Organic & Biomolecular Chemistry

A one-pot synthesis of 2,2'-disubstituted diindolylmethanes (DIMs) via a sequential Sonogashira coupling and cycloisomerization/C3-functionalization of 2-iodolanilines ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01701D, Paper Anirban Kayet, Vinod Singh A Pd(II)-Ag(I) catalyzed highly efficient synthesis of diindolylmethane has been developed. This transformation consists of a one pot sequential Sonogashira coupling (and desilylation) followed by cycloisomerization/C3-functionalization of 2‑iodoanilines. Six new... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Synthesis and Conformational Analysis of Peptides Embodying 2,3-Methanopipecolic Acids ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01617D, Paper Luciano Ricci, Lorenzo Sernissi, Dina Scarpi, Francesca Bianchini, Alessandro Contini, Ernesto Giovanni Occhiato The conformational analysis of linear and cyclic peptides incorporating 2,3-methanopipecolic acids (or Cyclopropane Pipecolic Acids, CPAs) as conformationally constrained [small alpha]-amino acids is reported. Compared to peptides containing proline or pipecolic... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Metal-Free Radical Aromatic Carbonylations Mediated by Very Weak Bases ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01572K, Communication Axel Jacobi von Wangelin, Denis Koziakov We report a new method of metal-free alkoxycarbonylation. This reaction involves the generation of aryl radicals from arenediazonium salts by a very weak base (HCO2Na) under mild conditions. Subsequent radical... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Synthesis of Dibenzo[a,c]carbazoles from 2-(2-Halophenyl)-indoles and Iodobenzenes via Palladium-Catalyzed Dual C-H Functionalization ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01638G, Paper Lijun Wu, Guobo Deng, Yun Liang An efficient palladium-catalyzed strategy for the synthesis of dibenzo[a,c]carbazole derivatives has been developed. In the presence of Pd(OAc)2, 2-(2-halophenyl)-indoles and iodobenzenes proceeded smoothly to obtain the corresponding dibenzo[a,c]carbazoles in moderate... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Effect of spermine-derived AGEs on oxidative stress and polyamine metabolism ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01346A, Communication Ayumi Tsutsui, Ambara R. Pradipta, Shinobu Kitazume, Naoyuki Taniguchi, Katsunori Tanaka Non-enzymatic glycation between proteins and carbohydrates, such as advanced glycation end products (AGEs), are naturally occuring compounds implicated in aging and numerous degenerative diseases. Methyl glyoxal (MG), which is an... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Fluorescent probes for hydrogen polysulfides (H2Sn, n>1): from design rationale to applications ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01615H, Review Article Neha Gupta, Shahi Imam Reja, Vandana Bhalla, Manoj Kumar Hydrogen polysulfides (H2Sn, n>1) being active members of reactive sulphur species family are gaining much research interest these days due to their involvement in signal transduction, anti-cancer activity and cytoprotection.... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Insights into the role of 3-O-sulfotransferase in Heparan Sulfate biosynthesis ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01533J, Paper Maria CZ Meneghetti, Tarsis Gesteira, Alexandre K. Tashima, Suely Chavante, Edwin Yates, Jian Liu, Helena B Nader, Marcelo A Lima 3-O-sulfotransferase enzyme (sHS) from Litopeneaus vannamei was cloned and its substrate specificity was investigated against a number of GAG structures, including modified heparin polysaccharides and model oligosaccharides. For the heparin... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Palladium-catalyzed decarboxylative, decarbonylative and dehydrogenative C(sp2)-H acylation at room temperature ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01466J, Paper Asik Hossian, Manash Kumar Manna, Kartic Manna, Ranjan Jana A practical and environmentally benign protocol for C(sp2)-H acylation at room temperature has been achieved via entropically favourable decarboxylative, decarbonylative and cross-dehydrogenative manifolds. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Synthesis of 3-acylindoles by oxidative rearrangement of 2-aminochalcones using a hypervalent iodine reagent and cyclization sequence ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01536D, Communication Akira Nakamura, Satoshi Tanaka, Akira Imamiya, Reo Takane, Chiaki Ohta, Kazuma Fujimura, Tomohiro Maegawa, Yasuyoshi Miki An efficient one-pot 3-acylindole synthesis by oxidative rearrangement of 2-aminochalcones and sequential cyclization has been developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

The mechanism and regioselectivities of (NHC)nickel(II)hydride-catalyzed cycloisomerization of dienes: a computational study ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01494E, Paper Yuan Gao, K. N. Houk, Chun-Yu Ho, Xin Hong Computation elucidates the mechanism and origins of regioselectivity of (NHC)Ni(II)hydride-catalyzed cycloisomerization of dienes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Ring strain-dictated divergent fluorinating Prins cyclization or semipinacol rearrangement ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01567D, Communication Yi Liu, Ying-Yeung Yeung We have developed ring-strain dictated divergent diastereoselective fluorinating Prins cyclizations or semipinacol rearrangements to access a range of tetrahydropyran derivatives. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Degradable polyesters via ring-opening polymerization of functional valerolactones for efficient gene delivery ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00822H, Paper Ling Song, Ai-Xiang Ding, Ke-Xin Zhang, Bing Gong, Zhong-Lin Lu, Lan He Degradable polymers as gene and drug carriers are emerging as one of the most promising types of materials in the biomedical and pharmaceutical areas. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

