Organic & Biomolecular Chemistry

Theoretical study on the palladium-catalyzed oxidative carbocyclization-alkoxycarbonylation of bisallenes to construct seven-membered carbocycles assisted by olefin ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01161J, Paper Ling-Li Han, Tao Liu The reaction mechanisms of the Pd(II)-catalyzed oxidative carbocyclization-alkoxycarbonylation of bisallenes to construct seven-membered carbocycles have been theoretically investigated with the aid of the density functional theory (DFT) calculations. Our calculation... The content of this RSS Feed (c) The Royal Society of Chemistry
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Correction: Phosphine-catalyzed Friedel-Crafts reaction of naphthols with para-quinone methides: expedient access to triarylmethanes ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB90087B, Correction Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Tao Zhou, Shenhuan Li, Ben Huang, Cao Li, Yang Zhao, Jieqiong Chen, Aoling Chen, Yuanjin Xiao, Lu Liu, Junliang Zhang To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Correction: nBu4NI-Mediated oxidation of methyl ketones to [small alpha]-ketoamides: using ammonium, primary and secondary amine-salt as an amine moiety ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB90088K, Correction Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Dan Wang, Kuan Zhang, Luhan Jia, Danting Zhang, Yue Zhang, Yujia Cheng, Chang Lin, Bo Wang To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Fluorous-tag assisted synthesis of bile acid-bisphosphonate conjugates via orthogonal click reactions: an access to potential anti-resorption bone drugs ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00774D, Paper Chiara Massarenti, Olga Bortolini, Giancarlo Fantin, Dario Cristofaro, Daniele Ragno, Daniela Perrone, Elena Marchesi, Gianluca Toniolo, Alessandro Massi Click reactions and fluorous separations afford bile acid-bisphosphonate conjugates. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of tetrafluoroethylene- and tetrafluoroethyl-containing azides and their 1,3-dipolar cycloaddition as synthetic application ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01151B, Communication Svatava Voltrova, Mickael Muselli, Josef Filgas, Vaclav Matousek, Blanka Klepetarova, Petr Beier Synthesis of tetrafluoroethylene-containing azides, 4-substituted N-tetrafluoroethyl- and N-tetrafluoroethylene-containing 1,2,3-triazoles is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Biomass-involved synthesis of N-substituted benzofuro[2,3-d]pyrimidine-4-amines and biological evaluation as novel EGFR tyrosine kinase inhibitors ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00793K, Paper Jianfei Sheng, Zhihong Liu, Ming Yan, Xuejing Zhang, Dejian Wang, Jun Xu, Ensheng Zhang, Yong Zou Facile synthesis of N-substituted benzofuro[2,3-d]pyrimidine-4-amines from shikimic acid and biological evaluation as novel EGFR TKIs is described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Pd(0)-Catalysed asymmetric reductive Heck-type cyclization of (Z)-1-iodo-1,6-dienes and enantioselective synthesis of quaternary tetrahydropyridines ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00762K, Communication Longlei Hou, Yuejie Yuan, Xiaofeng Tong The asymmetric reductive Heck reaction of (Z)-1-iodo-1,6-dienes has been developed, which affords quaternary tetrahydropyridines with good to excellent enantioselectivities. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Construction of polycyclic frameworks via a DMAP-catalysed tandem addition-(4 + 2) annulation sequence of [small delta]-acetoxy allenoate ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00688H, Communication Chunjie Ni, Yuejie Yuan, Yuwen Zhang, Jiangfei Chen, Dong Wang, Xiaofeng Tong The DMAP-catalyzed addition/(4 + 2) annulation domino reaction of [small delta]-acetoxy allenoate with either salicylaldehyde-derived oxadiene or pyrrolealdehyde-derived oxadiene has been developed, which provides a facile method toward polycyclic frameworks. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Unprecedented formation of 3-(tetrahydrofuran-2-yl)-4H-chromen-4-one in the reaction between 3,3a-dihydro-9H-furo[3,4-b]chromen-9-one with malononitrile ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00904F, Paper Jie-Jie Liu, Liang Cheng, Hong-Yan Huang, Feng Wei, Dong Wang, Li Liu Chromone skeletons are widespread among natural products as well as bioactive molecules. Here, we describe an unprecedented reaction of furo[3,4-b]chromen-9-one with malononitrile to afford 3-(tetrahydrofuran-2-yl)-4H-chromen-4-ones. Experimental data suggest that a... The content of this RSS Feed (c) The Royal Society of Chemistry
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Isonucleotide Incorporation into Middle and Terminal siRNA Duplexes Exhibits High Gene Silencing Efficacy and Nuclease Resistance ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01065F, Paper Yuan Ma, Shuang Liu, Yusi Wang, Yuanhe Zhao, Ye Huang, Lijun Zhong, Zhu Guan, Li-He Zhang, Zhenjun Yang In this study, we introduced a pair of nucleotide enantiomers, D-/L-isonucleotides (D-/L-isoNA), to examine the interactions between siRNAs and their relative proteins. The serum stability and gene-silencing activity of the... The content of this RSS Feed (c) The Royal Society of Chemistry
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Self-assembled artificial viral capsid bearing coiled-coils at the surface ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00998D, Paper Kazunori Matsuura, Seiya Fujita In order to construct artificial viral capsids bearing complementary dimeric coiled-coils on the surface, [small beta]-annulus peptide bearing a coiled-coil forming sequence at the C-terminal ([small beta]-annulus-coiled-coil-B) was synthesized by a native... The content of this RSS Feed (c) The Royal Society of Chemistry
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Sulfinyl Isobutyramide as an Auxiliary for Palladium(II)-Catalyzed C-H Arylation and Iodination of Benzylamine Derivatives ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01163F, Communication Rui Wang, Yongzheng Ding, Gang Li A novel readily available bidentate 2-methylsulfinyl isobutyramide directing group has been developed for benzylamine derivatives. It promoted ortho-C-H arylation and iodination of various substrates in good to excellent yields. The... The content of this RSS Feed (c) The Royal Society of Chemistry
