Organic & Biomolecular Chemistry



Effects of Charge Balance and Hydrophobicity of the Surface of Cytochrome c on the Distribution Behaviour in an Ionic Liquid/Buffer Biphasic System ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00900K, Paper Kazuma Ikeda, Kyoko Fujita, Hiroyuki Ohno, Nobuhumi Nakamura Factors contributing to the different distribution behaviour of cytochrome c were investigated in a biphasic tetrabutylphosphonium 2,4,6-trimethylbenzenesulfonate and potassium phosphate buffer system, which shows a lower critical solution temperature. To... The content of this RSS Feed (c) The Royal Society of Chemistry
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Bimetallic Cu/Pd-Catalyzed Three-Component Azide−Alkyne cycloaddition/Isocyanide Insertion: Synthesis of Fully Decorated Polycyclic Triazoles ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01175G, Communication Shiva Kumar Kota, Praveen Kumar Naikawadi, Rambabu Dandela, Ramanna Jatoth Construction of fully decorated 1,2,3-triazole-fused 5-, 6- and 7-membered rings has been disclosed via bimetallic relay-catalyzed cascade process combining azide−alkyne cycloaddition, C(sp2)−H functionalization of 1,2,3- triazoles and isocyanide insertion. The... The content of this RSS Feed (c) The Royal Society of Chemistry
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An unprecedented oxidised julolidine-BODIPY conjugate and its application in real-time ratiometric fluorescence sensing of sulfite ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01316D, Paper A C Benniston, Dumitru Sirbu, Paul G Waddell, Lingli Zeng Reaction of a julolidine-based BODIPY compound with silver (I) ions in the presence of white light produced the oxidised julolidine version (OXJUL) containing a quaternary nitrogen. The oxidation of one... The content of this RSS Feed (c) The Royal Society of Chemistry
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Aminophosphonates and aminophosphonic acids with tetrasubstituted stereogenic center: diastereoselective synthesis from cyclic ketimines ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01346F, Paper Tomasz K. Olszewski, Jakub Iwanejko, Anna Brol, Marek Daszkiewicz, Barlomiej Szyja, Elzbieta Wojaczynska New chiral tetrasubstituted aminophosphonic acid derivatives of hexahydroquinoxalin-2(1H)-one were synthesised via highly diastereoselective hydrophosphonylation of the corresponding imines with tris(trimethylsilyl) phosphite as phosphorus nucleophile. High asymmetric induction, good yields, mild... The content of this RSS Feed (c) The Royal Society of Chemistry
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An Organocatalytic method for Constructing Pyrroles via Cycloisomerisation of Z-1-iodo-4-N-methylbenzenesulfonyl-1,6-enynes ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01123D, Communication Long Meng, Xiaochen Chi, Xi Sun, Chengqiang Cao, Bing Ai, Qing Liu, Pingping Zhao, Zengdian Zhao, Yunhui Dong, Hui Liu A new cycloisomerisation of Z-1-iodo-4-N-methylbenzenesulfonyl-1,6-enynes to functionalized pyrroles was realized in the presence of organomolecule (4,4'-bis(1,1-dimethylethyl)-2,2'-bipyridine) and KOtBu. The transformations performed efficiently to produce kinds of functionalized pyrroles within 10... The content of this RSS Feed (c) The Royal Society of Chemistry
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Bio-Inspired Enantioselective Total Syntheses of (−)-Viminalins A, B, H, I, N and Structural Reassignment of (−)-Viminalin M ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01426H, Paper Dattatraya Dethe, Appasaheb Keshav Nirpal A bio-inspired enantioselective total synthesis of (−)-viminalins A, B, H, I, and N, isolated from Myrtaceae family, were accomplished in a convergent fashion in 5, 5, 1, 1, and 3... The content of this RSS Feed (c) The Royal Society of Chemistry
