Organic & Biomolecular Chemistry

Iron-catalysed carbene-transfer reactions of diazo acetonitrile ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01991F, Communication Claire Empel, Katharina J. Hock, Rene M Koenigs An iron catalysed insertion reaction of diazo acetonitrile into N—H and S—H bonds has been developed that can be readily applied to a broad range of substrate and can be... The content of this RSS Feed (c) The Royal Society of Chemistry
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Dirhodium(II)/P(t-Bu)3 Catalyzed Tandem Reaction of α,β-Unsaturated Aldehyde with Arylboronic Acids ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01997E, Paper Ziling Ma, Yuanhua Wang The phosphine ligated dirhodium(II) acetate is advocated as a catalyst for the synthesis of aryl alkyl ketones by the tandem reaction of α,β-unsaturated aromatic or aliphatic aldehydes with arylboronic acids.... The content of this RSS Feed (c) The Royal Society of Chemistry
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Magnolol dimer-derived fragments as PPARγ-selective probes ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01745J, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Dominik Dreier, Mirta Resetar, Veronika Temml, Lukas Rycek, Nicolas Kratena, Michael Schnürch, Daniela Schuster, Verena M. Dirsch, Marko D. Mihovilovic Sesqui magnolol A & B have been found to be selective partial PPARγ agonists while truncated magnolol dimer acts as an antagonist. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Brønsted Acid-Catalysed Regiodivergent Phosphorylation of 2-Indolylmethanols to Synthesize Benzylic Site or C3-Phosphorylated Indole Derivatives ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02033G, Paper Long Chen, Yun-Xiang Zou, Xin-Yue Fang, Jie Wu, Xiao Hua Sun A Brønsted acid catalysed regiodivergent phosphorylation of 2-indolylmethanols with diarylphosphine oxides has been established, which provides a brand-new strategy for accessing highly functionalized phosphorus-containing indoles with structural diversity. Under the... The content of this RSS Feed (c) The Royal Society of Chemistry
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A Concise Synthesis of (E)-3-aryl-2,3,4,5-tetrahydro-1H-3-benzazonines by Aryne induced [2,3] Stevens Rearrangement of 1,2,3,4-Tetrahydroisoquinolines ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02099J, Paper Xuan Pan, Yantao Ma, Zhan-zhu Liu A mild and transition-metal-free approach for the synthesis of (E)-3-aryl-2,3,4,5-tetrahydro-1H-3-benzazonines via [2,3] Stevens rearrangement of 1,2,3,4-tetrahydroisoquinolines with arynes is described. This protocol provides a straightforward access to (E)-3-aryl-2,3,4,5-tetrahydro-1H-3-benzazonines in moderate... The content of this RSS Feed (c) The Royal Society of Chemistry
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Atom-economic synthesis of cyclobuta[a]naphthalen-4-ols via a base-promoted [2 + 2] cycloaddition/1,6-nucleophilic addition cascade ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB02042F, Communication Jia-Yin Wang, Feng-Lie Xie, Jian-Qiang Hu, Shi-Zhao Yang, You-Jian Wang, Wen-Juan Hao, Shu-Jiang Tu, Bo Jiang An atom-economic [2 + 2] cycloaddition cascade of yne-allenones with C-nucleophiles has been established, enabling the direct generation of functionalized cyclobuta[a]naphthalen-4-ols with generally good yields. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Metal- and base-free synthesis of functionalized α,α-difluoroimines via electrophilic fluorination of N-substituted enamines ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01941J, Communication Fangyi Li, Changfu Qiu, Guangwei Yin, Chunhua Wang, Zheng Li A metal- and base-free synthesis of functionalized α,α-difluoroimines is presented. The reaction features mild condition, high E/Z control and broad functional group tolerance. The utility of the products was demonstrated through valuable synthetic transformations. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Preparation of oxazolines and oxazoles via a PhI(OAc)2-promoted cyclization of N-propargylamides ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01474D, Paper Wei Yi, Qing-Yun Liu, Xing-Xiao Fang, Sheng-Chun Lou, Gong-Qing Liu A metal-free cyclization of N-propargylamides for the synthesis of various oxazodines and oxazoles via a 5-exo-dig process is reported herein. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Efficient synthesis of tetrazole hemiaminal silyl ethers via three-component hemiaminal silylation ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB02089B, Communication Ming-Sheng Xie, Xuan Cheng, Yang-Guang Chen, Xiao-Xia Wu, Gui-Rong Qu, Hai-Ming Guo An efficient synthesis of 2,5-disubstituted tetrazoles was developed via three-component hemiaminal silylation of 5-substituted tetrazoles, aldehydes, and silyl triflates. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Caged siRNAs with single folic acid modification of antisense RNA for photomodulation of exogenous and endogenous gene expression in cells ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01952E, Paper Lijia Yu, Nannan Jing, Zhenjun Yang, Lihe Zhang, Xinjing Tang Photoregulating gene expression using folic acid modified caged siRNA through complex formation of folic acid/folate receptor. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Chemoselective synthesis of isolated and fused fluorenones and their photophysical and antiviral properties ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01733F, Paper Ismail Althagafi, Ranjay Shaw, Cheng-Run Tang, Rahul Panwar, Shally Shally, Chanda Sinha, Amit Kumar, Yong-Tang Zheng, Ramendra Pratap Highly functionalized fluorenones was synthesized by intramolecular cyclization of 2''-halo-[1,1':3',1''-terphenyl]-4'-carbonitriles in presence of n-butyllithium or lithium aluminium hydride. The precursor was synthesized by ring transformation of 2-oxo-6-aryl/heteroaryl-4-(sec.amino)-2H-pyran-3-carbonitriles or 2-oxobenzo[h]chromenes with... The content of this RSS Feed (c) The Royal Society of Chemistry
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Azlactone-based heterobifunctional linkers with orthogonal clickable groups: Efficient tools for bioconjugation with complete atom economy ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01807C, Communication Hien The Ho, Alexandre Bénard, Gwénaël Forcher, Maël Le Bohec, Véronique Montembault, Sagrario Pascual, Laurent Fontaine We report the efficient synthesis of a series of new azlactone-based heterofunctional linkers bearing two orthogonal clickable groups that proceed with full atom economy. These new linkers comprise an azlactone... The content of this RSS Feed (c) The Royal Society of Chemistry
