Organic & Biomolecular Chemistry

Synthesis of N,N-disubstituted 2-aminothiophenes by the cyclization of gem-difluoroalkenes with [small beta]-keto thioamides ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00368D, Paper Xuxue Zhang, Mingsheng Wu, Juan Zhang, Song Cao A novel and effective method for the construction of highly functionalized aminothiophenes via the cyclization of gem-difluoroalkenes with [small beta]-keto tertiary thioamides is described. The reactions proceed smoothly with the assistance... The content of this RSS Feed (c) The Royal Society of Chemistry
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Syntheses of C17-C27 fragments of 20-deoxybryostatins for assembly using Julia and metathesis reactions ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00076F, Paper Matthew Ball, Thomas Gregson, Hiroki Omori, E J Thomas Two approaches to the synthesis of compounds corresponding to the C17-C27 fragment of the 20-deoxybryostatins are described. The first approach is based on the palladium(0) catalysed coupling of tin enolates,... The content of this RSS Feed (c) The Royal Society of Chemistry
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Some limitations of an approach to the assembly of bryostatins by ring closing metathesis ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00079K, Paper Raphael Dumeunier, Thomas Gregson, Somhairle MacCormick, Hiroki Omori, E J Thomas Preliminary studies into the use of ring-closing metathesis (RCM) in a convergent approach for the total synthesis of bryostatins are described. An ester that would have provided an advanced intermediate... The content of this RSS Feed (c) The Royal Society of Chemistry
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Isolation and structure elucidation of natural products of three soft corals and a sponge from the coast of Madagascar ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00191F, Paper Marie Pascaline Rahelivao, Tilo Lubken, Margit Gruner, Olga Kataeva, Rahanira Ralambondrahety, Hanta Andriamanantoanina, Marek P. Checinski, Ingmar Bauer, Hans-Joachim Knolker We investigated the three soft corals Sarcophyton stellatum, Capnella fungiformis and Lobophytum crassum and the sponge Pseudoceratina arabica, which have been collected at the coast of Madagascar. In addition to... The content of this RSS Feed (c) The Royal Society of Chemistry
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A formal homo-Nazarov cyclization of enantioenriched donor-acceptor cyclopropanes and following transformations: asymmetric synthesis of multi-substituted dihydronaphthalenes ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00278E, Paper Seijiro Takada, Naoya Takaki, Kenta Yamada, Yoshinori Nishii Multi-substituted trans-dihydronaphthalenes were obtained in high eantiomeric excess from a TiCl4-mediated cyclization of enanitioenriched donor-acceptor cyclopropanes, followed by a triflation of the hydroxy groups. The C-OTf bond in these multi-substituted... The content of this RSS Feed (c) The Royal Society of Chemistry
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Palladium/Zinc Co-catalyzed Asymmetric Transfer Hydrogenation of Oxabenzonorbornadienes with Alcohols as Hydrogen Sources ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00175D, Communication Fujie Ma, Jingchao Chen, Fan Yang, Madhuri Vikas Shinde, Yongyun Zhou, Baomin Fan The asymmetric transfer hydrogenation of oxabenzonorbornadienes were realized by using alcohols as hydrogen sources under the co-catalytic system of palladium and zinc. Both primary and secondary alchols could serve as... The content of this RSS Feed (c) The Royal Society of Chemistry
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Photocatalytic N-Formylation of Amines via a Reductive Quenching Cycle in the Presence of Air ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00250E, Paper Tamal Ghosh, Amrita Das, Burkhard Koenig The photochemical N-formylation of amines was performed under simple and mild reaction conditions. Amines are common electron donors in reductive photocatalysis, which then typically decompose after donating an electron to... The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthetic applications of vinyl cyclopropane opening ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C6OB02647H, Review Article Marta Meazza, Hao Guo, Ramon Rios Vinyl cyclopropanes are amongst the most useful building blocks in organic synthesis. In this review we give an overview of their applications, focusing on the present century. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of non-symmetric viologen-containing ditopic ligands and their Pd(II)/Pt(II)-directed self-assembly ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00161D, Paper Olaya Domarco, Iago Neira, Tamara Rama, Arturo Blanco, Marcos D. Garcia, Carlos Peinador, Jose Quintela We present here an efficient method for the preparation of non-symmetric viologen-containing ditopic ligands, as well as the Pd(II)/Pt(II)-directed self-assembly of some of those into metallocyclic receptors. The designed synthetic... The content of this RSS Feed (c) The Royal Society of Chemistry
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Diversity-oriented synthesis and cytotoxic activity evaluation of biaryl-containing macrocycles ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C6OB02726A, Paper Karell Roberto Perez-Labrada, Marco Antonio Cruz-Mendoza, Alejandra Chavez-Riveros, Eduardo Hernandez-Vazquez, Tomas Torroba, Luis D. Miranda A collection of biarylic-containing macrocycles has been constructed through a four-step approach comprising two Ugi four component reactions and a Suzuki-Miyaura macrocyclization. The protocol allowed the synthesis of 12- and... The content of this RSS Feed (c) The Royal Society of Chemistry