A copper-templated, bifunctional organocatalyst: a strongly cooperative dynamic system for the aldol reaction ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01370A, Paper Anna Serra-Pont, Ignacio Alfonso, Jordi Sola, Ciril Jimeno A copper-templated bifunctional organocatalyst delivers aldol adducts in high yields and stereoselectivities. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Excited-state intermolecular proton transfer dependent on the substitution pattern of anthracene-diurea compounds involved in fluorescent ON1-OFF-ON2 response by the addition of acetate ions ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01376K, Paper Hisato Matsumoto, Yoshinobu Nishimura, Tatsuo Arai Anthracene-diurea compounds exhibit different excited-state intermolecular proton transfer (ESIPT) reactions depending on the pattern of the substituents. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Total synthesis of (-)-kainic acid and (+)-allo-kainic acid through SmI2-mediated intramolecular coupling between allyl chloride and an [small alpha],[small beta]-unsaturated ester ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01427A, Paper Junya Suzuki, Natsumi Miyano, Shunpei Yashiro, Taiki Umezawa, Fuyuhiko Matsuda A 3,4-disubsituted pyrrolidine ring was effectively cyclized through SmI2-mediated reductive coupling between allyl chloride and an [small alpha],[small beta]-unsaturated ester. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Nickel-Catalyzed N-Vinylation of Heteroaromatic amines via C-H bond Activation ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01791J, Communication Vinod Gokulkrishna Landge, Jagannath Rana, Murugan Subaramanian, Balaraman Ekambaram Here, we report a ligand- and reductant-free nickel-catalyzed N-Vinylation of heteroaromatic amines using biorenewable p-cymene as a solvent. This unprecedented cross-coupling strategy has high functional group tolerance (halides, alkoxy, cyano,... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Molecular dynamics simulations reveal disruptive self-assembly in dynamic peptide libraries ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01268C, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. I. R. Sasselli, I. P. Moreira, R. V. Ulijn, T. Tuttle Coarse grained molecular dynamic simulations demonstrate that interactions between species in dynamic peptide libraries can cause a disrupting self-assembly effect that affects the possible discovery of new materials. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Organocatalytic condensation-ring opening-annulation cascade reactions between N-Bocindolin-2-ones/benzofuran-2(3H)-ones and salicylaldehydes for synthesis of 3-arylcoumarins ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01730H, Communication Yuyu Cheng, Pengfei Zhang, Yanwen Jia, Zhiqiang Fang, Pengfei Li An organocatalytic cascade systhesis of 3-arylcoumarins has been developed. Mediated by 1,8-Diazabicyclo[5,4,0]-undec-7-ene or tetramethylguanidine, a number of 3-arylcoumarins were obtained in good to excellent yields via condensation-ring opening-annulation between N-Bocindolin-2-ones/benzofuran-2(3H)-ones... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Phenothiazine-linked Nucleosides and Nucleotides for Redox Labelling of DNA ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01439B, Paper Anna Simonova, Ludek Havran, Radek Pohl, Miroslav Fojta, Michal Hocek Nucleosides and 2'-deoxyribonucleoside triphosphates (dNTPs) bearing phenothiazine (PT) attached to nucleobase (cytosine or 7-deazaadenine) either directly or through acetylene linker were prepared through the Suzuki or Sonogashira cross-coupling and triphosphorylation... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Complexation of sesquiterpene lactones with cyclodextrins: synthesis and effects on their activities on parasitic weeds ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01394A, Paper Antonio Cala, Jose M. G. Molinillo, Monica Fernandez-Aparicio, Jesus Ayuso, Jose A. Alvarez, Diego Rubiales, Francisco A. Macias Cyclodextrin complexes were prepared by the kneading and coprecipitation methods; then theoretical complexes were calculated and different bioassays were carried out. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Drug design based on pentaerythritol tetranitrate reductase: synthesis and antibacterial activity of Pogostone derivatives ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01429E, Paper Biao Wang, Wei Huang, Jin Zhou, Xue Tang, Yang Chen, Cheng Peng, Bo Han We performed molecular docking studies of Pogostone with PETNR and analyzed structure-activity relationships, which guided the structure design and the subsequent facile organocatalytic synthesis of Pogostone derivatives. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Stereoselective synthesis of conformationally restricted KOR agonists based on the 2,5-diazabicyclo[2.2.2]octane scaffold ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01530E, Paper Christian Wittig, Dirk Schepmann, Michael Soeberdt, Constantin G. Daniliuc, Bernhard Wunsch A Dieckmann analogous cyclization represents the key step in the synthesis of bicyclic KOR agonists with high KOR affinity and agonistic activity. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Protein-induced fluorescence enhancement of two-photon excitable water-soluble diketopyrrolopyrroles ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01397C, Paper Simon Tang, Ebrahim H. Ghazvini Zadeh, Bosung Kim, Nikia T. Toomey, Mykhailo V. Bondar, Kevin D. Belfield Water soluble diketopyrrolopyrrole one- and two-photon fluorescent probes were prepared in high yield exhibiting fluorescence switch-on upon protein binding. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Facile synthesis of benzo[b]thiophenes via metal-free radical-triggered intramolecular C-S bond formation ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01515A, Paper Wei Fan, Kwong-Yuen Chen, Qi-Peng Chen, Guigen Li, Bo Jiang A facile method for the synthesis of benzo[b]thiophenes with good to excellent yields via metal-free intramolecular C-S bond formation has been developed by utilizing I2 as a catalyst and O2 from air as an oxidant (20 examples). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

The synthesis of polysubstituted indoles from 3-bromo-2-indolyl phosphates ()
Org. Biomol. Chem., 2017, 15,6233-6241 DOI: 10.1039/C7OB01127J, Paper Peter Polak, Tomas Tobrman A novel methodology for the synthesis of functionalised indoles based on the cross-coupling reactions of 3-bromo-2-indolyl phosphates is described. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

C-ON bond homolysis of alkoxyamines: when too high polarity is detrimental ()
Org. Biomol. Chem., 2017, 15,6167-6176 DOI: 10.1039/C7OB01312D, Paper Paulin Nkolo, Gerard Audran, Raphael Bikanga, Paul Bremond, Sylvain R. A. Marque, Valerie Roubaud In this article, previous multi-parameter linear relationships are amended using a parabolic model to describe the effect of EWGs in the alkyl fragment of alkoxyamines on the homolysis rate constant kd. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

