Organic & Biomolecular Chemistry

Pd-Catalyzed One-Pot Sequential Cross-Coupling Reactions of Tetrabromothiophene ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02601C, Paper Kapil Mohan Saini, Rakesh K Saunthwal, Akhilesh K. Verma Unsymmetrical one-pot sequential cross-coupling reactions of sterically hindered tetrabromo thiophene with aryl boronic acid and alkyne/alkene to afford selective bi-, tri-, and tetrasubstituted aryl/alkynyl-thiophenes with the aid of a palladium... The content of this RSS Feed (c) The Royal Society of Chemistry
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A biocatalytic cascade for the amination of unfunctionalised cycloalkanes ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02569F, Communication Michele Tavanti, Juan Mangas-Sanchez, Sarah L. Montgomery, Matthew P. Thompson, Nicholas J. Turner Here we describe a one-pot, three-enzyme, cascade involving a cytochrome P450 monooxygenase, an alcohol dehydrogenase and a reductive aminase for the synthesis of secondary amines from cycloalkanes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A fluorescent combinatorial logic gate with Na+/H+-enabled OR and H+-driven low-medium-high ternary logic functions ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01828B, Paper Jasmine Spiteri, Carl J Mallia, Glenn J Scerri, David C Magri A novel fluorescent molecular logic gate with a 'fluorophore-spacer1-receptor1-spacer2-receptor2' format is demonstrated in 1:1 (v/v) methanol/water. The molecule consists of an anthracene fluorophore, and tertiary alkyl amine and N-(2-methoxyphenyl)aza-15-crown-5 ether... The content of this RSS Feed (c) The Royal Society of Chemistry
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Conformational isomerism in cyclic peptoids and its specification ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02643A, Paper Assunta D'Amato, ROSARIA SCHETTINI, Giorgio Della Sala, Chiara COSTABILE, Consiglia Tedesco, Irene Izzo, Francesco DE RICCARDIS Most of the structural studies made on the secondary structure of peptoids describe their geometric attributes in terms of the classic Ramachandran plot (based on the local analysis of [small omega],... The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of 4-Subsituted Pyrazole-3,5-diamines via Suzuki-Miyaura Coupling and Iron-Catalyzed Reduction ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02373A, Paper Monika Tomanova, Lukas Jedinak, Jan Kosar, Lubomir Kvapil, Pavel Hradil, Petr Cankar The general and efficient synthesis of the 4-substituted-1H-pyrazole-3,5-diamines was develop to access the derivatives with an aryl, heteroaryl, or styryl group, which are otherwise relatively difficult to prepare. The first... The content of this RSS Feed (c) The Royal Society of Chemistry
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Prolonged bioluminescence imaging in living cells and mice using novel pro-substrates for Renilla luciferase ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01656E, Paper Mingliang Yuan, Xiaojie Ma, Tianyu Jiang, Yuqi Gao, Yuanyuan Cui, Chaochao Zhang, Xingye Yang, Yun Huang, Lupei Du, Ilia V Yampolsky, Minyong Li The prodrug or caged-luciferin strategy affords an excellent platform for persistent bioluminescence imaging. In the current work, we designed and synthesized ten novel pro-substrates for Renilla luciferase by introducing ester... The content of this RSS Feed (c) The Royal Society of Chemistry
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Nitrilium Ions - Synthesis and Applications ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02533E, Review Article Tom van Dijk, Chris Slootweg, Koop Lammertsma Nitrilium ions are well-established in organic chemistry for many decades, but recent developments show them to be far more versatile then hitherto recognized. They are known as stable salts, can... The content of this RSS Feed (c) The Royal Society of Chemistry
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Rhodium-catalyzed benzoisothiazoles synthesis by tandem annulation reactions of sulfoximines and activated olefins ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02586F, Communication Lin Dong, Yang Li A rhodium(III)-catalyzed N-directed ortho C-H activation reactions have been developed for the synthesis of unique heterocyclic benzoisothiazoles. Herein, the novel tandem annulation approach can efficiently construct benzoisothiazole compounds from free... The content of this RSS Feed (c) The Royal Society of Chemistry
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Charged probes: turn-on selective fluorescence for RNA ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02423A, Perspective Bahareh Shirinfar, Humaira Seema, Nisar Ahmed Imidazolium-based charged fluorescent probes for the selective in vitro and in vivo recognition of RNA over other biomolecules. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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1,3-Dibromo-5,5-dimethylhydantoin mediated oxidative amidation of terminal alkenes in water ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02329D, Paper Chunhua Ma, Guojie Fan, Ping Wu, Zhi Li, Yang Zhou, Qingjie Ding, Wei Zhang A variety of terminal alkenes were converted to the corresponding amides in yields of 25 to 86% in water via treatment with 1,3-dibromo-5,5-dimethylhydantoin, followed by reaction with molecular iodine and aq. NH3 (or amine) in one pot. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Organocatalytic umpolung annulative dimerization of ynones for the synthesis of 5-alkylidene-2-cyclopentenones ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02424J, Communication Dhevalapally B. Ramachary, T. Prabhakar Reddy, A. Suresh Kumar A novel phosphine-catalyzed umpolung [3 + 2]-annulative dimerization of ynones was developed to furnish functionally rich 5-alkylidene-2-cyclopentenones. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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[small beta]-Alanine and N-terminal cationic substituents affect polyamide-DNA binding ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02513K, Paper Beibei Liu, Shuo Wang, Karl Aston, Kevin J. Koeller, Shahrzad Fanny Hakami Kermani, Carlos H. Castaneda, M. Jose Scuderi, Rensheng Luo, James K. Bashkin, W. David Wilson The binding preference of a systematic set of designed polyamides with [small beta]-inserts and cationic-substitutions with cognate DNA. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Copper nitrate-catalyzed oxidative coupling of unactivated C(sp3)-H bonds of ethers and alkanes with N-hydroxyphthalimide: synthesis of N-hydroxyimide esters ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02249B, Paper Xiaohe Xu, Jian Sun, Yuyan Lin, Jingya Cheng, Pingping Li, Yiyan Yan, Qi Shuai, Yuanyuan Xie A novel oxygenative cross dehydrogenative coupling of ethers and alkanes with NHPI under a copper nitrate/oxygen catalytic system is described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A computational investigation of the solvent-dependent enantioselective intramolecular Morita-Baylis-Hillman Reaction of enones ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02025B, Paper Nitin Kumar Singh, Bishnupada Satpathi, P Balanarayan, S. S. V. Ramasastry The Intramolecular Morita-Baylis-Hillman reaction of [small beta]-mono and [small beta],[small beta] -disubstitued enones shows high yields and stereoselective products when the reaction is performed in the presence of 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) as a solvent.... The content of this RSS Feed (c) The Royal Society of Chemistry
