Organic & Biomolecular Chemistry

Cationic Polycyclization of Ynamides: Building up Molecular Complexity ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00850C, Paper Cedric Theunissen, Benoit Metayer, Morgan Lecomte, Nicolas Henry, Hwai-Chien Chan, Guillaume Compain, Phideline Gerard, Christian Bachmann, Naima Mokhtari, Jerome Marrot, Agnes Martin Mingot, Sebastien Thibaudeau, Gwilherm Evano Polycylization reactions are among the most efficient synthetic tools for the synthesis of complex, polycyclic molecules in a single operation from simple starting materials. We report in this manuscript a... The content of this RSS Feed (c) The Royal Society of Chemistry
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o,o-Difluorination of aromatic azide yields fast-response fluorescent probe for H2S detection and for improved bioorthogonal reactions ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00830A, Paper Long Yi, Jie Zhang, Zhengtao Zhu, Zhiqian Wang, Zhen Xi, Yasi Gao, Xueying Kang Development of efficient bioorthogonal reactions for sensing of endogenous biomolecules and for bioconjugation should be paramount importance in the field of chemical biology. In this work, the o,o'-difluorinated aromatic azide... The content of this RSS Feed (c) The Royal Society of Chemistry
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2,2,2-Trifluoroethanol as a Tool to Control Nucleophilic Peptide Arylation ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00295E, Communication Diana Gimenez, Anica Dose, Nicholas L Robson, Graham Sandford, Steven L Cobb, Christopher Robert Coxon The SNAr arylation of peptides with perfluoroaromatics provides a route by which to install a useful chemical handle that enables both 19F-NMR analysis and further chemical modification. However, chemo-selective arylation... The content of this RSS Feed (c) The Royal Society of Chemistry
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The Application of Perfluoroheteroaromatic Reagents in the Preparation of Modified Peptide Systems ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00283A, Paper Diana Gimenez, Caitlin A Mooney, Anica Dose, Graham Sandford, Christopher Robert Coxon, Steven L Cobb The perfluoroheteroaromatic reagent pentafluoropyridine has proved to be a highly reactive electrophile, undergoing SNAr arylation reactions in the presence of a range of nucleophilic peptide side chains (i.e. cysteine, tyrosine,... The content of this RSS Feed (c) The Royal Society of Chemistry
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An active catalytic system for Suzuki-Miyaura cross-coupling reactions using low levels of palladium loading ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00178A, Paper Meng-Qi Yan, Jia Yuan, Fang Lan, Si-Hao Zeng, Meng-Yue Gao, Sheng-Hua Liu, Jian Chen, Guang-Ao Yu An easily available catalytic system was developed, which shows high catalytic activity in the Suzuki-Miyaura cross-coupling reactions of a diverse array of aryl and heteroaryl chlorides with Pd loadings down to 0.01 mol%. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Giant vesicles from rehydrated crude mixtures containing unexpected mixtures of amphiphiles formed under plausibly prebiotic conditions ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00708F, Paper Michele Fiore, Warren Madanamoothoo, Alexandra Berlioz-barbier, Ofelia Maniti, Agnes Girard-Egrot, Rene Buchet, Peter Strazewski Giant lipid vesicles resemble compartments of biological cells, mimicking them in their dimension, membrane structure and partly in their membrane composition. The spontanenous appearance of closed membranes composed of bilayers... The content of this RSS Feed (c) The Royal Society of Chemistry
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Site-selective anion recognition of an interlocked dimer ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00328E, Paper Ryo Sekiya, Morihiko Fukuda, Reiko Kuroda Interlocked dimer 2, which is composed of two physically interlocked monomers 1, has three cavities (cavity A [times] 2 and cavity B [times] 1) and can encapsulate three anions, such... The content of this RSS Feed (c) The Royal Society of Chemistry
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Development of 19F-NMR chemical shift detection of DNA B-Z equilibrium using 19F-NMR ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00706J, Communication Shigetaka Nakamura, Hui Yang, Chihiro Hirata, Florian Kersaudy, Kenzo Fujimoto The various DNA conformational changes are correlation with biological event. In particular, DNA B-Z equilibrium was a high correlation with translation and transcription. In this study, we developed DNA probe... The content of this RSS Feed (c) The Royal Society of Chemistry
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Correction: Metal- and additive-free oxygen-atom transfer reaction: an efficient and chemoselective oxidation of sulfides to sulfoxides with cyclic diacyl peroxides ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB90060K, Correction Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Shaoyan Gan, Junjie Yin, Yuan Yao, Yang Liu, Denghu Chang, Dan Zhu, Lei Shi To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Visible-Light-Induced and Iron-Catalyzed Methylation of N-arylacrylamides with Dimethyl Sulphoxide:A Convenient Access to 3-Ethyl-3-Methyl Oxindoles ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00779E, Paper zuguang Xie, Pinhua Li, Yu Hu, Ning Xu, Lei Wang A visible-light-induced and iron-catalyzed methylation of arylacrylamides by dimethyl sulfoxide (DMSO) is achieved, leading to 3-ethyl-3-methyl indolin-2-ones in high yields. This reaction tolerates a series of functional groups, such as... The content of this RSS Feed (c) The Royal Society of Chemistry
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Probing the pharmacokinetics of cucurbit[7, 8 and 10]uril: and a dinuclear ruthenium antimicrobial complex encapsulated in cucurbit[10]uril ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00724H, Paper Fangfei Li, Anil Kumar Gorle, Marie Ranson, Kara L Vine, Robert Kinobe, Marshall Feterl, Jeffrey Warner, Frank Richard Keene, John Grant Collins, Anthony Day The relatively non-toxic family of cucurbit[n]uril, Q[n], have shown considerable potential in vitro as drug delivery agents, with only a few examples of pharmacokinetic (PK) studies for drug[subset or is implied by]Q[n]. Drug-free Q[n]... The content of this RSS Feed (c) The Royal Society of Chemistry
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A self-assembled fluorescent organic nanoprobe and its application for detection of sulfite in food samples and living system ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00580F, Paper Tang Gao, Xiaozheng Cao, Peng Ge, Jie Dong, Shuqi Yang, Huan Xu, Yong Wu, Feng Gao, Wenbin Zeng Sulfur dioxide (SO2) is a widely distributed air pollutant, and human exposure and inhalation of SO2 is easily transformed into sulfite thus to induce respiratory responses and diseases. Hence, to... The content of this RSS Feed (c) The Royal Society of Chemistry