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Stereoselective Synthesis of Enamino Ketones Through Aza-Michael/Hydrolysis Cascade ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01032J, Communication Hai-Lei Cui, Li-Jie Peng, Hai-Lin Zhou, Xiao-Lin You, Xiao-Jie Jiang We have developed a mild, convenient and efficient synthesis of highly functionalized (Z)-[small beta]-enamino ketones from readily available 3,4-dihydroisoquinoline imines and ynones through aza-Michael/hydrolysis cascade. This method is also suitable for... The content of this RSS Feed (c) The Royal Society of Chemistry
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Neobraclactones A-C, three unprecedented chaise longue-shaped xanthones from Garcinia bracteata ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01007A, Paper Sheng-Li Niu, Da-Hong Li, Yue-Tong Wang, Kai-Bo Wang, Bin Lin, Yong-Kui Jing, Hui-Ming Hua, Jiao Bai, Zhan-Lin Li Three novel caged-polyprenylated xanthone derivatives, featuring an unusual scaffold with significant antitumor activity, were isolated. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A sialosyl sulfonate as a potent inhibitor of influenza virus replication ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00947J, Communication Adam Hadhazi, Mauro Pascolutti, Benjamin Bailly, Jeffrey C. Dyason, Aniko Borbas, Robin J. Thomson, Mark von Itzstein A 2-deoxy-sialosyl sulfonate, synthesised in just four steps from sialic acid, is >500-fold more potent against influenza virus sialidase activity and cell infection than its carboxylate isostere. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Bis- and mono(m-benzoic acid)-functionalized pillar[5]arenes ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00984D, Paper Xin-Lang Wu, Yi Chen, Wen-Jing Hu, Yahu A. Liu, Xue-Shun Jia, Jiu-Sheng Li, Biao Jiang, Ke Wen Installation of m-benzoic acid functionalities on pillar[5]arene rims resulted in bis- and mono(m-benzoic acid)-functionalized pillar[5]arenes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Lipoic acid based core cross-linked micelles for multivalent platforms: design, synthesis and application in bio-imaging and drug delivery ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00927E, Communication Jingsheng Huang, Fang Wu, Yunlong Yu, Haolong Huang, Shiyong Zhang, Jingsong You Natural lipoic acid derived small-molecule amphiphiles self-assemble into micelles in water. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Recent advances in N-heterocyclic carbene catalyzed achiral synthesis ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00568G, Review Article Qiao Ren, Muyao Li, Lujiang Yuan, Jian Wang This review reveals the recent developments in NHC-promoted non-asymmetric umpolung transformations resulting in the expeditious construction of versatile achiral natural heterocycles, carbocycles and acylated products. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Imprinted micelles for chiral recognition in water: shape, depth, and number of recognition sites ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00764G, Paper Joseph K. Awino, Yan Zhao Molecular imprinting within cross-linked micelles yielded chiral receptors with excellent enantio- and diastereoselectivity for amino acid derivatives. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Control of the hierarchical assembly of [small pi]-conjugated optoelectronic peptides by pH and flow ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00923B, Paper Rachael A. Mansbach, Andrew L. Ferguson Coarse-grained molecular simulations reveal the influence of pH and flow on the self-assembly of DFAG-OPV3-GAFD optoelectronic peptides. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Diastereo- and enantioselective construction of spirooxindole scaffolds through a catalytic asymmetric [3 + 3] cycloaddition ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01059A, Communication Can Li, Han Lu, Xiao-Xue Sun, Guang-Jian Mei, Feng Shi A chiral phosphoric acid-catalyzed asymmetric [3 + 3] cycloaddition of C3-substituted 2-indolylmethanols with isatin-derived azomethine ylides has been established, which afforded chiral spirooxindoles in considerable yields, moderate to good stereoselectivities. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A polymer-based probe for specific discrimination of cysteine ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00956A, Paper Keyuan Liu, Ganhong Du, Mengna Zhao, Long Ye, Huifang Shen, Liming Jiang A kind of polymer-based turn-on fluorescent probe for specific detection of cysteine with high sensitivity has been developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Photochromic histone deacetylase inhibitors based on dithienylethenes and fulgimides ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00976C, Paper D. Wutz, D. Gluhacevic, A. Chakrabarti, K. Schmidtkunz, D. Robaa, F. Erdmann, C. Romier, W. Sippl, M. Jung, B. Konig The synthesis, photochromic properties, inhibition of different HDACs and corresponding molecular dockings of photochromic inhibitors are described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Palladium-mediated 11C-carbonylations using aryl halides and cyanamide ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01064H, Paper P. Nordeman, S. Y. Chow, A. F. Odell, G. Antoni, L. R. Odell A rapid, efficient and high-yielding synthesis of 11C-cyanobenzamides, including novel analogs of various drug molecules, is described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of benzil-o-carboxylate derivatives and isocoumarins through neighboring ester-participating bromocyclizations of o-alkynylbenzoates ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00845G, Paper Si-Tian Yuan, Hongwei Zhou, Lianpeng Zhang, Jin-Biao Liu, Guanyinsheng Qiu Neighboring ester-participating bromocyclizations of o-alkynylbenzoates are developed for the switchable synthesis of benzil-o-carboxylate derivatives and isocoumarins. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Ni and Cu-Catalyzed One Pot Synthesis of Unsymmetrical 1,3-Di(hetero)aryl-1H-indazoles from Hydrazine, o-Chloro(hetero)benzophenones, and (Hetero)aryl Bromides ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00841D, Paper Carson Wiethan, Christopher Lavoie, Andrey Borzenko, Jillian Clark, Helio Gauze Bonacorso, Mark Stradiotto The nickel-catalyzed cyclization of in situ generated ortho-chlorobenzophenone hydrazone derivatives, to afford 3-(hetero)aryl-1H-indazoles, is documented for the first time. The product 1H-indazoles can be transformed subsequently in a one-pot procedure... The content of this RSS Feed (c) The Royal Society of Chemistry