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Radical fluorination reactions by thermal and photoinduced methods ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02402A, Review Article Beatriz Lantano, Al Postigo Radical or radical ion-based fluorination reactions of organic compounds will be presented. These methodologies include fluorination processes accomplished through thermal or photoinduced radical/electron transfer methods. In doing so, the fluorination... The content of this RSS Feed (c) The Royal Society of Chemistry
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Perylenediimide-based glycoclusters as high affinity ligands of bacterial lectins: Synthesis, binding studies and anti-adhesive properties ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02749D, Paper Marion Donnier-Marechal, Nicolas Galanos, Teddy Grandjean, Yoann Pascal, Ding-Kun Ji, Lei Dong, Emilie Gillon, Xiao-Peng He, Anne Imberty, Eric Kipnis, Rodrigue Dessein, Sebastien Vidal The synthesis of eight perylenediimide-based glycoclusters was readily performed from hexa- and tetra-propargylated cores through azide-alkyne "click" conjugation. Variations on the carbohydrate epitope (Glc, Gal, Man, Fuc) and the linker... The content of this RSS Feed (c) The Royal Society of Chemistry
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Fe-catalyzed radical-type difunctionalization of styrenes with aliphatic aldehydes and trimethylsilyl azide via decarbonylative alkylation-azidation cascade ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02598J, Communication Wei-Yu Li, Qi-Qiang Wang, Luo Yang A convenient Fe-catalyzed decarbonylative alkylation-azidation cascade reaction of styrene derivatives with aliphatic aldehydes and TMSN3 to provide aliphatic azides is developed. With DTBP as an oxidant and radical-initiator, this reaction... The content of this RSS Feed (c) The Royal Society of Chemistry
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[18F]ODIBO: a prosthetic group for bioorthogonal radiolabeling of macromolecules via strain-promoted alkyne-azide cycloaddition. ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02532G, Communication Mehdi Boudjemeline, Christopher McNitt, Thomas Alan Singleton, VLADIMIR POPIK, Alexey Kostikov A novel prosthetic group for the efficient radiolabeling of macromolecules has been developed. [18F]oxadibenzocyclooctyne ([18F]ODIBO) is synthesized in high radiochemical yield and applied for nearly quantitative conjugation to azide-tagged peptides... The content of this RSS Feed (c) The Royal Society of Chemistry
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Design and self-assembly of PBLG-b-ELP hybrid diblock copolymers based on synthetic and elastin-like polypeptides ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01945A, Paper Gaelle Le Fer, Delphine Portes, Guillaume Goudounet, Jean-Michel Guigner, Elisabeth Garanger, Sebastien Lecommandoux The precision synthesis and self-assembly of amphiphilic copolypeptides containing a recombinant elastin-like polypeptide (ELP) block used as macroinitiator for the ring opening polymerization (ROP) of [gamma]-benzyl-L-glutamate ([gamma]-BLG NCA) are herein... The content of this RSS Feed (c) The Royal Society of Chemistry
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Complete tetraglycosylation of a calix[4]arene by a chemo-enzymatic approach ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02448G, Paper Silvia Bernardi, Dong Yi, Ning He, Alessandro Casnati, Wolf-Dieter Fessner, Francesco Sansone Polyglycosylated calixarenes are efficient and selective multivalent ligands for lectins. However, the chemical decoration of these macrocyclic scaffolds with saccharides of increasing complexity is hampered by the highly complex chemistry... The content of this RSS Feed (c) The Royal Society of Chemistry
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Differential array sensing for cancer cell classification and novelty detection ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02174G, Paper Alexandra M. Gade, Margaret K. Meadows, Andrew D. Ellington, Eric V. Anslyn A series of semi-specific peptides reported in the literature to bind various epitopes on cell surfaces were used in a differential sensing array to pattern cell line identity. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Dissociative reactions of benzonorbornadienes with tetrazines: scope of leaving groups and mechanistic insights ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02191G, Paper M. Xu, R. Galindo-Murillo, T. E. Cheatham, R. M. Franzini Hetero-substituted benzonorbornadiene derivatives react rapidly with tetrazines to release diverse leaving groups in high yields. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Rational design and synthesis of a novel laterally-tetrafluorinated tricyclic mesogen with large negative dielectric anisotropy ()
Org. Biomol. Chem., 2017, 15,9442-9454 DOI: 10.1039/C7OB02399E, Paper Shigeyuki Yamada, Ken Tamamoto, Takumi Kida, Tomoyuki Asai, Takashi Ishihara, Tsutomu Konno Laterally-tetrafluorinated tricyclic molecule was successfully developed and found to exhibit large negative dielectric anisotropy in the binary mixture. The content of this RSS Feed (c) The Royal Society of Chemistry
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Functional group manoeuvring for tuning stability and reactivity: synthesis of cicerfuran, moracins (D, E, M) and chromene-fused benzofuran-based natural products ()
Org. Biomol. Chem., 2017, 15,9415-9423 DOI: 10.1039/C7OB02459B, Paper Maddali L. N. Rao, Venneti N. Murty, Sachchida Nand The protecting group manoeuvring as a strategy was applied in tuning the stability and reactivity of substituted gem-dibromovinylphenols (12a and 22) for the domino synthesis of benzofuran-based natural products. (1-8). The content of this RSS Feed (c) The Royal Society of Chemistry
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NMR-based assignment of isoleucine vs. allo-isoleucine stereochemistry ()