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Dinuclear zinc cooperative catalytic three-component reactions for highly enantioselective synthesis of 3,3′-dihydrofuran spirooxindoles ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01233H, Paper Yu-Hang Miao, Yuan-Zhao Hua, Min-Can Wang A new dinuclear zinc cooperative catalytic enantioselective three-component reaction via a domino Knoevenagel/Michael/cyclization sequence has been developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A novel chemiluminescent probe for hydrazine detection in water and HeLa cells ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01407A, Communication Jiang Liu, Jianze Jiang, Yandong Dou, Fangfang Zhang, Xin Liu, Jiaojiao Qu, Qing Zhu A novel chemiluminescent probe based on intramolecular cyclization for hydrazine detection in living cells. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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N-Thiocyanato-dibenzenesulfonimide: a new electrophilic thiocyanating reagent with enhanced reactivity ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01340G, Communication Chengqiu Li, Pingliang Long, Haopeng Wu, Hongquan Yin, Fu-Xue Chen N-Thiocyanato-dibenzenesulfonimide: a new electrophilic thiocyanating reagent was readily prepared and exhibited enhanced reactivity with a wide scope of substrates. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Exploring the strength of a hydrogen bond as a function of steric environment using 1,2-azaborine ligands and engineered T4 lysozyme receptors ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01008D, Paper Yao Liu, Shih-Yuan Liu The relationship between the steric demand of the ligand and hydrogen bonding strength in the context of ligand–protein binding is revealed using engineered T4 lysozymes as the model biomacromolecules and 1,2-azaborines as ligands. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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TetraPh-Tol-BITIOPO: a new atropisomeric 3,3’-bithiophene based phosphine oxide as organocatalyst in Lewis Base-catalyzed Lewis Acid mediated reactions. ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01297D, Paper Abbinante Vincenzo Mirco, Maurizio Benaglia, Sergio Rossi, Tiziana Benincori, Roberto Cirilli, Marco Pierini A new chiral phosphine oxide based on 3,3’-bithiophene scaffold (tetraPh-Tol-BITIOPO) was synthesized, fully characterized and separate into antipodes through chiral HPLC. This new compound was successfully employed as organocatalyst in... The content of this RSS Feed (c) The Royal Society of Chemistry
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Consecutive multicomponent reactions for the synthesis of complex molecules ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00772E, Review Article Sanjun Zhi, Xiaoming Ma, Wei Zhang Multicomponent reactions (MCRs) involving a minimum of three reactants or reaction centers are conducted in one pot and with a single operation step. This synthetic method has good pot, atom... The content of this RSS Feed (c) The Royal Society of Chemistry
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A facile copper(I)-catalyzed homo-coupling of indanone derivatives using diaziridinone under mild conditions ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00901A, Communication Wenyong Han, Yihui Yang, Yingguang Zhu, Yian Shi A variety of 1,4-dicarbonyl compounds containing vicinal quaternary carbons are efficiently generated in high yields with high diastereoselectivities via Cu(I)-catalyzed homo-coupling of indanone derivatives using diaziridinone as an oxidant. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Copper-mediated direct thiolation of aryl C–H bonds with disulfides ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01255A, Paper Ke-Zuan Deng, Li-Li Zhang, Ye-Feng Chen, He-Xin Xie, Xiao-Bo Xu, Cheng-Cai Xia, Ya-Fei Ji A directing group-assisted copper-mediated thiolation of aromatic amides with disulfides via direct C(sp2)–H activation has been developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Phosphine-Catalyzed Michael Additions to α-Methylene-γ-Butyrolactones ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01401B, Communication Alexey V. Salin, Daut Islamov The highly efficient addition of phosphorus and carbon pronucleophiles to α-methylene-γ-butyrolactones (tulipalin A and arglabin) under n-Bu3P catalysis is reported. Kinetic experiments indicate that the unprecedentedly high reactivity of α-methylene-γ-butyrolactones... The content of this RSS Feed (c) The Royal Society of Chemistry
