Peggy Brunet-Lefeuvre, Francis Bitsch, Diana Graus-Porta, Pascal Furet Structurally diverse covalent and non-covalent series of selective FGFR4 inhibitors have been identified. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Assessing the performance of docking scoring function, FEP, MM-GBSA, and QM/MM-GBSA approaches on a series of PLK1 inhibitors ()
Med. Chem. Commun., 2017, Advance Article DOI: 10.1039/C7MD00184C, Research Article Chunlan Pu, Guoyi Yan, Jianyou Shi, Rui Li The ranking capability of FEP is the best with rs = 0.854. QM/MM-GBSA can reach 0.767 with much lower computation time. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Design, facile synthesis and anthelmintic activity of new O-substituted 6-methoxybenzothiazole-2-carbamates. Part II ()
Med. Chem. Commun., 2017, Advance Article DOI: 10.1039/C7MD00140A, Research Article A. Mohsen M. E. Omar, Omaima M. Aboulwafa, Doaa A. E. Issa, Mai S. M. El-Shoukrofy, May E. Amr, Ibrahim M. El-Ashmawy Hypothesis for the design of 6-substituted benzothiazolecarbamate prototype anthelmintics having planar heterocyclic systems at the 6-position of benzothiazole ring with different polar nature and hydrophilic-lipophilic properties. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synergic modulation of inflammatory state of macrophages utilizing anti-oxidant and phosphatidylserine containing polymer-lipid hybrid nanoparticles ()
Med. Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C7MD00174F, Research Article Md Zahangir Hosain, Kazuki Yuzuriha, Khadijah Zai, Masafumi Takeo, Akihiro Kishimura, Yoshihiko Murakami, Takeshi Mori, Yoshiki Katayama Inflammatory activation of macrophages is a key factor in chronic inflammatory diseases such as ulcerative colitis. The excessive production of reactive oxygen species (ROS)/reactive nitrogen species (RNS) by macrophages causes... The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of novel pentacyclic triterpene-Neu5Ac2en derivatives and investigation of their in vitro anti-influenza entry activity ()
Med. Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C7MD00245A, Research Article Yongying Shi, Longlong Si, Xu Han, Zibo Fan, Shouxin Wang, Man Li, Jiaqi Sun, Yongmin Zhang, Demin Zhou, Sulong Xiao Sialic acid (Neu5Ac) derivatives, analogs and their conjugates are important pharmacophores. Modification of C-4 of sialic acid can lead to derivatives with potent anti-influenza activities, such as Zanamivir. Herein, we... The content of this RSS Feed (c) The Royal Society of Chemistry
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Peptide-fluorophore/AuNP conjugate-based two-photon excited fluorescent nanosensor for caspase-3 activity imaging assay in living cells and tissue ()
Med. Chem. Commun., 2017, Advance Article DOI: 10.1039/C7MD00177K, Research Article Qingshan Ge, Ningning Wang, Jishan Li, Ronghua Yang Via the assembly of two-photon dye (TPdye)-labeled peptides on the gold nanoparticle's surface, a novel two-photon excited (TPE) fluorescent nanosensor has been developed for the measurement of caspase-3 activity in live cells and rat liver tissue slices. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Side chain-functionalized aniline-derived ursolic acid derivatives as multidrug resistance reversers that block the nuclear factor-kappa B (NF-[small kappa]B) pathway and cell proliferation ()
Med. Chem. Commun., 2017, Advance Article DOI: 10.1039/C7MD00105C, Research Article Ri-Zhen Huang, Shi-Xian Hua, Zhi-Xin Liao, Xiao-Chao Huang, Heng-Shan Wang A series of inhibitors of NF-[small kappa]B based on ursolic acid (UA) derivatives containing functionalized aniline or amide side chains were synthesized and evaluated for inhibition of NF-[small kappa]B as well as their antitumor effects. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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