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Catalytic Asymmetric Tamura Cycloaddition of Homophthalic Anhydrides with 2-Arylidene-1,3-diones ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01970C, Paper Han Xu, Feng Sha, Qiong Li, Xin-Yan Wu An organocatalytic enantioselective Tamura cycloaddition between homophthalic anhydrides and 2-arylidene-1,3-indanediones has been developed. With 2 mol% of commercially available (DHQD)2PYR, a wide range of enantioenriched spiro-1,3-indanedione derivatives were obtained in... The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of Near-Infrared Fluorescent Rhodamines via an SNArH Reaction and Their Biological Applications ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01701H, Paper Xianshun Zeng, Qing Wang, Kun Huang, Songtao Cai, Chang Liu, Xiaojie Jiao, Song He, Liancheng Zhao Near-infrared (NIR) dyes are of great interest in biomedicine due to diminished interfering absorption and fluorescence from biological samples, reduced scattering, and enhanced tissue penetration depth. In this context, we... The content of this RSS Feed (c) The Royal Society of Chemistry
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Metal-Free Visible-light Synthesis of Quaternary α-Perfluoroalkyl Aldehydes via an Enamine Intermediate ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02058B, Communication Haruna Matsui, Mao Murase, Tomoko Yajima Visible-light induced perfluoroalkylation of the α-position of aldehydes via enamines was developed. The reaction proceeds by electron donor-acceptor complexation of the enamine and perfluoroalkyl iodide without any additional redox catalyst.... The content of this RSS Feed (c) The Royal Society of Chemistry
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Cyclic imines – preparation and application in synthesis ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01874J, Review Article Jakub Iwanejko, Elżbieta Wojaczyńska Cyclic imines, available from various nitrogen-containing reactants, serve as versatile synthetic intermediates for biologically active compounds. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Phosphinatophenylporphyrins tailored for high photodynamic efficacy ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01984C, Paper Kamil Lang, Jan Hynek, Jaroslav Zelenka, Martina Koncošová, Ivana Křížová, Tomas Ruml, Jan Demel, Pavel Kubát The development of effective photosensitizers is particularly attractive for photodynamic therapy of cancer. Three novel porphyrin photosensitizers functionalized with phosphinic groups were synthesized and their physicochemical, photophysical, and photobiological properties... The content of this RSS Feed (c) The Royal Society of Chemistry
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Palladium-Catalyzed Sequential Carbonylation/Alkynylation of C(sp3)-Pd Species: Efficient Assembly of Structurally Diverse Ynones ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02092B, Paper Huanfeng Jiang, Miao Hu, Yang Gao, Wanqing Wu, Jianxiao Li, Chunsheng Li, Hao Zhang A convenient and efficient strategy to construct functionalized ynones by palladium-catalyzed cascade annulation reaction has been developed. Based on intramolecular Heck-type reaction, diverse heterocycle products were synthesized via the selection... The content of this RSS Feed (c) The Royal Society of Chemistry
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D-/L-isothymidine incorporation in core sequence of aptamer BC15 enhanced its binding affinity to hnRNP A1 protein ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01454J, Paper Liyu Li, Xiantao Yang, kunfeng Li, guangpu Zhang, yuan Ma, Baobin Cai, shaohua Li, hongmei Ding, jiali Deng, xiyan Nan, Jing Sun, Yun Wu, ningsheng Shao, Li-He Zhang, Zhenjun Yang The heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) was reported to participate in variety of tumors’ development. BC15 is a DNA aptemer targeting hnRNP A1. Firstly, through sequence trucation, we identified... The content of this RSS Feed (c) The Royal Society of Chemistry
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SuzukiMiyaura Coupling of Unstrained Ketones via Chelation-Assisted CC Bond Cleavage ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02075B, Paper Cheng Jiang, Zhao-Jing Zheng, Tian-Yang Yu, Hao Wei Herein, we report that unstrained ketones can be efficiently employed as electrophiles in SuzukiMiyaura reactions via catalytic activation of unstrained C-C bonds assist by an N-containing directing group. A wide... The content of this RSS Feed (c) The Royal Society of Chemistry
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Biomimetic synthesis of the bisindole framework present in sciodole, an alkaloid from Tricholoma sciodes ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB02142B, Communication Joshua A. Homer, Jonathan Sperry The unique bisindole bond present in the alkaloid sciodole can be forged by amination of an azafulvene, validating a biosynthetic hypothesis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Sialylated variants of lacto-N-tetraose exhibit antimicrobial activity against Group B Streptococcus ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB02080A, Paper Kelly M. Craft, Harrison C. Thomas, Steven D. Townsend Human milk oligosaccharides (HMOs) possess antimicrobial activity against a number of bacterial pathogens. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Self-assembly of a redox-active bolaamphiphile into supramolecular vesicles ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB02106F, Communication Simon Rothenbühler, Caroline D. Bösch, Simon M. Langenegger, Shi-Xia Liu, Robert Häner Self-assembly of a redox-active bolaamphiphile leads to the formation of narrow-bandgap supramolecular vesicles. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Rhodium(III)-catalyzed three-component cascade synthesis of 6H-benzo[c]chromenes through C–H activation ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01938J, Communication Wei Yang, Jingyi Wang, He Wang, Lei Li, Yuekai Guan, Xianxiu Xu, Dayu Yu An efficient procedure for 6H-benzo[c]chromenes via a new Rh(III)-catalyzed domino annulation is described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Light-driven exchange between extended and contracted lasso-like isomers of a bistable [1]rotaxane ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB02234H, Paper Adrian Saura-Sanmartin, Alberto Martinez-Cuezva, Aurelia Pastor, Delia Bautista, Jose Berna A photoactive hydrogen-bonded lasso having an amide-based [1]rotaxane structure has been constructed from acyclic precursors through a self-templating approach. The stability, structural integrity and switching are described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Stereo- and regioselective photocycloaddition of extended alkenes using γ-cyclodextrin ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01966E, Communication Akshay Kashyap, Treyvon K. Bokosike, Nattamai Bhuvanesh, Mahesh Pattabiraman Photoexcitation of dibenzalacetones in homogeneous media and solid state yields a mixture of products with poor conversions. Reactivity of the substrate encapsulated within γ-cyclodextrin results in efficient 2 + 2 photocycloaddition between two reactants on both alkenes groups, yielding a single product with remarkable regio- and stereoselectivity at high conversions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Dirhodium(II)-catalyzed ortho C–H amination of sterically congested N,N-dialkylanilines ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01974F, Communication Motoki Ito, Tomoya Nakagawa, Kazuhiro Higuchi, Shigeo Sugiyama Rhodium(II)-catalyzed C–H amination of N,N-dialkylanilines proceeded in excellent ortho selectivities regardless of whether the para position was substituted or not. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Stereoselective synthesis of 1,3-disubstituted dihydroisoquinolines via L-phenylalanine-derived dihydroisoquinoline N-oxides ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB02007H, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Jesús Flores-Ferrándiz, Nicholas Carter, Maria José González-Soria, Malgorzata Wasinska, Daniel Gill, Beatriz Maciá, Vittorio Caprio Addition of Grignard reagents and alkenes to readily available (S)-3-(hydroxymethyl)-3,4-dihydroisoquinoline-2-oxide allow the highly stereoselective synthesis of a range of 1,3-disubstituted tetrahydroisoquinolines. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Regioselective N-1 and C-2 diacylation of 3-substituted indoles with arylglyoxal hydrates for the synthesis of indolyl diketones ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01776J, Paper Dalong Pan, Jinpeng Chu, Xianrui Gao, Cuiping Wang, Qingtao Meng, Haijun Chi, Yan Dong, Chunying Duan, Zhiqiang Zhang A highly regioselective N-1 and C-2 diacylation of 3-substituted indoles with arylglyoxal hydrates to afford N-1 and C-2 indolyl diketones in moderate to good yields is described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Enantioselective synthesis of α-perfluoroalkylated prolines, their 6,7-membered homologues and derivatives ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01223G, Paper Natalia G. Voznesenskaia, Olga I. Shmatova, Victor N. Khrustalev, Valentine G. Nenajdenko The highly enantioselective Strecker reaction with alpha-perfluoroalkylated cyclic ketimines was reported. The corresponding asymmetric cyclic nitriles are a useful tool for obtaining amino acids and their derivatives. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A convenient synthetic route towards H-bisphosphinates ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01878B, Paper Jade Dussart, Nicolas Guedeney, Julia Deschamp, Maelle Monteil, Olivier Gager, Thibaut Legigan, Evelyne Migianu-Griffoni, Marc Lecouvey An easy to handle and rapid synthetic method of various aliphatic and (hetero)aryl 1-hydroxymethylene-1,1-bis(H-phosphinates) was developed and optimised. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and properties of dithienylethene-functionalized switchable antibacterial agents ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01824C, Paper Ziyong Li, Yangyang Wang, Mengna Li, Haining Zhang, Hui Guo, Huiyuan Ya, Jun Yin The ring-closed isomers showed stronger antibacterial activity than the corresponding ring-open isomers (E. coli up to 16 times). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Silver(I)/base-promoted propargyl alcohol-controlled regio- or stereoselective synthesis of furan-3-carboxamides and (Z)-enaminones ()
Org. Biomol. Chem., 2018, 16,6749-6759 DOI: 10.1039/C8OB01791C, Paper Sabera Sultana, Jae-Jin Shim, Sung Hong Kim, Yong Rok Lee A silver/base-promoted regio- or stereoselective synthesis of diverse furan-3-carboxamides and (Z)-enaminones starting from 3-oxo-amides and propargyl alcohols has been developed. The content of this RSS Feed (c) The Royal Society of Chemistry
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Recent advances in the synthesis of cyclopropanes ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01187G, Review Article Wanqing Wu, Zhiming Lin, Huanfeng Jiang Cyclopropanes have gained much attention by virtue of their interesting structure and unique reactivity. This review discusses the recent advances in the synthesis of cyclopropanes, and some of the related applications will be discussed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Correction: Stepwise triple-click functionalization of synthetic peptides ()
Org. Biomol. Chem., 2018, 16,6825-6825 DOI: 10.1039/C8OB90127A, Correction Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Anna Kovalová, Radek Pohl, Milan Vrabel The content of this RSS Feed (c) The Royal Society of Chemistry
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Purine-substituted imidazolium mesomeric betaines and their tautomeric N-heterocyclic carbenes. Formation of a cyclic borane adduct ()
Org. Biomol. Chem., 2018, 16,6801-6808 DOI: 10.1039/C8OB01916A, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Jiaxi Zhang, Eike G. Hübner, Jan C. Namyslo, Martin Nieger, Andreas Schmidt A purin-6-yl substituted imidazolium betaine underwent trapping reactions of its tautomeric N-heterocyclic carbene with sulfur, selenium, and triethylborane. The content of this RSS Feed (c) The Royal Society of Chemistry
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Androsterone-based gels enable diastereospecific reductions and diastereoselective epoxidations of gelators ()
Org. Biomol. Chem., 2018, 16,6791-6800 DOI: 10.1039/C8OB01505H, Paper Tao Li, Yu Chen, Chunbao Li A quantitative, diastereospecific and conventionally unachievable reduction of the carbonyl group was achieved in the gels of seven gelators. The content of this RSS Feed (c) The Royal Society of Chemistry
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Azodicarboxylate-free esterification with triphenylphosphine mediated by flavin and visible light: method development and stereoselectivity control ()