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Thermolysis and radiofluorination of diaryliodonium salts derived from anilines ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00253J, Paper Ethan J. Linstad, Amy L. Vavere, Bao Hu, Jayson J. Kempinger, Scott E. Snyder, Stephen G. DiMagno Mechanistic and theoretical studies reveal new reactions of Ar2I salts that can interfere with radiolabeling of these substrates. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Recent advances in organocatalytic enantioselective transfer hydrogenation ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00113D, Review Article Ana Maria Faisca Phillips, Armando J. L. Pombeiro Robust, environmentally friendly reductants enable highly enantioselective reactions in the presence of chiral catalysts. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Zwitterionic indenylammonium with carbon-centred reactivity towards reversible CO2 binding and catalytic reduction ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00364A, Paper Yanxin Yang, Linfan Yan, Qinyu Xie, Qiuming Liang, Datong Song Zwitterionic indenylammonium can reversibly insert CO2 into its C-H bond at ambient temperature and catalyze CO2 hydroboration. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Mechanistic investigations of the asymmetric hydrosilylation of ketimines with trichlorosilane reveals a dual activation model and an organocatalyst with enhanced efficiency ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C6OB02537D, Paper Xianfu Li, Andrew Reeder, Federica Torri, Harry Adams, Simon Jones Structural probes used to help elucidate mechanistic information of the organocatalyzed asymmetric ketimine hydrosilylation have revealed a new catalyst with unprecedented catalytic activity, maintaining adequate performance at 0.01 mol% loading.... The content of this RSS Feed (c) The Royal Society of Chemistry
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Recent advances in chiral imino-containing ligands for metal-catalyzed asymmetric transformations ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C6OB02817A, Review Article Xu Chen, Zhan Lu In this review, the recent applications of a variety of chiral imino-containing ligands classified by different types of metal-catalyzed asymmetric reactions are summarized. The progress made in this area would encourage us to design and synthesize more novel chiral imino-containing ligands, and explore their applications in metal-catalyzed asymmetric transformations. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Sc(OTf)3-catalyzed synthesis of anhydrides from twisted amides ()
Org. Biomol. Chem., 2017, 15,1780-1785 DOI: 10.1039/C7OB00086C, Communication Yongmei Liu, Ruzhang Liu, Michal Szostak A novel, one-step synthesis of anhydrides from twisted amides is reported. The content of this RSS Feed (c) The Royal Society of Chemistry
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Direct access to the optically active VAChT inhibitor vesamicol and its analogues via the asymmetric aminolysis of meso-epoxides with secondary aliphatic amines ()
Org. Biomol. Chem., 2017, 15,1913-1920 DOI: 10.1039/C6OB02479C, Paper Arun Sharma, Jyoti Agarwal, Rama Krishna Peddinti The VAChT inhibitor vesamicol and its analogues were synthesized in impressive chemical and optical yields via the catalytic asymmetric aminolysis of meso-epoxides. The content of this RSS Feed (c) The Royal Society of Chemistry
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CuBr/TBHP-mediated synthesis of N-acyl sulfonimidamides via the oxidative cross-coupling of sulfonimidamides and aldehydes ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C6OB02589G, Paper Ganesh Chandra Nandi, Cijil Raju N-Acyl sulfonimidamides were synthesized via a Cu-catalyzed double C-H/N-H activation protocol. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Cooperativity of axial and centre chirality in the biaryl disulfoxide/Rh(I)-catalysed asymmetric 1,4-addition of arylboronic aids to 2-cyclohexenone: a DFT study ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C6OB02651F, Paper Gao-Feng Zha, Hua-Li Qin, Eric Assen B. Kantchev Atropisomeric biaryl disulfoxides contain two synergistic chiral elements. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Stabilization of peptides against proteolysis through disulfide-bridged conjugation with synthetic aromatics ()
Org. Biomol. Chem., 2017, 15,1921-1929 DOI: 10.1039/C6OB02786E, Paper Yaqi Chen, Tao Li, Jianguo Li, Shiyan Cheng, Jinghui Wang, Chandra Verma, Yibing Zhao, Chuanliu Wu We developed an efficient strategy for the stabilization of peptides against proteolysis, which involves noncovalent [small pi]-[small pi] interactions between aromatic amino acid residues in peptides and synthetic electron-deficient aromatics. The content of this RSS Feed (c) The Royal Society of Chemistry
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A redox-economical synthesis of trifluoromethylated enamides with the Langlois reagent ()
Org. Biomol. Chem., 2017, 15,1771-1775 DOI: 10.1039/C7OB00203C, Communication Hai-Bin Yang, Nicklas Selander A copper-catalyzed trifluoromethylation of ketoxime acetates employing the Langlois reagent and the N-O bond as an internal oxidant is presented. The content of this RSS Feed (c) The Royal Society of Chemistry
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Mimics of pramanicin derived from pyroglutamic acid and their antibacterial activity ()
Org. Biomol. Chem., 2017, 15,1889-1912 DOI: 10.1039/C6OB02828D, Paper Song Wei Benjamin Tan, Christina L. L. Chai, Mark G. Moloney Mono and dihydroxypyrrolidinones are readily available by direct oxygenation of a pyroglutamate-derived bicyclic lactam with high diastereoselectivity, and these may be manipulated further in protected or unprotected form by Grignard addition to a pendant Weinreb amide to give acylhydroxypyrrolidinones. The content of this RSS Feed (c) The Royal Society of Chemistry
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A simple and efficient method for constructing azepino[4,5-b]indole derivatives via acid catalysis ()
Org. Biomol. Chem., 2017, 15,1872-1875 DOI: 10.1039/C6OB02722A, Paper Siva Senthil Kumar Boominathan, Mutra Mohana Reddy, Ruei-Jhih Hou, Hui-Fen Chen, Jeh-Jeng Wang A new and efficient synthetic methodology has been developed to prepare azepino[4,5-b]indole derivatives under Bronsted acid catalysis. The content of this RSS Feed (c) The Royal Society of Chemistry
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A facile synthesis of 3,4-dimercaptofurans via sulfenylation of (E)-[small beta]-chlorovinyl ketones and 1,2-sulfur migration ()
Org. Biomol. Chem., 2017, 15,1776-1779 DOI: 10.1039/C6OB02772E, Communication E. Song, H. Y. Kim, K. Oh A facile access to 3,4-dimercaptofurans was developed by the sulfenylation of [small beta]-chlorovinyl ketones followed by a novel 1,2-sulfur migration. The content of this RSS Feed (c) The Royal Society of Chemistry
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Torsional steering as friend and foe: development of a synthetic route to the briarane diterpenoid stereotetrad ()
Org. Biomol. Chem., 2017, 15,1876-1888 DOI: 10.1039/C7OB00124J, Paper Nicholas G. Moon, Andrew M. Harned Torsional steering controls the formation of the quaternary carbon stereocenter found in the briarane stereotetrad. The content of this RSS Feed (c) The Royal Society of Chemistry
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Total synthesis of (+)-herboxidiene/GEX 1A ()
