Organic & Biomolecular Chemistry



Use of Trichloroacetonitrile as a Hydrogen Chloride Generator for Ring-Opening Reactions of Aziridines ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00602H, Paper Yasunori Toda, Riki Matsuda, Shuto Gomyou, Hiroyuki Suga Regioselective ring-opening reactions of 2-aryl-N-tosylaziridines are described, in which hydrogen chloride is generated by photodegradation of trichloroacetonitrile. HCl adducts are obtained in high yields in 1,4-dioxane, whereas methanol adducts are... The content of this RSS Feed (c) The Royal Society of Chemistry
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Total Synthesis of Spiromastilactone A ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00547A, Paper Pauline Chaumont-Olive, Jacques Maddaluno, Anne Marie-Françoise HARRISON-MARCHAND The total synthesis of Spiromastilactone A is reported for the first time. A swift strategy is presented that is designed thanks to a pivotal enantioselective nucleophilic 1,2-alkylation involving an aldehyde... The content of this RSS Feed (c) The Royal Society of Chemistry
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Insights into the Thioamidation of Thiopeptins to Enhance the Understanding of the Biosynthetic Logic of Thioamide-containing Thiopeptides ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00402E, Communication Jingyu Liu, Zhi Lin, Yuqing Li, Qingfei Zheng, Dandan Chen, Wen Liu Thiopeptins are a complex of thiopeptide antibiotics similar in structure to thiostrepton and harboring a thioamide, a rare moiety among natural products. Here, we illustrate through a series of in... The content of this RSS Feed (c) The Royal Society of Chemistry
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An Efficient Synthesis and Bioactivity Evaluation of Oxazoles-Containing Natural Hinduchelins A-D and Their Derivatives ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00352E, Paper Shaoyong Ke, Zhigang Zhang, Liqiao Shi, Manli Liu, Wei Fang, Yani Zhang, Zhaoyuan Wu, Zhongyi Wan, Tong Long, Kaimei Wang Oxazoles are an important class of biologically active metabolites from nature, and which have broad biological activities as the lead for drug discovery. Hinduchelins are a class of unusual natural... The content of this RSS Feed (c) The Royal Society of Chemistry
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Acid–base controlled multiple conformation and aromaticity switches in tren-capped hexaphyrins ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00489K, Communication Stéphane Le Gac, Elsa Caytan, Vincent Dorcet, Bernard Boitrel Upon protonation, a tren-capped hexaphyrin undergoes simple conformational exchanges between rectangular, Möbius and triangular shapes affording different aromaticities and cage environments, and ultimately leading to a host–guest complex. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Palladium-catalyzed allylation of aminophenol with alkynes to construct C–N bonds ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00333A, Paper Chuan-Jun Lu, Xin Yu, Dong-Kai Chen, Hong Wang, Qing-Bao Song, Jian-Rong Gao A palladium catalyzed allylic of alkylation of aminophenol with alkynes was developed with high chemo-, regio-, and stereoselectivities. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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On the reactivity of anodically generated trifluoromethyl radicals toward aryl alkynes in organic/aqueous media ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00456D, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Wolfgang Jud, C. Oliver Kappe, David Cantillo Two competing pathways have been experimentally observed and the selectivity has been explained by means of DFT calculations. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A far-red to NIR emitting ultra-sensitive probe for the detection of endogenous HOCl in zebrafish and the RAW 264.7 cell line ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00143C, Paper Vijay Natarajan, Natesan Thirumalaivasan, Shu-Pao Wu, Velmathi Sivan We report the synthesis of a far-red to NIR emitting probe for its application to the endogenous fluorescence imaging of HOCl in zebrafish. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Gold(I) catalysed regio- and stereoselective intermolecular hydroamination of internal alkynes: towards functionalised azoles ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00587K, Paper Christophe Michon, Joachim Gilbert, Xavier Trivelli, Fady Nahra, Catherine Cazin, Francine Agbossou-Niedercorn, Steven P Nolan Gold(I) catalysed regio- and stereoselective intermolecular hydroamination of internal alkynes was developed for the effective synthesis of a series of (Z)-functionalised vinylazoles under solvent free conditions. The catalytic hydrogenation of... The content of this RSS Feed (c) The Royal Society of Chemistry
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Elevated Reaction Order of 1,3,5-tri-tert-butylbenzene Bromination as Evidence of a Clustered Polybromide Transition State: a Combined Kinetic and Computational Study ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00607A, Paper Alexander Genaev, Henry S Rzepa, Andrey Vladimirovich Shernyukov, George Salnikov, Vyacheslav Shubin 1,3,5-tri-tert-butylbenzene at different bromine concentrations were studied experimentally and theoretically. Both reactions have high order in bromine (experimental kinetic orders ~5 and ~7, respectively). According to quantum chemical DFT calculations,... The content of this RSS Feed (c) The Royal Society of Chemistry
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Green Hydroboration of Carboxylic Acids and Mechanism Investigation ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00485H, Paper Weifan Wang, Man Luo, Da Zhu, Weiwei Yao, Li Xu, Mengtao Ma A catalyst-free and solvent-free method for the hydroboration of a variety of carboxylic acids with pinacolborane was developed. The hydroboration of various aromatic and aliphatic carboxylic acids as well as... The content of this RSS Feed (c) The Royal Society of Chemistry
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Small isomeric push-pull chromophores based on thienothiophenes with tuneable optical (non)linearities ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00487D, Paper Jan Podlesný, Oldřich Pytela, Milan Klikar, Veronika Jelínková, Iwan V Kityk, Katarzyna Ozga, Jaroslaw Jedryka, Myron Ya. Rudysh, Filip Bureš Fourteen new D-π-A push pull chromophores based on thieno[3,2-b]thiophene and thieno[2,3-b]thiophene were designed and synthesised. The property tuning has been achieved by structural variation of the attached electron donor/acceptor. Fundamental... The content of this RSS Feed (c) The Royal Society of Chemistry