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Antimicrobial peptide-inspired NH125 analogues: bacterial and fungal biofilm-eradicating agents and rapid killers of MRSA persisters ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01028A, Paper Akash Basak, Yasmeen Abouelhassan, Ran Zuo, Hussain Yousaf, Yousong Ding, Robert W. Huigens A novel series of 30 NH125 analogues leads to improved biofilm-eradicating agents that rapidly kill MRSA persister cells. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Total synthesis of marine natural products separacenes A and B ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00345E, Paper Subhendu Das, Rajib Kumar Goswami A short and convergent route for the stereoselective total synthesis of separacenes A and B has been developed using (+)-methyl D-lactate and D-(-)-tartaric acid as the chiral pools. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Biosynthetically-inspired oxidations of capillobenzopyranol ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00868F, Paper Henry P. Pepper, Hiu C. Lam, Jonathan H. George The marine sponge meroterpenoid capillobenzopyranol has been converted into the co-isolated verrubenzospirolactone using simple and selective chemical transformations. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Divergent syntheses of iodinated isobenzofuranones and isochromenones by iodolactonization of 2-alkynylbenzoic acids in ionic liquids ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00962C, Paper Raffaella Mancuso, Christian C. Pomelli, Francesco Malafronte, Asif Maner, Nadia Marino, Cinzia Chiappe, Bartolo Gabriele 2-Alkynylbenzoic acids can be divergently iodocyclized to either isobenzofuranones or isochromenones by changing the nature of the ionic liquid medium. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Formal total synthesis of selaginpulvilin D ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00950J, Paper Bhavani Shankar Chinta, Beeraiah Baire An efficient formal total synthesis of selaginpulvilin D has been achieved, employing a chemoselective dehydro Diels-Alder reaction as the key step. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Chemical differentiation of three DMSP lyases from the marine Roseobacter group ()
Org. Biomol. Chem., 2017, 15,4432-4439 DOI: 10.1039/C7OB00913E, Paper Immo Burkhardt, Lukas Lauterbach, Nelson L. Brock, Jeroen S. Dickschat The kinetics of three bacterial DMSP lyases with natural and artificial substrates were studied. Their mechanisms and possible ecological functions are discussed. The content of this RSS Feed (c) The Royal Society of Chemistry
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FeCl3 catalysed 7-membered ring formation in a single pot: a new route to indole-fused oxepines/azepines and their cytotoxic activity ()
Org. Biomol. Chem., 2017, 15,4468-4476 DOI: 10.1039/C7OB00715A, Paper K. Shiva Kumar, Meesa Siddi Ramulu, Bandari Rajesham, N. Praveen Kumar, Vani Voora, Rama Krishna Kancha FeCl3 catalysed construction of 7 membered ring, oxepine and azepine derivatives by the reaction of 2,3-dichloro N-heterocycles with 2-(1H-indol-2-yl)phenol/aniline. Several of these compounds were found anti-proliferative properties against cancer cell lines. The content of this RSS Feed (c) The Royal Society of Chemistry
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A NHC-catalyzed 1,3-dipolar cycloaddition reaction of allyl ketones with azides: direct access to 1,4,5-trisubstituted 1,2,3-triazoles ()
Org. Biomol. Chem., 2017, 15,4286-4290 DOI: 10.1039/C7OB00906B, Communication Huijun Yuan, Lili Zhang, Zhantao Liu, Yang Liu, Jian Wang, Wenjun Li A NHC-catalyzed 1,3-dipolar cycloaddition reaction of allyl ketones with azides has been developed. This strategy could generate 1,4,5-trisubstituted 1,2,3-triazoles in high yields and regioselectivities in the presence of a 20 mol% N-heterocyclic carbene catalyst. A broad substrate scope of this process is also presented. The content of this RSS Feed (c) The Royal Society of Chemistry
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On the enzymatic incorporation of an imidazole nucleotide into DNA ()
Org. Biomol. Chem., 2017, 15,4449-4455 DOI: 10.1039/C7OB00858A, Paper Pascal Rothlisberger, Fabienne Levi-Acobas, Ivo Sarac, Philippe Marliere, Piet Herdewijn, Marcel Hollenstein We have evaluated the possibility for using an imidazole modified nucleoside triphosphate for the enzymatic construction of artificial metal base pair with view on an expansion of the genetic code. The content of this RSS Feed (c) The Royal Society of Chemistry
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A room temperature cyanation of (hetero)aromatic chlorides by an air stable nickel(II) XantPhos precatalyst and Zn(CN)2 ()
Org. Biomol. Chem., 2017, 15,4291-4294 DOI: 10.1039/C7OB00892A, Communication D. Dawson Beattie, Thomas Schareina, Matthias Beller A methodology using a nickel(II) XantPhos precatalyst for the room-temperature synthesis of (hetero)aromatic nitriles from aryl chlorides been developed. The content of this RSS Feed (c) The Royal Society of Chemistry
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Natural product driven diversity via skeletal remodeling of caryophyllene [small beta]-lactam ()
Org. Biomol. Chem., 2017, 15,4456-4463 DOI: 10.1039/C7OB00741H, Paper Qiang Zhang, Hao-Yu Tang, Min Chen, Jie Yu, Hui Li, Jin-Ming Gao Diverse skeletons were generated from caryophyllene via cascade rearrangements. One of them was identified as an alpha-glucosidase inhibitor. The content of this RSS Feed (c) The Royal Society of Chemistry
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Highly selective and rapidly activatable fluorogenic Thrombin sensors and application in human lung tissue ()
Org. Biomol. Chem., 2017, 15,4344-4350 DOI: 10.1039/C7OB00663B, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Alicia Megia-Fernandez, Bethany Mills, Chesney Michels, Sunay V. Chankeshwara, Kevin Dhaliwal, Mark Bradley A fast and selective fluorogenic probe for Thrombin is reported and applied in ex vivo fibrotic human lung tissue. The content of this RSS Feed (c) The Royal Society of Chemistry
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Structural insights into the ene-reductase synthesis of profens ()
Org. Biomol. Chem., 2017, 15,4440-4448 DOI: 10.1039/C7OB00163K, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. J. Waller, H. S. Toogood, V. Karuppiah, N. J. W. Rattray, D. J. Mansell, D. Leys, J. M. Gardiner, A. Fryszkowska, S. T. Ahmed, R. Bandichhor, G. P. Reddy, N. S. Scrutton New insight into the general utility of ene reductases for the synthesis of profens is established using structural and biocatalytic approaches. The content of this RSS Feed (c) The Royal Society of Chemistry