Org. Biomol. Chem., 2017, 15,1842-1862 DOI: 10.1039/C7OB00072C, Paper Alejandro Gomez-Palomino, Miquel Pellicena, Katrina Kramer, Pedro Romea, Felix Urpi, Gabriel Aullon, Jose M. Padron An efficient synthesis of herboxidiene is granted from highly stereoselective aldol reactions from two lactate-derived ketones and an oxa-Michael cyclization. The content of this RSS Feed (c) The Royal Society of Chemistry
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Imidazo[1,5-a]pyridin-3-ylidenes as [small pi]-accepting carbene ligands: substituent effects on properties of N-heterocyclic carbenes ()
Org. Biomol. Chem., 2017, 15,1810-1820 DOI: 10.1039/C6OB02827F, Paper Yuma Koto, Fumitoshi Shibahara, Toshiaki Murai Imidazo[1,5-a]pyridine-derived NHCs gained strong [small pi]-accepting character due to their structural features. The content of this RSS Feed (c) The Royal Society of Chemistry
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Addition of nitrogen dioxide to carbon-carbon double bond followed by a cyclization to construct nitromethylated isoquinolinediones ()
Org. Biomol. Chem., 2017, 15,1821-1827 DOI: 10.1039/C6OB02797K, Paper Xuanxuan Li, Shengyi Zhuang, Xinxin Fang, Ping Liu, Peipei Sun 4-(Nitromethyl)isoquinoline-1,3(2H,4H)-diones were synthesized via a tandem nitration/cyclization reaction of N-alkyl-N-methacryloyl benzamides using CO2 as the nitro source. The content of this RSS Feed (c) The Royal Society of Chemistry
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Stereoisomers of oseltamivir - synthesis, in silico prediction and biological evaluation ()
Org. Biomol. Chem., 2017, 15,1828-1841 DOI: 10.1039/C6OB02673G, Paper Viktoria Hajzer, Roman Fisera, Attila Latika, Julius Durmis, Jakub Kollar, Vladimir Frecer, Zuzana Tucekova, Stanislav Miertus, Frantisek Kostolansky, Eva Vareckova, Radovan Sebesta Three diastereoisomers of oseltamivir were synthesized, their properties predicted by quantum-chemical calculations and their antiviral activities evaluated. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of tri-functionalized MMP2 FRET probes using a chemo-selective and late-stage modification of unprotected peptides ()
Org. Biomol. Chem., 2017, 15,1792-1800 DOI: 10.1039/C7OB00150A, Paper Sean Oriana, Ye Cai, Jeffrey W. Bode, Yoko Yamakoshi A polymeric FRET probe for the detection of MMP2 was prepared using a new N-hydroxylamine derivative of lysine, which was successfully incorporated into the natural peptide sequence by solid phase peptide synthesis, allowing dual orthogonal ligations of the fully unprotected peptides. The content of this RSS Feed (c) The Royal Society of Chemistry
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First asymmetric total synthesis of aspergillide D ()
Org. Biomol. Chem., 2017, 15,1863-1871 DOI: 10.1039/C6OB02435A, Paper Bighnanshu K. Jena, G. Sudhakar Reddy, Debendra K. Mohapatra The first asymmetric total synthesis of aspergillide D was achieved in a longest linear sequence of 18 steps following Sharpless resolution, Yamaguchi esterification, RCM reaction and Shiina macrolactonization. The content of this RSS Feed (c) The Royal Society of Chemistry
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DNA as an environmental sensor: detection and identification of pesticide contaminants in water with fluorescent nucleobases ()
Org. Biomol. Chem., 2017, 15,1801-1809 DOI: 10.1039/C6OB02830F, Paper Hyukin Kwon, Ke Min Chan, Eric T. Kool Fluorescent chemosensors built on a DNA backbone were able to differentiate micromolar levels of 14 different common pesticides in water. The content of this RSS Feed (c) The Royal Society of Chemistry
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Niobium(V)-catalyzed defluorinative triallylation of [small alpha],[small alpha],[small alpha]-trifluorotoluene derivatives by triple C-F bond activation ()
Org. Biomol. Chem., 2017, 15,1767-1770 DOI: 10.1039/C6OB02825J, Communication Kodai Saito, Taishi Umi, Takayuki Yamada, Takuya Suga, Takahiko Akiyama The conjugation between the carbocation center and the adjacent fluorine atoms worked effectively in the cascade defluorinative triallylation of [small alpha],[small alpha],[small alpha]-trifluorotoluene derivatives. The content of this RSS Feed (c) The Royal Society of Chemistry
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Indium triflate catalysed 3-aza-Cope rearrangement of amino acid derived [small alpha],[small beta]-unsaturated esters to alkylidene oxindoles ()
Org. Biomol. Chem., 2017, 15,1762-1766 DOI: 10.1039/C6OB02419J, Communication M. Srinivas Lavanya Kumar, Sudipta Kumar Manna, Saroj Maji, Gautam Panda The first examples of amino acid derived [small alpha],[small beta]-unsaturated esters to Z-alkylidene oxindoles via 3-aza-Cope rearrangement using In(OTf)3 are reported. The content of this RSS Feed (c) The Royal Society of Chemistry
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Recent advances in reactions of aryl sulfonyl isocyanates ()
Org. Biomol. Chem., 2017, 15,1753-1761 DOI: 10.1039/C6OB02720B, Review Article Dayun Huang, Guobing Yan This review focuses on recent advances in the use of aryl sulfonyl isocyanates in organic synthesis, mainly including three special characteristics. The content of this RSS Feed (c) The Royal Society of Chemistry
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Incorporation of large guest molecules into liposomes via chemical reactions in lipid membranes ()
Org. Biomol. Chem., 2017, 15,1786-1791 DOI: 10.1039/C6OB02343F, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Yuki Tsuchiya, Kouta Sugikawa, Masafumi Ueda, Atsushi Ikeda Stable lipid-membrane-incorporated fullerene derivatives with large substituent(s) were prepared by Diels-Alder reactions in lipid membranes. The content of this RSS Feed (c) The Royal Society of Chemistry
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Acylboranes: synthetic strategies and applications ()
Org. Biomol. Chem., 2017, 15,1738-1752 DOI: 10.1039/C6OB02425D, Review Article Florian Korbinian Scharnagl, Shubhankar Kumar Bose, Todd B. Marder Acylboranes are an attractive class of compounds, of which the synthesis has very recently been documented as summarised in this review. Access to these compounds provides a path to study their properties and reactivity. The content of this RSS Feed (c) The Royal Society of Chemistry
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Ratiometric Electrochemical Detection of Hydrogen Peroxide and Glucose ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00211D, Paper Sean Goggins, Ellen A Apsey, Mary F Mahon, Christopher G Frost Hydrogen peroxide (H2O2) detection is of high importance as it is a versatile (bio)marker whose detection can indicate the presence of explosives, enzyme activity and cell signalling pathways. Herein, we... The content of this RSS Feed (c) The Royal Society of Chemistry