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N-Heterocyclic carbene-catalyzed stereoselective construction of olefinic carbon-sulfur bonds via cross-coupling reaction of gem-difluoroalkenes and thiols ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00599G, Communication Zi-Song Cong, Yang-Guo Li, Lei Chen, Fen Xing, Guang-Fen Du, Cheng-Zhi Gu, Lin He A novel organocatalytic olefinic carbon-sulfur bond forming reaction was developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of 2-amino- and 2-arylazoazulenes via nucleophilic aromatic substitution of 2-chloroazulenes with amines and arylhydrazines ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00691H, Paper Taku Shoji, Shuhei Sugiyama, Takanori Araki, Akira Ohta, Ryuta Sekiguchi, Shunji Ito, Shigeki Mori, Tetsuo Okujima, Masafumi Yasunami The SNAr reaction of 2-chloroazulene derivative 1 with ethoxycarbonyl groups at the 1,3-positions of the azulene ring with several amines afforded the corresponding 2-aminoazulenes 3-9 in excellent yields. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Selective construction of quaternary stereocentres in radical cyclisation cascades triggered by electron-transfer reduction of amide-type carbonyls ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00739F, Paper Huan-Ming Huang, Pablo Bonilla, David J. Procter Radical cyclisation cascades triggered by electron-transfer to amide-type carbonyls using SmI2-H2O-LiBr, result in the selective construction of quaternary carbon stereocentres. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Circularly polarised luminescence of pyrenyl di- and tri-peptides with mixed D- and L-amino acid residues ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00503B, Paper Yuki Mimura, Tomoki Nishikawa, Ryo Fuchino, Shiho Nakai, Nobuo Tajima, Mizuki Kitamatsu, Michiya Fujiki, Yoshitane Imai Multiple pyrenes as pendants of enantioimpure di-/tripeptides showed pyrene-origin CPL and CD signals, which were associated with conflicting CPL-/CD-signs. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Multicomponent reaction through cooperative trio catalysis incorporating enamine, Bronsted acid and metal Lewis acid catalysis: a concise route to access chromans ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00753A, Communication Chamini V. Karunaratne, Ryan G. Sarkisian, Jennifer Reeves, Yongming Deng, Kraig A. Wheeler, Hong Wang Chroman formation is achieved through a tricatalytic system incorporating enamine, metal Lewis acid and Bronsted acid catalysis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Regioselective 1,2-additon of allenamides with N-haloimides: synthesis of 2-halo allylic aminal derivatives ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00882A, Paper Honghe Li, Xiao-Xiao Li, Zhi-Gang Zhao, Xiao Yuan, Chenyang Sun A strategy for the synthesis of 2-halo allylic aminal derivatives through regioselective 1,2-addition of allenamides with N-haloimides is presented. This reaction was conducted under very mild conditions and gave up... The content of this RSS Feed (c) The Royal Society of Chemistry
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The Dearomative Annulation between N-2-Pyridylamidine and CO2 toward Pyrido[1,2-a]-1,3,5-triazin-4-ones ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00777A, Communication Minfang Xia, Weiming Hu, Song Sun, Jin-Tao Yu, Jiang Cheng A base-promoted dearomative annulation between N-2-pyridylamidine and an atmospheric pressure of CO2 was developed, affording a series of pyrido[1,2-a]-1,3,5-triazin-4-ones in moderate to excellent yields. CO2 served as a carbonyl source,... The content of this RSS Feed (c) The Royal Society of Chemistry
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Metal Ion-induced Supramolecular pKa Tuning and Fluorescence Regeneration of p-Sulfonatocalixarene Encapsulated Neutral Red Dye ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00506G, Paper Meenakshi N Shinde, Raman Khurana, Nilotpal Barooah, Achikanath C Bhasikuttan, Jyotirmayee Mohanty The host-guest interactions and the consequent modulation in the prototropic equilibrium of a phenazine dye, neutral red, with p-sulfonatocalix[4]arene (SCX4) and p-sulfonatocalix[6]arene (SCX6) macrocyclic hosts have been investigated. Both the... The content of this RSS Feed (c) The Royal Society of Chemistry
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Alcohol-mediated direct dithioacetalization of alkynes with 2-chloro-1,3-dithiane for the synthesis of Markovnikov dithianes ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00795G, Communication Teng Liu, Lixia Tian, Junshan Lai, Deng Min, Mengnan Qu, Shouchu Tang An alcohol-mediated dithioacetalization process that direct gain access to the corresponding Markovnikov-selective 1,3-dithianes using unactivated alkynes and nonthiolic/odorless 2-chloro-1,3-dithiane in a highly efficient manner has been developed. This methodology has... The content of this RSS Feed (c) The Royal Society of Chemistry
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Asymmetric Synthesis of ent-Fragransin C1 ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00749C, Paper Santikorn Chaimanee, Manat Pohmakotr, Chutima Kuhakarn, Vichai Reutrakul, Darunee Soorukram The first asymmetric synthesis of ent-fragransin C1 was reported. The key step involves an intramolecular C-O bond formation (furan ring formation) via chemoselective generation of the benzylic carbocation leading to... The content of this RSS Feed (c) The Royal Society of Chemistry
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Use of AlCl3 in Friedel Crafts arylation type reactions and beyond: An overview on the development of unique methodologies leading to N-heteroarenes ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00468K, Review Article Rajnikanth Sunke, Suresh Babu Nallapati, Jetta Sandeep Kumar, Shiva Kumar Kota, Manojit Pal As a privileged class of heterocyclic compounds N-heteroarenes have found enormous applications in many areas including medicinal / pharmaceutical chemistry and drug discovery. Consequently, a wide variety of methods have... The content of this RSS Feed (c) The Royal Society of Chemistry