Org. Biomol. Chem., 2017, 15,9372-9378 DOI: 10.1039/C7OB01995E, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Zoe J. Anderson, Christian Hobson, Rebecca Needley, Lijiang Song, Michael S. Perryman, Paul Kerby, David J. Fox A simple 1H and 13C NMR spectrometric analysis is demonstrated that permits differentiation of isoleucine and allo-isoleucine residues by inspection of the chemical shift and coupling constants of the signals associated with the proton and carbon at the [small alpha]-stereocentre. The content of this RSS Feed (c) The Royal Society of Chemistry
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Harnessing the potential of natural products in drug discovery from a cheminformatics vantage point ()
Org. Biomol. Chem., 2017, 15,9275-9282 DOI: 10.1039/C7OB02193C, Review Article Tiago Rodrigues Cheminformatics tools provide a viable means to unravel chemistry and biology in natural product space. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthetic approaches to the C11-C27 fragments of bryostatins ()
Org. Biomol. Chem., 2017, 15,9475-9496 DOI: 10.1039/C7OB02127E, Paper Anthony P. Green, Simon Hardy, Eric J. Thomas Modified Julia reactions and reactions of lithated dithianes have been used to prepare intermediates for a synthesis of bryostatins. The content of this RSS Feed (c) The Royal Society of Chemistry
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Stereochemistry and mechanistic insights in the [2t + 2i + 2i] annulations of thioketenes and imines ()
Org. Biomol. Chem., 2017, 15,9424-9432 DOI: 10.1039/C7OB02212C, Paper Wei He, Junpeng Zhuang, Hongguang Du, Zhanhui Yang, Jiaxi Xu The mechanism and stereochemistry of [2t + 2i + 2i] annulations between one thioketene molecule and two imine molecules have been studied experimentally and theoretically. The content of this RSS Feed (c) The Royal Society of Chemistry
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Total synthesis of 7-des-O-pivaloyl-7-O-benzylbryostatin 10 ()
Org. Biomol. Chem., 2017, 15,9497-9526 DOI: 10.1039/C7OB02129A, Paper Anthony P. Green, Simon Hardy, Alan T. L. Lee, Eric J. Thomas The modified Julia reaction was used to assemble the (E)-16,17-double bond in the first total synthesis of a derivative of a 20-deoxybryostatin, namely 7-des-O-pivaloyl-7-O-benzylbryostatin 10. The content of this RSS Feed (c) The Royal Society of Chemistry
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Structural investigation of cyclo-dioxo maleimide cross-linkers for acid and serum stability ()
Org. Biomol. Chem., 2017, 15,9305-9310 DOI: 10.1039/C7OB01757J, Paper Elisabetta Tobaldi, Igor Dovgan, Michel Mosser, Jean-Michel Becht, Alain Wagner The size of the acetal ring and the length of the carbon chain strongly influence the serum stability of cyclo-dioxo-based amino-to-thiol coupling reagents. The content of this RSS Feed (c) The Royal Society of Chemistry
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A pseudopericyclic [3,5]-sigmatropic rearrangement of a coumarin trichloroacetimidate derivative ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02335A, Communication Trideep Rajale, Shikha Sharma, Daniel K. Unruh, Daniel A. Stroud, David M. Birney A Woodward-Hoffmann forbidden, eight-centered transition state leads to the sole product of a pentadienyl imidate rearrangement. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Copper-catalyzed chalcogenation of imidazoheterocycles with sulfur/selenium powder and coumarinyl triflates ()
Org. Biomol. Chem., 2017, 15,9455-9464 DOI: 10.1039/C7OB02278F, Paper Tao Guo, Xu-Ning Wei, Hong-Yan Wang, Ying-Li Zhu, Yun-Hui Zhao, Yong-Cheng Ma An efficient and convenient copper-catalyzed chalcogenation of imidazoheterocycles with sulfur/selenium powder and coumarinyl triflates has been described. The content of this RSS Feed (c) The Royal Society of Chemistry
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Electrophilic activation of aminocarboxylic acid by phosphate ester promotes Friedel-Crafts acylation by overcoming charge-charge repulsion ()
Org. Biomol. Chem., 2017, 15,9398-9407 DOI: 10.1039/C7OB02158E, Paper Akinari Sumita, Yuko Otani, Tomohiko Ohwada o-Methyl salicylates enhance the reactivity of the phosphate ester via a protonation-induced conformational change to generate acyl phosphate, thereby overwhelming the charge-charge repulsion associated with formation of the acylium ion, enabling aromatic ketones to be generated from various carboxylic acids. The content of this RSS Feed (c) The Royal Society of Chemistry
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Stereoselective annulation between an allene, an alkene, and two nitrosoarenes to access bis(isoxazoliodine) derivatives ()
Org. Biomol. Chem., 2017, 15,9389-9397 DOI: 10.1039/C7OB02087B, Paper Pankaj Sharma, Prakash D. Jadhav, Manisha Skaria, Rai-Shung Liu This work reports metal-free annulations among one allene, two nitrosoarenes and one electron-deficient alkene to afford bis(isoxazolidine) derivatives stereoselectively. The content of this RSS Feed (c) The Royal Society of Chemistry
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Azetidine-derived dinuclear zinc catalyzed asymmetric phospha-Michael addition of dialkyl phosphite to [small alpha],[small beta]-unsaturated carbonyl compounds ()
Org. Biomol. Chem., 2017, 15,9465-9474 DOI: 10.1039/C7OB02222K, Paper Shanshan Liu, Na Shao, Feng-Zhen Li, Xiao-Chao Yang, Min-Can Wang The asymmetric phospha-Michael addition of dialkyl phosphite to [small alpha],[small beta]-unsaturated carbonyl compounds by using an azetidine-derived dinuclear zinc catalyst was described. The content of this RSS Feed (c) The Royal Society of Chemistry
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Photochemical and oxidative cyclisation of tetraphenylpyrroles ()
Org. Biomol. Chem., 2017, 15,9293-9296 DOI: 10.1039/C7OB02537H, Communication Jayne L. Ferguson, Marie A. Squire, Christopher M. Fitchett The cyclisation of tetraphenylpyrroles under complementary conditions allows controlled cyclisation giving products dependent on N-substitution, with both tandem rearrangement and halogenation being observed. The content of this RSS Feed (c) The Royal Society of Chemistry
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Total syntheses of all tri-oxygenated 16-phytoprostane classes via a common precursor constructed by oxidative cyclization and alkyl-alkyl coupling reactions as the key steps ()
Org. Biomol. Chem., 2017, 15,9408-9414 DOI: 10.1039/C7OB02505J, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Jakub Smrcek, Radek Pohl, Ullrich Jahn A parallel total synthesis of 16-F1t-, 16-E1-phytoprostanes and a first synthesis of 16-D1t-phytoprostanes based on a common precursor are described. The content of this RSS Feed (c) The Royal Society of Chemistry
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Chemoselective N-arylation of aminobenzamides via copper catalysed Chan-Evans-Lam reactions ()