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Transition-metal-free synthesis of 3-(1-pyrrolidinyl)quinolines and 3-(1-pyrrolidinyl)quinoline 1-oxides via one-pot reaction of 3-(1-pyrrolidinyl)crotonates with nitrobenzenes ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C6OB02658C, Paper Robert Bujok, Piotr Cmoch, Zbigniew Wrobel, Krzysztof Wojciechowski A carbanion of tert-butyl 3-(1-pyrrolidinyl)crotonate adds to nitrobenzenes to form [sigma]H-adducts, which in the presence of pivaloyl chloride and triethylamine are converted into 3-(1-pyrrolidinyl)quinolines or 3-(1-pyrrolidinyl)quinoline 1-oxides depending on nitrobenzene... The content of this RSS Feed (c) The Royal Society of Chemistry
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An efficient Sn(II)-catalyzed one-pot synthesis of 3-substituted azetidine-2,4-dione framework[dagger] ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00294G, Paper Gurunath M Suryavanshi, Santosh S. Chavan, anil maruti shelke, Mrudul V. Supekar, Pralhad A. Burate, Bapurao D. Rupanawar A novel Sn(II)-catalyzed tandem cyclization reaction of aromatic aldehydes with ethyl cyanoacetate has been achieved to afford a series of 3-substituted azetidine-2,4-diones in good to excellent yields. This tandem protocol... The content of this RSS Feed (c) The Royal Society of Chemistry
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Iridium Catalyzed Acceptor/Acceptor Carbene Insertion into the N-H Bond in Water Medium ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00177K, Paper Chinnappan Sivasankar, Ramakrishna Kankanala The chemistry of A and D/A carbenes ( D and A are donor and acceptor groups respectively) are known to the great extent in the literature, nevertheless the chemistry of... The content of this RSS Feed (c) The Royal Society of Chemistry
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Gold/Silver-Catalyzed Controllable Regioselective Vinylcarbene Insertion into O-H Bonds ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00338B, Communication Guangyang Xu, Kai Liu, Zhenya Dai, jiangtao sun An unprecedented regioselective metallo-vinylcarbene insertion into O-H bonds has been achieved with the vinyldiazoacetates and 2-pyridones/benzyl alcohols as the ideal substrates, which displayed distinct regioselectivity by employing gold and silver... The content of this RSS Feed (c) The Royal Society of Chemistry
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A 4,5-quinolimide-based fluorescent sensor for the turn-on detection of Cd2+ with live-cell imaging ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00201G, Paper Yu Zhang, Xiangfeng Guo, Mengmeng Zheng, Rui Yang, Hongming Yang, Lihua Jia, Mengmeng Yang The first 4,5-quinolimide sensor, BNA, bearing the amide-DPA receptor, was reported for sensing Cd2+ with live-cell imaging. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Spatial mismatch, non-additive binding energies and selectivity in supramolecular complexes ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C6OB02755E, Review Article Hans-Jorg Schneider A geometric mismatch in supramolecular complexes often leads to deviations from the additivity of binding energies with the consequence of large changes in selectivity and binding mode. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Mg(OMe)2 promoted allylic isomerization of [gamma]-hydroxy-[small alpha],[small beta]-alkenoic esters to synthesize [gamma]-ketone esters ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00131B, Paper Luhao Lai, A-Ni Li, Jiawei Zhou, Yarong Guo, Li Lin, Wei Chen, Rui Wang Herein we report a facile Mg(OMe)2 promoted allylic isomerization to afford [gamma]-keto esters involving an in situ dienolate intermediate. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Characterization of drug encapsulation and retention in archaea-inspired tetraether liposomes ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C6OB02832B, Communication Geoffray Leriche, Jessica L. Cifelli, Kevin C. Sibucao, Joseph P. Patterson, Takaoki Koyanagi, Nathan C. Gianneschi, Jerry Yang Archaea-inspired lipids exhibit reduced membrane permeability and increased retention of hydrophilic drugs in liposomes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of C6[prime or minute][prime or minute]-modified [small alpha]-C-GalCer analogues as mouse and human iNKT cell agonists ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00081B, Paper Joren Guillaume, Toshiyuki Seki, Tine Decruy, Koen Venken, Dirk Elewaut, Moriya Tsuji, Serge Van Calenbergh [small alpha]-GalCer analogues that combine known Th1 polarizing C6[prime or minute][prime or minute]-modifications with a C-glycosidic linkage were synthesized and evaluated as iNKT cell antigens. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Intramolecular Minisci acylation under silver-free neutral conditions for the synthesis of azafluorenones and fluorenones ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00077D, Paper Joydev K. Laha, Ketul V. Patel, Gurudutt Dubey, Krupal P. Jethava An intramolecular Minisci acylation under silver-free neutral conditions providing access to azafluorenones and fluorenones has been developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A photo-degradable supramolecular hydrogel for selective delivery of microRNA into 3D-cultured cells ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C6OB02667B, Paper Zhengquan Zhou, Qikun Yi, Tingting Xia, Wencui Yin, Adnan A. Kadi, Jinbo Li, Yan Zhang A multi-functional supramolecular hydrogel was developed for long-term 3D cell culture, targeted miRNA delivery and easy collection of encapsulated cells. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Discovery of (S)-3[prime or minute]-hydroxyblebbistatin and (S)-3[prime or minute]-aminoblebbistatin: polar myosin II inhibitors with superior research tool properties ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00006E, Paper Sigrid Verhasselt, Bart I. Roman, Olivier De Wever, Kristof Van Hecke, Rik Van Deun, Marc E. Bracke, Christian V. Stevens Chemical optimization of (S)-blebbistatin resulted in the discovery of (S)-3[prime or minute]-hydroxyblebbistatin and (S)-3[prime or minute]-aminoblebbistatin, myosin II inhibitors with superior research tool properties. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Rapid Chemoenzymatic Route to Glutamate Transporter Inhibitor L-TFB-TBOA and Related Amino Acids ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00305F, Communication Haigen Fu, Sabry Younes, Mohammad Saifuddin, Pieter Tepper, Jielin Zhang, Erik Keller, Andre Heeres, Wiktor Szymanski, Gerrit J Poelarends The complex amino acid (L-threo)-3-[3-[4-(trifluoromethyl)benzoylamino] benzyloxy]aspartate (L-TFB-TBOA) and its derivatives are privileged compounds for studying the roles of excitatory amino acid transporters (EAATs) in regulation of glutamatergic neurotransmission, animal behavior,... The content of this RSS Feed (c) The Royal Society of Chemistry