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Catalyst-free synthesis of novel dimeric [small beta]-carboline derivatives via an unexpected [2 + 2 + 2] annulation ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00689F, Communication Hai-Lei Cui, Jing-Fang Wang, Hai-Lin Zhou, Xiao-Lin You, Xiao-Jie Jiang An unexpected catalyst-free [2 + 2 + 2] annulation reaction has been developed, allowing access to novel complex dimeric [small beta]-carboline derivatives in a single step. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Zwitterionic pyrrolidene-phosphonates: inhibitors of the glycoside hydrolase-like phosphorylase Streptomyces coelicolor GlgEI-V279S ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00388A, Paper Sri Kumar Veleti, Cecile Petit, Donald R. Ronning, Steven J. Sucheck We synthesized and evaluated new zwitterionic inhibitors against glycoside hydrolase-like phosphorylase Streptomyces coelicolor (Sco) GlgEI-V279S which plays a role in [small alpha]-glucan biosynthesis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Umpolung of protons from H2O: a metal-free chemoselective reduction of carbonyl compounds via B2pin2/H2O systems ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00820A, Paper Qingqing Xuan, Cong Zhao, Qiuling Song H2O is routinely described as a proton donor, however, in the presence of diboron compounds, the umpolung reaction of H2O under metal-free conditions was successfully developed, which could afford hydride species, leading to a highly efficient and chemoselective reduction of C[double bond, length as m-dash]O bonds. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of oxazolidinones: rhodium-catalyzed C-H amination of N-mesyloxycarbamates ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00378A, Paper Helene Lebel, Laura Mamani Laparra, Maroua Khalifa, Carl Trudel, Clement Audubert, Mathieu Szponarski, Cedric Dicaire Leduc, Emna Azek, Matthias Ernzerhof N-Mesyloxycarbamates undergo intramolecular C-H amination reactions to afford oxazolidinones in good to excellent yields in the presence of rhodium(II) carboxylate catalysts. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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"Anti-Michael addition" of Grignard reagents to sulfonylacetylenes: synthesis of alkynes ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00783C, Paper Francisco Esteban, Lazhar Boughani, Jose L. Garcia Ruano, Alberto Fraile, Jose Aleman The addition of Grignard reagents to arylsulfonylacetylenes, which undergoes an "anti-Michael addition", resulting in their alkynylation under very mild conditions is described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Cp*Co(III)-catalyzed ortho-amidation of azobenzenes with dioxazolones ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00540G, Communication Gongutri Borah, Preetismita Borah, Pitambar Patel Herein we have reported a decarboxylative ortho-amidation of azobenzene via cobalt catalyzed C-H amidation with dioxazolone. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Rifamorpholines A-E, potential antibiotics from locust-associated actinobacteria Amycolatopsis sp. Hca4 ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00614D, Paper Yong Sheng Xiao, Bo Zhang, Mei Zhang, Zhi Kai Guo, Xin Zhao Deng, Jing Shi, Wei Li, Rui Hua Jiao, Ren Xiang Tan, Hui Ming Ge Five unusual rifamycin-type antibiotics with potent antibacterial activity were characterized from locust-associated rare actinobacteria, Amycolatopsis sp. HCa4. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Exploring the reversal of enantioselectivity on a Zinc-dependent Alcohol Dehydrogenase ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00482F, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Miguel Angel Maria-Solano, Adrian Romero-Rivera, Silvia Osuna Alcohol Dehydrogenase (ADH) enzymes catalyse the reversible reduction of prochiral ketones to the corresponding alcohols. These enzymes present two differently shaped active site pockets, which dictate their substrate scope and... The content of this RSS Feed (c) The Royal Society of Chemistry
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[3, 3]-Sigmatropic Rearrangement of Allenic Alcohols: Stereoselective Synthesis of 1,3-Diene-2-ol Sulfonates ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00578D, Paper Yuyang Zhao, Yurong Wang, Zhanshou Gu, Zhiming Wang An efficient synthetic pathway to 1,3-diene-2-ol sulfonates involving the [3, 3]-sigmatropic rearrangement of allenic alcohols with sulfonic acids under mild reaction conditions was described. These products can easily undergo reduction... The content of this RSS Feed (c) The Royal Society of Chemistry
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Near-Infrared Fluorescent Dyes with Large Stokes Shifts: Light Generation in BODIPYs Undergoing the Excited State Intramolecular Proton Transfer ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00383H, Communication Qiang Fei, Xianfeng Gu, Yajing Liu, Ben Shi, Hengyan Liu, Ge Xu, Chunbao Li, Ping Shi, Chunchang Zhao Novel BODIPYs undergoing the excited state intramolecular proton transfer are reported. The molecules afford NIR emission with a large Stokes shift and possess a free hydroxyl unite facile to be... The content of this RSS Feed (c) The Royal Society of Chemistry
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Asymmetric conjugate additions of 2-substituted benzofuran-3(2H)-ones to [small alpha], [small beta]-unsaturated ketones catalyzed by chiral copper complexes ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00677B, Paper Haojiang Wang, Yifeng Wang, Cheng Zhang, Yidong Jiang, Mingming Chu, Zhaobo Li, Xiao-Hua Du, Danqian Xu A highly enantioselective conjugate addition of 2-substituted benzofuran-3(2H)-ones with [small alpha], [small beta]-unsaturated ketones promoted by chiral copper complexes has been developed, affording the Michael addition products with quaternary stereocenters in good... The content of this RSS Feed (c) The Royal Society of Chemistry
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Lanthanide amide-catalyzed one-pot functionalization of isatins: synthesis of spiro[cyclopropan-1,3[prime or minute]-oxindoles] and 2-oxoindolin-3-yl phosphates ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00640C, Paper Cheng Peng, Jiaojiao Zhai, Mingqiang Xue, Fan Xu The lanthanide amide-catalyzed one-pot reaction of isatins, dialkyl phosphite, and activated alkenes was developed and a series of spiro[cyclopropan-1,3[prime or minute]-oxindoles] was obtained in moderate to excellent yields. The reaction is stereoselective... The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and structural investigation of 2-aminomethyl-3-(4-methoxy-phenyl)-propionic acid containing peptide analogue of amyloidogenic AS(6-7) sequence: Inhibition of fibril formation ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00797C, Paper Arpita Paikar, Mintu Debnath, Debasish Podder, Supriya Sasmal, Debasish Haldar The incorporation of a single beta-amino acid moiety in a highly amyloidogenic peptide sequence resulted in a complete loss of amyloid fibril formation. The Boc-L-Phe-L-Leu-OMe 1 having sequence identity with... The content of this RSS Feed (c) The Royal Society of Chemistry