2-Nitroimidazole based fluorescent probes for nitroreductase; monitoring reductive stress in cellulo ()
Org. Biomol. Chem., 2017, 15,6104-6108 DOI: 10.1039/C7OB01406F, Communication X. Ao, S. A. Bright, N. C. Taylor, R. B. P. Elmes Two 2-nitroimidazole-1,8-naphthalimide conjugates, 1 and 2, have been synthesised as fluorescence probes for the detection of reductive stress in HeLa cells. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Pd-Catalyzed regioselective C-H halogenation of quinazolinones and benzoxazinones ()
Org. Biomol. Chem., 2017, 15,6264-6268 DOI: 10.1039/C7OB01534H, Paper Minoo Dabiri, Noushin Farajinia Lehi, Siyavash Kazemi Movahed, Hamid Reza Khavasi A Pd-catalyzed ortho-selective halogenation of benzoxazinone and quinazolinone scaffolds has been described employing N-halosuccinimide via C-H bond activation. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Strategy towards the enantioselective synthesis of schiglautone A ()
Org. Biomol. Chem., 2017, 15,6242-6256 DOI: 10.1039/C7OB00766C, Paper Camille Le Chapelain The enantioselective synthesis of a functionalized intermediate comprising 6 of the 7 stereocenters of schiglautone A is reported and features a lithiation-borylation enzymatic resolution sequence. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Synthesis of trifluoromethylated pyrazolidines by [3 + 2] cycloaddition ()
Org. Biomol. Chem., 2017, 15,6214-6222 DOI: 10.1039/C7OB01299C, Paper Xiansha Peng, Danfeng Huang, Ke-Hu Wang, Yalin Wang, Juanjuan Wang, Yingpeng Su, Yulai Hu [3 + 2] cycloaddition between trifluoromethylated N-acylhydrazones and nitroolefins in the presence of potassium hydroxide and Bu4NI is developed to afford potentially bioactive trifluoromethylated pyrazolidines. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Synthesis and biological evaluation of the ascidian blood-pigment halocyamine A ()
Org. Biomol. Chem., 2017, 15,6194-6204 DOI: 10.1039/C7OB01122A, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Hugo K. H. Fong, Jean Michel Brunel, Arlette Longeon, Marie-Lise Bourguet-Kondracki, David Barker, Brent R. Copp The first synthesis of the (Z)-indolic enamide-containing antibacterial marine natural product halocyamine A is reported. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Selective synthesis of nitrogen bi-heteroarenes by a hydrogen transfer-mediated direct [small alpha],[small beta]-coupling reaction ()
Org. Biomol. Chem., 2017, 15,6093-6097 DOI: 10.1039/C7OB01434A, Communication Xiu-Wen Chen, He Zhao, Biao Xiong, Huan-Feng Jiang, Pierre. H. Dixneuf, Min Zhang By an external hydrogen transfer-mediated activation mode, a new palladium-catalyzed [small alpha],[small beta]-coupling of different types of N-heteroarenes, enabling direct access to nitrogen bi-heteroarenes, has been demonstrated. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Self-assembly of porphyrin-DNA hybrids into large flat nanostructures ()
Org. Biomol. Chem., 2017, 15,6257-6263 DOI: 10.1039/C7OB01267E, Paper G. Chatelain, G. Clave, C. Saint-Pierre, D. Gasparutto, S. Campidelli Two complementary 21-mer oligonucleotide/porphyrin hybrids were synthesized and assembled into nanostructures. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Chiral squaramide-catalysed enantioselective Michael/cyclization cascade reaction of 3-hydroxyoxindoles with [small alpha],[small beta]-unsaturated N-acylated succinimides ()
Org. Biomol. Chem., 2017, 15,6205-6213 DOI: 10.1039/C7OB01307H, Paper Sheng Ming, Bo-Liang Zhao, Da-Ming Du A squaramide-catalysed asymmetric Michael/cyclization cascade reaction of 3-hydroxyoxindoles with [small alpha],[small beta]-unsaturated N-acylated succinimides afforded spirooxindole lactones in good yields with high stereoselectivities. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