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Mitsunobu-initiated cascade cyclization of p-quinamines and 2-furanylmethanols: highly regio- and diastereoselective synthesis of functionalized hydrobenzo[c,d]indoles ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00585D, Communication Min Shi, Bo Cao, Yin Wei A cascade cyclization of para-quinamines and 2-furanylmethanol has been achieved, affording a series of functionalized hydrobenzo[c,d]indoles in moderate to good yields and excellent diastereoselectivities under mild conditions. This reaction was... The content of this RSS Feed (c) The Royal Society of Chemistry
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Ketoreductase Catalyzed Stereoselective Bioreduction of -Nitro Ketones ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00051H, Paper Zexu Wang, Xiaofan Wu, Zhining Li, Zedu Huang, Fen er Chen We report here the stereoselective bioreduction of -nitro ketones catalyzed by ketoreductases (KREDs) with publicly known sequences. YGL039w and RasADH/SyADH were able to reduce 23 class I substrates (1-aryl-2-nitro-1-ethanone (1))... The content of this RSS Feed (c) The Royal Society of Chemistry
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Reaction condition controlled nickel(II)-catalyzed C-C cross coupling of alcohols ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00418A, Paper Meng-Juan Zhang, Hong-Xi Li, david James Young, Hai-Yan Li, Jian-Ping Lang The challenge in the C-C cross-coupling of secondary and primary alcohols using acceptorless dehydrogenation coupling (ADC) is the difficulty of accurately controlling product selectivities. Herein we report a controlled approach... The content of this RSS Feed (c) The Royal Society of Chemistry
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Visible-light promoted aerobic difunctionalization of alkenes with sulfonyl hydrazides for the synthesis of β-keto/hydroxyl sulfones ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00278B, Paper Jie Wu, Yulan Zhang, Xinchi Gong, Yunge Meng, Chunyin Zhu A practical method has been developed for the conversion of alkenes to β-keto/hydroxyl sulfones by their reaction with sulfonyl hydrazides under metal-free conditions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Oligopeptide-CB[8] complexation with switchable binding pathways ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00592G, Paper Guanglu Wu, David E. Clarke, Ce Wu, Oren A. Scherman Two-stage binding of dipeptide with CB[8] leads to the unambiguous determination of n : n stoichiometric complexation. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Versatility of glycals in synthetic organic chemistry: coupling reactions, diversity oriented synthesis and natural product synthesis ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00343F, Review Article Henok H. Kinfe Versatility of glycals in the stereoselective synthesis of natural products. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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DFT mechanistic investigation into phenol dearomatization mediated by an iodine(III) reagent ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00028C, Paper Babak Ganji, Alireza Ariafard The key intermediate for the oxidative dearomatization of phenols by phenyliodine(III) diacetate (PIDA) was found to be a dearomatized phenolate species. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Poloxin-2HT+: changing the hydrophobic tag of Poloxin-2HT increases Plk1 degradation and apoptosis induction in tumor cells ()
Org. Biomol. Chem., 2019, 17,3113-3117 DOI: 10.1039/C9OB00080A, Communication Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Stefan Rubner, Sabine Schubert, Thorsten Berg Hydrophobically-tagged Poloxin-2HT+ selectively degrades the tumor target Plk1 and induces apoptosis in tumor cells with higher potency than Poloxin-2HT. The content of this RSS Feed (c) The Royal Society of Chemistry
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Correlations between secondary structure- and protein–protein interface-mimicry: the interface mimicry hypothesis ()
Org. Biomol. Chem., 2019, 17,3267-3274 DOI: 10.1039/C9OB00204A, Paper Jaru Taechalertpaisarn, Rui-Liang Lyu, Maritess Arancillo, Chen-Ming Lin, Lisa M. Perez, Thomas R. Ioerger, Kevin Burgess Preferred conformations of several peptidomimetics (specifically, minimalist mimics) were elucidated and compared with protein-protein interfaces on a huge scale, leading to a hypothesis regarding how these compounds mimic protein interface segments. The content of this RSS Feed (c) The Royal Society of Chemistry
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Trehalose-cored amphiphiles for membrane protein stabilization: importance of the detergent micelle size in GPCR stability ()
Org. Biomol. Chem., 2019, 17,3249-3257 DOI: 10.1039/C8OB03153C, Paper Manabendra Das, Yang Du, Jonas S. Mortensen, Manuel Ramos, Lubna Ghani, Ho Jin Lee, Hyoung Eun Bae, Bernadette Byrne, Lan Guan, Claus J. Loland, Brian K. Kobilka, Pil Seok Chae A novel class of non-chromophoric trehalose-cored amphiphiles was developed and some of the detergents displayed favorable behavior in stabilizing membrane proteins. The content of this RSS Feed (c) The Royal Society of Chemistry
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Photochromic, organogelating and self-sorting behaviour of di-(dithienylethene) derivatives ()
Org. Biomol. Chem., 2019, 17,3285-3291 DOI: 10.1039/C9OB00220K, Paper Kun Zheng, Huaizhen Wang, Hak-Fun Chow They wouldn't mix! – Narcissistic self-sorting was found to exist in a 1 : 1 mixture of the two photoisomers of a di-(dithienylethene)-containing organgelator. The content of this RSS Feed (c) The Royal Society of Chemistry
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Rapid one-pot synthesis of pyrrole-appended isocorroles ()
Org. Biomol. Chem., 2019, 17,3159-3166 DOI: 10.1039/C9OB00168A, Paper Simon Larsen, Laura J. M c Cormick, Abhik Ghosh Free-base meso-triarylcorroles and pyrrole undergo oxidative coupling in dichloromethane in the presence of DDQ affording 35–60% yields of 5/10-pyrrole-appended isocorroles in a matter of seconds. The content of this RSS Feed (c) The Royal Society of Chemistry
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High photodynamic activities of water-soluble inclusion complexes of 5,15-diazaporphyrins in cyclodextrin ()