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A novel metal-free method for the selenocyanation of aromatic ketones to afford [small alpha]-carbonyl selenocyanates ()
Org. Biomol. Chem., 2017, 15,4464-4467 DOI: 10.1039/C7OB00958E, Paper Kai Sun, Yunhe Lv, Yao Chen, Tingting Zhou, Yanyan Xing, Xin Wang A rapid access to [small alpha]-carbonyl selenocyanates has been developed through the direct selenocyanation of aromatic ketones. The content of this RSS Feed (c) The Royal Society of Chemistry
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A theoretical study of ascorbic acid oxidation and HOO[radical dot]/O2[radical dot]- radical scavenging ()
Org. Biomol. Chem., 2017, 15,4417-4431 DOI: 10.1039/C7OB00791D, Paper Yi-Jung Tu, David Njus, H. Bernhard Schlegel Ascorbate radical disproportionates by forming a dimer, cyclizing and dissociating to yield ascorbic acid and the most stable hydrated, bicyclic form of dehydroascorbic acid; radical scavenging by ascorbate radical can proceed by a similar mechanism. The content of this RSS Feed (c) The Royal Society of Chemistry
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A novel off-on fluorescent probe for sensitive imaging of mitochondria-specific nitroreductase activity in living tumor cells ()
Org. Biomol. Chem., 2017, 15,4383-4389 DOI: 10.1039/C7OB00781G, Paper Bo Huang, Wen Chen, Yong-Qing Kuang, Wei Liu, Xian-Jun Liu, Li-Juan Tang, Jian-Hui Jiang We have developed a novel fluorescent probe of a benzoindocyanine probe (BICP), which is able to target mitochondria and realize sensitive and selective detection of NTR. The content of this RSS Feed (c) The Royal Society of Chemistry
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Zinc-mediated [small alpha]-regioselective Barbier-type cinnamylation reactions of aldehydes, ketones and esters ()
Org. Biomol. Chem., 2017, 15,4359-4366 DOI: 10.1039/C7OB00723J, Paper Li-Ming Zhao, Hua-Shuai Gao, De-Feng Li, Jing Dong, Lan-Lin Sang, Jie Ji A simple and general protocol for the synthesis of [small alpha]-cinnamylated alcohols under Barbier-type conditions has been described. The content of this RSS Feed (c) The Royal Society of Chemistry
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Copper-catalyzed oxidative decarboxylative coupling of [small alpha]-keto acids and sulfoximines ()
Org. Biomol. Chem., 2017, 15,4320-4327 DOI: 10.1039/C7OB00776K, Paper Chaleena Pimpasri, Ladawan Sumunnee, Sirilata Yotphan The formation of N-aroylsulfoximines via a copper-catalyzed oxidative decarboxylative coupling of [small alpha]-keto acids with NH-sulfoximines is reported. The content of this RSS Feed (c) The Royal Society of Chemistry
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Efficient chiral 1H NMR analysis of indoloquinazoline alkaloids phaitanthrin A, cephalanthrin-A and their analogues with a chiral phosphoric acid ()
Org. Biomol. Chem., 2017, 15,4314-4319 DOI: 10.1039/C7OB00823F, Paper Chong-Xing Liu, Longzhangdi Zheng, Linjing Zhu, Hong-Ping Xiao, Xinhua Li, Jun Jiang A chiral phosphoric acid promoted enantioselective NMR recognition and determination of indoloquinazoline alkaloids phaitanthrin A, cephalanthrin-A and their analogues was described, which conveniently reveals their optical purities with high accuracy. The content of this RSS Feed (c) The Royal Society of Chemistry
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Copper-catalyzed fluoroalkylation of alkynes, and alkynyl & vinyl carboxylic acids with fluoroalkyl halides ()
Org. Biomol. Chem., 2017, 15,4295-4299 DOI: 10.1039/C7OB00641A, Communication Jing-Jing Ma, Wen-Bin Yi Copper-catalyzed fluoroalkylation of alkynes and alkynyl carboxylic acids has been achieved with high functional-group tolerance and excellent regio- and stereoselectivities. The content of this RSS Feed (c) The Royal Society of Chemistry
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18F-Labelling of electron rich iodonium ylides: application to the radiosynthesis of potential 5-HT2A receptor PET ligands ()
Org. Biomol. Chem., 2017, 15,4351-4358 DOI: 10.1039/C7OB00628D, Paper I. N. Petersen, J. Villadsen, H. D. Hansen, J. Madsen, A. A. Jensen, N. Gillings, S. Lehel, M. M. Herth, G. M. Knudsen, J. L. Kristensen Nucleophilic 18F-labelling of electron aromatic systems. The content of this RSS Feed (c) The Royal Society of Chemistry
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Fluorescence enhancement and pKa shift of a rho kinase inhibitor by a synthetic receptor ()
Org. Biomol. Chem., 2017, 15,4336-4343 DOI: 10.1039/C7OB00547D, Paper Hang Yin, Linmin Chen, Binrui Yang, David Bardelang, Chunming Wang, Simon M. Y. Lee, Ruibing Wang The significant fluorescence enhancement and pKa shift of fasudil upon encapsulation by cucurbit[7]uril may provide a traceable enteric formulation. The content of this RSS Feed (c) The Royal Society of Chemistry
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Regioselective dehydration of [small alpha]-hydroxymethyl tetrahydrofurans using Burgess' reagent under microwave irradiation ()
Org. Biomol. Chem., 2017, 15,4282-4285 DOI: 10.1039/C7OB00607A, Communication Leona J. Gross, Christian B. W. Stark We here present a highly efficient and high yielding procedure for the preparation of 2-vinyl tetrahydrofurans starting from [small alpha]-hydroxymethyl tetrahydrofurans. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthetic water soluble di-/tritopic molecular receptors exhibiting Ca2+/Mg2+ exchange ()
Org. Biomol. Chem., 2017, 15,4367-4374 DOI: 10.1039/C6OB02732F, Paper Aurelie Lavie-Cambot, Arnaud Tron, Aurelien Ducrot, Frederic Castet, Brice Kauffmann, Louis Beaute, Hassan Allouchi, Jean-Luc Pozzo, Celia S. Bonnet, Nathan D. McClenaghan Structure and binding properties of two synthetic receptors, simultaneously integrating Ca2+ and Mg2+ binding sites, are described. The content of this RSS Feed (c) The Royal Society of Chemistry
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One-pot sequential reaction to 2-substituted-phenanthridinones from N-methoxybenzamides ()
Org. Biomol. Chem., 2017, 15,4390-4398 DOI: 10.1039/C7OB00649G, Paper Dongdong Liang, Deanna Sersen, Chao Yang, Jeffrey R. Deschamps, Gregory H. Imler, Chao Jiang, Fengtian Xue A one-pot synthesis of 2-bromo/chloro-phenanthridinones via an amidation of arenes followed by a regioselective halogenation reaction has been developed using a hypervalent iodine reagent. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs ()