DDQ-promoted direct C5-alkylation of oxazoles with alkylboronic acids via palladium-catalysed C-H bond activation ()
Org. Biomol. Chem., 2017, 15,6084-6088 DOI: 10.1039/C7OB01083D, Communication Bowen Lei, Xiaojiao Wang, Lifang Ma, Huixuan Jiao, Lisi Zhu, Ziyuan Li The first protocol for the direct C5-alkylation of oxazoles through transition-metal-catalysed C(5)-H bond activation. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Mechanism of Pd-catalyzed acylation/alkenylation of aryl iodide: a DFT study ()
Org. Biomol. Chem., 2017, 15,6147-6156 DOI: 10.1039/C7OB01021D, Paper Yujie Liang, Yuan-Ye Jiang, Yuxia Liu, Siwei Bi The detailed mechanism of the Pd(0)-catalyzed cross-coupling of aryl iodide, benzoic anhydride and ethyl acrylate was clarified by theoretical methods. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Borata-Wittig olefination reactions of ketones, carboxylic esters and amides with bis(pentafluorophenyl)borata-alkene reagents ()
Org. Biomol. Chem., 2017, 15,6223-6232 DOI: 10.1039/C7OB01591G, Paper Tongdao Wang, Sonja Kohrt, Constantin G. Daniliuc, Gerald Kehr, Gerhard Erker Borata-alkenes containing the [double bond, length as m-dash]B(C6F5)2 unit are employed in borata-Wittig olefination reactions. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Synthesis of pyrrolidine-3-carboxylic acid derivatives via asymmetric Michael addition reactions of carboxylate-substituted enones ()
Org. Biomol. Chem., 2017, 15,6089-6092 DOI: 10.1039/C7OB01484H, Communication Feng Yin, Ainash Garifullina, Fujie Tanaka An enantioselective Michael addition reaction system was developed. Using the reaction system, 5-methylpyrrolidine-3-carboxylic acid was synthesized in two steps. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Copper-catalyzed synthesis of indolyl diketones via C-H oxidation/diacylation of indoles with arylglyoxal hydrates ()
Org. Biomol. Chem., 2017, 15,6185-6193 DOI: 10.1039/C7OB01255A, Paper Cuiping Wang, Zhiqiang Zhang, Kui Liu, Jingbo Yan, Tiexin Zhang, Gonghao Lu, Qingtao Meng, Haijun Chi, Chunying Duan Copper-catalyzed synthesis of indolyl diketones via C-H oxidation/diacylation of indoles with arylglyoxal hydrates is described. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Synthesis of fluorescent heterocycles via a Knoevenagel/[4 + 1]-cycloaddition cascade using acetyl cyanide ()
Org. Biomol. Chem., 2017, 15,6076-6079 DOI: 10.1039/C7OB01239J, Communication Guillermo Martinez-Ariza, Bereketab T. Mehari, Ludmila A. G. Pinho, Christopher Foley, Kendall Day, John C. Jewett, Christopher Hulme Acetyl cyanide is utilized to synthesize fluorescent indolizines, benzo[d]pyrrolo[2,1-b]thiazoles, and pyrrolo[1,2-a]pyrazines in a single step. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Chain-breaking antioxidant activity of hydroxylated and methoxylated magnolol derivatives: the role of H-bonds ()
Org. Biomol. Chem., 2017, 15,6177-6184 DOI: 10.1039/C7OB01195D, Paper Andrea Baschieri, Luana Pulvirenti, Vera Muccilli, Riccardo Amorati, Corrado Tringali The chain-breaking antioxidant activity of four new hydroxylated and methoxylated magnolol derivatives is boosted by intramolecular hydrogen bonds. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Synthesis of 1H-indole-3-sulfonates via palladium-catalyzed tandem reactions of 2-alkynyl arylazides with sulfonic acids ()
Org. Biomol. Chem., 2017, 15,6080-6083 DOI: 10.1039/C7OB01337J, Communication Xiaoxiang Zhang, Ping Li, Chang Lyu, Wanxiong Yong, Jing Li, Xinbao Zhu, Weidong Rao An efficient method for the synthesis of 1H-indole-3-sulfonates via palladium-catalyzed tandem reactions of 2-alkynyl arylazides with sulfonic acids has been developed. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Copper(I) catalyzed oxidative hydrolysis of Ugi 3-component and Ugi-azide reaction products towards 2[degree] [small alpha]-ketoamides and [small alpha]-ketotetrazoles ()
Org. Biomol. Chem., 2017, 15,6132-6135 DOI: 10.1039/C7OB00881C, Paper Jurrien W. Collet, Christopher Foley, Arthur Y. Shaw, Romano V. A. Orru, Eelco Ruijter, Christopher Hulme Catalytic Cu(I) mediated C-N oxidation of Ugi-3-component and Ugi-azide reaction products affords 2[degree] [small alpha]-ketoamides 1 and [small alpha]-ketotetrazoles 2. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

A practical approach to asymmetric synthesis of dolastatin 10 ()
Org. Biomol. Chem., 2017, 15,6119-6131 DOI: 10.1039/C7OB01395G, Paper Wen Zhou, Xiao-Di Nie, Yu Zhang, Chang-Mei Si, Zhu Zhou, Xun Sun, Bang-Guo Wei Dolastatin 10 has been effectively synthesized through SmI2-induced cross-coupling for Dap, asymmetric addition for Doe and an alternative route to Val-Dil. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Regioselective Diels-Alder reaction to open-cage ketolactam derivatives of C60 ()
Org. Biomol. Chem., 2017, 15,6136-6146 DOI: 10.1039/C7OB01347G, Paper Teruhiko Tanaka, Ryuichi Nojiri, Yoshiki Sugiyama, Ryouhei Sawai, Toshikazu Takahashi, Norihisa Fukaya, Jun-Chul Choi, Yoshio Kabe Open-cage ketolactam fullerenes reacted with dienes on the rim of the orifice both regio- and endo-selectively, which were confirmed by 2D INADEQUATE 13C NMR of 13C enriched material/HMBC spectra as well as the theoretical calculations. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

SmI2-mediated reductive cyclization of [small beta]-arylthio ketones: a facile and diastereoselective synthesis of thiochroman derivatives ()
Org. Biomol. Chem., 2017, 15,6157-6166 DOI: 10.1039/C7OB01082F, Paper Hui Mao, Bing-Xin You, Lie-Jin Zhou, Ting-Ting Xie, Yi-Hang Wen, Xin Lv, Xiao-Xia Wang SmI2-mediated reductive cyclization of [small beta]-arylthio ketones afforded a general approach to dihydrothiochroman-ols in good yields and high degrees of diastereoselectivity. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Asymmetric synthesis of new [gamma]-butenolides via organocatalyzed epoxidation of chalcones ()
Org. Biomol. Chem., 2017, 15,6098-6103 DOI: 10.1039/C7OB00165G, Communication Lucas C. C. Vieira, Bianca T. Matsuo, Lorena S. R. Martelli, Mayara Gall, Marcio W. Paixao, Arlene G. Correa A greener three-step sequence, with only one single chromatographic purification, afforded [gamma]-butenolides in moderate overall yield and high enantiomeric excess. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Aromatic C-H amination: a radical approach for adding new functions into biology- and materials-oriented aromatics ()
Org. Biomol. Chem., 2017, 15,6071-6075 DOI: 10.1039/C7OB00985B, Perspective Kei Murakami, Gregory J. P. Perry, Kenichiro Itami Recent developments in the radical C-H amination of biology- and materials-oriented aromatics are summarized in this perspective. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Transition from disordered aggregates to ordered lattices: kinetic control of the assembly of a computationally designed peptide ()
Org. Biomol. Chem., 2017, 15,6109-6118 DOI: 10.1039/C7OB01197K, Paper Yu Tian, Huixi Violet Zhang, Kristi L. Kiick, Jeffery G. Saven, Darrin J. Pochan This work is showing the ability to control the kinetics of peptide assembly while leaving both the designed [small alpha]-helical and tetrameric helical bundle intact. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Chemical Optimization Of Macrocyclic HIV-1 Inactivators For Improving Potency and Increasing the Structural Diversity at The Triazole Ring ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01448A, Paper Adel A R Ahmed, Kriti Acharya, Ann Haftl, Rachna Aneja, Alexej Dick, Andrew P Holmes ‎, Irwin Chaiken HIV-1 entry inhibition remains an urgent need for AIDS drug discovery and development. We previously reported the discovery of cyclic peptide triazoles (cPTs) that retain the HIV-1 irreversible inactivation functions... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