Org. Biomol. Chem., 2019, 17,3141-3149 DOI: 10.1039/C9OB00101H, Paper Shuhei Satake, Hideyuki Shinmori, Shigeki Kawabata, Kouta Sugikawa, Hisakage Funabashi, Akio Kuroda, Atsushi Ikeda Inclusion complexes of 5,15-diazaporphyrin derivatives in trimethyl-β-cyclodextrin exhibited high photodynamic activity under visible-light irradiation at wavelengths greater than 620 nm. The content of this RSS Feed (c) The Royal Society of Chemistry
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Gold catalysed transformation of 2-arylindoles to terphenyl amines via 3-dienyl indoles and Brønsted acid promoted formation of 2-carboxyindoles to 3-indenylindoles via 3-allenylindoles ()
Org. Biomol. Chem., 2019, 17,3275-3284 DOI: 10.1039/C9OB00232D, Paper Anasuyamma Uruvakili, K. C. Kumara Swamy Gold catalysed reactions of 3-dienyl-indoles (or 2-arylindoles with propargylic alcohols) afford terphenylamines, while indole-2-carboxylates give 3-indenylindoles under p-TsOH mediation. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of the tetrasaccharide repeating unit of the cryoprotectant capsular polysaccharide from Colwellia psychrerythraea 34H ()
Org. Biomol. Chem., 2019, 17,3129-3140 DOI: 10.1039/C9OB00104B, Paper Giulia Vessella, Angela Casillo, Antonio Fabozzi, Serena Traboni, Alfonso Iadonisi, Maria Michela Corsaro, Emiliano Bedini Synthesis of the threonine-decorated tetrasaccharide repeating unit of a cryoprotectant polysaccharide with a glycosaminoglycan-like structure. The content of this RSS Feed (c) The Royal Society of Chemistry
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High-throughput screen for sorting cells capable of producing the biofuel feedstock botryococcene ()
Org. Biomol. Chem., 2019, 17,3195-3201 DOI: 10.1039/C8OB02589D, Paper Allen R. Chacko, Daniel E. Amster, Tyler E. Johnson, Sara R. Newman, Angelina V. Gladchuk, Christine J. Sohn, Donna E. Prunkard, Neal A. Yakelis, Jon O. Freeman Botryococcene is a branched triterpene produced by the algae Botryococcus braunii. The content of this RSS Feed (c) The Royal Society of Chemistry
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Asymmetric total synthesis of (+)-asenapine ()
Org. Biomol. Chem., 2019, 17,3225-3231 DOI: 10.1039/C9OB00178F, Paper Piotr Szcześniak, Olga Staszewska-Krajewska, Jacek Mlynarski Asymmetric total synthesis of (+)-asenapine involving the organocatalytic Michael addition reaction and subsequent Zn-promoted reductive cyclization as the key steps. The content of this RSS Feed (c) The Royal Society of Chemistry
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Enhancing the kinetics of hydrazone exchange processes: an experimental and computational study ()
Org. Biomol. Chem., 2019, 17,3218-3224 DOI: 10.1039/C9OB00058E, Paper Patrick L. Higgs, Antonio J. Ruiz-Sanchez, Milene Dalmina, Benjamin R. Horrocks, Andrew G. Leach, David A. Fulton Hydrogen-bond acceptors (A) stabilize the transition state, lowering the energy barrier to rapid hydrazone exchange, without need for exogenous catalyst. The content of this RSS Feed (c) The Royal Society of Chemistry
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Lewis base catalyzed regioselective cyclization of allene ketones or α-methyl allene ketones with unsaturated pyrazolones ()
Org. Biomol. Chem., 2019, 17,3232-3238 DOI: 10.1039/C9OB00179D, Paper Cheng Cheng, Xiaobin Sun, Zelin Wu, Qianwei Liu, Liqiang Xiong, Zhiwei Miao Highly efficient nitrogen-containing Lewis base catalyzed regioselective [4 + 2] cycloaddition of allene ketones or α-methyl allene ketones with unsaturated pyrazolones. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis, structural characterisation, and synthetic application of stable seleniranium ions ()
Org. Biomol. Chem., 2019, 17,3181-3185 DOI: 10.1039/C9OB00078J, Paper Jonathan Bock, Constantin G. Daniliuc, Klaus Bergander, Christian Mück-Lichtenfeld, Ulrich Hennecke Stable seleniranium ions were prepared, their solid state structures determined and their application as highly efficient selenenylating agents was demonstrated. The content of this RSS Feed (c) The Royal Society of Chemistry
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Catalyst-free direct cross-dehydrogenative coupling of imidazoheterocycles with glyoxal hydrates: an efficient approach to 1,2-diketones ()
Org. Biomol. Chem., 2019, 17,3150-3158 DOI: 10.1039/C9OB00095J, Paper Tao Guo, Xiang-Heng Fu, Miao Zhang, Yu-Liu Li, Yong-Cheng Ma An efficient and convenient catalyst-free synthesis of 1,2-diketones via cross-dehydrogenative coupling of imidazoheterocycles with glyoxal hydrates is described. The content of this RSS Feed (c) The Royal Society of Chemistry
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Modular synthesis and immunological evaluation of suspected allergenic galactooligosaccharides ()
Org. Biomol. Chem., 2019, 17,3108-3112 DOI: 10.1039/C9OB00108E, Communication Hidde Elferink, Emiel Rossing, Chiung-Hui Huang, Bee Wah Lee, Linqiu Cao, Dianne J. Delsing, Andre Groeneveld, Thomas J. Boltje The synthesis of suspected GOS-related allergens using a flexible modular approach and their immunological evaluation are reported. The content of this RSS Feed (c) The Royal Society of Chemistry
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Palladium-catalyzed allylic C–H oxidation under simple operation and mild conditions ()
Org. Biomol. Chem., 2019, 17,3103-3107 DOI: 10.1039/C9OB00209J, Communication Yunlong Guo, Zengming Shen We discovered an effective and simple system (Pd/BQ/air/r.t.) for making allylic alcohols through Pd-catalyzed allylic C–H bond functionalization. The content of this RSS Feed (c) The Royal Society of Chemistry
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Diastereoselectivity in the boron aldol reaction of α-alkoxy and α,β-bis-alkoxy methyl ketones ()
Org. Biomol. Chem., 2019, 17,3167-3180 DOI: 10.1039/C9OB00358D, Paper Alessandra A. G. Fernandes, Ives A. Leonarczyk, Marco A. B. Ferreira, Luiz Carlos Dias We investigated the asymmetric induction in boron enolate aldol reactions of α-alkoxy and α,β-bisalkoxy methyl ketones and elucidated the synergistic effect between the stereocenters. The content of this RSS Feed (c) The Royal Society of Chemistry
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Na2S-promoted reduction of azides in water: synthesis of pyrazolopyridines in one pot and evaluation of antimicrobial activity ()
Org. Biomol. Chem., 2019, 17,3186-3194 DOI: 10.1039/C8OB03171A, Paper Ashok Kale, Nagaraju Medishetti, Sirisha Kanugala, Ganesh Kumar C, Krishnaiah Atmakur Reduction of various azides using Na2S has been accomplished in water, and, in situ, the resulting amines on reaction with various ketones lead to pyrazolo[3,4-b]pyridines in one pot. The content of this RSS Feed (c) The Royal Society of Chemistry
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Reversible chemoselective transetherification of vinylogous esters using Fe-catalyst under additive free conditions ()