Org. Biomol. Chem., 2018, 16,6809-6817 DOI: 10.1039/C8OB01822G, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Michal März, Michal Kohout, Tomáš Neveselý, Josef Chudoba, Dorota Prukała, Stanislaw Niziński, Marek Sikorski, Gotard Burdziński, Radek Cibulka Photoredox catalysis: A new way to induce triphenylphosphine to be able to mediate nucleophilic substitution reactions of alcohols and acids. The content of this RSS Feed (c) The Royal Society of Chemistry
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Reinvestigation of the iodine-mediated phosphoramidation reaction of amines and P(OR)3 and its synthetic applications ()
Org. Biomol. Chem., 2018, 16,6783-6790 DOI: 10.1039/C8OB01840E, Paper Xunwei Chen, Zecai Xiao, Hanyu Chu, Bo Wang, Ai-Yun Peng A convenient and effective iodine-mediated phosphoramidation reaction of amines and P(OR)3 has been provided. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of protectin D1 analogs: novel pro-resolution and radiotracer agents ()
Org. Biomol. Chem., 2018, 16,6818-6823 DOI: 10.1039/C8OB01232F, Paper J. E. Tungen, M. Aursnes, S. Ramon, R. A. Colas, C. N. Serhan, D. E. Olberg, S. Nuruddin, F. Willoch, T. V. Hansen The first synthetic analog of protectin D1 with potent pro-resolving and anti-inflammatory properties is reported. The content of this RSS Feed (c) The Royal Society of Chemistry
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Regio-specific prenylation of pterocarpans by a membrane-bound prenyltransferase from Psoralea corylifolia ()
Org. Biomol. Chem., 2018, 16,6760-6766 DOI: 10.1039/C8OB01724G, Paper Junbin He, Zeyuan Dong, Zhimin Hu, Yi Kuang, Jingran Fan, Xue Qiao, Min Ye PcM4DT represents the first prenyltransferase identified from the Psoralea genus that catalyzed the C-4 prenylation of pterocarpans and exhibited strict substrate specificity. The content of this RSS Feed (c) The Royal Society of Chemistry
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Preparation of homoallylic amines via a three-component coupling process ()
Org. Biomol. Chem., 2018, 16,6652-6654 DOI: 10.1039/C8OB01831F, Communication Xiaoxu Ou, Ricardo Labes, Claudio Battilocchio, Steven V. Ley A three-component synthesis of homoallylic amines is described. The content of this RSS Feed (c) The Royal Society of Chemistry
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Grafting of porphyrin oligomers on single-walled carbon nanotubes by Hay coupling ()
Org. Biomol. Chem., 2018, 16,6767-6772 DOI: 10.1039/C8OB01577E, Paper Ismail Hijazi, Khaoula Khedhiri, Stéphane Campidelli Two different Zn-porphyrin oligomers were synthesized on single-walled carbon nanotubes via Hay coupling and the formation of 1,3-butadiyne linkers. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of indole-fused heteroacenes by cascade cyclisation involving rhodium(II)-catalysed intramolecular C–H amination ()
Org. Biomol. Chem., 2018, 16,6703-6707 DOI: 10.1039/C8OB01837E, Paper Takanori Matsuda, Hirotaka Ito Indole-fused heteroacenes have been synthesised from cascade cyclisation of 2-[(2-azidophenyl)ethynyl]anilines and -phenols in a catalytic manner under redox-neutral conditions. The content of this RSS Feed (c) The Royal Society of Chemistry
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Visible light-induced aerobic oxidative cross-coupling of glycine esters with α-angelicalactone: a facile pathway to γ-lactams ()
Org. Biomol. Chem., 2018, 16,6728-6734 DOI: 10.1039/C8OB01844H, Paper Huang Zhou, Xiaorong Yang, Shilin Li, Yin Zhu, Ying Li, Yuan Zhang A rapid synthesis of substituted γ-lactams is achieved via metal-free photocatalyzed aerobic oxidative dehydrogenative formal [2 + 3] cyclization of glycine esters with α-angelicalactone. The content of this RSS Feed (c) The Royal Society of Chemistry
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Exploring the potential of phosphotriazole 5′ mRNA cap analogues as efficient translation initiators ()
Org. Biomol. Chem., 2018, 16,6741-6748 DOI: 10.1039/C8OB01720D, Paper Sylwia Walczak, Pawel J. Sikorski, Renata Kasprzyk, Joanna Kowalska, Jacek Jemielity New phosphotriazole cap analogues proved to enhance translation in vitro and in vivo making them applicable in the design of RNA with increased translational potential. The content of this RSS Feed (c) The Royal Society of Chemistry
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Organic dye-photocatalyzed fluoroalkylation of heteroarene-N-oxide derivatives ()
Org. Biomol. Chem., 2018, 16,6718-6727 DOI: 10.1039/C8OB01653D, Paper Beatriz Lantaño, Sebastián Barata-Vallejo, Al Postigo A direct CHet–H perfluoroalkylation reaction of heteroaromatic-N-oxides has been achieved. Acid-catalyzed transformation of the perfluoroalkylated-N-oxides leads to 2-(perfluoroalkyl)benzo[f][1,3]oxazepines. De-oxygenation of the perfluoroalkylated heteroaromatic-N-oxides affords a regioselective radical perfluoroalkylation protocol. The content of this RSS Feed (c) The Royal Society of Chemistry
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Phosphine-mediated partial reduction of alkynes to form both (E)- and (Z)-alkenes ()
Org. Biomol. Chem., 2018, 16,6659-6662 DOI: 10.1039/C8OB01848K, Communication Brett M. Pierce, Brittany F. Simpson, Kane H. Ferguson, Rachel E. Whittaker A mild, tunable method to form both (E)- and (Z)-alkenes from alkynes is reported using PPh3 as a reductant. The content of this RSS Feed (c) The Royal Society of Chemistry
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Studies on sugar puckering and glycosidic stabilities of 3′-amino-5′-carboxymethyl-3′,5′-dideoxy nucleoside mimics ()
Org. Biomol. Chem., 2018, 16,6735-6740 DOI: 10.1039/C8OB01788C, Paper Chandan Pal, Arventh Velusamy, Yashoda Krishna Sunkari, Tushar Kanti Chakraborty Nucleoside amino acids and their dimers show a predilection of these backbone modified molecules towards an N-type conformation with a slightly weaker glycosidic linkage. The content of this RSS Feed (c) The Royal Society of Chemistry
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Potentiation of the activation of cholinergic receptors by multivalent presentation of ligands supported on gold nanoparticles ()
Org. Biomol. Chem., 2018, 16,6680-6687 DOI: 10.1039/C8OB01686K, Paper A. Mattern, F. Machka, M. S. Wickleder, O. S. Ilyaskina, M. Bünemann, M. Diener, E. Pouokam The multivalent presentation of carbachol-functionalized gold nanoparticles leads to a strong potentiation of native agonist effects on the corresponding cholinergic receptors. The content of this RSS Feed (c) The Royal Society of Chemistry