An efficient one-pot approach for the regio and diastereoselective synthesis of trans-dihydrofuran derivatives: Cytotoxicity and DNA-binding studies ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01456B, Paper Yellaiah Tangella, Manasa Lakshmi Kesari, Lakshma Nayak V, Sathish Manda, Sridhar Balasubramanian, Abd-Allah Alarifi, Narayana Nagesh, Ahmed Kamal An operationally facile and high yielding one-pot, three-component protocol has been developed for the preparation of selectively trans-2,3-dihydrofuro[3,2-c]coumarins and trans-1,2-dihydrobenzo[h]furo[3,2-c]quinolinones. This protocol proceeds through a domino Knoevenagel condensation, Michael addition... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Calcium Carbide Catalytically Ac-tivated with Tetra-n-butyl Ammonium Fluoride for Sonogashira Cross Coupling Reactions ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01334E, Paper Abolfazl Hoseini, Afsaneh Pilevar, Eimear Hogan, Boris Mogwitz, Anne Sophie Schulze, Peter Richard SCHREINER We report a novel method for the direct synthesis of mono- and bis-arylated alkynes utilizing catalytically activated CaC2 as the alkyne component. This fluoride-activated cross coupling reaction provides advantages over... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

A facile I2-catalyzed synthesis of imidazo[1,2-a]pyridines via sp3 C-H functionalization of azaarenes and evaluation of anticancer activity ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01384A, Paper Ahmed Kamal, Geeta Sai Mani, Siddiq Pasha Shaik, Yellaiah Tangella, Swarna Bale, Chandraiah Godugu A facile and efficient metal-free one-pot, three component synthetic protocol has been developed for the synthesis of medicinally important substituted imidazo[1,2-a]pyridines via iodine-catalysed oxidative amination of benzylic C-H bonds of... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Facile functionalization of peptide nucleic acids (PNAs) for antisense and single nucleotide polymorphism detection ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01592E, Communication Digvijay Gahtory, Merita Murtola, Maarten M. J. Smulders, Tom Wennekes, Han Zuilhof, Roger Stromberg, Bauke Bauke Albada In this report, we show how a convenient on-resin copper-click functionalization of azido-functionalized peptide nucleic acids (PNAs) allows various PNA-based detection strategies. Firstly, a thiazole orange (TO) clicked PNA probes... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Highly stereoselective construction of the C2 stereocentre of [small alpha]-tocopherol (vitamin E) by asymmetric addition of Grignard reagents to ketones ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00751E, Paper Bartosz Bieszczad, Declan G. Gilheany Both C2-diastereomers of [small alpha]-tocopherol can be prepared in three ways by asymmetric addition of Grignard reagents to ketones in up to 96 : 4 dr. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Efficient Active-Template Synthesis of Calix[6]Arene-Based Oriented Pseudorotaxanes and Rotaxanes ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01642E, Paper Valeria Zanichelli, Giulio Ragazzon, Guido Orlandini, Margherita Venturi, Alberto Credi, Serena Silvi, Arturo Arduini, Andrea Secchi A substrate can modify its chemical features, up to a change of its reactivity, as a consequence of non-covalent interactions upon inclusion within a molecular host. Since the rise of... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Enzyme-Instructed Self-Assembly with Photo-Responses for Photo-Regulation of Cancer Cells ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01548H, Communication Zhengquan Zhou, Xian Xie, Qikun Yi, Wencui Yin, Adnan Kadi, Jinbo Li, Yan Zhang Using a short peptide precursor modified by the biaryltetrazole with intramolecular photo-click reactivity, we realized photo-regulation of the pericellular nanofibers formed by the enzyme-instructed self-assembly on the cell membrane. Upon... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

19 F CEST imaging probes for metal ion detection ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01068K, Paper Qiaoli Peng, Yaping Yuan, Huaibin Zhang, Shaowei Bo, Yu Li, Shizhen Chen, Zhigang Yang, Xin Zhou, Zhong-Xing Jiang An easily available fluorinated chelator was developed as a highly sensitive 19F iCEST MRI probe for selectively detecting metal ions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