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Construction of protein assemblies by host-guest interactions with cucurbiturils ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00686A, Review Article Chunxi Hou, Zupeng Huang, Yu Fang, Junqiu Liu Protein assemblies are inspiring biomaterials for biomedicine and bioanalysis. Design of protein assemblies with maintained activities is especially important for applications. To address this challenge, cucurbiturils (CB[n]s) that are a... The content of this RSS Feed (c) The Royal Society of Chemistry
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Transition-metal-free synthesis of 1,1-diboronate esters with a fully substituted benzylic center via diborylation of lithiated carbamates ()
Org. Biomol. Chem., 2017, 15,3418-3422 DOI: 10.1039/C7OB00654C, Communication Haonan Zhao, Min Tong, Haijun Wang, Senmiao Xu Diborylation of lithiated carbamates is reported for the first time to synthesize 1,1-diboronate esters with a fully substituted benzylic center. The content of this RSS Feed (c) The Royal Society of Chemistry
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Amidation of unactivated ester derivatives mediated by trifluoroethanol ()
Org. Biomol. Chem., 2017, 15,3507-3518 DOI: 10.1039/C7OB00593H, Paper Christopher G. McPherson, Nicola Caldwell, Craig Jamieson, Iain Simpson, Allan J. B. Watson A catalytic amidation protocol mediated by 2,2,2-trifluoroethanol has been developed, facilitating the condensation of unactivated esters and amines, furnishing both secondary and tertiary amides. The content of this RSS Feed (c) The Royal Society of Chemistry
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Ru(II)-Catalyzed annulation of benzamidines and alkynes by C-H/N-H activation: a facile synthesis of 1-aminoisoquinolines ()
Org. Biomol. Chem., 2017, 15,3491-3498 DOI: 10.1039/C7OB00389G, Paper P. P. Kaishap, G. Duarah, D. Chetia, S. Gogoi Ru(II)-Catalyzed annulation reaction of benzamidines and disubstituted alkynes affords 1-aminoisoquinolines. The content of this RSS Feed (c) The Royal Society of Chemistry
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Palladium-catalyzed C-H olefination of uracils and caffeines using molecular oxygen as the sole oxidant ()
Org. Biomol. Chem., 2017, 15,3499-3506 DOI: 10.1039/C7OB00616K, Paper Xinyu Zhang, Lv Su, Lin Qiu, Zhenwei Fan, Xiaofeng Zhang, Shen Lin, Qiufeng Huang The palladium-catalyzed oxidative C-H olefination of uracils or caffeines with alkenes using an atmospheric pressure of molecular oxygen as the sole oxidant has been disclosed. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and conformations of [2.n]metacyclophan-1-ene epoxides and their conversion to [n.1]metacyclophanes ()
Org. Biomol. Chem., 2017, 15,3519-3527 DOI: 10.1039/C7OB00400A, Paper Thamina Akther, Md. Monarul Islam, Shofiur Rahman, Paris E. Georghiou, Taisuke Matsumoto, Junji Tanaka, Carl Redshaw, Takehiko Yamato Acid catalyzed rearrangement reactions of [2.n]metacyclophan-1-enes afford new chiral [n.1]metacyclophanes; DFT calculations have been used to estimate the energy-minimized structures of the metacyclophanes. The content of this RSS Feed (c) The Royal Society of Chemistry
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Copper-catalyzed tandem aryl-halogen hydroxylation and CH2Cl2-based N,O-acetalization toward the synthesis of 2,3-dihydrobenzoxazinones ()
Org. Biomol. Chem., 2017, 15,3423-3426 DOI: 10.1039/C7OB00625J, Communication Xuwen Chen, Wenyan Hao, Yunyun Liu Copper-catalyzed tandem reactions consisting of Ar-halogen hydroxylation and N,O-acetalization are designed for the concise synthesis of 2,3-dihydrobenzoxazinones. The content of this RSS Feed (c) The Royal Society of Chemistry
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Tf2NH-catalyzed formal [3 + 2] cycloaddition of oxadiazolones with ynamides: a simple access to aminoimidazoles ()
Org. Biomol. Chem., 2017, 15,3413-3417 DOI: 10.1039/C7OB00701A, Communication Yingying Zhao, Yancheng Hu, Xincheng Li, Boshun Wan We herein develop a formal [3 + 2] approach to access aminoimidazoles through the Tf2NH-catalyzed cycloaddition of oxadiazolones with ynamides, in which oxadiazolones are first employed as the three-atom building units. The content of this RSS Feed (c) The Royal Society of Chemistry
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Mechanistic model for the firefly luciferin regeneration in biomimetic conditions: a model for the in vivo process? ()
Org. Biomol. Chem., 2017, 15,3479-3484 DOI: 10.1039/C7OB00603A, Paper Carla T. Salatino, Diego U. Melo, Ariane M. Yoshitake, Lucas S. Sgarbi, Paula Homem-de-Mello, Fernando H. Bartoloni, Luiz F. M. L. Ciscato Firefly luciferin is recycled back in vivo by 2-cyano-6-hydroxybenzothiazole coupling with cysteine in a complex multi-step process involving specific base catalysis. The content of this RSS Feed (c) The Royal Society of Chemistry
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Enantioselective total synthesis of (+)-arborescidine C and related tetracyclic indole alkaloids using organocatalysis ()
Org. Biomol. Chem., 2017, 15,3408-3412 DOI: 10.1039/C7OB00473G, Communication Vishal M. Sheth, Bor-Cherng Hong, Gene-Hsiang Lee Enantioselective synthesis of (+)-arborescidine C was achieved by the key step of Pictet-Spengler cyclization reaction with a Jacobsen-type thiourea organocatalyst. The content of this RSS Feed (c) The Royal Society of Chemistry
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A formal intermolecular [4 + 2] cycloaddition reaction of 1,3-disubstituted indoles and alkylquinones ()
Org. Biomol. Chem., 2017, 15,3472-3478 DOI: 10.1039/C7OB00392G, Paper Chao Lin, Hong-Jin Du, Hui Zhao, Ding-Fei Yan, Nai-Xin Liu, Hongbin Sun, Xiaoan Wen, Qing-Long Xu A formal [4 + 2] cycloaddition reaction of 1,3-disubstituted indoles and alkylquinones was realized to afford polycyclic indolines in good yields. The content of this RSS Feed (c) The Royal Society of Chemistry
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Semi-continuous multi-step synthesis of lamivudine ()
Org. Biomol. Chem., 2017, 15,3444-3454 DOI: 10.1039/C7OB00480J, Paper Devender Mandala, Sravanthi Chada, Paul Watts We report the first semi-continuous flow synthesis of lamivudine, an antiretroviral drug used in the treatment of HIV/AIDS. The content of this RSS Feed (c) The Royal Society of Chemistry
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Acceptorless dehydrogenation and dehydrogenative coupling of alcohols catalysed by protic NHC ruthenium complexes ()
Org. Biomol. Chem., 2017, 15,3466-3471 DOI: 10.1039/C7OB00542C, Paper Weihong Chang, Xue Gong, Shuizhong Wang, Ling-Ping Xiao, Guoyong Song A new family of protic NHC Ru complexes can serve as efficient catalysts for acceptorless dehydrogenative transformations of alcohols. The content of this RSS Feed (c) The Royal Society of Chemistry
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Syntheses and kinetic studies of cyclisation-based self-immolative spacers ()