Org. Biomol. Chem., 2017, 15,4308-4313 DOI: 10.1039/C7OB00789B, Paper Bogdan Barnych, Amy A. Rand, Tomas Cajka, Kin Sing Stephen Lee, Bruce D. Hammock COX metabolites of 8,9-EET, previously observed as potent mitogenic lipid mediators, were synthesized for the first time by using two synthetic approaches. The content of this RSS Feed (c) The Royal Society of Chemistry
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Cationic polycyclization of ynamides: building up molecular complexity ()
Org. Biomol. Chem., 2017, 15,4399-4416 DOI: 10.1039/C7OB00850C, Paper Cedric Theunissen, Benoit Metayer, Morgan Lecomte, Nicolas Henry, Hwai-Chien Chan, Guillaume Compain, Phideline Gerard, Christian Bachmann, Naima Mokhtari, Jerome Marrot, Agnes Martin-Mingot, Sebastien Thibaudeau, Gwilherm Evano Simple activation of readily available ynamides under acidic conditions triggers an unprecedented cationic polycyclization yielding highly substituted polycyclic nitrogen heterocycles. The content of this RSS Feed (c) The Royal Society of Chemistry
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Site-selective anion recognition of an interlocked dimer ()
Org. Biomol. Chem., 2017, 15,4328-4335 DOI: 10.1039/C7OB00328E, Paper Ryo Sekiya, Morihiko Fukuda, Reiko Kuroda An interlocked dimer with three internal cavities is reported. We found that the interlocked dimer site-selectively encapsulated different anions simultaneously. This site selectivity originated from the different steric environments of the cavities. The content of this RSS Feed (c) The Royal Society of Chemistry
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A self-assembled fluorescent organic nanoprobe and its application for sulfite detection in food samples and living systems ()
Org. Biomol. Chem., 2017, 15,4375-4382 DOI: 10.1039/C7OB00580F, Paper Tang Gao, Xiaozheng Cao, Peng Ge, Jie Dong, Shuqi Yang, Huan Xu, Yong Wu, Feng Gao, Wenbin Zeng An AIEE-based nanoprobe has been rationally developed for detection of sulfite in food samples and living systems with excellent selectivity and an extremely low detection limit. The content of this RSS Feed (c) The Royal Society of Chemistry
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Construction of protein assemblies by host-guest interactions with cucurbiturils ()
Org. Biomol. Chem., 2017, 15,4272-4281 DOI: 10.1039/C7OB00686A, Review Article Chunxi Hou, Zupeng Huang, Yu Fang, Junqiu Liu Protein assembly is important in nature and bionics. Herein, we have reviewed the recent progress in protein assemblies induced by cucurbituril-based supramolecular interactions and their applications. The content of this RSS Feed (c) The Royal Society of Chemistry
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Palladium-catalyzed tandem addition/cyclization in aqueous medium: synthesis of 2-arylindoles ()
Org. Biomol. Chem., 2017, 15,4300-4307 DOI: 10.1039/C7OB00572E, Paper Shuling Yu, Kun Hu, Julin Gong, Linjun Qi, Jianghe Zhu, Yetong Zhang, Tianxing Cheng, Jiuxi Chen Pd-catalyzed tandem reaction of potassium aryltrifluoroborates with nitriles for the synthesis of 2-arylindoles in aqueous medium. The content of this RSS Feed (c) The Royal Society of Chemistry
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Spatial organization of multi-enzyme biocatalytic cascades ()
Org. Biomol. Chem., 2017, 15,4260-4271 DOI: 10.1039/C7OB00391A, Review Article M. B. Quin, K. K. Wallin, G. Zhang, C. Schmidt-Dannert Multi-enzyme cascades provide a wealth of valuable chemicals. Efficiency of reaction schemes can be improved by spatial organization of biocatalysts. This review will highlight various methods of spatial organization of biocatalysts: fusion, immobilization, scaffolding and encapsulation. The content of this RSS Feed (c) The Royal Society of Chemistry
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Is More Better? A Comparison of Tri- and Tetrapeptidic Catalysts ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01039G, Communication Helma Wennemers, Tobias Schnitzer, Markus Wiesner From an enzymatic perspective, there is a general notion that the bigger and more complex a catalytically active peptide is the more enzyme-like and the better it should become. But... The content of this RSS Feed (c) The Royal Society of Chemistry
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Oxalic acid as the in situ carbon monoxide generator in palladium-catalyzed hydroxycarbonylation of arylhalides ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01052D, Paper Changdong Shao, Ailan Lu, Xiaoling Wang, Bo Zhou, xiaohong guan, Yanghui Zhang An efficient palladium-catalyzed hydroxycarbonylation reaction of arylhalides using oxalic acid as CO source has been developed. The reaction features high safety, low catalyst loading, and broad substrate scope, and provides... The content of this RSS Feed (c) The Royal Society of Chemistry
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Blue-Light-Promoted Carbon-Carbon Double Bond Isomerization and Its Application in Syntheses of Quinolines ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00558J, Paper Hongbin Zhai, Xinzheng Chen, Shuxian Qiu, Sasa Wang, Huifei Wang A blue-light-promoted carbon-carbon double bond isomerization in the absence of any photoredox catalyst is reported. It provides rapid access to a series of quinolines in good to excellent yields under... The content of this RSS Feed (c) The Royal Society of Chemistry
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New selenosteroids as antiproliferative agents ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00458C, Paper Alma G. Fuentes-Aguilar, Laura L. Romero-Hernandez, Ailed V. Arenas-Gonzalez, Penelope Merino-Montiel, Sara Montiel-Smith, Socorro Meza-Reyes, Jose Luis Vega-Baez, Gabriela B Plata, Jose M. Padron, Oscar Lopez, Jose G Fernandez-Bolanos Starting from natural steroids (diosgenin, hecogenin, smilagenin, estrone), we have prepared a wide panel of selenoderivatives, including benzoselenazolones, selenosemicarbazones, isoselenocyanates, selenoureas, selenocyanates and diselenides, with the aim of developing new... The content of this RSS Feed (c) The Royal Society of Chemistry