Org. Biomol. Chem., 2017, 15,9288-9292 DOI: 10.1039/C7OB02491F, Communication Shuai Liu, Weisai Zu, Jinli Zhang, Liang Xu Chemoselective N-arylation of unprotected aminobenzamides was achieved via Cu-catalysed Chan-Evans-Lam cross-coupling with aryl boronic acids for the first time. The content of this RSS Feed (c) The Royal Society of Chemistry
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Multicomponent, fragment-based synthesis of polyphenol-containing peptidomimetics and their inhibiting activity on beta-amyloid oligomerization ()
Org. Biomol. Chem., 2017, 15,9331-9351 DOI: 10.1039/C7OB02182H, Paper Chiara Lambruschini, Denise Galante, Lisa Moni, Francesco Ferraro, Giulio Gancia, Renata Riva, Alessia Traverso, Luca Banfi, Cristina D'Arrigo A new and short fragment-based approach towards artificial (but "natural-based") complex polyphenols has been developed, exploiting the Ugi multicomponent reaction of phenol-containing simple substrates. The content of this RSS Feed (c) The Royal Society of Chemistry
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The iso-Nazarov reaction ()
Org. Biomol. Chem., 2017, 15,9255-9274 DOI: 10.1039/C7OB02220D, Review Article Martin J. Riveira, Lucia A. Marsili, Mirta P. Mischne The acid-promoted cycloisomerization of conjugated dienals and linearly-conjugated dienones for the synthesis of five-membered ring systems is reviewed. The content of this RSS Feed (c) The Royal Society of Chemistry
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Discovery of novel BET inhibitors by drug repurposing of nitroxoline and its analogues ()
Org. Biomol. Chem., 2017, 15,9352-9361 DOI: 10.1039/C7OB02369C, Paper Hao Jiang, Jing Xing, Chen Wang, Hao Zhang, Liyan Yue, Xiaozhe Wan, Wei Chen, Hong Ding, Yiqian Xie, Hongru Tao, Zhifeng Chen, Hualiang Jiang, Kaixian Chen, Shijie Chen, Mingyue Zheng, Yuanyuan Zhang, Cheng Luo The BET family of bromodomain-containing proteins (BRDs) is believed to be a promising drug target for therapeutic intervention in a number of diseases. The content of this RSS Feed (c) The Royal Society of Chemistry
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A Cu(II)-promoted tandem decarboxylative halogenation and oxidative diamination reaction of 2-aminopyridines with alkynoic acids for the synthesis of 2-haloimidazo[1,2-a]pyridines ()
Org. Biomol. Chem., 2017, 15,9311-9318 DOI: 10.1039/C7OB02014G, Paper Yun Liu, Wenhui Wang, Junwen Han, Jinwei Sun 2-Bromo and 2-chloro imidazo[1,2-a]pyridines with different 3-aryl or alkyl groups were selectively synthesized. The content of this RSS Feed (c) The Royal Society of Chemistry
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Substituent effects on stereoselectivity of dihalocarbene reactions with cyclohexadiene and on the reactivity of bis-dihalocyclopropanes in electrophilic nitrations en route to pyrimidine N-oxides ()
Org. Biomol. Chem., 2017, 15,9433-9441 DOI: 10.1039/C7OB02463K, Paper Kseniya N. Sedenkova, Elena B. Averina, Yuri K. Grishin, Julia V. Kolodyazhnaya, Victor B. Rybakov, Tamara S. Kuznetsova, Audrey Hughes, Gabriel dos Passos Gomes, Igor V. Alabugin, Nikolay S. Zefirov Bis-adducts of cyclohexa-1,4-diene with dihalocarbenes were synthesized and investigated in heterocyclization. The content of this RSS Feed (c) The Royal Society of Chemistry
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Recognition of mixed-sequence DNA using double-stranded probes with interstrand zipper arrangements of O2[prime or minute]-triphenylene- and coronene-functionalized RNA monomers ()
Org. Biomol. Chem., 2017, 15,9362-9371 DOI: 10.1039/C7OB01920C, Paper Saswata Karmakar, Dale C. Guenther, Bradley C. Gibbons, Patrick J. Hrdlicka Energetically activated double-stranded probes with interstrand arrangements of intercalator-functionalized nucleotides enable recognition of mixed-sequence DNA hairpins with excellent binding specificity. The content of this RSS Feed (c) The Royal Society of Chemistry
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Facile access to functionalized indenes and fused quinolines by regioselective 5-enolexo-dig Michael addition and cyclization reactions ()
Org. Biomol. Chem., 2017, 15,9319-9330 DOI: 10.1039/C7OB02498C, Paper Tohasib Yusub Chaudhari, Sandeep K. Ginotra, Vibha Tandon Herein we report a facile approach to synthesise multi-substituted indenes and cyclopenta[b]quinolines under mild conditions. The content of this RSS Feed (c) The Royal Society of Chemistry
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Arginine modification of lycosin-I to improve inhibitory activity against cancer cells ()
Org. Biomol. Chem., 2017, 15,9379-9388 DOI: 10.1039/C7OB02233F, Paper Peng Zhang, Jing Ma, Yujie Yan, Bo Chen, Bobo Liu, Cui Jian, Baode Zhu, Songping Liang, Youlin Zeng, Zhonghua Liu Herein, arginine modification rendered Lycosin-I with higher anticancer activity, penetrability, and dissemination ability against solid tumor cells due to the optimized physicochemical properties and high serum stability. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of carbazole-based BODIPY dimers showing red fluorescence in the solid state ()
Org. Biomol. Chem., 2017, 15,9283-9287 DOI: 10.1039/C7OB02419C, Communication Chihiro Maeda, Takumi Todaka, Tomomi Ueda, Tadashi Ema Carbazole-based BODIPY dimers 2a-g were synthesized via direct arylation. The content of this RSS Feed (c) The Royal Society of Chemistry
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In silico analyses of essential interactions of iminosugars with the Hex A active site and evaluation of their pharmacological chaperone effects for Tay-Sachs disease ()
Org. Biomol. Chem., 2017, 15,9297-9304 DOI: 10.1039/C7OB02281F, Paper Atsushi Kato, Izumi Nakagome, Shinpei Nakagawa, Kyoko Kinami, Isao Adachi, Sarah F. Jenkinson, Jerome Desire, Yves Bleriot, Robert J. Nash, George W. J. Fleet, Shuichi Hirono DMDP amide restored Hex A activity in the G269S Tay-Sachs patient cells up to 43% of the wild type. The content of this RSS Feed (c) The Royal Society of Chemistry
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Selective C-H Bond Electro-oxidation of Benzylic Acetates and Alcohols to Benzaldehydes ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02300F, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Mateus R Barone, Alan Morenc Jones A chemical oxidant-free and mediator-free, direct electro-oxidation of both benzylic alcohols and benzylic esters are reported. The scope of the reaction is explored as a function of both steric and... The content of this RSS Feed (c) The Royal Society of Chemistry