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Copper-catalyzed C–N bond formation with imidazo[1,2-a]pyridines ()
Org. Biomol. Chem., 2018, 16,6655-6658 DOI: 10.1039/C8OB01853G, Communication Kai Sun, Shiqiang Mu, Zhenhua Liu, Ranran Feng, Yali Li, Kui Pang, Bing Zhang An efficient Cu-catalyzed C–N bond formation with imidazo[1,2-a]pyridines on the C-3 position via a radical pathway is reported. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of functionalized 2,5-dihydropyrrole derivatives via a convenient [3 + 2] annulation of azomethine ylides with allenoates ()
Org. Biomol. Chem., 2018, 16,6638-6646 DOI: 10.1039/C8OB01946K, Communication Zhusheng Huang, Zonghao Dai, Jin Zhu, Fulai Yang, Qingfa Zhou A convenient [3 + 2] annulation of azomethine ylides with allenoates to synthesize highly functionalized 2,5-dihydropyrrole derivatives was developed. The content of this RSS Feed (c) The Royal Society of Chemistry
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Switching a regular tryptophan C4-prenyltransferase to a reverse tryptophan-containing cyclic dipeptide C3-prenyltransferase by sequential site-directed mutagenesis ()
Org. Biomol. Chem., 2018, 16,6688-6694 DOI: 10.1039/C8OB01735B, Paper Liujuan Zheng, Peter Mai, Aili Fan, Shu-Ming Li The site-directed mutagenesis of FgaPT2 switches a regular C4-prenylation to a reverse C3-prenylation of tryptophan-containing cyclic dipeptides. The content of this RSS Feed (c) The Royal Society of Chemistry
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Tuning the biomimetic performances of 4-hydroxyproline-containing cyclic peptoids ()
Org. Biomol. Chem., 2018, 16,6708-6717 DOI: 10.1039/C8OB01522H, Paper R. Schettini, C. Costabile, G. Della Sala, J. Buirey, M. Tosolini, P. Tecilla, M. C. Vaccaro, I. Bruno, F. De Riccardis, I. Izzo Five new cyclic peptoids containing (2S,4R)-4-hydroxyproline (Hyp) residues have been designed and synthesized using a mixed “submonomer/monomer” approach. The content of this RSS Feed (c) The Royal Society of Chemistry
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Organobase catalyzed straightforward synthesis of phosphinyl functionalized 2H-pyran cores from allenylphosphine oxides and 1,3-diones ()
Org. Biomol. Chem., 2018, 16,6675-6679 DOI: 10.1039/C8OB01640B, Paper Yao-Zhong Chen, Jie Zhu, Jin-Jin Wu, Lei Wu A cost-effective system is revealed here to construct polyfunctionalized 2H-pyran cores containing phosphinyl groups with an organobase as a catalyst. The content of this RSS Feed (c) The Royal Society of Chemistry
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Unusual anti-inflammatory meroterpenoids from the marine sponge Dactylospongia sp. ()
Org. Biomol. Chem., 2018, 16,6773-6782 DOI: 10.1039/C8OB01580E, Paper Jing Li, Fan Yang, Zhuo Wang, Wei Wu, Li Liu, Shu-Ping Wang, Bin-Xin Zhao, Wei-Hua Jiao, Shi-Hai Xu, Hou-Wen Lin Nine new meroterpenoids, dactylospongins A–D, melemeleones C–E, dysidaminone N, and 19-O-methylpelorol, were isolated from the marine sponge Dactylospongia sp., which showed potent inhibitory effects on the production of IL-6, IL-1β, IL-8, and PEG2 in LPS-induced THP-1 cells with IC50 values of 5.1–9.2 μM. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of polycyclic spirooxindoles via an asymmetric catalytic one-pot stepwise Aldol/chloroetherification/aromatization procedure ()
Org. Biomol. Chem., 2018, 16,6647-6651 DOI: 10.1039/C8OB01713A, Communication Yan Jiang, Shuo-Wen Yu, Yi Yang, Ying-Le Liu, Xiao-Ying Xu, Xiao-Mei Zhang, Wei-Cheng Yuan A general method for the synthesis of chiral pentacyclic spirooxindoles containing a tetrahydropyrano[2,3-b]indole scaffold through a one-pot stepwise sequence is reported. The content of this RSS Feed (c) The Royal Society of Chemistry
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Attenuation of guanine oxidation via DNA-mediated electron transfer in a crowded environment using small cosolutes ()
Org. Biomol. Chem., 2018, 16,6695-6702 DOI: 10.1039/C8OB02003E, Paper Makiko Tanaka, Takayuki Matsumoto, Hiroki Iida Guanine oxidation induced by photoirradiation on a pyrene-modified oligonucleotide was investigated under molecular crowding using small cosolutes such as glycerol. The content of this RSS Feed (c) The Royal Society of Chemistry
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Correction: Synthesis of highly substituted 2-spiropiperidines ()
Org. Biomol. Chem., 2018, 16,6824-6824 DOI: 10.1039/C8OB90117A, Correction Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Samuel D. Griggs, Nathan Thompson, Daniel T. Tape, Marie Fabre, Paul A. Clarke The content of this RSS Feed (c) The Royal Society of Chemistry
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Cu-Catalyzed/mediated synthesis of N-fluoroalkylanilines from arylboronic acids: fluorine effect on the reactivity of fluoroalkylamines ()
Org. Biomol. Chem., 2018, 16,6634-6637 DOI: 10.1039/C8OB01581C, Communication Hui Wang, Yuan-Hong Tu, De-Yong Liu, Xiang-Guo Hu A copper catalyzed/mediated oxidative coupling of arylboronic acids and fluoroalkylated amines with an interesting reactivity trend is disclosed. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of highly substituted 2-spiropiperidines ()
Org. Biomol. Chem., 2018, 16,6663-6674 DOI: 10.1039/C8OB01272E, Paper Samuel D. Griggs, Nathan Thompson, Daniel T. Tape, Marie Fabre, Paul A. Clarke Highly substituted novel 2-spiropiperidines, which are scaffolds suitable for drug discovery or natural products synthesis, were synthesized in a simple one-pot or two-pot procedure. The content of this RSS Feed (c) The Royal Society of Chemistry
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Strategies for the synthesis of spiropiperidines – a review of the last 10 years ()
Org. Biomol. Chem., 2018, 16,6620-6633 DOI: 10.1039/C8OB01271G, Review Article Samuel D. Griggs, Daniel T. Tape, Paul A. Clarke In this review we highlight various methods from recent literature for the synthesis of 2-, 3- and 4-spiropiperidines. The content of this RSS Feed (c) The Royal Society of Chemistry
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Dual function of Amino Acids Ionic Liquids (Bmim[AA]) on the Degradation of Organophosphorus Pesticide, Paraoxon® ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01928B, Paper Paulina Pavez, Javiera I Morales, Roberto Figueroa, Mabel Rojas, Daniela Millan, Ricardo Tapia The synthesis of a series of ionic liquids using 1-butyl 3-methylimidazolium (Bmim+) as cation and different amino acids (AA) as anions (Bmim[AA]) is described. These ILs were used for the... The content of this RSS Feed (c) The Royal Society of Chemistry