Org. Biomol. Chem., 2017, 15,3435-3443 DOI: 10.1039/C7OB00121E, Paper Steve Huvelle, Ahmed Alouane, Thomas Le Saux, Ludovic Jullien, Frederic Schmidt Photochemical activation has allowed the precise determination of the disassembly times of cyclisation-based self-immolative spacers. Results confirmed large differences with previously studied elimination-based self-immolative spacers. The content of this RSS Feed (c) The Royal Society of Chemistry
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ZnBr2-Mediated oxidative spiro-bromocyclization of propiolamide for the synthesis of 3-bromo-1-azaspiro[4.5]deca-3,6,9-triene-2,8-dione ()
Org. Biomol. Chem., 2017, 15,3485-3490 DOI: 10.1039/C7OB00293A, Paper Yicheng He, Guanyinsheng Qiu ZnBr2-Mediated oxidative ipso-bromocyclization of N-arylpropoilamide was utilized herein for the synthesis of 3-bromo-1-azaspiro[4.5]deca-3,6,9-triene-2,8-dione with high efficiency and a broad tolerance for functional groups. The content of this RSS Feed (c) The Royal Society of Chemistry
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Post-translational modifications involved in the biosynthesis of thiopeptide antibiotics ()
Org. Biomol. Chem., 2017, 15,3376-3390 DOI: 10.1039/C7OB00466D, Review Article Qingfei Zheng, Hui Fang, Wen Liu Thiopeptide antibiotics are generated from ribosomally synthesized peptides via a cascade of post-translational modifications (PTMs). The content of this RSS Feed (c) The Royal Society of Chemistry
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A highly enantioselective Friedel-Crafts reaction of 3,5-dimethoxylphenol with nitroolefins mediated by a bifunctional quinine derived thiourea catalyst ()
Org. Biomol. Chem., 2017, 15,3401-3407 DOI: 10.1039/C7OB00372B, Communication Xiaoyu Han, Can Ye, Fenfen Chen, Qu Chen, Yongjiang Wang, Xiaofei Zeng A useful and highly enantioselective Friedel-Crafts reaction of 3,5-dimethoxylphenol with nitroolefins catalyzed by a bifunctional quinine derived thiourea catalyst was developed. The content of this RSS Feed (c) The Royal Society of Chemistry
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Post-synthetic modification of tryptophan containing peptides via NIS mediation ()
Org. Biomol. Chem., 2017, 15,3396-3400 DOI: 10.1039/C7OB00329C, Communication Chen-Xue Gu, Qing-Wei Bi, Chu-Kun Gao, Jian Wen, Zhi-Gang Zhao, Zili Chen A new method to provide modified tryptophan peptides through NIS mediated N2-selective coupling of a Trp unit with 1,2,3-triazoles, of which, the preliminary spectral properties were studied. The content of this RSS Feed (c) The Royal Society of Chemistry
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Rational design, synthesis, and biological evaluation of Pan-Raf inhibitors to overcome resistance ()
Org. Biomol. Chem., 2017, 15,3455-3465 DOI: 10.1039/C7OB00518K, Paper Lu Wang, Gaoyuan Zhu, Qing Zhang, Chunqi Duan, Yanmin Zhang, Zhimin Zhang, Yujun Zhou, Tao Lu, Weifang Tang We describe the design and characterization of a series of pyrimidine scaffolds as Pan-Raf inhibitors, which may overcome the resistance associated with current BRafV600E inhibitors. The content of this RSS Feed (c) The Royal Society of Chemistry
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New mechanistic interpretations for nitrone reactivity ()
Org. Biomol. Chem., 2017, 15,3364-3375 DOI: 10.1039/C7OB00429J, Review Article Pedro Merino, Tomas Tejero, Ignacio Delso, Rosa Matute The reactivity of nitrones in cycloadditions and related reactions is revisited by introducing a topological perspective. The content of this RSS Feed (c) The Royal Society of Chemistry
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nBu4NI-Mediated oxidation of methyl ketones to [small alpha]-ketoamides: using ammonium, primary and secondary amine-salt as an amine moiety ()
Org. Biomol. Chem., 2017, 15,3427-3434 DOI: 10.1039/C7OB00270J, Paper Dan Wang, Kuan Zhang, Luhan Jia, Danting Zhang, Yue Zhang, Yujia Cheng, Chang Lin, Bo Wang Presented is the first example of synthesizing an array of primary-, secondary-, and tertiary-[small alpha]-ketoamides in moderate to excellent yields with a catalyst nBu4NI from methyl ketones and amine/ammonium salts under mild conditions using oxidant TBHP. The content of this RSS Feed (c) The Royal Society of Chemistry
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JA-Ile-macrolactones uncouple growth and defense in wild tobacco ()
Org. Biomol. Chem., 2017, 15,3391-3395 DOI: 10.1039/C7OB00249A, Communication Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Guillermo H. Jimenez-Aleman, Ricardo A. R. Machado, Ian T. Baldwin, Wilhelm Boland JA-Ile-lactones: small molecules that uncoupled growth and defense in wild tobacco plants. The content of this RSS Feed (c) The Royal Society of Chemistry
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A carbonyl reductase from Candida parapsilosis ATCC 7330: Substrate selectivity and enantiospecificity ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00340D, Paper Sneha Sudhakara, Anju Chadha Candida parapsilosis ATCC 7330, a rich source of highly stereospecific oxidoreductases, catalyzes oxidation-reduction of a plethora of compounds yielding industrially important intermediates. An (S)-specific carbonyl reductase (SRED) purified and characterized... The content of this RSS Feed (c) The Royal Society of Chemistry
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Mechanistic insights into the selective cyclization of indolines with alkynes and alkenes to produce six- and seven-membered 1,7-fused indolines via Rh(III) catalysis: a theoretical study ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00261K, Paper Ling-Li Han, Xingyu Zhang, Xingdong Wang, Fengyue Zhao, Shao-Jing Liu, Tao Liu The coupling reaction mechanisms of the Rh(III)-catalyzed redox-neutral C7-selective aryl C-H functionalization of indolines with alkynes and alkenes have been theoretically investigated with the aid of the density functional theory... The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis, duplex-forming ability, enzymatic stability, and in vitro antisense potency of oligonucleotides including 2ʹ-C,4ʹ-C-ethyleneoxy-bridged thymidine derivatives ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00698E, Paper Takashi Osawa, Motoki Sawamura, Fumito Wada, Tsuyoshi Yamamoto, Satoshi Obika, Yoshiyuki Hari We synthesized thymidine derivatives of 2ʹ-C,4ʹ-C-ethyleneoxy-bridged 2ʹ-deoxyribonucleic acids with 8ʹ-methyl group ((R)-Me-EoDNA and (S)-Me-EoDNA) and without any substituent (EoDNA). Oligonucleotides including these EoDNAs showed high hybridization abilities with complementary RNA... The content of this RSS Feed (c) The Royal Society of Chemistry