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Divergent Synthesis from Reactions of 2-Trifluoromethyl-1, 3-Conjugated Enynes with N-Acetylated 2-Aminomalonates ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C6OB02749K, Paper Jieru Yang, Xiaofan Zhou, Yu Zeng, Chaoqian Huang, Yuanjing Xiao, Junliang Zhang A simple base mediated reaction of 2-trifluoromethyl-1,3-conjugated enynes with N-acetylated 2-Aminomalonates was developed, which could deliver two distinct types of products depending on substrates, i. e. 4-trifluoromethyl pyrrolidines derivatives, or... The content of this RSS Feed (c) The Royal Society of Chemistry
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Recent Advances in Overman Rearrangement: Synthesis of Natural Products and Valuable Compounds ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C6OB02625G, Review Article Rodney Agustinho Fernandes, Pullaiah Kattanguru, Sachin P Gholap, Dipali Arun Chaudhari In the past decade, the Overman rearrangement, an important C-N bond forming reaction has been intensely used in the synthesis of natural products, synthetic intermediates, building blocks and valuable compounds.... The content of this RSS Feed (c) The Royal Society of Chemistry
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Post-synthetic conversion of 5-pivaloyloxymethyluridine present in a support-bound RNA oligomer into biologically relevant derivatives of 5-methyluridine ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C6OB02674E, Paper Karolina Bartosik, Elzbieta Sochacka, Grazyna Leszczynska A reliable post-synthetic method to access the modified RNA oligomers containing biologically important 5-methyluridines: mnm5U, cmnm5U, [small tau]m5U, nm5U, inm5U and cnm5U. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Copper-Catalyzed Aerobic Oxidative Coupling of o-Phenylenediamines with 2-Aryl/Heteroarylethylamines: Direct Access to Construct Quinoxalines ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00122C, Paper Gopalaiah Kovuru, Anupama Saini, Sankala Naga Chandrudu, Chenna Rao Devarapalli, Harsh Yadav, Binay Kumar A copper-catalyzed oxidative coupling reaction of o-phenylenediamines with 2-aryl/heteroarylethylamines using molecular oxygen as an oxidant has been developed. This novel approach provides a practical and direct access to construct quinoxalines... The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of 2-Aryloxy Butenoates by Copper-Catalysed Allylic C-H Carboxylation of Allyl Aryl Ethers with Carbon Dioxide ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00341B, Paper Atsushi Ueno, Masanori Takimoto, Zhaomin Hou The efficient synthesis of 2-aryloxy-3-butenoic acid esters by the allylic C-H bond carboxylation of allyl aryl ethers with CO2 has been achieved through the deprotonative alumination with an aluminium ate... The content of this RSS Feed (c) The Royal Society of Chemistry
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Structure-Activity Relationships of the ATP cofactor in Ligase-Catalysed Oligonucleotide Polymerisations ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C6OB02792J, Communication Yi Lei, Ryan Hili The T4 DNA ligase-catalysed oligonucleotide polymerisation process has been recently developed to enable the incorporation of multiple functional groups throughout a nucleic acid polymer. T4 DNA ligase requires ATP as... The content of this RSS Feed (c) The Royal Society of Chemistry
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Protecting group free synthesis of glycosyl thiols from reducing sugars in water; application to the production of N-glycan glycoconjugates ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00112F, Communication S. R. Alexander, D. Lim, Z. Amso, M. A. Brimble, A. J. Fairbanks Un-protected 2-acetamido terminated reducing sugars may be converted into the corresponding glycosyl thiols in water, and conjugated to peptides using the thiol-ene click reaction without recourse to any protecting groups. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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One-pot construction of sterically challenging and diverse polyarylphenols via transition-metal-free benzannulation and their potent in vitro antioxidant activity ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00078B, Paper Shizuka Mei Bautista Maezono, Tej Narayan Poudel, Yong Rok Lee One pot novel synthesis of highly functionalized polyarylphenols via benzannulation under transition-metal-free conditions and their antioxidant activities are described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of HU-210 and HU-211 as novel candidate PET tracers ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C6OB02796B, Paper Chiara Zanato, Alessia Pelagalli, Katie F. M. Marwick, Monica Piras, Sergio Dall'Angelo, Andrea Spinaci, Roger G. Pertwee, David J. A. Wyllie, Giles E. Hardingham, Matteo Zanda Prospective PET tracers HU-210F and HU-211F were synthesised and tested as ligands of cannabinoid (CB1 and CB2) and N-methyl D-aspartate (NMDAR) receptors. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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3[prime or minute]-Pyrene-modified unlocked nucleic acids: synthesis, fluorescence properties and a surprising stabilization effect on duplexes and triplexes ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C6OB02773C, Paper Maria Ejlersen, Niels Langkjaer, Jesper Wengel Synthesis of a novel 3[prime or minute]-pyrene-functionalized UNA monomer with unprecedented thermal stabilization of duplexes and triplexes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Catalyst free synthesis of [small alpha]-fluoro-[small beta]-hydroxy ketones/[small alpha]-fluoro-ynols via electrophilic fluorination of tertiary propargyl alcohols using Selectfluor[trade mark sign] (F-TEDA-BF4) ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00140A, Paper Naganaboina Naveen, Rengarajan Balamurugan A facile access to [small alpha]-fluoro-[small beta]-hydroxyketones via electrophilic fluorination. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Biosynthetic 4,6-Dehydratase Gene Deletion: Isolation of a Glucosylated Jadomycin Natural Product Provides Insight into the Substrate Specificity of Glycosyltransferase JadS ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00259A, Communication Stephanie M. Forget, Jungwook Na, Nicole E McCormick, David L Jakeman Deletion of the biosynthetic 4,6-dehydratase gene, jadT, present in the angucycline jadomycin dideoxysugar biosynthetic pathway, led to the isolation of a novel C12 glucosylated jadomycin. JadS was identified as the... The content of this RSS Feed (c) The Royal Society of Chemistry