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Organic amines-mediated free-radicals carbocyclization reactions of 2,2,2-trihalogeno substituted N-(2-alkynylphenyl)acetamides ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01870G, Paper Che-Ping Chuang, Tsung-Han Chuang An efficient method for the synthesis of 3-halogeno substituted 4-benzoylquinolin-2-(1H)-ones from N-(2-alkynylphenyl) substituted trihaloacetamides has been developed, in which organic amines (TNPA and DIEA) act as the electron donors. In... The content of this RSS Feed (c) The Royal Society of Chemistry
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Biosurfactant-functionalized porphyrin chromophore that forms J-aggregates ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01655K, Paper Shekar Mekala, Kyle C Peters, Kenneth Singer, Richard Gross Structurally complex biosynthesized building blocks whose structures can be systematically varied are of great interest for the synthesis of manipulable self-organizing supramolecular systems. Sophorolipids (SLs) are an important class of... The content of this RSS Feed (c) The Royal Society of Chemistry
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Activation of the hypervalent fluoroiodane reagent by hydrogen bonding to hexafluoroisopropanol ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02236D, Paper Alison M Stuart, Harsimran K Minhas, William Riley, Martyna Urbonaite Hexafluoroisopropan-2-ol (HFIP) is an excellent solvent for promoting fluorinations with the hypervalent fluoroiodane reagent 1 and crucially, it removes the need for transition metals or TREAT-HF activators. The fluoroiodane reagent... The content of this RSS Feed (c) The Royal Society of Chemistry
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Ru-Catalyzed dehydrogenative synthesis of antimalarial arylidene oxindoles ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01852A, Paper Girishsingh Bisht, Akanksha M Pandey, Moreshwar Bhagwan Chaudhari, Sandip G Agalave, Abhishek Kanyal, Krishanpal Karmodiya Karmodiya, Boopathy Gnanaprakasam Ru(II)-NHC catalyzes α-olefination of 2-oxindole using secondary alcohols in the absence of an acceptor. A wide array of symmetrical and unsymmetrical secondary alcohols undergoes dehydrogenative coupling with 2-oxindole selectively to... The content of this RSS Feed (c) The Royal Society of Chemistry
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Robust Buchwald–Hartwig amination enabled by ball-milling ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01781F, Communication Qun Cao, William I. Nicholson, Andrew C. Jones, Duncan L. Browne An operationally simple mechanochemical method for the Pd catalysed Buchwald–Hartwig amination of arylhalides with secondary amines has been developed using a Pd PEPPSI catalyst system. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Syntheses of the plant auxin conjugate 2-O-(indole-3-acetyl)-myo-inositol IAInos ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB02096E, Communication Saúl Silva, Osvaldo S. Ascenso, Eva C. Lourenço, Margarida Archer, Christopher D. Maycock, M. Rita Ventura The two first chemical syntheses of IAInos (2-O-(indole-3-acetyl)-myo-inositol), an important plant hormone, are described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Catalytic enantioselective one-pot approach to cis- and trans-2,3-diaryl substituted 1,5-benzothiazepines ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01988F, Paper Sara Meninno, Ilaria Quaratesi, Chiara Volpe, Andrea Mazzanti, Alessandra Lattanzi A first enantioselective one-pot organocatalytic sulfa-Michael/lactamization sequence provided cis- and trans-2,3-diaryl substituted 1,5-benzothiazepines in satisfactory yields and good to high enantioselectivity. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of difluoromethylated enynes by the reaction of α-(trifluoromethyl)styrenes with terminal alkynes ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB02117A, Paper Mingsheng Wu, Xianghu Zhao, Yisen Liu, Song Cao A novel and efficient method for the synthesis of difluoromethylated enynes by the reaction of α-(trifluoromethyl)styrenes with terminal alkynes with the assistance of NaOtBu was developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Dimericursones A and B: two unprecedented hexacyclic dimeric diterpenoids from the root barks of Jatropha curcas ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB02082E, Paper Jie-Qing Liu, Ying Xu, Qin Xiao, Jin-Di Huang, Jun-Jie Ma, Chen-Lei Lian, Mei-Ying Huang, Zhen-bo Du, Cui-Fang Wang Two unprecedented hexacyclic dimeric diterpenoids from Jatropha curcas and 2 showed significant NO inhibitory activity with IC50 values of 5.65 μM. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of α-amino ketones through aminations of umpoled enolates ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB02004C, Paper Xiaowen Xia, Bocheng Chen, Xiaojun Zeng, Bo Xu An efficient synthesis of α-amino ketones is developed using the umpolung strategy. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Glycodendron–rhenium complexes as luminescent probes for lectin sensing ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01838C, Paper Alessandro Palmioli, Monica Panigati, Anna Bernardi Enhanced emission intensity of novel Re(I)-glycoprobes resulting from the specific recognition of carbohydrate-binding proteins as a potential tool in bioimaging applications. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of macrocyclic precursors of the vioprolides ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01756E, Paper Eibhlin Butler, Lucia Florentino, Damien Cornut, Gonzalo Gomez-Campillos, Hao Liu, Andrew C. Regan, Eric J. Thomas Convergent syntheses have been developed of macrocycles that may be useful for the synthesis of vioprolide D. Preliminary studies have also been carried out into the introduction of the thiazoline and (E)-dehydrobutyrine components. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A Combined Synthetic and Computational Study of Novel Binaphthyl and Biphenyl α- and β-Amino Acids and Esters: Organocatalysis of Asymmetric Diels Alder Reactions ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01795F, Paper Philip Charles Bulman Page, Francesca Serafina Kinsey, Yohan Chan, Ian Strutt, Alexandra Slawin, Garth Jones Asymmetric catalysis of the Diels-Alder reaction between cyclopentadiene and cinnamaldehydes has been studied using as catalysts a range of novel - and - aminoacids and aminoesters with binaphthyl and biphenyl... The content of this RSS Feed (c) The Royal Society of Chemistry