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syn-Selective crotylation of aldehydes using bismuth-crotyl bromide-(1-butyl-3-methylimidazolium bromide) combination: some synthetic applications ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00626H, Paper Dibakar Goswami, Mrunesh R. Koli, Sucheta Chatterjee, Subrata Chattopadhyay, Anubha Sharma Highly syn-selective crotylation of aldehydes was achieved using Bi-[bmim][Br]-crotyl bromide combination, leading to an easy, stereodivergent method to synthesise important targets. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Dissection of the neocarazostatin: a C4 alkyl side chain biosynthesis by in vitro reconstitution ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00617A, Communication Li Su, Rui Zhang, Kwaku Kyeremeh, Zixin Deng, Hai Deng, Yi Yu The biosynthetic origin of the C4 alkyl side chain in the "A" ring of neocarazostatin A was reconstituted in vitro. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A divergent and metal free synthesis of sulfoximine tethered imidazoles, imidazopyridines, imidazothiazoles, imidazobenzothiazines, thiazoles and selenazoles ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00601B, Paper S. R. K. Battula, V. P. Rama Kishore Putta, G. V. Subbareddy, I. E. Chakravarthy, V. Saravanan A divergent and metal free approach has been successfully developed for the synthesis of sulfoximine tethered heterocycles from a [small alpha]-bromoalkanone building block. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Copper-catalysed enantioselective Michael addition of malonic esters to [small beta]-trifluoromethyl-[small alpha],[small beta]-unsaturated imines ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00595D, Communication Miguel Espinosa, Jorge Herrera, Gonzalo Blay, Luz Cardona, M. Carmen Munoz, Jose R. Pedro A diastereo- and enantioselective Michael addition of methyl malonate to [small beta]-trifluoromethyl unsaturated imines is presented. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A multicomponent macrocyclization strategy to natural product-like cyclic lipopeptides: synthesis and anticancer evaluation of surfactin and mycosubtilin analogues ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00459A, Paper Micjel C. Morejon, Annegret Laub, Goran N. Kaluderovic, Alfredo R. Puentes, Ali N. Hmedat, Anselmo J. Otero-Gonzalez, Daniel G. Rivera, Ludger A. Wessjohann Two birds in one shot: oligopeptides can be cyclized and lipidated in one step with multicomponent reactions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Dynamic covalent chemistry in aqueous solution by photoinduced radical disulfide metathesis ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00667E, Communication Florian Klepel, Bart Jan Ravoo Photoinduced radical disulfide metathesis (PRDM) is a dynamic covalent reaction that requires UV light to induce the homolytic cleavage of the disulfide bond, thus offering the opportunity to construct dynamic covalent systems that are dormant and can be photo-activated on demand. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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One-step formation of dihydrofuranoindoline cores promoted by a hypervalent iodine reagent ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00326A, Paper Elsa Deruer, Sylvain Canesi Treatment of aniline derivatives in the presence of a hypervalent iodine reagent and furan produces dihydrofuranoindoline cores in one step. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Biochemical studies of inositol N-acetylglucosaminyltransferase involved in mycothiol biosynthesis in Corynebacterium diphtheria ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00555E, Paper Yuchuan Guo, Lizhen Wang, Jiatong Guo, Guofeng Gu, Zhongwu Guo First-time expression, isolation, biochemical characterization, and mutagenesis studies of a MshA from Corynebacterium diphtheria involved in its mycothiol biosynthesis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Enantioselective total synthesis of colomitides and their absolute configuration determination and structural revision ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00539C, Paper Hongguang Yang, Xiaoyu Liu, Xiaoyu Li, Xiang Shi, Feilong Yang, Xiaozhen Jiao, Ping Xie An efficient stereoselective synthetic approach to colomitides, 2,7-dioxabicyclo[3.2.1]octane-type natural products, is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of 2,3-dihydro-1H-pyrroles by intramolecular cyclization of N-(3-butynyl)-sulfonamides ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00528H, Paper Min-Ching Chung, Yung-Hsiang Chan, Wen-Jung Chang, Duen-Ren Hou Hydroamination of 3-butynamine derivatives to give non-aromatic 2,3-dihydropyrroles was achieved by using PdCl2 or AuCl as the catalyst. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of fused cyanopyrroles and spirocyclopropanes via addition of N-ylides to chalconimines ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00529F, Paper Siba Prasad Midya, Elumalai Gopi, Nishikant Satam, Irishi N. N. Namboothiri DABCO-ylides react as a one-carbon source with chalconimines to afford fused cyanopyrroles via [4 + 1] annulation and spirocyclopropanes via [2 + 1] annulation. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Expanding the substrate scope of phenylalanine ammonia-lyase from Petroselinum crispum towards styrylalanines ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00562H, Paper Laszlo Csaba Bencze, Alina Filip, Gergely Banoczi, Monica Ioana Tosa, Florin Dan Irimie, Akos Gellert, Laszlo Poppe, Csaba Paizs The substrate scope of phenylalanine ammonia-lyase from Petroselinum crispum (PcPAL) towards the L-enantiomers of racemic styrylalanines rac-1a-d were extended by reshaping the aromatic binding pocket of the active site of PcPAL by point mutations of F137. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Organocatalytic Decarboxylative Aldol Reaction of [small beta]-Ketoacids with [small alpha]-Ketophosphonates en route for the Enantioselective Synthesis of Tertiary [small alpha]-Hydroxyphosphonates ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00796E, Communication Ganga B Vamisetti, Raghunath Chowdhury, Sunil Kumar Ghosh First example of asymmetric organocatalyzed decarboxylative aldol reaction of [small beta]-ketoacids (aroylacetic acids) with [small alpha]-ketophosphonates that produces a quaternary chiral centre has been developed. A quinidine based bifunctional urea derivative was... The content of this RSS Feed (c) The Royal Society of Chemistry
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Solvent-Free, Uncatalyzed Asymmetric "Ene" Reactions of N-tert-Butylsulfinyl-3,3,3-trifluoroacetaldimines: General Approach to Enantiomerically Pure alfa-(Trifluoromethyl)tryptamines. ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00670E, Paper Renzo Ruzziconi, Giuseppe Mazzeo, Giovanna Longhi, Sergio Abbate, Martina Palomba, Luana Bagnoli, Francesca Marini, Claudio Santi, Jianlin Han, Vadim A Soloshonok, Emilio Di Crescenzo A novel approach to regioselectively substituted and stereoselectively -trifluoromethylated tryptamines is reported based on the ene reaction of Boc-protected 3-methyleneindolines with optically pure (R)- or (S)-tert-butanesulfinyltrifluoroacetaldimine. Boc- and sulfinylamido-protected -trifluoromethyltryptamines... The content of this RSS Feed (c) The Royal Society of Chemistry