The potential of pnicogen bonding for catalysis - A computational study ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01599B, Paper Julie Schmauck, Martin Breugst Pnicogen bonding is a noncovalent interaction between the electrophilic region of a phosphorus atom and a Lewis base. Although this interaction can be comparable in strength to other noncovalent interactions,... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Discovery of 2-(pyridin-2-yl)aniline as a Directing Group for the sp2 C-H Bond Amination Mediated by Cupric Acetate ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01353A, Paper Hong-Yi Zhao, Hui-Yan Wang, Shuai Mao, Minhang Xin, Hao Zhang, San-Qi Zhang 2-(Pyridin-2-yl) aniline was designed as a new removable directing group in promoting C-H amination mediated by cupric acetate. Employing this auxiliary, the [small beta]-C(sp2)-H bonds of benzamide derivatives can be effectively... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Structural and mechanistic studies of the base-induced Sommelet-Hauser rearrangement of N-[small alpha]-branched benzylic azetidine-2-carboxylic acid-derived ammonium salts ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01391D, Paper Eiji Tayama, Kazutoshi Watanabe, Sho Sotome The base-induced Sommelet-Hauser rearrangement of N-[small alpha]-branched benzylic azetidine-2-carboxylic acid ester-derived ammonium salts to obtain [small alpha]-arylazetidine-2-carboxylic acid esters was investigated. The substrates, two diastereomeric salts (1S,2S,1'S)- and (1R,2R,1'S)-2, showed different reactivities.... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Amide rotation trajectories probed by symmetry ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01421J, Paper Vladimir Kubyshkin, Nediljko Budisa The amide rotation of peptidyl-prolyl fragments is an important factor in backbone structure organization of proteins. Computational studies have indicated that this rotation preferentially proceeds through a defined transition-state structure... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Inhibitors of nicotinamide N-methyltransferase designed to mimic the methylation reaction transition state ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01357D, Paper Matthijs van Haren, Rebecca Taig, Jilles Kuppens, Javier Sastre Torano, Ed E. Moret, Richard B. Parsons, Davide Sartini, Monica Emanuelli, Nathaniel I. Martin Nicotinamide N-methyltransferase (NNMT) is an enzyme that catalyses the methylation of nicotinamide to form N'-methylnicotinamide. Both NNMT and its methylated product have recently been linked to a variety of diseases,... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Three-Step Synthesis of 2,5,7-Trisubstituted Indoles from N-Acetyl-2,4,6-trichloroaniline Using Pd-Catalyzed Site-Selective Cross-Coupling ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01547J, Paper Miyuki Yamaguchi, Kei Manabe We report a facile three-step synthesis of 2,5,7-trisubstituted indoles from N-acetyl-2,4,6-trichloroaniline, with the first step featuring Pd/dihydroxyterphenylphosphine (DHTP)-catalyzed ortho-selective Sonogashira coupling followed by cyclization to afford 2-substituted 5,7-dichloroindoles. Subsequent introduction... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Ag(I)-Catalyzed Cycloisomerization Reactions: Synthesis of Substituted Phenanthrenes and Naphthothiophenes ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01646H, Paper Rakesh K Saunthwal, abhinandan K. Danodia, Kapil Mohan Saini, Akhilesh K. Verma Ag-catalyzed synthesis of substituted phenanthrenes and naphthothiophenes from ortho-alkylated biaryl derivatives via 6-endo-dig intramolecular alkyne-arene coupling has been described. The mechanistic study reveals that 6-endo-dig cyclization proceeds through initial [small pi]-coordination... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Stereoselective synthesis of viridiofungin analogue NA808 from chiral tetrahydrofurancarboxylic acid ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01608E, Paper Masatoshi Murakata, Takuma Ikeda Viridiofungin analogue NA808 was synthesized by stereoselective Ireland-Claisen rearrangement of dienylmethyl ester, regioselective bromolactonization of [small beta]-divinylpropanoic acid and retro-bromolactonization. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Nonlinear Effects at Soft Interface of an Emulsion in List-Lerner-Barbas Aldol Reaction ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01576C, Paper Jyoti Dutta, Nutan Wakdikar, Shraeddha Tiwari Nonlinear effects have been observed for List-Lerner-Barbas aldol reaction catalyzed by a proline-based surfactant catalyst at the aqueous - organic interface under emulsifying conditions. The differential partitioning of the amphiphilic... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Direct arylation of inactivated benzene with aryl acyl peroxides toward biaryls ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01564J, Communication Changduo Pan, Jiawei Zhu, Rongzhen Chen, Jin-Tao Yu A direct arylation of inactivated benzene with acyl peroxides toward biaryls under metal-free, base-free and additive-free conditions was developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Rationalising the effects of ionic liquids on a nucleophilic aromatic substitution reaction ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01476G, Paper Rebecca R. Hawker, Michaela J. Wong, Ronald S. Haines, Jason B. Harper The nucleophilic aromatic substitution reaction between 1-fluoro-2,4-dinitrobenzene and ethanol was examined in a series of ionic liquids across a range of mole fractions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Asymmetric synthesis of isoquinolinonaphthyridines catalyzed by a chiral Bronsted acid ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01527E, Communication Jianjun Li, Yiwei Fu, Cong Qin, Yang Yu, Hao Li, Wei Wang A mild and efficient asymmetric cyclization reaction catalyzed by chiral Bronsted acids has been developed for the synthesis of chiral isoquinolinonaphthyridines. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Poly(methylhydrosiloxane) as a green reducing agent in organophosphorus-catalysed amide bond formation ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01510K, Paper Daan F. J. Hamstra, Danny C. Lenstra, Tjeu J. Koenders, Floris P. J. T. Rutjes, Jasmin Mecinovic In situ reduction of phosphine oxide by poly(methylhydrosiloxane) leads to efficient amidation reaction between carboxylic acids and amines. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

A metal-free cascade reaction of [small beta]-halo-[small alpha],[small beta]-unsaturated aldehydes and 1,4-dithiane-2,5-diols: synthesis of polycyclic 2-formylthiophenes ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01641G, Communication Limi Goswami, Kashmiri Neog, Kumud Sharma, Pranjal Gogoi A cascade reaction of [small beta]-halo-[small alpha],[small beta]-unsaturated aldehydes and 1,4-dithiane-2,5-diols for the synthesis of 2-formylthiophenes has been described employing a polymer supported organic base. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Recent advances in asymmetric total synthesis of prostaglandins ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01341H, Review Article Haihui Peng, Fen-Er Chen Prostaglandins (PGs) are a series of hormone-like chemical messengers and play a critical role in regulating physiological activity. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Self-assembly of amphipathic [small alpha][small alpha][small beta]-tripeptide into cationic spherical particles for intracellular delivery ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01693J, Paper Raffaella Bucci, Priyadip Das, Filomena Iannuzzi, Marco Feligioni, Raffaella Gandolfi, Maria Luisa Gelmi, Meital Reches, Sara Pellegrino The development of molecular carriers able to carry molecules directly into the cell is an intense area of research. Cationic nanoparticles are effective delivery systems for several classes of molecules,... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Rapid and selective synthesis of spiropyrazolines and pyrazolylphthalides employing Seyferth-Gilbert reagent ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01417A, Paper Ashis Kumar Gupta, Narendra Kumar Vaishanv, Ruchir Kant, Kishor Mohanan An efficient protocol for the selective synthesis of spiropyrazoline phosphonates and pyrazolylphthalides employing Seyferth-Gilbert reagent is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Lasiodiplactone A, a novel lactone from the mangrove endophytic fungus Lasiodiplodia theobromae ZJ-HQ1 ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01657C, Communication Senhua Chen, Zhaoming Liu, Hongju Liu, Yuhua Long, Dongni Chen, Yongjun Lu, Zhigang She Lasiodiplactone A (1), an unprecedented lactone, was obtained from the mangrove endophytic fungus Lasiodiplodia theobromae ZJ-HQ1. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