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Cobalt carbonyl-catalyzed carbonylation of functionalized aziridines to versatile [small beta]-lactam building blocks ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00832E, Paper Nicola Piens, Kristof Van Hecke, Dieter Vogt, Matthias D'hooghe Aziridine to azetidin-2-one carbonylation as a convenient entry to pyrrolidines, C-fused bi- and tricyclic [small beta]-lactams and monocyclic carbapenem analogs. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Active metal template synthesis of a neutral indolocarbazole-containing [2]rotaxane host system for selective oxoanion recognition ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01040K, Paper Asha Brown, Thomas Lang, Kathleen M. Mullen, Paul D. Beer A CuAAC active metal template approach is used to prepare a new neutral indolocarbazole-containing [2]rotaxane anion host system which exhibits a rare interlocked host selectivity for oxoanions over halides. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Palladium-Catalyzed Geometrically Selective Hydrogenation of (Z)-Trifluoromethyl Alkenyl Triflate: An Efficient Approach to (Z) or (E)-3,3,3-Trifluoropropenyl Derivatives ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00970D, Paper Yilong Zhao, Yuhan Zhou, Chunxia Zhang, Huan Wang, Jinfeng Zhao, Kun Jin, Jihong Liu, Jian-Hui Liu, Jingping Qu A Pd-catalyzed hydrogenation of (Z)-trifluoromethyl alkenyl triflate providing either (Z)- or (E)-3,3,3-trifluoropropenyl derivatives with excellent divergent geometric control in good yield is described. Catalyzed by Pd(OAc)2/PPh3, the reduction of (Z)-trifluoromethyl... The content of this RSS Feed (c) The Royal Society of Chemistry
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Metal-free I2O5-mediated direct construction of sulfonamides from thiols and amines ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00668C, Communication Minghui Zhu, Wei Wei, Daoshan Yang, Huanhuan Cui, Leilei Wang, Guoqing Meng, Hua Wang A simple and efficient metal-free I2O5-mediated one-pot procedure for the construction of sulfonamides from thiols and amines has been developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Intramolecular cascade rearrangements of enynamine derived ketenimines: access to acyclic and cyclic amidines ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00499K, Paper Dinesh Pratapsinh Chauhan, Sreejith J. Varma, Mahesh Gudem, Nihar Panigrahi, Khushboo Singh, Anirban Hazra, Pinaki Talukdar Copper-catalyzed reaction of enynamine with sulfonylazide generates a ketenimine intermediate which further undergoes rearrangements to form acyclic and cyclic amidines. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Urotensin-II peptidomimetic incorporating a non-reducible 1,5-triazole disulfide bond reveals a pseudo-irreversible covalent binding mechanism to the urotensin G-protein coupled receptor ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00959C, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Salvatore Pacifico, Aidan Kerckhoffs, Andrew J. Fallow, Rachel E. Foreman, Remo Guerrini, John McDonald, David G. Lambert, Andrew G. Jamieson New high affinity peptidomimetic ligands have been developed that provided new insight into the mechanism of binding of U-II peptide with the urotensin-II receptor. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Asymmetric synthesis of CF3-containing tetrahydroquinoline via a thiourea-catalyzed cascade reaction ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01013C, Communication Yuanyuan Zhu, Boyu Li, Cui Wang, Zhenghao Dong, Xiaoling Zhong, Kairong Wang, Wenjin Yan, Rui Wang The first example of the asymmetric introduction of CF3 into the 2-position of tetrahydroquinolines was described by using [small beta]-CF3-nitroalkene as the building block. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Endomorphin-1 analogs containing [small alpha]-methyl-[small beta]-amino acids exhibit potent analgesic activity after peripheral administration ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01115F, Communication Yuan Wang, Junxian Yang, Xin Liu, Long Zhao, Dongxu Yang, Jingjing Zhou, Dan Wang, Lingyun Mu, Rui Wang This study describes the design and synthesis of endomorphin-1 analogs containing a C-terminal aromatic [small alpha]-methyl-[small beta]-amino acids and an N-terminal native tyrosine or 2,6-dimethyl-tyrosine. We show that, in comparison with the... The content of this RSS Feed (c) The Royal Society of Chemistry
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Application of Primary Halogenated Hydrocarbons for the Synthesis of 3-Aryl and 3-Alkyl Indolizines ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00980A, Paper Yan Liu, Huayou Hu, Junyu Zhou, Wenhui Wang, Youliang He, Chao Wang Indolizine is an important heterocyclic compound with several interesting properties that make it suitable for numerous applications in many fields, such as biology, medicine and materials. However, the synthesis of... The content of this RSS Feed (c) The Royal Society of Chemistry
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Photo-Controlled Cell-Specific Metabolic Labeling of RNA ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01009E, Communication Chao Feng, Ying Li, Robert C. Spitale Herein we present a chemical method for photo-controlled metabolic labeling of RNA. Our technique relies on photo-"caging" a metabolic intermediate. Once un-"caged" with long-wavelength UV light, the nucleoside analog can... The content of this RSS Feed (c) The Royal Society of Chemistry
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AlCl3 Catalyzed Coupling of N-benzylic Sulfonamides with 2-Substituted Cyanoacetates through Carbon-Nitrogen Bond Cleavage ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01025G, Paper Chen Hu, Gang Hong, Xiaofei Qian, Kwang Rim Kim, Xiaoyan Zhu, Limin Wang A new cross-coupling reaction of N-benzylic sulfonamides with 2-substituted cyanoacetates for the synthesis of 2-substituted benzylbenzene was reported. In the presence of the AlCl3, a broad range of N-benzylic sulfonamides... The content of this RSS Feed (c) The Royal Society of Chemistry
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A Greener and Efficient Access to Substituted Four- and Six-membered Sulfur-bearing Heterocycles ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00846E, Paper Giovanna Parisi, Leonardo Degennaro, Claudia Carlucci, Modesto de Candia, Pietro Mastrorilli, Alexander Roller, Wolfgang Holzer, Cosimo Damiano Altomare, Vittorio Pace, Renzo Luisi The regioselective functionalization of four- and six-membered cyclic sulfones was investigated using a lithiation/electrophile trapping strategy. The protocol features an interesting eco-compatibility profile because of the use of 2-MeTHF as... The content of this RSS Feed (c) The Royal Society of Chemistry