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Pd(0)-catalysed asymmetric reductive Heck-type cyclization of (Z)-1-iodo-1,6-diene: enantioselective synthesis of quaternary tetrahydropyridines ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00762K, Communication Longlei Hou, Yuejie Yuan, Xiaofeng Tong A Pd(0)/(S)-p-MeO-BnPHOX catalytic system has been established for the asymmetric reductive Heck reaction of (Z)-1-iodo-1,6-diene, which affords quaternary tetrahydropyridines with good to excellent enantioselectivity. This reaction tolerates a wide range... The content of this RSS Feed (c) The Royal Society of Chemistry
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Selective S-Arylation of 2-Oxazolidinethiones and N-Arylation of 2-Benzoxazolinones/2-Benzimidazolinones ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00040E, Communication Chu-Han Sun, Yi Lu, Qing Zhang, Rong Lu, Lin-Qing Bao, Mei-Hua Shen, Hua-Dong Xu There exist three possible patterns for the reaction of cyclic 2-oxazolidinethione and 2-benzoxazolidinethione with aryne, namely (a) S-arylation, (b) N-arylation, and (c) aryne insertion into thiocarbonyl group (C=S). Our studies... The content of this RSS Feed (c) The Royal Society of Chemistry
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Highly selective and sensitive fluorescent probe for Cu2+ based a novel naphthalimide-rhodamine platform and its application in live cell imaging ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00538E, Paper Xianshun Zeng, Chang Liu, Xiaojie Jiao, Song He, Liancheng Zhao Copper plays important roles in a variety of fundamental physiological processes. At the cell organelles level, aberrant copper homeostasis in lysosomes can lead to various serious diseases. Herein, a bifluorophore-based,... The content of this RSS Feed (c) The Royal Society of Chemistry
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Polyvalent C-glycomimetics based on L-fucose or D-mannose as potent DC-SIGN antagonists ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00322F, Paper Benedetta Bertolotti, Ieva Sutkeviciute, Martino Ambrosini, Renato Ribeiro-Viana, Javier Rojo, Franck Fieschi, Hana Dvorakova, Martina Kasakova, Kamil Parkan, Martina Hlavackova, Katerina Novakova, Jitka Moravcova The C-type lectin DC-SIGN expressed on immature dendritic cells is a promising target for antiviral drug development. Previously, we have demonstrated that mono- and divalent C-glycosides based on D-manno and... The content of this RSS Feed (c) The Royal Society of Chemistry
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Stereodivergent synthesis of right- and left-handed iminoxylitol heterodimers and monomers. Study of their impact on [small beta]-glucocerebrosidase activity ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00443E, Paper Fabien Stauffert, Jenny Serra-Vinardell, Marta Gomez-Grau, Helen Michelakakis, Irene Mavridou, Daniel Grinberg, Lluisa Vilageliu, Josefina Casas, Anne Bodlenner, Antonio Delgado, Philippe Compain Unprecedented Janus-faced iminosugars act as pharmacological chaperones for the treatment of Gaucher disease. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Bronsted acid-catalyzed, enantioselective synthesis of 1,4-dihydroquinoline-3-carboxylates via in situ generated ortho-quinone methide imines ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00488E, Paper Tomas Hodik, Christoph Schneider A straightforward approach toward the synthesis of a broad range of 1,4-dihydroquinoline-3-carboxylates is described. Under phosphoric acid catalysis in situ-generated ortho-quinone methide imines reacted with [small beta]-keto esters to form the nitrogen heterocycles with good chemical yields and enantioselectivities. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Efficient construction of C-N and C-S bonds in 2-iminothiazoles via cascade reaction of enaminones with potassium thiocyanate ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00306D, Paper Xue-Bing Chen, Xue-Quan Wang, Jia-Na Song, Qing-Li Yang, Chao Huang, Wei Liu Regioselective cascade reactions have been developed by using enaminones and potassium thiocyanate, offering a novel protocol for the synthesis of thiazoles from enaminones. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Imidazolium-labeled glycosides as probes to harness glycosyltransferase activity in human breast milk ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00550D, Communication I. Sittel, M. C. Galan Imidazolium-labeled (ITag-) glycosides have been used to harness the glycosyltransferase activity directly from human breast milk (HBM). The technology is exemplified in the synthesis of biologically relevant oligosaccharide analogs, ITag-LacNAc, ITag-Lewisx and ITag-Lewisa, in a matter of days from (HBM) without isolating the enzymes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Recent progress in transition-metal-catalyzed enantioselective indole functionalizations ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00413C, Review Article Jing-Biao Chen, Yi-Xia Jia Recent progress on the transition-metal-catalyzed enantioselective functionalization reaction of indoles is reviewed, which is mainly focused on asymmetric indole alkylations, arylations, cycloaddition reactions, and other reactions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Regiocontrolled functionalization of 2,3-dihalogenoimidazo[1,2-a]pyridines by Suzuki-Miyaura and Sonogashira cross-coupling reactions ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00624A, Paper Pierre-Olivier Delaye, Melanie Penichon, Hassan Allouchi, Cecile Enguehard-Gueiffier, Alain Gueiffier An efficient method for regiocontrolled functionalization of 2,3-dihalogenoimidazo[1,2-a]pyridine was developed. This sequence allowed the selective introduction of aryl, heteroaryl, alkyl and alkynyl substituents at both 2- and 3-positions, by using... The content of this RSS Feed (c) The Royal Society of Chemistry
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A New Four-Component Reaction Involving Michael Addition and Gewald Reaction, Leading to Diverse Biologically Active 2-Aminothiophenes ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00707H, Paper Joice Thomas, Sampad Jana, Mahendra Sonawane, Bert Fiey, Jan Balzarini, Sandra Liekens, Wim Dehaen The Gewald three-component reaction yielding highly substituted 2-aminothiophene heterocycles has been known for a long time and holds an extraordinary potential in pharmaceutical industry. Herein, we describe a four-component reaction... The content of this RSS Feed (c) The Royal Society of Chemistry