Org. Biomol. Chem., 2019, 17,3258-3266 DOI: 10.1039/C9OB00307J, Paper Nenavath Parvathalu, Sandip G. Agalave, Nirmala Mohanta, Boopathy Gnanaprakasam An additive/Brønsted acid/base free, highly efficient and chemoselective transetherification of vinylogous esters and water mediated de-alkylation using Fe-catalyst is described. The content of this RSS Feed (c) The Royal Society of Chemistry
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Metal-free, radical 1,6-conjugated addition of cyclic ethers with para-quinone methides (p-QMs) ()
Org. Biomol. Chem., 2019, 17,3239-3248 DOI: 10.1039/C9OB00127A, Paper Satish G. More, Gurunath Suryavanshi An efficient method for metal-free C–C bond formation between p-quinone methides (p-QMs) and cyclic ethers via a radical pathway to afford substituted diarylmethanes and triarylmethanes or to effect the α-alkylation of the cyclic ethers has been developed. The content of this RSS Feed (c) The Royal Society of Chemistry
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Catalytic enantioselective iodolactonization reactions ()
Org. Biomol. Chem., 2019, 17,3079-3092 DOI: 10.1039/C8OB03160F, Review Article Renate Kristianslund, Jørn Eivind Tungen, Trond Vidar Hansen The recent advances of catalytic enantioselective iodolactonizations of γ- or δ-substituted alkenoic carboxylic acids have been reviewed. The different catalysts and substrates are highlighted. The content of this RSS Feed (c) The Royal Society of Chemistry
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Targeting the hydrophobic channel of NNIBP: discovery of novel 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs with high potency against wild-type and K103N mutant virus ()
Org. Biomol. Chem., 2019, 17,3202-3217 DOI: 10.1039/C9OB00032A, Paper Zhongxia Zhou, Tao Liu, Gaochan Wu, Dongwei Kang, Zhipeng Fu, Zhao Wang, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu Novel 1,2,3-triazole-derived diarylpyrimidines were discovered as potent HIV-1 NNRTIs. The content of this RSS Feed (c) The Royal Society of Chemistry
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α-Thiocarbonyl synthesis via the FeII-catalyzed insertion reaction of α-diazocarbonyls into S–H bonds ()
Org. Biomol. Chem., 2019, 17,3098-3102 DOI: 10.1039/C9OB00261H, Communication Hoda Keipour, Angela Jalba, Nour Tanbouza, Virginie Carreras, Thierry Ollevier Fe(OTf)2 was used to catalyze the insertion reaction of α-diazocarbonyls into S–H bonds at 40 °C. The content of this RSS Feed (c) The Royal Society of Chemistry
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Telescoped synthesis of C3-functionalized (E)-arylamidines using Ugi–Mumm and regiospecific quinazolinone rearrangements ()
Org. Biomol. Chem., 2019, 17,3118-3128 DOI: 10.1039/C9OB00073A, Paper Victor A. Jaffett, Alok Nerurkar, Xufeng Cao, Ilia A. Guzei, Jennifer E. Golden An efficient, telescoped, multicomponent assembly and regiospecific rearrangement of highly diversified quinazolinones affords C3 modified, N-aryl- and N-alkylamide arylamidines requiring only a single purification. The content of this RSS Feed (c) The Royal Society of Chemistry
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Metal-free aza-Claisen type ring expansion of vinyl aziridines: an expeditious synthesis of seven membered N-heterocycles ()
Org. Biomol. Chem., 2019, 17,3093-3097 DOI: 10.1039/C8OB03029D, Communication Deepak Singh, Hyun-Joon Ha A metal-free approach for the synthesis of 7-membered aza-heterocycles has been developed by the intermolecular [5 + 2] cycloaddition of non-activated vinylaziridines and alkynes. The content of this RSS Feed (c) The Royal Society of Chemistry
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Metal- and Chloride Reagent-Free Synthesis of Mixed Thiophosphates ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00370C, Paper Jeffrey Ash, Hai Huang, Jun Yong Kang A mild, efficient synthetic strategy for the synthesis of mixed thiophosphate compounds from thiophosphates has been developed. A highly reactive thiophosphorylpyridinium salt, generated in-situ by treating thiophosphates with Tf2O/pyridine, transiently... The content of this RSS Feed (c) The Royal Society of Chemistry
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The Synthesis of Cyanoformamides via a CsF-Promoted Decyanation/Oxidation Cascade of 2-Dialkylamino-Malononitriles ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00510B, Communication Lin-Sheng Lei, Cao-Gen Xue, Xuetao Xu, Da-Ping Jin, Shao-Hua Wang, Wen Bao, Huan Liang, Kun Zhang, Abdullah M. Asiri A mild and efficient method for the synthesis of cyanoformamides has been developed from N,N-disubstituted aminomalononitriles with CsF as the promoter. This method features a wide substrate scope and high... The content of this RSS Feed (c) The Royal Society of Chemistry
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Modular design for fluorophore homodimer probes using diethylentriamine as a common spacer ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00406H, Paper Shuhei Kusano, Keisuke Matsumoto, Osamu Hayashida Fluorophore homodimer probes 1 and 2 bearing 7-aminocoumarin and naphthalimide dyes, respectively, connected via diethylenetriamine (DETA) spacer, have been developed to demonstrate the validity of our modular probe design employing... The content of this RSS Feed (c) The Royal Society of Chemistry
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A Cell-Permeant Small Molecule for Super-Resolution Imaging of Endoplasmic Reticulum in Live Cells ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00408D, Communication Adiki Raja Sekhar, Bhagaban Mallik, Vimlesh Kumar, Sankar Jeyaraman Endoplasmic reticulum (ER) constitutes about half of the total membrane in a eukaryotic cell and defects in the ER have been shown to be linked with a variety of diseases.... The content of this RSS Feed (c) The Royal Society of Chemistry
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DANPY (dimethylaminonaphthylpyridinium): an economical and biocompatible fluorophore ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB02536C, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Lewis E. Johnson, Jason S. Kingsbury, Delwin L. Elder, Rose Ann Cattolico, Luke N. Latimer, William Hardin, Evelien De Meulenaere, Chloe Deodato, Griet Depotter, Sowmya Madabushi, Nicholas W. Bigelow, Brittany A. Smolarski, Trevor K. Hougen, Werner Kaminsky, Koen Clays, Bruce H. Robinson DANPY-1 is a prototype for a family of NLO-active, low-toxicity fluorescent dyes for biological imaging and biophotonics. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Transition metal-free α-Csp3-H oxidative sulfuration of benzyl thiosulfates with anilines to form N-aryl thioamides ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00336C, Paper Mengjun Qiao, Jinli Zhang, Ling Chen, Fengyi Zhou, Yali Zhang, Lingfei Zhou, Yangjie Wu A metal-free approach to N-aryl thioamides from Bunte salts and anilines in DMSO has been developed. This access tolerated a wide range of functional groups on the aromatic ring, providing... The content of this RSS Feed (c) The Royal Society of Chemistry