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Recent advances in homogeneous borrowing hydrogen catalysis using earth-abundant first row transition metals ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01895B, Review Article Benjamin G. Reed-Berendt, Kurt Polidano, Louis C. Morrill The review highlights the recent advances (2013-present) in the use of earth-abundant first row transition metals in homogeneous borrowing hydrogen catalysis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Xylopsides A–D, four rare guaiane dimers with two unique bridged pentacyclic skeletons from Xylopia vielana ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01689E, Paper Yang-Guo Xie, Yi-Gong Guo, Guo-Jing Wu, Sheng-Lan Zhu, Tao-Fang Cheng, Yu Zhang, Shi-Kai Yan, Hui-Zi Jin, Wei-Dong Zhang Four compounds with two bridged pentacyclic skeletons between two guaiane-type sesquiterpenes, which were characterized as two different bridged ring systems. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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First catalyst-free CO2 trapping of N-acyliminium ions under ambient conditions: sustainable multicomponent synthesis of thia- and oxazolidinyl carbamates ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01865K, Paper Max Franz, Timo Stalling, Henning Steinert, Jürgen Martens A sustainable multicomponent approach through catalyst-free utilization of carbon dioxide under ambient conditions for the preparation of carbamates is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Dimethylamine adducts of allylic triorganoboranes as effective reagents for Petasis-type homoallylation of primary amines with formaldehyde ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02152J, Communication Nikolai Kuznetsov, Rabdan Tikhov, Tatyana V. Strelkova, Yurii N. Bubnov Dimethylamine adducts of triallyl-, triprenyl- and trans-cinnamyl(dipropyl)borane are effective reagents for mild homoallylation of primary amines with aqueous formaldehyde in MeOH without an inert atmosphere. For explanaiton of high stability... The content of this RSS Feed (c) The Royal Society of Chemistry
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Efficient Construction of Tetrahydroquinoline via Fluorinated Alcohol Mediated Cascade [1,5]-Hydride Transfer/Cyclization ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02012D, Communication Chunqi Chen, Lubin Xu, Liang Wang, Shuai-Shuai Li An environmentally benign cascade redox process was developed for the efficient construction of the pharmaceutically significant spirocyclic tetrahydro-quinolines via 3-step cascade Knoevenagel condensation/[1,5]-hydride transfer/cyclization, which features green and additive-free condition,... The content of this RSS Feed (c) The Royal Society of Chemistry
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Ag(I) nitrate catalyzed facile synthesis of 3-substituted quinolin-2(1H)‑ones through cyclization of o-alkynylisocyanobenzenes ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01882K, Paper Ailada Charoenpol, Jatuporn Meesin, Onnicha Khaikate, Vichai Reutrakul, Manat Pohmakotr, Pawaret Leowanawat, Darunee Soorukram, Chutima Kuhakarn A synthesis of various functionalized 3-substituted quinolin-2(1H)‑ones is described. A collection of o-alkynylisocyanobenzenes were examined for their ability to undergo cyclization to yield the corresponding 3-substituted quinolin-2(1H)‑ones. The reaction allows... The content of this RSS Feed (c) The Royal Society of Chemistry
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Disassembly-driven Signal Turn-on Probes for Bimodal Detection of DNA with 19F NMR and Fluorescence ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02218F, Paper Takashi Sakamoto, Daisaku Hasegawa, Kenzo Fujimoto To image DNAs in vivo, molecular probes that can detect DNA with a highly transparent signal are required. In this study, we designed and synthesized amphiphilic molecular probes that can... The content of this RSS Feed (c) The Royal Society of Chemistry
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Molecular iodine-mediated synthesis of thiocarbamates from thiols, isocyanides and water under metal-free conditions ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01820K, Paper Wen-Hu Bao, Chao Wu, Jing-Ting Wang, Wen Xia, Ping Chen, Zilong Tang, Xinhua Xu, Wei-Min He A metal-free and efficient molecular iodine-mediated protocol has been developed to prepare thiocarbamates from readily available thiols, isocyanides and water. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Facile synthesis of Triphenylenes and Triphenylene/ Phenanthrene fused heteroaromatics ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01930D, Communication vijay gupta, Satish K. Pandey, Ravi Prakash Singh We report a simple and facile method for the synthesis of substituted triphenylenes and their heteroaryl analogue using ceric ammonium nitrate (CAN) via oxidative biaryl coupling. We describe the structural... The content of this RSS Feed (c) The Royal Society of Chemistry
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Cyclic arylopeptoid oligomers: synthesis and conformational propensities of peptide-mimetic aromatic macrocycles ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01962B, Paper Masahide Hayakawa, Ayaka Ohsawa, Kumi Takeda, Ryo Torii, Yoshiaki Kitamura, Hiroshi Katagiri, Masato Ikeda Dynamic macrocyclic peptide-mimetic molecule bearing sequence-controlled side chains. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Organocatalytic asymmetric Michael/hemiketalization/acyl transfer reaction of 1,3-propanediones with (E)-2-(2-nitrovinyl)phenols ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01771A, Communication Nimisha Bania, Subhas Chandra Pan An organocatalytic asymmetric cascade Michael/hemiketalization/acyl transfer reaction between (E)-2-(2-nitrovinyl)phenols and 1,3-propanediones is disclosed to generate products having keto, ester and nitro functionalities. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Copper-catalyzed synthesis of 2-aminophenyl benzothiazoles: a novel approach ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB02018C, Communication S. N. Murthy Boddapati, Chandra Mohan Kurmarayuni, Baby Ramana Mutchu, Ramana Tamminana, Hari Babu Bollikolla Substituted 2-aminophenyl benzothiazoles have been constructed from thiourea via copper-catalyzed desulfurization/nucleophilic substitution followed by domino intra- and intermolecular C–N cross-coupling reactions under moderate reaction conditions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Ruthenium (II)-Catalyzed C-H Coupling with Diazo compounds: [4+2] Annulation and Facile Synthesis of Indazolone-Fused Cinnolines ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02071J, Paper Lin Su, Zheng Yu, Peiling Ren, Zhi Luo, Wei Hou, Hongtao Xu A robust, efficient and scalable method for the synthesis of 12H-indazolo[2,1-a]cinnolin-12-ones was developed. Significantly, this reaction was the first Ru(II)-catalyzed [4+2] annulation of diazo compounds via C-H activation and a... The content of this RSS Feed (c) The Royal Society of Chemistry