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Cobalt salt-catalyzed carbocyclization reactions of [small alpha]-bromo-N-phenylacetamide derivatives ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00009J, Paper Yi-Chen Cheng, Ying-Yu Chen, Che-Ping Chuang A Co(II)-catalyzed carbocyclization reaction for the synthesis of 4-substituted quinolin-2-(1H)-ones is described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Amphipathic guanidine-embedded glyoxamide-based peptidomimetics as novel antibacterial agents and biofilm disruptors ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00053G, Paper Shashidhar Nizalapur, Onder Kimyon, Eugene Yee, Kitty Ho, Thomas Berry, Mike Manefield, Charles G. Cranfield, Mark Willcox, David StC Black, Naresh Kumar Novel antibacterial peptidomimetics that inhibit the growth of planktonic cells and reduce biofilm formation in both Gram-positive and Gram-negative bacteria. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of perfluoroalkylated pentacenes and evaluation of their fundamental physical properties ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00043J, Paper Shigeyuki Yamada, Keita Kinoshita, Shota Iwama, Takashi Yamazaki, Toshio Kubota, Tomoko Yajima, Kyoko Yamamoto, Shinya Tahara Symmetrical and unsymmetrical pentacenes carrying two perfluoroalkyl (Rf) chains at 6 and 13 position were synthesized from easily available pentacene-6,13-quinone via facile three or four step reactions. After their extensive... The content of this RSS Feed (c) The Royal Society of Chemistry
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Computational studies on the cyclization of squalene to the steroids and hopenes ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00222J, Review Article B. Andes Hess A review of computational studies of the related biosyntheses of steroids and hopenes reported during the last two decades is presented. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A stereoselective synthesis of (E)- or (Z)-[small beta]-arylvinyl halides via a borylative coupling/halodeborylation protocol ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00054E, Paper Jakub Szyling, Adrian Franczyk, Piotr Pawluc, Bogdan Marciniec, Jedrzej Walkowiak A new highly selective method for the synthesis of (E)-arylvinyl iodides and (E)- or (Z)-[small beta]-arylvinyl bromides from easily accessible styrenes and vinyl boronates, on the basis of a one-pot procedure via borylative coupling/halodeborylation is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Enantioselective synthesis of spiro [gamma]-butyrolactones by N-heterocyclic carbene (NHC)-catalyzed formal [3 + 2] annulation of enals with 3-hydroxy oxindoles ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00148G, Paper Subrata Mukherjee, Sumi Joseph, Anup Bhunia, Rajesh G. Gonnade, Santhivardhana Reddy Yetra, Akkattu T. Biju The NHC-catalyzed enantioselective, oxidative formal [3 + 2] annulation of [small alpha],[small beta]-unsaturated aldehydes with 3-hydroxy oxindoles is presented. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Correction: Self-assembled 4-(1,2-diphenylbut-1-en-1-yl)aniline based nanoparticles: podophyllotoxin and aloin as building blocks ()
Org. Biomol. Chem., 2017, 15,1725-1725 DOI: 10.1039/C7OB90018J, Correction Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Gaia Fumagalli, Michael S. Christodoulou, Benedetta Riva, Inigo Revuelta, Cristina Marucci, Veronica Collico, Davide Prosperi, Sergio Riva, Dario Perdicchia, Ivan Bassanini, Aida Garcia-Argaez, Lisa Dalla Via, Daniele Passarella The content of this RSS Feed (c) The Royal Society of Chemistry
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Glyco-functionalized dinuclear rhenium(I) complexes for cell imaging ()
Org. Biomol. Chem., 2017, 15,1686-1699 DOI: 10.1039/C6OB02559E, Paper Alessandro Palmioli, Alessandro Aliprandi, Dedy Septiadi, Matteo Mauro, Anna Bernardi, Luisa De Cola, Monica Panigati New luminescent glycosilated rhenium complexes were synthesized and evaluated as dyes for optical imaging. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of aminopyrazoles from sydnones and ynamides ()
Org. Biomol. Chem., 2017, 15,1575-1579 DOI: 10.1039/C6OB02518H, Communication T. Wezeman, J. Comas-Barcelo, M. Nieger, J. P. A. Harrity, S. Brase Both copper-catalyzed and strain-mediated cycloadditions between ynamides and sydnones allow for a novel synthetic access to aminopyrazoles. The content of this RSS Feed (c) The Royal Society of Chemistry
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Chiral GAP catalysts of phosphonylated imidazolidinones and their applications in asymmetric Diels-Alder and Friedel-Crafts reactions ()
Org. Biomol. Chem., 2017, 15,1718-1724 DOI: 10.1039/C6OB02801B, Paper Shuo Qiao, Junming Mo, Cody B. Wilcox, Bo Jiang, Guigen Li Chiral recoverable/re-usable GAP catalysts based on phosphonylated imidazolidinones have been designed, synthesized and applied for asymmetric Diels-Alder and Friedel-Crafts reactions. The content of this RSS Feed (c) The Royal Society of Chemistry
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Stereocontrolled semi-syntheses of deguelin and tephrosin ()
Org. Biomol. Chem., 2017, 15,1593-1596 DOI: 10.1039/C6OB02659A, Communication David A. Russell, Julien J. Freudenreich, Joe J. Ciardiello, Hannah F. Sore, David R. Spring We describe stereocontrolled semi-syntheses of deguelin and tephrosin, anti-cancer rotenoids isolated from Tephrosia vogelii. The content of this RSS Feed (c) The Royal Society of Chemistry
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Gold(I)-catalyzed addition of carboxylic acids to internal alkynes in aqueous medium ()
Org. Biomol. Chem., 2017, 15,1670-1679 DOI: 10.1039/C6OB02800D, Paper Pedro J. Gonzalez-Liste, Sergio E. Garcia-Garrido, Victorio Cadierno A broad scope catalytic system for the intermolecular addition of carboxylic acids to internal alkynes, in water under mild conditions, has been developed. The content of this RSS Feed (c) The Royal Society of Chemistry
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Divergent response of homologous ATP sites to stereospecific ligand fluorination for selectivity enhancement ()