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A chemo- and regioselective C6-functionalization of 2,3-disubstituted indoles: highly efficient synthesis of diarylindol-6-ylmethanes ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00283A, Paper Qiong Wu, Gui-Lin Li, Shuang Yang, Xiao-Qin Shi, Tian-Zi Huang, Xi-Hua Du, Yan Chen An organocatalytic chemo- and regioselective C6-functionalization of 2,3-disubstituted indoles has been established via a reaction with ortho-hydroxybenzyl alcohols, which afforded biologically important diarylindol-6-ylmethanes in high yields. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Acid/base- and base/acid-switchable complexation between anionic-/cationic-pillar[6]arenes and a viologen ditosylate salt ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00398C, Communication Qunpeng Duan, Hongsong Zhang, Wenpeng Mai, Fei Wang, Kui Lu Acid/base and base/acid-controllable molecular switches were constructed based on water-soluble anionic pillar[6]arene or cationic pillar[6]arene and a viologen ditosylate salt. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Cp*Co(III)-catalyzed annulation of azines by C–H/N–N bond activation for the synthesis of isoquinolines ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00174C, Paper Dewal S. Deshmukh, Prashant A. Yadav, Bhalchandra M. Bhanage An atom economic and external oxidant free methodology has been developed for the synthesis of isoquinolines by Cp*Co(III) catalyzed annulation of azines via C–H/N–N activation. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Bifunctional organocatalysts for the conversion of CO2, epoxides and aryl amines to 3-aryl-2-oxazolidinones ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00224C, Paper Ya-Fei Xie, Cheng Guo, Lei Shi, Bang-Hua Peng, Ning Liu A route to synthesize 3-aryl-2-oxazolidinones is developed, which is achieved through a three component reaction between CO2, aryl amines, and epoxides with a binary organocatalytic system composed of organocatalysts and DBU (1,8-diazabicyclo[5.4.0]undec-7-ene). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Cobalt-catalyzed C2α-acyloxylation of 2-substituted indoles with tert-butyl peresters ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00159J, Communication Yuxiang Zhou, Chenglong Li, Xiaoyan Yuan, Feiyan Zhang, Xiaozu Liu, Peijun Liu An efficient cobalt-catalyzed C2α selective C(sp3)–H acyloxylation of 2-substituted indoles with tert-butyl peresters to synthesize diverse 2α-acyloxylated indole derivatives is described. This developed method exhibits mild conditions, low-cost catalyst, and high functional group compatibility. The effectiveness of this chemistry is illuminated by a late-stage modification of methylated indomethacin. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Iodine-mediated oxidative N–N coupling of secondary amines to hydrazines ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00279K, Paper Linning Ren, Manman Wang, Benyao Fang, Wenquan Yu, Junbiao Chang An I2-mediated oxidative N–N coupling reaction of secondary amines to access hydrazines has been established under transition-metal-free conditions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Chemoselective cyclization of N-sulfonyl ketimines with ethenesulfonyl fluorides: access to trans-cyclopropanes and fused-dihydropyrroles ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00433E, Paper Sanjeeva Kumar Arupula, Santosh K. Gudimella, Soumitra Guin, Shaikh M. Mobin, Sampak Samanta A stereo- and chemoselective ring closing reaction of N-sulfonyl ketimines with ethene sulfonyl fluorides promoted by DBU is reported. This selective C–C vs. C–N bond cyclization process delivers to trans-cyclopropanes (dr up to ≤99 : 1) and fused-dihydropyrroles. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Gram-scale synthesis of luciferins derived from coelenterazine and original insights into their bioluminescence properties ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00459A, Communication Eloi P. Coutant, Sophie Goyard, Vincent Hervin, Glwadys Gagnot, Racha Baatallah, Yves Jacob, Thierry Rose, Yves L. Janin An original three component synthetic access to coelenterazine and analogues can lead to grams of marine luciferins which are extensively used in bioluminescence-based assays. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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I2-Catalyzed oxidative synthesis of N,4-disubstituted quinazolines and quinazoline oxides ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00349E, Communication Nagesh Jatangi, Radha Krishna Palakodety An easy and efficient synthetic approach to the title compounds is described, proceeding smoothly in the presence of molecular iodine. The metal-free protocol is insensitive to air moisture, is operationally simple and broadly applicable to a variety of N,4-disubstituted quinazoline-2-amine and oxides and synthesized in good to excellent yields starting from readily available inexpensive precursors. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Thieno[3,2-b]thiophene fused BODIPYs: synthesis, near-infrared luminescence and photosensitive properties ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00030E, Paper Yijuan Sun, Zhi-Rong Qu, Zhikuan Zhou, Lizhi Gai, Hua Lu The fusion of π-sufficient heteroaryl moieties has proven to be an effective strategy for achieving red shift of the main spectral bands of BODIPY. In this paper, thieno[3,2-b]thiophene-fused BODIPY derivatives... The content of this RSS Feed (c) The Royal Society of Chemistry