The synthesis of cycloalka[b]furans via an Au(I)-catalyzed tandem reaction of 3-yne-1,2-diols ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01179B, Communication Wei-Ting Liu, Zheng-Liang Xu, Xue-Qing Mou, Bang-Hong Zhang, Wen Bao, Shao-Hua Wang, Dongjun Lee, Lin-Sheng Lei, Kun Zhang A rapid and convenient approach toward substituted cycloalka[b]furan compounds has been developed via an Au(I)-catalyzed cyclization/1,2-rearrangement/aromatization cascade. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Copper-catalyzed, stereoconvergent, cis-diastereoselective borylative cyclization of [small omega]-mesylate-[small alpha],[small beta]-unsaturated esters and ketones ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01382E, Communication Ya-Jie Zuo, Xiao-Tong Chang, Zhi-Ming Hao, Chong-Min Zhong The cis-[small beta]-boron-substituted carbocyclic and heterocyclic esters or ketones were obtained from E- and Z-substrates with >99% cis-selectivity. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Heptafluoroisopropyl diazomethane (i-C3F7CHN2): in situ generation and synthesis of pyrazoles ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01579H, Paper Pavel K. Mykhailiuk A novel chemical reagent, heptafluoroisopropyl diazomethane (i-C3F7CHN2), has been generated in situ in aqueous media. It reacts with electron-deficient alkynes towards polyfluorinated pyrazoles that are important in agrochemistry. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

tert-Butyl nitrite (TBN) as the N atom source for the synthesis of substituted cinnolines with 2-vinylanilines and a relevant mechanism was studied ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01553D, Communication XiaoBo Pang, LianBiao Zhao, DaGang Zhou, Ping Yong He, ZhenYu An, Ji Xiang Ni, RuLong Yan A green method to synthesize cinnolines by 6[small pi] electrocyclic reaction with alkenyl amines and TBN has been developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Selective synthesis of pyrrolo[1,2-a]azepines or 4,6-dicarbonyl indoles via tandem reactions of alkynones with pyrrole derivatives ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01516J, Communication Yulei Zhao, Yang Yuan, Murong Xu, Zhong Zheng, Runhua Zhang, Yanzhong Li Selective synthesis of pyrrolo[1,2-a]azepines catalyzed by ZnI2 or 4,6-dicarbonyl indoles promoted by silica gel via tandem reactions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

First stereoselective total synthesis of brevipolide M ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01438D, Paper Kasa Shiva Raju, Gowravaram Sabitha The first stereoselective total synthesis of a cytotoxic brevipolide M, which shares a pyrone framework bearing a tetrahydrofuran moiety and a cinnamate group with the readily available (-)-DET, is described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Unified total synthesis of (+)-chinensiolide B and (+)-8-epigrosheimin ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01217A, Paper Saumen Hajra, Susit Acharyya, Abhisek Mandal, Ramkrishna Maity The combination of stereocontrolled Evans syn-aldol, intramolecular ene and RCM reactions is shown to be a general protocol for the synthesis of C8-deoxy- and -oxy guaianolides. Unified total synthesis of (+)-chinensiolide B and (+)-8-epigrosheimin is demonstrated from a common precursor. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

The preference for dual-gold(I) catalysis in the hydro(alkoxylation vs. phenoxylation) of alkynes ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01457K, Paper Eric Casals-Cruanas, Oscar F. Gonzalez-Belman, Pau Besalu-Sala, David J. Nelson, Albert Poater Dinuclear gold complexes and their use in catalysis have received significant recent attention, but there are few critical comparisons of mono- versus dual gold-catalysed pathways. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Computationally Guided Discovery of a Reactive, Hydrophilic trans-5-Oxocene Dienophile for Bioorthogonal Labeling ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01707C, Paper William Duane Lambert, Samuel Scinto, Olga Dmitrenko, Samantha Brannick Boyd, Ronald Magboo, Ryan Mehl, Jason W Chin, Joseph Fox, Stephen Wallace The use of organic chemistry principles and prediction techniques has enabled the development of new bioorthogonal reactions. As this "toolbox" expands to include new reaction manifolds and orthogonal reaction pairings,... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Proof of Principle of a Three-Input AND-INHIBIT-OR Combinatorial Logic Gate Array ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01223C, Communication David C Magri, Jake C Spiteri A designed molecule fluoresces according to a combinatorial logic circuit equivalent to wiring together three-input AND, three-input INHIBIT and two-input OR logic gates. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

A [small beta]-galactosidase probe for the detection of cellular senescence by mass cytometry ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01227F, Paper M. A. Lumba, L. M. Willis, S. Santra, R. Rana, L. Schito, S. Rey, B. G. Wouters, M. Nitz Enzyme substrates for mass cytometry applications enable new dimensions in multiparametric cellular assays. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Improved i-Motif Thermal Stability by Insertion of Anthraquinone Monomers ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01393K, Paper Alaa S. Gouda, Mahasen Amine, Erik B. Pedersen In order to gain insight in how to improve thermal stability of i-motifs when used in the context of biomedical and nanotechnological applications, novel anthraquinone-modified i-motifs were synthesized by insertion... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