Org. Biomol. Chem., 2017, 15,1570-1574 DOI: 10.1039/C7OB00129K, Communication Alpesh Ramanlal Patel, Ari Hardianto, Shoba Ranganathan, Fei Liu Enhanced selectivity for homologous ATP sites by composite chemical and conformational perturbation by stereospecific fluorination. The content of this RSS Feed (c) The Royal Society of Chemistry
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SuFEx: a metal-free click ligation for multivalent biomolecules ()
Org. Biomol. Chem., 2017, 15,1549-1553 DOI: 10.1039/C6OB02458K, Perspective Alessandro Dondoni, Alberto Marra Sulfonamide-linked glycoclusters and sulfamate-linked BSA-PEG were prepared by coupling a sugar sulfonyl fluoride with a calixarene tetra-amine and a PEG-fluorosulfate with native bovine serum albumin, respectively. The content of this RSS Feed (c) The Royal Society of Chemistry
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CBr4 promoted intramolecular aerobic oxidative dehydrogenative arylation of aldehydes: application in the synthesis of xanthones and fluorenones ()
Org. Biomol. Chem., 2017, 15,1589-1592 DOI: 10.1039/C7OB00080D, Communication Jing Tang, Shijun Zhao, Yuanyuan Wei, Zhengjun Quan, Congde Huo A carbon tetrabromide promoted intramolecular aerobic oxidative dehydrogenative coupling reaction has been developed to provide a straightforward ring closure protocol to furnish xanthones and fluorenones. The content of this RSS Feed (c) The Royal Society of Chemistry
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Converting Pasteurella multocida [small alpha]2-3-sialyltransferase 1 (PmST1) to a regioselective [small alpha]2-6-sialyltransferase by saturation mutagenesis and regioselective screening ()
Org. Biomol. Chem., 2017, 15,1700-1709 DOI: 10.1039/C6OB02702D, Paper John B. McArthur, Hai Yu, Jie Zeng, Xi Chen A sialyltransferase mutant for selectively [small alpha]2-6-sialylating terminal galactose in polyLacNAc-glycan was identified using a novel microtiter plate-based screening assay. The content of this RSS Feed (c) The Royal Society of Chemistry
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Iterative direct C(sp3)-H functionalization of amines: diastereoselective divergent syntheses of [small alpha],[small alpha][prime or minute]-disubstituted alicyclic amines ()
Org. Biomol. Chem., 2017, 15,1655-1660 DOI: 10.1039/C6OB02257J, Paper Sujit Mahato, Chandan K. Jana Facile access to the syn-[small alpha],[small alpha][prime or minute]-disubstituted N-heterocycles via iterative C-H oxygenation and C-C bond formation. The content of this RSS Feed (c) The Royal Society of Chemistry
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Double-stranded RNA-binding artificial cationic oligosaccharides stabilizing siRNAs with a low N/P ratio ()
Org. Biomol. Chem., 2017, 15,1710-1717 DOI: 10.1039/C6OB02690G, Paper Rintaro Iwata Hara, Yusuke Maeda, Taiichi Sakamoto, Takeshi Wada Novel double-stranded RNA (dsRNA)-binding molecules were developed for the effective thermodynamic and biological stabilization of nucleic acids including short interfering RNAs (siRNAs). The content of this RSS Feed (c) The Royal Society of Chemistry
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A red-NIR emissive probe for the selective detection of albumin in urine samples and live cells ()
Org. Biomol. Chem., 2017, 15,1584-1588 DOI: 10.1039/C6OB02760A, Communication K. Rajasekhar, Chaithra J. Achar, Thimmaiah Govindaraju A red-NIR fluorescence probe (TG-SA) has been designed, synthesised and its utility is demonstrated for staining human serum albumin (HSA) in gel electrophoresis, quantification of HSA in clinical urine samples and monitoring serum albumin homeostasis in live cells. The content of this RSS Feed (c) The Royal Society of Chemistry
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Chiral discrimination of [small alpha]-hydroxy acids and N-Ts-[small alpha]-amino acids induced by tetraaza macrocyclic chiral solvating agents by using 1H NMR spectroscopy ()
Org. Biomol. Chem., 2017, 15,1642-1650 DOI: 10.1039/C6OB02578A, Paper Caixia Lv, Lei Feng, Hongmei Zhao, Guo Wang, Pericles Stavropoulos, Lin Ai Several [small alpha]-hydroxy acids and N-Ts-[small alpha]-amino acids were effectively discriminated in the presence of tetraaza macrocyclic chiral solvating agents (TAMCSAs) 1a-1d by 1H NMR spectroscopy. The content of this RSS Feed (c) The Royal Society of Chemistry
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Redox reaction between benzyl azides and aryl azides: concerted synthesis of aryl nitriles and anilines ()
Org. Biomol. Chem., 2017, 15,1636-1641 DOI: 10.1039/C6OB02615J, Paper Yongjin Kim, Young Ho Rhee, Jaiwook Park A unique and novel reaction between benzyl azides and aryl azides is described to synthesize aryl nitriles and anilines concurrently, which is catalyzed with a photoactivated diruthenium complex. The content of this RSS Feed (c) The Royal Society of Chemistry
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Palladium-catalyzed carbonylative synthesis of isocoumarins and phthalides by using phenyl formate as a carbon monoxide source ()
Org. Biomol. Chem., 2017, 15,1628-1635 DOI: 10.1039/C6OB02409B, Paper Qing Yuan, Zhen-Bang Chen, Fang-Ling Zhang, Yong-Ming Zhu An efficient palladium-catalyzed carbonylative synthesis of isocoumarins and phthalides by employing phenyl formate as a CO surrogate has been developed. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthetic minimalistic tryptophan zippers as a chiroptical switch ()
Org. Biomol. Chem., 2017, 15,1661-1669 DOI: 10.1039/C6OB02617F, Paper V. Haridas, Sandhya Sadanandan, Sameer Dhawan, Rituraj Mishra, Ishani Jain, Gaurav Goel, Yuan Hu, Sandeep Patel Supramolecular helices with left and right handed chirality were designed and synthesized based on L-tryptophan that undergo helical inversion upon addition of H2PO4-. The content of this RSS Feed (c) The Royal Society of Chemistry
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Silver-mediated radical coupling reaction of isocyanides and alcohols/phenols in the presence of water: unprecedented hydration and radical coupling reaction sequence ()
Org. Biomol. Chem., 2017, 15,1580-1583 DOI: 10.1039/C7OB00019G, Communication Lin Zhang, Pin Xiao, Xiaoxue Guan, Zhouliang Huang, Jingping Zhang, Xihe Bi The first radical coupling of isocyanides and alcohols/phenols promoted by silver in the presence of water is reported. The content of this RSS Feed (c) The Royal Society of Chemistry
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Transfer of axial chirality through the nickel-catalysed hydrocyanation of chiral allenes ()