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A palladium-catalyzed multi-component annulation approach towards the synthesis of phenanthrenes ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00228F, Communication Juan Song, Songjiang Wang, Haisen Sun, Yuxuan Fan, Kang Xiao, Yan Qian An efficient palladium-catalyzed three-component cascade reaction has been developed for the facile construction of phenanthrene frameworks. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Organo-selenium mediated regio- and stereoselective iodoselenylation of alkynes in an aqueous medium: simple access to (E)-β-iodoalkenyl selenides ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00524B, Communication Xianghua Zeng, Lu Chen A method for the simple, efficient, and atom economical iodoselenylation of simple alkynes under mild conditions using molecular iodine (I2) and 1,2-diselanes as starting materials was developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A visible-light-induced cascade reaction of etherification/C–C cyclization: efficient synthesis of dibenzo[b,d]oxepin-7(6H)-ones ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00247B, Communication Wanyong Fu, Aixia Yu, Hongshuo Jiang, Minghui Zuo, Hongfeng Wu, Zhongwen Yang, Qi An, Zhizhong Sun, Wenyi Chu A visible-light-induced palladium-catalyzed cascade reaction was developed by etherification/C–C coupling cyclization of α-bromoacetophenones with phenols. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Copper-catalyzed C–H/N–H cross-coupling reactions for the synthesis of 3-heteroaryl quinoxalin-2(1H)-ones ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00294D, Communication Tao Guo, Chuan-Chuan Wang, Xiang-Heng Fu, Yu Liu, Pan-Ke Zhang An effective copper-catalyzed C–H/N–H cross-coupling of quinoxalin-2(1H)-ones with diverse unprotected 2-quinoxalinones and 2-quinolinones was developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of macrocyclic peptidomimetics via the Ugi-click-strategy ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00229D, Paper Elena A. Zakharova, Olga I. Shmatova, Irina V. Kutovaya, Victor N. Khrustalev, Valentine G. Nenajdenko The Ugi-click-strategy was employed for the synthesis of 12–28 membered 1,2,3-triazole derived macrocyclic peptidomimetics. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Recent advances in the asymmetric synthesis of pharmacology-relevant nitrogen heterocycles via stereoselective aza-Michael reactions ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB03034K, Review Article Maxim G. Vinogradov, Olga V. Turova, Sergei G. Zlotin In this review, recent applications of a stereoselective aza-Michael reaction for asymmetric synthesis of naturally occurring N-containing heterocyclic scaffolds and their usefulness to pharmacology are summarized. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Highly Efficient Regio-Selective Ring-Opening Nucleophilic Fluorination of Aziridines and Azetidines: Access to β- or γ-Fluorinated Amino Acid Derivatives ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00172G, Paper Liping Zhu, Jiale Xiong, Junkai An, Nannan Chen, Jijun Xue, Xianxing Jiang Herein, we have presented a facile and efficient method of ring-opening nucleophilic fluorination of aziridines, affording the highly regio-selective β-fluorinated amines. Especially, the example of ring-opening hydrofluorination of azetidines was... The content of this RSS Feed (c) The Royal Society of Chemistry
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Substitution of unsaturated lipid chains by thioether containing lipid chains in cationic amphiphiles: physico-chemical consequences and application for gene delivery ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00473D, Paper Amal Bouraoui, Mathieu Berchel, Rosy Ghanem, Véronique Vié, Gilles Paboeuf, Laure Deschamps, Olivier Lozach, Tony Le Gall, Tristan Montier, Paul-Alain Jaffres The hydrophobic moiety of cationic amphiphiles plays an important role in the transfection process because its structure has an impact on both the type of the supramolecular assembly and the... The content of this RSS Feed (c) The Royal Society of Chemistry
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Chiral Benzazaborole as Catalyst for Enantioselective Sulfonylation of cis-1,2-Diols ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C8OB03205J, Paper Satoru Kuwano, Yusei Hosaka, Takayoshi Arai A newly developed benzazaborole smoothly catalyzed the enantioselective sulfonylation of cis-1,2-diols. Using a chiral benzazaborole/NMI co-catalyst system, various sulfonate esters were prepared in high yields with good enantioselectivities. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis, bioactivity, and enzymatic modification of antibacterial thiotetromycin derivatives ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB03109F, Paper Marlene L. Rothe, Jie Li, Ernesto Garibay, Bradley S. Moore, Shaun M. K. McKinnie Interrogating the bioactivities and enzymatic modification potential of a focused library of novel synthetic thiotetronate compounds. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Electrochemical trifluoromethylation/semipinacol rearrangement sequences of alkenyl alcohols: synthesis of β-CF3-substituted ketones ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00373H, Communication Hye Im Jung, Yubin Kim, Dae Young Kim Electrochemical oxidative radical trifluoromethylation/semipinacol rearrangement sequences of alkenyl alcohols were developed in this study. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Aggregation-induced emission and polymorphism/shape/size-dependent emission behaviours of fenamates for potential drug evaluation ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00338J, Paper Xinyi Wang, Yifu Chen, Junbo Gong, Jinze Hou Aggregation-induced emission and polymorphism/shape/size-dependent emission behaviors were found coexisting in fenamates, which provides a novel approach toward future drug evaluation. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Mechanistic investigation and further optimization of the aqueous Glaser−Hay bioconjugation ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00327D, Paper Christopher R. Travis, Lauren E. Mazur, Emily M. Peairs, Gillian H. Gaunt, Douglas D. Young The Glaser–Hay bioconjugation has emerged as an efficient method to generate bioconjugates with therapeutic applications. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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C31-Selective substitution of cationic N-heteroaromatic groups into a 3-vinylated chlorophyll-a derivative ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00130A, Communication Tatsuya Takahashi, Shin Ogasawara, Shihoko Echizen, Yoshinao Shinozaki, Hitoshi Tamiaki A variety of N-heteroarenes were C31-selectively introduced for a chlorophyll-a derivative through a C–N+ bond by using iodine and a silver(I) salt. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Direct access to bis-S-heterocycles via copper-catalyzed three component tandem cyclization using S8 as a sulfur source ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00377K, Paper Peiqi Zhou, Yubing Huang, Wanqing Wu, Wentao Yu, Jianxiao Li, Zhongzhi Zhu, Huanfeng Jiang An elemental sulfur atom donor strategy for constructing a thiophene-fused thiazole bis-S-heterocyclic skeleton via Cu-catalyzed three-component tandem cyclization has been developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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N-Hydroxyphthalimide/benzoquinone-catalyzed chlorination of hydrocarbon C–H bond using N-chlorosuccinimide ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00216B, Paper Zi-Hao Li, Béla Fiser, Biao-Lin Jiang, Jian-Wei Li, Bao-Hua Xu, Suo-Jiang Zhang A metal-free protocol of chlorination of C–H bond with NCS is presented. Both experiments and theoretical analysis suggest NHPI functions as a catalyst rather than an initiator. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Selective red-emission detection for mercuric ions in aqueous solution and cells using fluorescent probe based on unnatural peptide receptor ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C8OB03224F, Paper Lok Nath Neupane, Pramod Kumar Mehta , Joon-Uk Kwon, see-young Park , Keun-Hyeung Lee It is still a significant challenge for the selective ratiometric red-emission detection for Hg2+ ions in aqueous buffered solutions and live cells. In the present study, we synthesized a fluorescent... The content of this RSS Feed (c) The Royal Society of Chemistry
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Intramolecular dehydrogenative C–S bond coupling of thioamides to form 1,3-benzothiazines under metal-free conditions ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00237E, Paper Li-Rong Wen, Cheng-Cheng Zhou, Ming-Zhe Zhu, Shu-Guang Xie, Wei-Si Guo, Ming Li A new protocol for the synthesis of 1,3-benzothiazines was developed through direct intramolecular dehydrogenative C–S bond coupling. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Facile synthesis of 2-azaspiro[3.4]octane ()
Org. Biomol. Chem., 2019, 17,3056-3065 DOI: 10.1039/C9OB00306A, Paper Subbiah Ramesh, Ramadas Balakumar, John R. Rizzo, Tony Y. Zhang Synthesis of 2-azaspiro[3.4]octane was achieved by ring annulation of five-membered as well as four-membered rings. The merits and limitations of the three efficient synthetic methodologies developed are discussed. The content of this RSS Feed (c) The Royal Society of Chemistry
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Correction: The expanding spectrum of diketopiperazine natural product biosynthetic pathways containing cyclodipeptide synthases ()
Org. Biomol. Chem., 2019, 17,3066-3066 DOI: 10.1039/C9OB90038A, Correction Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Paul Borgman, Ryan D. Lopez, Amy L. Lane The content of this RSS Feed (c) The Royal Society of Chemistry
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One-pot synthesis of 4-arylidene imidazolin-5-ones by reaction of amino acid esters with isocyanates and α-bromoketones ()
Org. Biomol. Chem., 2019, 17,3040-3047 DOI: 10.1039/C8OB03111H, Paper Jia-Yun Haung, Indrajeet J. Barve, Chung-Ming Sun A one-pot multicomponent reaction for assembling substituted 4-arylidene imidazolin-5-ones from L-amino acid methyl esters, iso-, isothio- or isoselenocyanates, and α-bromoketones has been discovered. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and nano-Pd catalyzed chemoselective oxidation of symmetrical and unsymmetrical sulfides ()
Org. Biomol. Chem., 2019, 17,3048-3055 DOI: 10.1039/C8OB03209B, Paper Xing Li, Jia Du, Yongli Zhang, Honghong Chang, Wenchao Gao, Wenlong Wei A highly chemoselective nano-Pd catalyzed protocol for the construction of sulfoxides and sulfones via the oxidation of symmetrical and unsymmetrical sulfides using H2O2 as an oxidant has been developed, respectively. The content of this RSS Feed (c) The Royal Society of Chemistry
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The asymmetric construction of CF3-containing spiro-thiazolone-pyrrolidine compounds via [3 + 2] cycloaddition ()
Org. Biomol. Chem., 2019, 17,2892-2895 DOI: 10.1039/C9OB00325H, Communication Boyu Li, Jikun Liu, Fengyun Gao, Mengmeng Sun, Yifei Guo, Yuan Zhou, Dongwa Wen, Yabo Deng, Hui Chen, Kairong Wang, Wenjin Yan An organocatalytic method for the asymmetric construction of CF3-containing spiro-thiazolone-pyrrolidine compounds has been developed. The content of this RSS Feed (c) The Royal Society of Chemistry
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Understanding exo-selective Diels–Alder reactions involving Fischer-type carbene complexes ()
Org. Biomol. Chem., 2019, 17,2985-2991 DOI: 10.1039/C9OB00132H, Paper Jorge Juan Cabrera-Trujillo, Israel Fernández Exo-selective Diels–Alder cycloaddition reactions can be successfully achieved by the proper selection of an initial Fischer carbene complex. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and characterization of new D–π-A and A–π-D–π-A type oligothiophene derivatives ()
Org. Biomol. Chem., 2019, 17,3018-3025 DOI: 10.1039/C8OB03077D, Paper Fabiana Pandolfi, Daniele Rocco, Leonardo Mattiello New conjugated oligothiophenes with different donor/acceptor architectures were synthesized, with potential applications in the field of organic electronics. The content of this RSS Feed (c) The Royal Society of Chemistry
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An efficient preparation of β-ketophosphine oxides from alkynylphosphine oxides with benzaldehyde oxime as a hydroxide source ()
Org. Biomol. Chem., 2019, 17,3003-3009 DOI: 10.1039/C9OB00251K, Paper Lu-Lu Chen, Jing-Wen Zhang, Wan-Wan Yang, Pei Chen, Dan-Yun Chen, Yan-Bo Wang An effective transition-metal-free method has been developed for the preparation of β-ketophosphine oxides from alkynylphosphine oxides with benzaldehyde oxime. The content of this RSS Feed (c) The Royal Society of Chemistry
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Expanding the “minimalist” small molecule tagging approach to different bioactive compounds ()
Org. Biomol. Chem., 2019, 17,3010-3017 DOI: 10.1039/C8OB03175D, Paper Wenjie Lang, Chaonan Yuan, Biwei Zhu, Sijun Pan, Jian Liu, Jie Luo, Shikun Nie, Qing Zhu, Jun-Seok Lee, Jingyan Ge “Minimalist” small molecule tagging (MSMT) is a promising approach that easily converts bioactive compounds into affinity-based probes (AfBPs) for proteomic studies. The content of this RSS Feed (c) The Royal Society of Chemistry
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Zinc-catalyzed regioselective C–P coupling of p-quinol ethers with secondary phosphine oxides to afford 2-phosphinylphenols ()