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Structure-reactivity correlations of the abnormal Beckmann reaction of dihydrolevoglucosenone oxime ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02499A, Paper Amani Alhifthi, Benjamin L Harris, Lars Goerigk, Jonathan White, Spencer J Williams A structural, spectroscopic and computational study of a series of oximes was undertaken to investigate how geometric and structural changes relevant to the reaction coordinate for the Beckmann reaction (normal... The content of this RSS Feed (c) The Royal Society of Chemistry
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Na2S mediated synthesis of terminal alkynes from gem-dibromoalkenes ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02431B, Communication Radhey M Singh, Durgesh Nandini, Kishor Chandra Bharadwaj, Tanu Gupta, Raj Pal Singh Na2S-mediated facile synthesis of terminal alkynes from gem- dibromoalkenes, at 20/40 ¬[degree]C under open flask conditions has been developed. Various precursors derived from heteroaromatic/aromatic/aliphatic aldehydes were found compatible. The reaction... The content of this RSS Feed (c) The Royal Society of Chemistry
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Improved Synthesis of Symmetrically & Asymmetrically N-Substituted Pyridinophane Derivatives ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02508D, Paper Andrew J. Wessel, Jason W. Schultz, Fenghzi Tang, Hui Duan, Liviu M. Mirica The N,N'-di(toluenesulfonyl)-2,11-diaza[3,3](2,6)pyridinophane (TsN4) precursor was sought after as a starting point for the preparation of various symmetric and asymmetric pyridinophane-derived ligands. Various procedures to synthesize TsN4 had been published, but... The content of this RSS Feed (c) The Royal Society of Chemistry
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Elemental sulfur mediated 2-substituted benzothiazole formation from 2-aminobenzenethiols and arylacetylenes or styrenes under metal-free condition ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02430D, Paper Guo-Jun Deng, Guozheng Li, Jingjing Jiang, Feng Zhang, Fuhong Xiao An oxidative cyclization of 2-aminothiophenols and arylacetylenes or styrenes for the synthesis of 2-alkyl benzothiazoles and 2-acylbenzothiazoles has been developed. Elemental sulfur was used as the effective oxidant to give... The content of this RSS Feed (c) The Royal Society of Chemistry
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Specifically targeting mixed-type dimeric G-quadruplexes by berberine dimers ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02326J, Paper Zi-Qi Li, Ting-Cong Liao, Cheng Dong, Jian-Wei Yang, Xiao-Jie Chen, Li-Hong Liu, Yuan Luo, Yuan-Yuan Liang, Wen-Hua Chen, Chun-qiong Zhou Three polyether-tethered berberine dimers (1a-c) have been studied on their binding affinity, selectivity and thermal stabilization towards human telomeric dimeric quadruplex DNA (G2T1). Compound 1a with the shortest polyether linker... The content of this RSS Feed (c) The Royal Society of Chemistry
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Controlling miRNA-like Off-target Effects of an siRNA with Nucleobase Modifications ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02654D, Paper Scott Ryan Suter, Alexi A Ball-Jones, Madeline M. Mumbleau, Rachel Valenzuela, Jose M. Ibarra-Soza, Hassan Owens, Andrew Fisher, Peter A Beal SiRNAs can cause unintended gene silencing due to miRNA-like effects because of the similarity in function of an siRNA guide strand and a miRNA. Here we evaluate the effect on... The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of 2,2-bis(pyridin-2-yl amino)cyclobutanols and their conversion into 5-(pyridin-2-ylamino)dihydrofuran-2(3H)-ones ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02567J, Communication Lorenza Ghisu, Nicola Melis, Francesco Secci, Pierluigi Caboni, Massimiliano Arca, Regis Guillot, Thomas Boddaert, David J. Aitken, Angelo Frongia 2,2-Bis(pyridin-2-ylamino)cyclobutanols are prepared easily from 2-hydroxycyclobutanone and are transformed into 5-(pyridin-2-ylamino)dihydrofuran-2(3H)-ones via a periodinane-mediated ring expansion. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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25 years and still going strong: 2[prime or minute]-O-(pyren-1-yl)methylribonucleotides - versatile building blocks for applications in molecular biology, diagnostics and materials science ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02152F, Review Article Patrick J. Hrdlicka, Saswata Karmakar This review highlights the synthesis, biophysical properties, and wide range of applications of oligonucleotides modified with 2[prime or minute]-O-(pyren-1-yl)methyl-RNA monomers reported over the past 25 years. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Differentiation of enantiomeric anions by NMR spectroscopy with chiral bisurea receptors ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02318A, Paper Suguru Ito, Manami Okuno, Masatoshi Asami Enantiomeric 1H NMR signals of chiral anions are separated by forming 1 : 1 and 1 : 2 host-guest complexes with chiral bisurea. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Metal-free oxidative para-acylation of unprotected anilines with N-heteroarylmethanes ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02490H, Paper Min Liu, Xue Chen, Tieqiao Chen, Qing Xu, Shuang-Feng Yin A selective oxidative para-acylation of unprotected anilines with methyl groups in N-heteroarylmethanes was achieved. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Thermally induced N-S bond insertion reaction of diazo compounds with N-sulfenylsuccinimides: synthresis of sulfides and mechanism studies ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02488F, Paper Xinfang Xu, Xiaolu Zhang, Yang Zheng, Lihua Qiu A metal-free gem-functionalization reaction of diazo compounds with N-sulfenylsuccinimides via a formal N-S bond insert process has been reported. The transformation features mild reaction conditions, broad substrate scope and functional... The content of this RSS Feed (c) The Royal Society of Chemistry
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Withapubesides A-D, natural inducible nitric oxide synthase (iNOS) inhibitors from Physalis pubescens ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02551C, Paper Guiyang Xia, Tie Yao, Bing-Yang Zhang, Yang Li, Ning Kang, Shijie Cao, Liqin Ding, Lixia Chen, Feng Qiu Four new steroid glycosides, withapubesides A-D (1-4) were isolated from the stems of Physalis pubescens L. Their structures were elucidated primarily by NMR experiments. The absolute configurations of 1 and... The content of this RSS Feed (c) The Royal Society of Chemistry