Org. Biomol. Chem., 2017, 15,1612-1617 DOI: 10.1039/C7OB00047B, Paper Yuka Amako, Shigeru Arai, Atsushi Nishida The transfer of axial chirality of allenes is beginning to be exploited as a powerful method for creating central chirality, particularly through the use of transition metal catalysis. The content of this RSS Feed (c) The Royal Society of Chemistry
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Iodine-catalyzed direct C-H thiolation of imidazo[1,5-a]quinolines for the synthesis of 3-sulfenylimidazo[1,5-a]quinolines ()
Org. Biomol. Chem., 2017, 15,1680-1685 DOI: 10.1039/C6OB02736A, Paper Song-Song Wu, Cheng-Tao Feng, Di Hu, Ye-Kai Huang, Zhong Li, Zai-Gang Luo, Shi-Tang Ma An iodine-catalyzed regioselective sulfenylation of imidazo[1,5-a]quinolines was developed under metal- and oxidant-free reaction conditions. The content of this RSS Feed (c) The Royal Society of Chemistry
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N-Iodosuccinimide involved one-pot metal-free synthesis of 2-heteroaromatic benzothiazole compounds ()
Org. Biomol. Chem., 2017, 15,1606-1611 DOI: 10.1039/C6OB02731H, Paper Xianglong Chu, Tiantian Duan, Xuan Liu, Lei Feng, Jiong Jia, Chen Ma A metal-free and operationally simple protocol for the synthesis of structurally diverse 2-hetarylbenzothiazoles via oxidative condensation of the sp3 C-H bond with benzothiazoles has been described. The content of this RSS Feed (c) The Royal Society of Chemistry
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A molecular electron density theory study of the [3 + 2] cycloaddition reaction of nitrones with ketenes ()
Org. Biomol. Chem., 2017, 15,1618-1627 DOI: 10.1039/C6OB02768G, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Mar Rios-Gutierrez, Andrea Daru, Tomas Tejero, Luis R. Domingo, Pedro Merino The zw-type 32CA reactions of nitrones with ketenes are controlled by the nucleophilic character of the nitrone and the electrophilic character of the ketene. They are chemo- and regio-selective and the use of electrophilic ketenes changes the mechanism from one-step to two-step. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of fused indoline heterocycles via dearomatization of indoles with [small alpha]-bromohydrazones: a systematic study on the substrates ()
Org. Biomol. Chem., 2017, 15,1651-1654 DOI: 10.1039/C6OB02362B, Paper Wen-Bin Cao, Xiao-Ping Xu, Shun-Jun Ji An efficient metal-free dearomatization of indoles with [small alpha]-bromohydrazones is reported. Various fused indoline heterocycles, which are potentially biologically active, were achieved in good yields (up to 94%) under mild conditions. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and characterization of photoaffinity labelling reagents towards the Hsp90 C-terminal domain ()
Org. Biomol. Chem., 2017, 15,1597-1605 DOI: 10.1039/C6OB02097F, Paper Binto Simon, Xuexia Huang, Huangxian Ju, Guoxuan Sun, Min Yang The synthesis of diazirine type photoaffinity labelling reagents to probe the Hsp90 C-terminal domain binding pocket and the structure-activity relationship. The structure illustrates probe positions only. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synergy between experimental and computational studies of aromatic stacking interactions ()
Org. Biomol. Chem., 2017, 15,1554-1564 DOI: 10.1039/C6OB01985D, Review Article Jung wun Hwang, Ping Li, Ken D. Shimizu This review highlights the synergetic exchange of ideas and results between experimental and theoretical chemists en route to the better understanding of aromatic stacking interactions. The content of this RSS Feed (c) The Royal Society of Chemistry
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Lipid-membrane-incorporated arylboronate esters as agents for boron neutron capture therapy ()
Org. Biomol. Chem., 2017, 15,1565-1569 DOI: 10.1039/C6OB02142E, Communication Masafumi Ueda, Kengo Ashizawa, Kouta Sugikawa, Kazuya Koumoto, Takeshi Nagasaki, Atsushi Ikeda An arylboronate ester bearing a methyl group at both of its ortho positions was stably incorporated into lipid membranes at high concentrations without hydrolysis. The content of this RSS Feed (c) The Royal Society of Chemistry
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Correction: Synthesis and immunological evaluation of MUC1 glycopeptide conjugates bearing N-acetyl modified STn derivatives as anticancer vaccines ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB90028G, Correction Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. An Xiao, Xiu-Jing Zheng, Chengcheng Song, Yue Gui, Chang-Xin Huo, Xin-Shan Ye To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Broad Scope Gold(I)-Catalysed Polyenyne Cyclisations for the Formation of up to Four Carbon-Carbon Bonds ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00235A, Communication Zhouting Rong, Antonio M. Echavarren The cyclisation of 1,5-enynes containing alkenes, arenes, heteroarenes, and hydroxyl groups to form polycyclic compounds has been achieved with a cationic dicyclohexylphosphinobiphenyl gold(I) complex as catalyst under mild conditions and... The content of this RSS Feed (c) The Royal Society of Chemistry
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Eight at one stroke - a synthetic tetra-disulfide peptide epitope ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C6OB02746F, Paper Andreas Schrimpf, Uwe Linne, Armin Geyer A tetra-disulfide peptide dimer, representing an antiparallel hinge, is synthesised without the need for orthogonal cysteine protecting groups. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Diastereoselective synthesis of tetrahydropyrans via Prins-Ritter and Prins-arylthiolation cyclization reactions ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C6OB02692C, Paper Nabajyoti Hazarika, Barnali Sarmah, Manobjyoti Bordoloi, Prodeep Phukan, Gakul Baishya Highly diastereoselective Prins-Ritter and Prins-arylthiolation cyclization reactions have been developed for the synthesis of two novel classes of tetrahydropyran derivatives. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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One-pot synthesis of ɑ,[small beta]-epoxy ketones through domino reaction between alkenes and aldehydes catalyzed by proline based chiral organocatalysts ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00031F, Paper Veeramanoharan Ashokkumar, Siva Ayyanar A proline based metal free organocatalysts developed by new approach for the synthesis of epoxide derivatives through domino reaction. This domino reaction (oxidative coupling) allows the direct access to epoxides... The content of this RSS Feed (c) The Royal Society of Chemistry
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