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Improving target amino acid selectivity in a permissive aminoacyl tRNA synthetase through counter-selection ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00582B, Paper Itthipol Sungwienwong, Zachary M. Hostetler, Robert J. Blizzard, Joseph J. Porter, Camden M. Driggers, Lea Z. Mbengi, Jose A. Villegas, Lee C. Speight, Jeffery G. Saven, John J. Perona, Rahul M. Kohli, Ryan A. Mehl, E. James Petersson We report the selection and characterization of an improved acridon-2-ylalanine aminoacyl tRNA synthetase. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Copper(I)-catalyzed ring-opening cyanation of cyclopropanols ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00627F, Communication Yi-Si Feng, Yong-Jin Shu, Ping Cao, Tao Xu, Hua-Jian Xu A copper(I)-catalyzed ring-opening cyanation of cyclopropanols is developed. The reaction provides an efficient protocol to synthesize [small beta]-cyano ketones. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of AHMOD-containing aminolipopeptides, unique bioactive peptaibiotics ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00541E, Review Article Louise A. Stubbing, Iman Kavianinia, Margaret A. Brimble An interesting family of bioactive aminolipopeptides contain the unusual building block 2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid (AHMOD). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Enantioselective [4 + 1] cycloaddition of ortho-quinone methides and bromomalonates under phase-transfer catalysis ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00484B, Paper Xiao-Lei Lian, Alafate Adili, Bin Liu, Zhong-Lin Tao, Zhi-Yong Han An enantioselective [4 + 1] cycloaddition reaction of ortho-quinone methides and bromomalonates using a quinine and BINOL derived phase-transfer catalyst is described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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One-pot three-component selective synthesis of isoindolo[2,1-a]quinazoline derivatives via a palladium-catalyzed cascade cyclocondensation/cyclocarbonylation sequence ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00256D, Paper Shenghai Guo, Jianhui Zhai, Fang Wang, Xuesen Fan An efficient route to 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-diones via Pd-catalyzed carbonylative cyclization of 2-aminobenzamides with 2-bromobenzaldehydes and CO is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Changing the path of least resistance, or access to endo-dig products via a sequence of three exo-trig transition states: electronic effects in homoallyic ring expansion cascades of alkenyl isonitriles ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00527J, Paper Gabriel dos Passos Gomes, Christopher J. Evoniuk, Michelle Ly, Igor V. Alabugin Substituent effects reshape the potential energy surfaces for radical homoallylic expansion/fragmentation cascades that transform alkenyl isonitriles into N-heteroaromatics To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A method for accessing sulfanylfurans from homopropargylic alcohols and sulfonyl hydrazides ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00566K, Communication Xiaodong Yang, Rulong Yan A sulfenylation/cyclization reaction has been developed for the synthesis of sulfanylfurans in the presence of iodine. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of N-alkyl-3-sulfonylindoles and N-alkyl-3-sulfanylindoles by cascade annulation of 2-alkynyl-N,N-dialkylanilines ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00366H, Paper Jatuporn Meesin, Manat Pohmakotr, Vichai Reutrakul, Darunee Soorukram, Pawaret Leowanawat, Chutima Kuhakarn Divergent synthesis of N-alkyl-3-sulfonylindoles and N-alkyl-3-sulfanylindoles from 2-alkynyl-N,N-dialkylanilines and sulfonyl hydrazides has been described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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An Ir(III)-catalyzed aryl C-H bond carbenoid functionalization cascade: access to 1,3-dihydroindol-2-ones ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00367F, Paper Siyi Bai, Xun Chen, Xinwei Hu, Yuanfu Deng, Huanfeng Jiang, Wei Zeng An Ir(III)-catalyzed relay aryl C-H bond carbenoid insertion cascade of N-aryl-2-pyridinamines with diazo Meldrum's acid has been developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Cleavage of 1,3-dicarbonyls through oxidative amidation ()
Org. Biomol. Chem., 2017, 15,3184-3187 DOI: 10.1039/C7OB00731K, Communication Phillip Biallas, Andreas P. Haring, Stefan F. Kirsch The oxidative cleavage of 1,3-diketones with amines is shown in the presence of iodine and azide anions, amides are obtained. The content of this RSS Feed (c) The Royal Society of Chemistry
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Signal transduction in oligoamide foldamers by selective non-covalent binding of chiral phosphates at a urea binding site ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00660H, Communication Katharina Gratzer, Vincent Diemer, Jonathan Clayden Non-covalent interactions between a chiral phosphate anion and a urea binding site induce a conformational preference in an amide foldamer. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A study of diketopiperazines as electron-donor initiators in transition metal-free haloarene-arene coupling ()
Org. Biomol. Chem., 2017, 15,3324-3336 DOI: 10.1039/C7OB00036G, Paper Florimond Cumine, Shengze Zhou, Tell Tuttle, John A. Murphy The electron-donating ability of enolates of N,N[prime or minute]-disubstituted diketopiperazines is strongly influenced by the nature of the substituents. The content of this RSS Feed (c) The Royal Society of Chemistry
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Discovery and optimization of selective inhibitors of protein arginine methyltransferase 5 by docking-based virtual screening ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00070G, Paper Yan Ye, Bidong Zhang, Ruifeng Mao, Chenhua Zhang, Yulan Wang, Jing Xing, Yu-Chih Liu, Xiaomin Luo, Hong Ding, Yaxi Yang, Bing Zhou, Hualiang Jiang, Kaixian Chen, Cheng Luo, Mingyue Zheng A series of highly selective and potent inhibitors against PRMT5 have been achieved using virtual screening and medicinal chemistry approaches. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Metal-free enantioselective addition of nucleophilic silicon to aromatic aldehydes catalyzed by a [2.2]paracyclophane-based N-heterocyclic carbene catalyst ()
Org. Biomol. Chem., 2017, 15,3202-3206 DOI: 10.1039/C7OB00243B, Communication Ping An, Yuwen Huo, Zhen Chen, Chun Song, Yudao Ma A transition metal-free enantioselective 1,2-silylation of aromatic aldehydes to yield chiral [small alpha]-hydroxysilanes was developed for the first time. The content of this RSS Feed (c) The Royal Society of Chemistry
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