An expeditious method to synthesize difluoroboron complexes of [small beta]-keto amides from [small beta]-keto nitriles and BF3[middle dot]OEt2 ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01356F, Paper Chuangchuang Xu, Jiaxi Xu An expeditious and convenient method has been developed to synthesize difluoroboron complexes of [small beta]-keto amides from [small beta]-keto nitriles and BF3[middle dot]OEt2. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Reductive amination catalyzed by iridium complexes using carbon monoxide as a reducing agent ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01005B, Paper Alexey P. Moskovets, Dmitry L. Usanov, Oleg I. Afanasyev, Vasilii A. Fastovskiy, Alexander P. Molotkov, Karim M. Muratov, Gleb L. Denisov, Semen S. Zlotskii, Alexander F. Smol'yakov, Dmitry A. Loginov, Denis Chusov N-benzyl, dioxalane, halo-, cyclopropanes tolerates. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Comment on "An unexpected formation of the novel 7-oxa-2-azabicyclo[2.2.1]hept-5-ene skeleton during the reaction of furfurylamine with maleimides and their bioprospection using a zebrafish embryo model" by C. E. Puerto Galvis and V. V. Kouznetsov, Org. Biomol. Chem., 2013, 11, 407 ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB01207A, Comment Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. F. I. Zubkov, E. A. Kvyatkovskaya, E. V. Nikitina, P. N.-A. Amoyaw, V. V. Kouznetsov, V. A. Lazarenko, V. N. Khrustalev It has been proved that the reaction between furfuryl amines and N-R-maleimides leads to the formation of aza-Michael addition products - 3-(furylmethylamino)-N-R-pyrrolidine-2,5-diones, instead of 7-oxa-2-azabicyclo[2.2.1]hept-5-enes, as this journal reported previously. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

An Aryne-Based Three-Component Access to [small alpha]-Aroylamino Amides ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB01715D, Paper Marta Serafini, Alessia Griglio, Sara Viarengo, Silvio Aprile, Tracey Pirali Aryne chemistry has recently received widespread attention and isocyanides have been reported as efficient nucleophilic partners in a set of multicomponent transformations. In this study, we demonstrate that tertiary [small alpha]-monosubstituted... The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Correction: Synthesis of L-rhamnose derived chiral bicyclic triazoles as novel sodium-glucose transporter (SGLT) inhibitors ()
Org. Biomol. Chem., 2017, 15,6057-6057 DOI: 10.1039/C7OB90112G, Correction Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Siddamal Reddy Putapatri, Abhinav Kanwal, Balasubramanian Sridhar, Sanjay K. Banerjee, Srinivas Kantevari The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

One-step synthesis of conjugated enynenitriles from bromocyanoacetylene ()
Org. Biomol. Chem., 2017, 15,6050-6056 DOI: 10.1039/C6OB02590K, Paper Romain Ligny, Etienne S. Gauthier, Manuel Yanez, Thierry Roisnel, Jean-Claude Guillemin, Yann Trolez Bromocyanoacetylene is able to provide conjugated enynenitriles stereoselectively in one step from alkynes, secondary amines and co-catalysts. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Collagen mimetic peptide discs promote assembly of a broad range of natural protein fibers through hydrophobic interactions ()
Org. Biomol. Chem., 2017, 15,5893-5898 DOI: 10.1039/C7OB01073G, Communication Kenneth McGuinness, Vikas Nanda Collagen mimetic peptides bind to a variety of fiber-forming proteins through complementary hydrophobic interactions, resulting in discs-on-a-string nanostructures and bundling of fibers. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Design, synthesis, and biological activity of second-generation synthetic oleanane triterpenoids ()
Org. Biomol. Chem., 2017, 15,6001-6005 DOI: 10.1039/C7OB01420A, Paper Liangfeng Fu, Qi-xian Lin, Evans O. Onyango, Karen T. Liby, Michael B. Sporn, Gordon W. Gribble Synthetic manipulation of oleanolic acid affords a novel and biologically active C-24 demethylated CDDO-Me. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Copper-mediated trifluoroacetylation of indoles with ethyl trifluoropyruvate ()
Org. Biomol. Chem., 2017, 15,5904-5907 DOI: 10.1039/C7OB01335C, Communication Guobing Yan, Xihan Cao, Wanbin Zheng, Qiumin Ke, Jieyu Zhang, Dayun Huang Direct trifluoroacetylation of indoles with ethyl trifluoropyruvate as a trifluoroacetylating reagent has been developed. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Enhancing a long-range salt bridge with intermediate aromatic and nonpolar amino acids ()
Org. Biomol. Chem., 2017, 15,5882-5886 DOI: 10.1039/C7OB01198A, Communication Mason S. Smith, Wendy M. Billings, Frank G. Whitby, McKenzie B. Miller, Joshua L. Price Nonpolar residues enhance a long-range salt-bridge interaction in an [small alpha]-helix. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Dual visible-light photoredox and palladium(II) catalysis for dehydrogenative C2-acylation of indoles at room temperature ()
Org. Biomol. Chem., 2017, 15,5899-5903 DOI: 10.1039/C7OB01418J, Communication Manash Kumar Manna, Gurupada Bairy, Ranjan Jana A mild protocol for direct C2-acylation of indoles with aldehydes is reported at room temperature through the merger of visible light photoredox and palladium(II) catalysis. Late-stage acylation of tryptophan and selective mono-acylation of carbazoles are also demonstrated. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

[18F]Fluoroalkyl azides for rapid radiolabeling and (Re)investigation of their potential towards in vivo click chemistry ()
Org. Biomol. Chem., 2017, 15,5976-5982 DOI: 10.1039/C7OB00880E, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Christoph Denk, Martin Wilkovitsch, Philipp Skrinjar, Dennis Svatunek, Severin Mairinger, Claudia Kuntner, Thomas Filip, Johannes Frohlich, Thomas Wanek, Hannes Mikula [18F]Fluoroalkyl azides were developed as efficient click agents for rapid radiolabeling, and (re)investigated towards application in pretargeted PET imaging. The content of this RSS Feed (c) The Royal Society of Chemistry
>> Read More

Site Search