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Generation of a cell-permeable cycloheptapeptidyl inhibitor against the peptidyl-prolyl isomerase Pin1 ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00430C, Communication Walaa Bedewy, Hui Liao, Nageh A. Abou-Taleb, Sherif F. Hammad, Tamer Nasr, Dehua Pei Integration of Pin1-binding and cell-penetrating sequences results in a cell-permeable, biologically active cycloheptapeptide inhibitor against Pin1. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis, properties, and crystal structures of [small pi]-extended double [6]helicenes: contorted multi-dimensional stacking lattice ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00987A, Paper Takao Fujikawa, Nobuhiko Mitoma, Atsushi Wakamiya, Akinori Saeki, Yasutomo Segawa, Kenichiro Itami Synthesis, structures, packing modes, and electronic properties of two [small pi]-extended double helicene molecules are described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Genetic incorporation of 4-fluorohistidine into peptides enables selective affinity purification ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00844A, Communication Christine M. Ring, Emil S. Iqbal, David E. Hacker, Matthew C. T. Hartman, T. Ashton Cropp Fluorohistidine allows for selective affinity enrichment of peptides bearing F-his tags. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Re-characterization of hammerhead ribozymes as molecular tools for intermolecular RNA cleavage ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00995J, Paper Getong Liu, Xin Huang, Qinlin Pu, Yongyun Zhao, Feng Du, Juan Dong, Xin Cui, Zhuo Tang A new guideline for the use of hammerhead ribozymes as molecular tools in intermolecular RNA-cleaving. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Exploitation of new structurally diverse D-glucuronamide-containing N-glycosyl compounds: synthesis and anticancer potential ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00472A, Paper Nuno M. Xavier, Alexandre Porcheron, Daniela Batista, Radek Jorda, Eva Reznickova, Vladimir Krystof, M. Conceicao Oliveira The synthesis of novel D-glucuronamide-based N-glycosyl derivatives is described. An N-dodecyl-containing N9-glycosylpurine displayed anticancer effects with single-digit micromolar GI50 values. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Regioselective 6-endo-dig iodocyclization: an accessible approach for iodo-benzo[a]phenazines ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00671C, Paper Sonu Kumar, Mohammad Mujahid, Akhilesh K. Verma A tandem approach for the synthesis of iodo benzo[a]phenazine derivatives using molecular iodine has been described under mild reaction conditions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Strained alkynes derived from 2,2[prime or minute]-dihydroxy-1,1[prime or minute]-biaryls; synthesis and copper-free cycloaddition with azides ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00991G, Communication Alessandro Del Grosso, Lavrentis-Dimitrios Galanopoulos, Cookson K. C. Chiu, Guy J. Clarkson, Peter B. O[prime or minute] Connor, Martin Wills A series of strained alkynes were prepared from 2,2[prime or minute]-dihydroxy-biaryls, and were demonstrated to react with azides without a copper catalyst. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Macrocyclic peptides inhibitors for the protein-protein interaction of Zaire Ebola virus protein 24 and Karyopherin alpha 5 ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00012J, Paper Xiao Song, Lu-yi Lu, Toby Passioura, Hiroaki Suga Ebola virus infection leads to severe hemorrhagic fever in human and non-human primate with an average case fatality rate of 50%. To date, numerous potential therapies are in development, but... The content of this RSS Feed (c) The Royal Society of Chemistry
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Divergent synthesis of biflavonoids yields novel inhibitors of the aggregation of amyloid [small beta] (1-42) ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00804J, Paper Tze Han Sum, Tze Jing Sum, Suil Collins, Warren R. J. D. Galloway, David G. Twigg, Florian Hollfelder, David R. Spring Biflavonoids inhibit the aggregation of A[small beta]42, the pathological hallmark of Alzheimer's disease, with an IC50 of 16 [small mu ]M. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Dimeric and trimeric derivatives of the azinomycin B chromophore show enhanced DNA binding ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00944E, Communication Milena Balazy, Alejandra Fausto, Christina Voskanian, Bianca Chavez, Harmanpreet Panesar, Thomas G. Minehan Compound 1d (Kapp = 2.4 [times] 107 M-1), a derivative of the azinomycin B chromophore, strongly associates with DNA by intercalation and major groove binding. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Selective trihydroxylated azepane inhibitors of NagZ, a glycosidase involved in Pseudomonas aeruginosa resistance to [small beta]-lactam antibiotics ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00838D, Paper J. Bouquet, D. T. King, G. Vadlamani, G. R. Benzie, B. Iorga, D. Ide, I. Adachi, A. Kato, D. J. Vocadlo, B. L. Mark, Y. Bleriot, J. Desire Fluorination of the NHCOCH3 moiety of a trihydroxylated azepane-based broad hexosaminidase inhibitor significantly improves its selectivity toward bacterial NagZ. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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In situ generation of less accessible Boc-imines from aldehydes: construction of a quaternary carbon by the Mannich reaction or unprecedented aldol reaction ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01126A, Communication Taichi Kano, Chihiro Homma, Keiji Maruoka Mannich reactions of [small beta]-dicarbonyls with in situ generated less accessible Boc-imines from aldehydes were achieved. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Two-step conversion of carboxylic esters into distally fluorinated ketones via ring cleavage of cyclopropanol intermediates: application of sulfinate salts as fluoroalkylating reagents ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00680B, Paper Yulia A. Konik, Marina Kudrjashova, Nele Konrad, Sandra Kaabel, Ivar Jarving, Margus Lopp, Dzmitry G. Kananovich Synthesis of distally fluorinated ketones from easily available cyclopropanols using sulfinate salts as fluoroalkylating reagents. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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High-affinity recognition of the human C-reactive protein independent of phosphocholine ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00684E, Paper Jie Yang, Anna-Lena Gustavsson, Martin Haraldsson, Goran Karlsson, Thomas Norberg, Lars Baltzer The design of a small organic molecule based on hits from NMR screening of a building block collection enabled the synthesis of a polypeptide conjugate that binds human CRP with high affinity and selectivity independently of phosphocholine. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Enantioselective magnesium-catalyzed transformations ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00903H, Review Article Helene Pellissier This review updates the major progress in the field of enantioselective transformations promoted by chiral magnesium catalysts, covering the literature since 2007, illustrating the power of these green catalysts to promote many types of reactions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Push-pull type meso-ester substituted BODIPY near-infrared dyes as contrast agents for photoacoustic imaging ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00965H, Communication Yong Ni, Ravi Kumar Kannadorai, Sidney W.-K. Yu, Young-Tae Chang, Jishan Wu Push-pull meso-ester BODIPYs with intense NIR absorption and good photo-stability were used for in vitro and in vivo photoacoustic imaging. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Structure-functionality relationship and pharmacological profiles of Pseudomonas aeruginosa alkylquinolone quorum sensing modulators ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00263G, Paper Ahmed A. M. Kamal, Lucia Petrera, Jens Eberhard, Rolf W. Hartmann Alkylquinolone derived compounds revealed four pharmacological profiles for PqsR modulation. Molecular docking illuminated the structural requirements. Only inverse agonists were effective pathoblockers inhibiting pyocyanin. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Refinement of labile hydrogen positions based on DFT calculations of 1H NMR chemical shifts: comparison with X-ray and neutron diffraction methods ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01019B, Paper Michael G. Siskos, M. Iqbal Choudhary, Ioannis P. Gerothanassis High resolution structures of hydrogen bonds: experimental ([small delta]exp) and GIAO calculated 1H NMR chemical shifts, [small delta]calc, in combination with DFT energy minimization, are an excellent means for obtaining high resolution structures of labile protons. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Iodine-mediated synthesis of sulfur-bridged enaminones and chromones via double C(sp2)-H thiolation ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00619E, Paper Yong Gao, Li Wei, Yunyun Liu, Jie-Ping Wan The synthesis of sulfur-bridged enaminones and chromones has been readily achieved via double vinyl C-H thiolation under metal-free conditions by using enaminones and elemental sulfur. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A facile synthesis of Sulfonylureas via water assisted preparation of Carbamates ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00872D, Paper Dinesh Kumar Tanwar, Anjali Ratan, manjinder singh gill A novel and simple approach to the synthesis of Sulfonylureas has been reported. It involved the reaction of various amines with diphenyl carbonate to yield the corresponding carbamates, which subsequetly... The content of this RSS Feed (c) The Royal Society of Chemistry
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Metal-free Regioselective Formation of C-N and C-O Bonds with the Utilization of Diaryliodonium Salts in Water: Facile Synthesis of N-Arylquinolones and Aryloxyquinolines ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00940B, Communication Manish Kumar Mehra, Mukund P Tantak, V Arun, Indresh Kumar, Dalip Kumar Regioselective construction of crucial C-N and C-O bonds leading to N-arylquinolones and aryloxyquinolines has been accomplished by employing easily accessible diaryliodonium salts and quinolones in water under metal- and ligand-free... The content of this RSS Feed (c) The Royal Society of Chemistry
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Elucidation of inhibitor-binding pockets of D-amino acid oxidase using docking simulation and N-sulfanylethylanilide-based labeling technology ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00633K, Paper Taiki Kohiki, Yusuke Kato, Yusuke Nishikawa, Kazuko Yorita, Ikuko Sagawa, Masaya Denda, Tsubasa Inokuma, Akira Shigenaga, Kiyoshi Fukui, Akira Otaka Binding pockets of a schizophrenia-related D-amino acid oxidase to its inhibitor were clarified by docking simulation and protein labeling experiments. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Palladium(0)-catalyzed [2 + 2 + 1] cyclization of 1,6-enynes with vinyl bromides: a highly diastereoselective synthesis of tetrahydro-1H-cyclopenta[c]furans bearing two quaternary carbon centers ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00768J, Paper Yunxia Diao, Zhijun Zuo, Hui Wang, Jingjing Liu, Xinjun Luan A highly efficient method for the diastereoselective synthesis of cyclopenta[c]furans was developed by Pd(0)-catalyzed [2 + 2 + 1] cyclization of 1,6-enynes with vinyl bromides. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Phosphine-catalyzed Friedel-Crafts reaction of naphthols with para-quinone methides: expedient access to triarylmethanes ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00911A, Communication Tao Zhou, Shenhuan Li, Ben Huang, Cao Li, Yang Zhao, Jieqiong Chen, Aoling Chen, Yuanjin Xiao, Lu Liu, Junliang Zhang A novel phosphine-catalyzed Friedel-Crafts reaction of naphthols with para-quinone methides has been developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Diastereoselective synthesis and biological evaluation of enantiomerically pure tricyclic indolines ()
Org. Biomol. Chem., 2017, 15,4241-4245 DOI: 10.1039/C7OB00897J, Paper W. He, B. M. Griffiths, W. Wang, X. Wang Tricyclic indolines are common in both natural products and synthetic chemical probes. The content of this RSS Feed (c) The Royal Society of Chemistry
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Evolution inspired engineering of antibiotic biosynthesis enzymes ()
Org. Biomol. Chem., 2017, 15,4036-4041 DOI: 10.1039/C7OB00189D, Perspective M. Metsa-Ketela Chimeragenesis is an effective tool to probe the structure/function relationships of proteins without high-throughput screening systems. Here the proof-of-principle is presented with three pairs of proteins. The content of this RSS Feed (c) The Royal Society of Chemistry
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