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Copper-catalyzed high selectively synthesis of 2-benzyl- and 2-benzylidene-substituted benzo[b]thiazinones from 2-iodophenyl cinnamamides and potassium sulfide ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02585H, Communication Wenjuan Liu, Hao Min, Xiaoming Zhu, Guobo Deng, Yun Liang An efficient and practical procedure for the synthesis of 2-benzyl- and 2-benzylidene-substituted benzo[b]thiazinones from easily available 2-iodophenylcinnamamides and potassium sulfide has been developed. In the presence of DBU, the reaction... The content of this RSS Feed (c) The Royal Society of Chemistry
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Highly regioselective gold-catalyzed formal hydration of propargylic gem-difluorides ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02406A, Paper Jean-Denys Hamel, Tatsuru Hayashi, Melissa Cloutier, Paul R. Savoie, Olivier Thibeault, Meggan Beaudoin, Jean-Francois Paquin A highly regioselective gold-catalyzed formal hydration of propargylic gem-difluorides is presented. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Manipulating the stereoselectivity of the thermostable Baeyer-Villiger monooxygenase TmCHMO by directed evolution ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02692G, Paper Guangyue Li, Maximilian J. L. J. Furst, Hamid Reza Mansouri, Anna K. Ressmann, Adriana Ilie, Florian Rudroff, Marko D. Mihovilovic, Marco W. Fraaije, Manfred T. Reetz The thermostable Baeyer-Villiger monooxygenase TmCHMO and evolved mutants are viable catalysts in stereoselective reactions of structurally different ketones. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Boronic acid recognition of non-interacting carbohydrates for biomedical applications: increasing fluorescence signals of minimally interacting aldoses and sucralose ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01893B, Paper Angel Resendez, Md Abdul Halim, Jasmeet Singh, Dominic-Luc Webb, Bakthan Singaram To address carbohydrates that are commonly used in biomedical applications with low binding affinities for boronic acid based detection systems, two chemical modification methods were utilized to increase sensitivity. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Switch-on Fluorescent/FRET Probes to Study Human Histidine Triad Nucleotide Binding Protein 1 (hHint1), a Novel Target for Opioid Tolerance and Neuropathic Pain ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02472J, Paper Rachit Shah, Andrew Zhou, Carston R. Wagner Histidine Triad Nucleotide Binding Protein 1 (Hint1) has emerged to be an important post-synaptic protein associated with a variety of central nervous system disorders such as pain, addiction, and schizophrenia.... The content of this RSS Feed (c) The Royal Society of Chemistry
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Taking Advantage of Co(II) Induced Enhanced VCD for the Fast and Sensitive Determination of Enantiomeric Excess ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02380D, Communication Lorenzo Arrico, Gaetano Angelici, Lorenzo Di Bari Co(II) induces large VCD signal enhancement, which overcomes the low sensitivity of VCD and opens new perspectives in quantitative VCD. We used a stereodynamic system, where the analyte determines the... The content of this RSS Feed (c) The Royal Society of Chemistry
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Copper-catalyzed ipso-selenation of aromatic carboxylic acids ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02066J, Paper Jing Wang, Hongchen Li, Tao Leng, Miaochang Liu, Jinchang Ding, Xiaobo Huang, Huayue Wu, Wenxia Gao, Ge Wu Study of the synthesis of diaryl and methyl aryl selenides in good to excellent yields, including mechanistic studies and demonstration of the utility of the products in the facile synthesis of 10H-phenoselenazine and 11-methyldibenzo-(b,f)-1,4-selenazepine. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Efficient Cross-Coupling of Aryl/Alkenyl Triflates with Acyclic Secondary Alkylboronic Acids ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02531A, Paper Tengda Si, Bowen Li, Wenrui Xiong, Bin Xu, Wenjun Tang Aryl-secondary alkyl cross-coupling with aryl sulfonate esters as coupling partners remains a significant challenge. Efficient cross-coupling between aryl/alkenyl triflates and acyclic secondary alkylboronic acids is realized for the first time... The content of this RSS Feed (c) The Royal Society of Chemistry
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Cu-Catalyzed asymmetric Friedel-Crafts propargylic alkylation of phenol derivatives ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02133J, Paper Long Shao, Xiang-Ping Hu A copper-catalyzed asymmetric Friedel-Crafts propargylic alkylation of electron-rich phenol derivatives with a variety of propargylic esters has been described. With Cu(OTf)2 decorated with a chiral tridentate ketimine P,N,N-ligand as the catalyst, the reaction proceeded smoothly in high yields and with good to excellent enantioselectivities (up to 95% ee). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Acid-Catalyzed Reaction of 2-Hydroxycyclobutanone with Benzylic Alcohols ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02545A, Paper Francesco Secci, Regis Guillot, David J Aitken, Angelo Frongia, Massimiliano Arca, Giorgia Sarais, Alberto Luridiana, Alberto Martis The acid-promoted syntheses of 2-(benzyloxy)cyclobutanones and bis(benzyloxy)dioxatricyclo decanes were achieved starting from 2-hydroxycyclobutanone and variously functionalized benzyl alcohols. The reaction sequences afforded the desired products in good to high yields... The content of this RSS Feed (c) The Royal Society of Chemistry
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[small alpha]-Trifluoromethylated tertiary homoallylic amines: diastereoselective synthesis and conversion into [small beta]-aminoesters, [gamma]- and [small delta]-aminoalcohols, azetidines and pyrrolidines ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02506H, Paper Fabienne Grellepois, Abdelkhalek Ben Jamaa, Nathalie Saraiva Rosa The diastereoselective synthesis and the functionalization of homoallylic tertiary carbinamines containing a tetrasubstituted carbon stereocentre bearing a trifluoromethyl group are described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Short synthesis of polyfunctional sp3-rich threonine-derived morpholine scaffolds ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02454A, Paper Elena Lenci, Alessio Rossi, Gloria Menchi, Andrea Trabocchi A convenient synthesis of sp3-rich complex morpholines was achieved in two steps involving a Petasis three-component coupling reaction followed by an acid- or base-mediated cyclization. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Regioselective phosphinylation of coumarins under green LED irradiation and its mechanism ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02478A, Communication Qingrui Li, Xiuli Zhao, Yabo Li, Mengmeng Huang, Jung Keun Kim, Yangjie Wu A regioselective and efficient approach to 3-phosphinylated coumarins was developed via the active P-centered radical generated by energy transfer and electron transfer processes under green LED irradiation. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Palladium-catalyzed tandem reaction of 2-chloroquinoline-3-carbaldehydes and isocyanides ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02043K, Paper Morteza Shiri, Maryam Ranjbar, Zahra Yasaei, Fatemeh Zamanian, Behrouz Notash A facile and domino reaction of 2-chloroquinoline-3-carbaldehydes in one and two equivalents of isocyanide has been investigated. Three-component reactions of 2-chloroquinoline-3-carbaldehydes, isocyanides and amines are also described. In this Pd-catalyzed... The content of this RSS Feed (c) The Royal Society of Chemistry