Org. Biomol. Chem., 2019, 17,2972-2984 DOI: 10.1039/C9OB00129H, Paper Ming Zhang, Xiaoyu Jia, Haowei Zhu, Xutong Fang, Chenyi Ji, Sizhuo Zhao, Li-Biao Han, Ruwei Shen A highly regioselective C–P coupling reaction of p-quinol ethers with secondary phosphine oxides is developed as a new synthesis method for 2-phosphinylphenols by using Zn(OTf)2 as the catalyst. The content of this RSS Feed (c) The Royal Society of Chemistry
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A parallel permeability assay of peptides across artificial membranes and cell monolayers using a fluorogenic reaction ()
Org. Biomol. Chem., 2019, 17,2887-2891 DOI: 10.1039/C9OB00133F, Communication Jumpei Morimoto, Rei Amano, Takahiro Ono, Shinsuke Sando An alkyne tag and a fluorogenic reaction enabled the rapid parallel evaluation of membrane permeability of peptides across artificial membranes and cell monolayers. The content of this RSS Feed (c) The Royal Society of Chemistry
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N-Arylations of trifluoromethylated N-acylhydrazones with diaryliodonium salts as arylation reagents ()
Org. Biomol. Chem., 2019, 17,2940-2947 DOI: 10.1039/C9OB00236G, Paper Huaiyuan Zhang, Ke-Hu Wang, Junjiao Wang, Yingpeng Su, Danfeng Huang, Yulai Hu A novel and efficient N-arylation of trifluoromethylated N-acylhydrazones is described by using diaryliodonium salts as arylation reagents in the presence of copper salts. A wide variety of N-aryl acylhydrazones are obtained with good to excellent yields under mild reaction conditions. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and antitubercular activity of 1- and 3-substituted benzo[g]isoquinoline-5,10-diones ()
Org. Biomol. Chem., 2019, 17,2923-2939 DOI: 10.1039/C8OB02690D, Paper Robert J. Smets, Eveline Torfs, Filip Lemière, Paul Cos, Davie Cappoen, Kourosch Abbaspour Tehrani The synthesis of a new class of 1- and 3-substituted benzo[g]isoquinoline-5,10-diones and their anti-mycobacterial activities against Mycobacterium tuberculosis H37Rv is reported. The content of this RSS Feed (c) The Royal Society of Chemistry
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Aptamer-guided acridine derivatives for cervical cancer ()
Org. Biomol. Chem., 2019, 17,2992-3002 DOI: 10.1039/C9OB00318E, Paper Josué Carvalho, Jéssica Lopes-Nunes, Ana Catarina Lopes, Maria Paula Cabral Campello, António Paulo, João A. Queiroz, Carla Cruz An AT11-L0 G4 drug delivery system for the selective conveyance of acridine orange ligands to cervical cancer cells. The content of this RSS Feed (c) The Royal Society of Chemistry
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Dicyclohexylurea derivatives of amino acids as dye absorbent organogels and anion sensors ()
Org. Biomol. Chem., 2019, 17,3026-3039 DOI: 10.1039/C9OB00014C, Paper Karabi Roy, Suvankar Ghosh, Monikha Chetia, Priyadarshi Satpati, Sunanda Chatterjee Dicyclohexyl urea (DCU) derivatives of amino acids Fmoc-Phe-DCU (M1), Fmoc-Phg-DCU (M2) and Fmoc-Gaba-DCU (M3) have been shown to form phase selective, thermoreversible and mechanically robust gels in a large range of organic solvents. Organogels act as dye adsorbants and M1–M3 act as selective anion sensors for F−, OH− and OAc−. The content of this RSS Feed (c) The Royal Society of Chemistry
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Thiosquaramide-catalysed asymmetric double Michael addition of 2-(3H)-furanones to nitroolefines ()
Org. Biomol. Chem., 2019, 17,2883-2886 DOI: 10.1039/C9OB00330D, Communication Mengchen Yang, Chen Chen, Xing Yi, Yuan Li, Xiaoqin Wu, Qingshan Li, Shurong Ban 2,2,4-Trisubstituted butenolides bearing a quaternary stereogenic center were smoothly constructed with excellent stereoselectivities under mild conditions. The content of this RSS Feed (c) The Royal Society of Chemistry
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Photoredox-catalyzed cascade annulation of N-propargylindoles with sulfonyl chlorides: access to 2-sulfonated 9H-pyrrolo[1,2-a]indoles ()
Org. Biomol. Chem., 2019, 17,2873-2876 DOI: 10.1039/C9OB00218A, Communication Pengbo Zhang, Shanshan Shi, Xia Gao, Shuang Han, Jinming Lin, Yufen Zhao A photoredox-catalyzed cascade radical reaction of N-propargylindoles and sulfonyl chlorides to 2-sulfonated 9H-pyrrolo[1,2-a]indoles under external oxidant-free conditions was developed. The content of this RSS Feed (c) The Royal Society of Chemistry
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Structure elucidation and biosynthetic gene cluster analysis of caniferolides A–D, new bioactive 36-membered macrolides from the marine-derived Streptomyces caniferus CA-271066 ()
Org. Biomol. Chem., 2019, 17,2954-2971 DOI: 10.1039/C8OB03115K, Paper Ignacio Pérez-Victoria, Daniel Oves-Costales, Rodney Lacret, Jesús Martín, Marina Sánchez-Hidalgo, Caridad Díaz, Bastien Cautain, Francisca Vicente, Olga Genilloud, Fernando Reyes The structures of caniferolides A–D have been determined combining NMR and bioinformatics prediction of the absolute configuration. The content of this RSS Feed (c) The Royal Society of Chemistry
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Rhodium-catalyzed direct C–H bond alkynylation of aryl sulfonamides with bromoalkynes ()
Org. Biomol. Chem., 2019, 17,2948-2953 DOI: 10.1039/C9OB00061E, Paper Hongcen Hou, Yongli Zhao, Shouzhi Pu, Junmin Chen This protocol selectively provides a straightforward route to prepare ortho-(1-alkynyl) benzenesulfonamides or six-membered benzosultams by using different silyl protected bromoalkynes. The content of this RSS Feed (c) The Royal Society of Chemistry
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Recent advances in metal-free aerobic C–H activation ()
Org. Biomol. Chem., 2019, 17,2865-2872 DOI: 10.1039/C9OB00339H, Review Article André Shamsabadi, Vijay Chudasama An overview of recent reactions based on the metal-free, dioxygen-induced, C–H activation of various radical precursors. The content of this RSS Feed (c) The Royal Society of Chemistry
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Recent advances in the synthesis of C2-spiropseudoindoxyls ()
Org. Biomol. Chem., 2019, 17,2850-2864 DOI: 10.1039/C8OB03122C, Review Article Yanling Ji, Xianghong He, Cheng Peng, Wei Huang This review summarizes the recent development of novel approaches to construct structurally unique oxindoles featuring a spirocycle at the C2 position. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of trisaccharide repeating unit of fucosylated chondroitin sulfate ()
Org. Biomol. Chem., 2019, 17,2877-2882 DOI: 10.1039/C9OB00057G, Communication Haiqing He, Dong Chen, Xiaomei Li, Chengji Li, Jin-Hua Zhao, Hong-Bo Qin A synthesis of repeating unit of trisaccharide, complete stereoselectivity of glycosylation and flexible synthetic strategy. The content of this RSS Feed (c) The Royal Society of Chemistry
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