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Catalyst-free synthesis of α-thioacrylic acids via cascade thiolation and 1,4-aryl migration of aryl alkynoates at room temperature ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01349G, Paper Wei Wei, Leilei Wang, Huilan Yue, Yuan-Ye Jiang, Daoshan Yang A simple and facile catalyst-free strategy has been developed for the synthesis of α-thioacrylic acids from readily-available aryl alkynoates and thiols at room temperature under air. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Ruthenium-catalyzed tandem annulation/arylation for the synthesis of unsymmetrical bis(heteroaryl)methanes ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01892H, Paper Sadhanendu Samanta, Alakananda Hajra A new Ru-catalyzed tandem annulation/arylation strategy has been developed to afford unsymmetrical bis(heteroaryl)methanes containing furan and indole as well as indole and imidazopyridine moieties in high yields. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Toward the total synthesis of patellazole B: synthesis of an advanced C1–C25 fragment corresponding to the macrocyclic skeleton ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01621F, Paper Andrew W. Phillips, Matthew J. Anketell, Tudor Balan, Nelson Y. S. Lam, Simon Williams, Ian Paterson A modular and highly convergent approach enables the assembly of an advanced intermediate towards the total synthesis of patellazole B – a promising anticancer agent. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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tert-Butyl nitrite mediated nitrogen transfer reactions: synthesis of benzotriazoles and azides at room temperature ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01950A, Paper Sadaf Azeez, Priyanka Chaudhary, Popuri Sureshbabu, Shahulhameed Sabiah, Jeyakumar Kandasamy A conversion of o-phenylenediamines into benzotriazoles is reported with tert-butyl nitrite at room temperature. The optimized condition is also well suited for the transformation of sulfonyl and acyl hydrazines into corresponding azides. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Mutated variants of squalene-hopene cyclase: enzymatic syntheses of triterpenes bearing oxygen-bridged monocycles and a new 6,6,6,6,6-fusded pentacyclic scaffold, named neogammacerane, from 2,3-oxidosqualene ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB02009D, Paper Yoriyuki Fukuda, Takashi Watanabe, Tsutomu Hoshino First enzymatic syntheses of triterpenes bearing a 7-oxabicyclo[2.2.1]heptane moiety and a novel scaffold, named neogammacerane, by the mutated cyclases. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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The [4 + 2] cyclization/retro-Mannich reaction cascade of para-quinone methide derivatives with Pd-containing 1,4-dipoles ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01274A, Paper Xiao-Li Jiang, Shu-Fang Wu, Jin-Rong Wang, Han Lu, Guang-Jian Mei, Feng Shi The first [4 + 2] cyclization/retro-Mannich reaction cascade of para-quinone methides with Pd-containing 1,4-dipoles generated in situ from vinyl benzoxazinanones has been established. The corresponding rearrangement products were obtained in generally good yields. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Cobalt-catalyzed cyclization of benzamides with alkynes: a facile route to isoquinolones with hydrogen evolution ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01924J, Paper Ramasamy Manoharan, Masilamani Jeganmohan A cobalt-catalyzed 8-aminoquinoline-directed oxidative cyclization of benzamides with alkynes giving substituted isoquinolones with the liberation of hydrogen in good to excellent yields is presented. The present cyclization reaction was compatible with terminal alkynes and 1,3-diynes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Direct C-4 alkylation of quinazoline N-oxides with ethers via an oxidative cross-coupling reaction under metal-free conditions ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01429A, Paper Qin Yang, Minhao Lou, Zhijian Yin, Zhihong Deng, Qiuping Ding, Yiyuan Peng A novel and efficient protocol for the direct C-4 alkylation of quinazoline-3-oxides via radical oxidative coupling between quinazoline 3-oxides and ethers in the presence of TBHP is presented. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Highly regioselective α-alkylation of α,β,γ,δ-unsaturated aldehydes ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB02059K, Communication Venkata M. D. Padmaja, Sachin Jangra, Chandrakumar Appayee The first regioselective MBH-type α-alkylation of α,β,γ,δ-unsaturated aldehydes is achieved using diarylcarbinols with an excellent E/Z selectivity under mild reaction conditions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Rhodium-catalyzed cyclization of acceptor-substituted biphenyl α-diazoketones: a study of the substitution effect on chemoselectivity ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01489B, Paper Kuo-Hsin Chen, Yi-Jung Chiang, Jia-Liang Zhu A range of biphenyl α-diazoketones containing different α-electron withdrawing groups exhibits divergent chemoselectivity toward rhodium(II) catalysis, delivering phenanthrols, benz[α]azulenones, aromatic ketones and/or 1,2-diketones in varying ratios. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Recent advances in β-lactam synthesis ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01833B, Review Article Seyedmorteza Hosseyni, Aliasghar Jarrahpour During the past century, β-lactams have been identified as the core of penicillin and since then several strategies have been developed for their synthesis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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