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Peramivir analogues bearing hydrophilic side chains exhibit higher activities against H275Y mutant than wild-type influenza virus ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02374J, Paper Din-Chi Chiu, Tzu-Chen Lin, Wen-I Huang, Ting-Jen R. Cheng, Keng-Chang Tsai, Jim-Min Fang Peramivir is an effective anti-influenza drug in clinical treatment of influenza, but its efficacy toward the H275Y mutant is reduced. The previously reported cocrystal structures of inhibitors in the mutant... The content of this RSS Feed (c) The Royal Society of Chemistry
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Correction: Formation of [small beta]-(1,3-1,6)-D-glucan-complexed [70]fullerene and its photodynamic activity towards macrophages ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB90179H, Correction Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Atsushi Ikeda, Motofusa Akiyama, Kouta Sugikawa, Kazuya Koumoto, Yuta Kagoshima, Jiawei Li, Toshio Suzuki, Takeshi Nagasaki To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A Modular Approach Towards Functionalized Highly Stable Self-complementary Quadruple Hydrogen Bonded Systems ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02358H, Paper Suresh Rayavarapu, Sanjeev Kheria, Dinesh R Shinde, Rajesh G. Gonnade, G. J. Sanjayan Self-complementary quadruple hydrogen bonded systems have shown potential as key building blocks for developing various supramolecular polymers. Opportunities for introduction of multiple functionalities would further augment, in principle, their application... The content of this RSS Feed (c) The Royal Society of Chemistry
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Pd-Catalyzed Regioselective Intramolecular Dehydrogenative C-5 Cross Coupling in an N-substituted Pyrrole-Azole System ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02676E, Paper Ravi Prakash Singh, Krishna Nand Tripathi, Devalina Ray Functionalized polycyclic pyrrole-azole structures possessing fused six membered and seven membered rings were directly synthesized via ligand-enabled Pd-catalyzed site selective intramolecular cross coupling of N-substituted pyrrole-azole. The C5-H activation in... The content of this RSS Feed (c) The Royal Society of Chemistry
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Cooperative bimetallic catalysis in asymmetric allylic substitution ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02476B, Review Article Jingke Fu, Xiaohong Huo, Bowen Li, Wanbin Zhang Strategies using a chiral metal catalyst and the cooperative effect of a second achiral or chiral metal catalyst for asymmetric allylic substitution reactions are discussed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Water-soluble and UV traceable isatoic anhydride-based reagents for bioconjugation ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02377D, Communication Adam Fessler, Corey Garmon, Thomas Heavey, Anthony Fowler, Craig Ogle A new "clickable" bioconjugation platform based on isatoic anhydride. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A photoredox-neutral Smiles rearrangement of 2-aryloxybenzoic acids ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02579C, Paper Jose. C. Gonzalez-Gomez, Nieves P. Ramirez, Teresa Lana-Villarreal, Pedro Bonete The radical Smiles rearrangement of 2-aryloxybenzoic acids can be promoted by visible light at room temperature, in the presence of air and water, and free of noble metals. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Control of porphyrin interactions via structural changes of a peptoid scaffold ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02398G, Paper Woojin Yang, Boyeong Kang, Vincent A. Voelz, Jiwon Seo A template to control porphyrin interactions is constructed by displaying porphyrins at defined positions on a helical peptoid. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A study of the reactivity of S(VI)-F containing warheads with nucleophilic amino-acid side chains under physiological conditions ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02028G, Paper H. Mukherjee, J. Debreczeni, J. Breed, S. Tentarelli, B. Aquila, J. E. Dowling, A. Whitty, N. P. Grimster Profiling the reactivity and stability of SVI-F warheads towards nucleophilic amino acids for the development of biochemical probe compounds. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis, Computational, and Spectroscopic Analysis of Tunable Highly Fluorescent BN-1,2-Azaborine Derivatives Containing the N-BOH Moiety ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02415K, Paper Carl Jacky Saint-Louis, Renee N. Shavnore, Caleb D. C. McClinton, Julie A. Wilson, Lacey L. Magill, Breanna M. Brown, Robert W Lamb, Charles Edwin Webster, Alan K Schrock, Michael T Huggins Nine new polycyclic aromatic BN-1,2-azaborine analogues containing the N-BOH moiety were synthesized using a convenient two-step, one-pot procedure. Characterization of the prepared compounds show the luminescence wavelength and the quantum... The content of this RSS Feed (c) The Royal Society of Chemistry
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The diaza-Nazarov cyclization involving a 2,3-diaza-pentadienyl cation for the synthesis of polysubstituted pyrazoles ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01949A, Paper Balakrishna Aegurla, Rama Krishna Peddinti Functionally-rich pyrazoles in a cascade reaction from in situ generated hydrazones and acetophenones under aerobic conditions were synthesized through novel enamine-imino diaza-Nazarov 4[small pi]-electrocyclization which is supported by DFT calculations. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Cell-permeable bicyclic peptidyl inhibitors against T-cell protein tyrosine phosphatase from a combinatorial library ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02562A, Communication Hui Liao, Dehua Pei Cell-permeable, biologically active bicyclic peptidyl inhibitors against T-cell protein-tyrosine phosphatase were directly isolated from a combinatorial library. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Regioselective synthesis of 2,3[prime or minute]-biindoles mediated by an NBS-induced homo-coupling of indoles ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02312J, Paper Panpan Huang, Xiangjun Peng, Dan Hu, Huiwu Liao, Shaobin Tang, Liangxian Liu An efficient method for the synthesis of 2,3[prime or minute]-biindole and [3,2-a]carbazole derivatives via an NBS-induced homo-coupling of indoles with high regioselectivity. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Efficient dehydrative alkylation of thiols with alcohols catalyzed by alkyl halides ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02461D, Paper Yaqi Yang, Zihang Ye, Xu Zhang, Yipeng Zhou, Xiantao Ma, Hongen Cao, Huan Li, Lei Yu, Qing Xu Alcohols can be efficiently converted into thioethers by a transition metal- and base-free alkyl halide-catalyzed S-alkylation reaction with thiols or disulfides. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A general method of Suzuki-Miyaura cross-coupling of 4- and 5-halo-1,2,3-triazoles in water ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02091K, Communication Pavel S. Gribanov, Gleb A. Chesnokov, Maxim A. Topchiy, Andrey F. Asachenko, Mikhail S. Nechaev A general method of the synthesis of 1,4,5-trisubstituted-1,2,3-triazoles by Suzuki-Miyaura cross-coupling from 4- and 5-halo-1,2,3-triazoles. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Regioselective three-component synthesis of 2,3-disubstituted quinolines via the enaminone modified Povarov reaction ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02411H, Communication Yi Li, Xiaoji Cao, Yunyun Liu, Jie-Ping Wan The enaminone modified three-component Povarov reactions enable the regioselective synthesis of 2,3-disubstituted quinolines. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Dendrimeric amide- and carbamate-linked lysine-based efficient molecular transporters ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02552A, Communication Amit Kumar Yadav, Namit Dey, Sabyasachi Chattopadhyay, Munia Ganguli, Moneesha Fernandes Carbamate- and amide-linked lysine-based generation-2 dendrimeric oligomers transport pDNA into cells very efficiently when complexed by incubation overnight. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of a library of variously modified 4-methylumbelliferyl xylosides and a structure-activity study of human [small beta]4GalT7 ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02530K, Paper Samir Dahbi, Jean-Claude Jacquinet, Isabelle Bertin-Jung, Anne Robert, Nick Ramalanjaona, Sandrine Gulberti, Sylvie Fournel-Gigleux, Chrystel Lopin-Bon Various modified xylosides were prepared and tested as substrates/inhibitors of human [small beta]4GalT7, a key enzyme involved in the biosynthesis of proteoglycans. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Visible-light-promoted selective C-H amination of heteroarenes with heteroaromatic amines under metal-free conditions ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02504A, Communication Supravat Samanta, Chitrakar Ravi, Sadu Nageswara Rao, Abhisek Joshi, Subbarayappa Adimurthy The regioselective C-H amination of quinoline amides (C5) and imidazopyridines (C3) under transition-metal-free conditions at room temperature with a high degree of functional group tolerance is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Construction of tetrahydropyranoquinoline derivatives via an asymmetric organocatalytic aza-Michael-IED/HAD cascade reaction ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB02231J, Paper Lu Dai, Yuxuan Hou, Lvye Zhang, Zhangtao Chen, Xiaofei Zeng, Guofu Zhong A highly efficient organocatalytic asymmetric aza-Michael-IED/HAD cascade reaction of (E)-ethyl 4-(2-(4-methylphenylsulfonamido)phenyl)-2-oxobut-3-enoate and enals is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Recent advances in fluoride-free aryne generation from arene precursors ()
Org. Biomol. Chem., 2017, 15,9044-9056 DOI: 10.1039/C7OB01947E, Review Article Fahima I. M. Idiris, Christopher R. Jones Aryne chemistry has flourished in the past few decades. This review highlights new aryne precursors that operate under fluoride-free conditions as alternative methodologies to the popular fluoride-mediated ortho-silylaryl triflates. The content of this RSS Feed (c) The Royal Society of Chemistry
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Experimental and mechanistic insights into copper(II)-dioxygen catalyzed oxidative N-dealkylation of N-(2-pyridylmethyl)phenylamine and its derivatives ()
Org. Biomol. Chem., 2017, 15,9164-9168 DOI: 10.1039/C7OB02192E, Paper Yang Wang, Haixiong Liu, Xiaofeng Zhang, Zilong Zhang, Deguang Huang An efficient Cu(II)/O2 catalytic system was experimentally explored for the N-dealkylation of PyCH2NHPh and its derivatives via C-H bond activation. The content of this RSS Feed (c) The Royal Society of Chemistry
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A low-temperature, photoinduced thiol-ene click reaction: a mild and efficient method for the synthesis of sugar-modified nucleosides ()
Org. Biomol. Chem., 2017, 15,9226-9233 DOI: 10.1039/C7OB02184D, Paper Miklos Bege, Ilona Bereczki, Mihaly Herczeg, Mate Kicsak, Daniel Eszenyi, Pal Herczegh, Aniko Borbas While studying the radical mediated hydrothiolation of nucleoside enofuranosides, an unusual temperature effect was observed by the exploitation of which various thio-substituted nucleoside analogues were produced. The content of this RSS Feed (c) The Royal Society of Chemistry
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Cycloadduct formation of [small alpha],[small beta]-unsaturated esters with azides catalyzed by NHC systems ()
Org. Biomol. Chem., 2017, 15,9066-9070 DOI: 10.1039/C7OB02469J, Communication Huijun Yuan, Hua Gao, Kun Liu, Zhantao Liu, Jian Wang, Wenjun Li NHC-catalyzed cycloadduct formation of [small alpha],[small beta]-unsaturated esters with azides has been developed. This strategy could generate 1,2,3-triazoles and dihydropyrazoles with high yields and regioselectivities. The broad substrate scope and mechanistic survey of this process are also presented. The content of this RSS Feed (c) The Royal Society of Chemistry
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Formation of N-sulfonyl imines from iminoiodinanes by iodine-promoted, N-centered radical sulfonamidation of aldehydes ()
Org. Biomol. Chem., 2017, 15,9209-9216 DOI: 10.1039/C7OB02120H, Paper Megan D. Hopkins, Kristina A. Scott, Brettany C. DeMier, Heather R. Morgan, Jesse A. Macgruder, Angus A. Lamar A light-promoted, non-traditional carbonyl activation via a N-centered radical (NCR) species to produce activated imines using iminoiodinanes is reported. The content of this RSS Feed (c) The Royal Society of Chemistry
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