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Organocatalytic synthesis of enantiopure spiro acenaphthyl-pyrrolizidine/pyrrolidines: justifying the regioselectivity based on a distortion/interaction model ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01197H, Paper Naeimeh Shahrestani, Hormoz Khosravi, Khosrow Jadidi, Behrouz Notash, Soheila Naderi An efficient organocatalytic synthesis of chiral spiroacenaphthyl-pyrrolidines/pyrrolizidines with high regio- and diastereoselectivity (up to 99%) with exact specification of the absolute configuration is described for the first time. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Rhodium(I)-catalyzed vinylation/[2 + 1] carbocyclization of 1,6-enynes with α-diazocarbonyl compounds ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01028A, Paper Junmin Huang, Xinwei Hu, Fengjuan Chen, Jiao Gui, Wei Zeng Rh(I)-catalyzed coupling–cyclization of enynes with diazo compounds has been developed to obtain versatile vinyl-substituted azabicyclo[3.1.0]hexanes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Stereoselective Construction of Deoxy-Cruciferane Alkaloids by NHC-Catalyzed Intramolecular Annulation of Homoenolate with Quinazolinone ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01243E, Communication Milind M Ahire, Mahesh D. Pol, Dattatry S. Kavale, Rajesh G. Gonnade, Santosh B. Mhaske Chiral N-heterocyclic carbene (NHC)-catalyzed intramolecular [3 + 2] annulation of enals with unactivated imine moiety of quinazolinone via formal homoenolate cycloaddition has been demonstrated. It is an excellent approach for... The content of this RSS Feed (c) The Royal Society of Chemistry
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(Z)-Tetrahydrothiophenes and (Z)-Tetrahydrothiopyrans Synthesis through Nucleophilic Substitution and Intramolecular Cycloaddition of Alkynyl Halide and EtOCS2K ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01370A, Communication XIanglin Luo, Xiuwen Chen, Zhiyan Song, Junyi Liang, Chunshu Liao, Zhongzhi Zhu, Lu Chen, Yibiao Li This protocol provides a novel, environmentally friendly and simple method for synthesis of (Z)-tetrahydrothiophene derivatives using the nucleophilic thiyl radical intramolecular cycloaddition cascade process to construct C–S bonds under transition-metal-free.... The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and glycosidase inhibition of conformationally locked DNJ and DMJ derivatives exploiting a 2-oxo-C-allyl iminosugar ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01402K, Paper quentin foucart, Yuna Shimadate, Jérome Marrot, Atsushi Kato, Jerome Desire, Yves Blériot A series of analogs of the iminosugars deoxynojirimycin (DNJ) and deoxymannojirimycin (DMJ), in which an extra five or six-membered ring has been fused to the C1-C2 bond have been prepared.... The content of this RSS Feed (c) The Royal Society of Chemistry
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Catalytic asymmetric (4 + 1) annulation of nitroalkenes with allylic acetates: stereoselective synthesis of isoxazoline N-oxides ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01058K, Communication Jinghua Luo, Rongshun Chen, Xia Fan, Junyu Gong, Jie Han, Zhengjie He A highly enantioselective catalytic asymmetric (4 + 1) annulation reaction of nitroalkenes and ammonium ylides is reported for the first time. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Regiospecific formation of sugar-derived ketonitrone towards unconventional C-branched pyrrolizidines and indolizidines ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01419E, Paper Fabien Massicot, Gatien Messire, Alexis Vallée, Jean-Luc Vasse, Sandrine Py, Jean-Bernard Behr The synthesis of unprecedented branched pyrrolizidines and indolizidines was accomplished via nitrone chemistry. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of thiazolo[2,3-b]quinazoline derivatives via base-promoted cascade bicyclization of o-alkenylphenyl isothiocyanates with propargylamines ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01098J, Communication Jiankang Miao, Xiaoyan Sang, Yi Wang, Shufeng Deng, Wenyan Hao A highly efficient base-promoted cascade bicyclization of o-alkenylphenyl isothiocyanates with propargylamines for constructing thiazolo[2,3-b]quinazolines has been demonstrated. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Unified synthesis and cytotoxic activity of 8-O-methylfusarubin and its analogues ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01221D, Paper Pongsit Vijitphan, Vatcharin Rukachaisirikul, Chatchai Muanprasat, Panata Iawsipo, Jiraporn Panprasert, Kwanruthai Tadpetch A unified total synthesis of 8-O-methylfusarubin, 8-O-methylanhydrofusarubin, fusarubin and anhydrofusarubin and their cytotoxic activities against six cancer cell lines are described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Boosting the singlet oxygen photosensitization abilities of Zn(II) phthalocyanines through functionalization with bulky fluorinated substituents ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00872A, Paper Tomás Torres, Miguel Angel Revuelta-Maza, Santi Nonell, Gema de la Torre In-depth, systematic photophysical studies have been performed on a series of ABAB, A3B and A4 ZnPcs functionalized with a varying number of trifluoromethylphenyl units (i.e. at the B isoindoles) and... The content of this RSS Feed (c) The Royal Society of Chemistry
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A Rink-Amide Soluble Support: High Purity Conotoxins and Other Peptides Accessed with Minimal Reagents ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01214A, Paper Babita Bisht, Nimmashetti Naganna, Nandita Madhavan The use of peptides as therapeutics has been growing due to their biocompatibility. Solid phase peptide synthesis typically used to access these peptides requires excess reagents and/or microwave irradiation to... The content of this RSS Feed (c) The Royal Society of Chemistry
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Combining enzymes and organometallic complexes: novel artificial metalloenzymes and hybrid systems for C–H activation chemistry ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01091B, Review Article Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Carlos Perez-Rizquez, Alba Rodriguez-Otero, Jose M. Palomo This review describes the advances in the design and application of novel artificial metalloenzymes in C–H activation reactions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Extended scaffold glucuronides: en route to the universal synthesis of O-aryl glucuronide prodrugs ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01384A, Communication Raoul Walther, Morten T. Jarlstad Olesen, Alexander N. Zelikin An extended scaffold is the key to facile glucuronidation for the synthesis of prodrugs. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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CATALYTIC ENANTIOSELECTIVE MICHAEL ADDITION OF 2-SUBSTITUTED BENZOFURAN-3-ONES WITH 2-ENOYL PYRIDINES ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01069F, Paper Sivamuthuraman Koilpitchai, Venkitasamy Kesavan An organocatalytic diastereo- and enantioselective synthesis of 2,2-disubstituted benzofuran-3-one bearing adjacent quaternary and tertiary stereocenter has been achieved through Michael addition of 2-substituted benzofuran-3-one with 2-enoyl pyridine. Both the enantiomeric... The content of this RSS Feed (c) The Royal Society of Chemistry
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A biomimetic approach towards phorone sesterterpenoids ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00745H, Communication Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Harry J. Shirley, Christopher D. Bray We report efforts towards a unified total synthesis of Korean sponge derived sesterterpenoids phorones A and B, using a biomimetic strategy. This work has established a new synthetic approach to the parent ansellane sesterterpenoid skeleton with unanticipated diversion along a biogenetically related pathway. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Palladium-Catalyzed Intermolecular Allenylation Reactions of 2,3-Disubstituted Indoles and Allenyl Carbonate ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01435G, Communication Yizhan Zhai, Shuli You, Shengming Ma A palladium-catalyzed intermolecular allenylation of non-strained 2,3-disubstituted indoles and allenyl carbonate has been developed, providing a convenient access to indolenines bearing an allene unit by taking advantage of the C-3... The content of this RSS Feed (c) The Royal Society of Chemistry
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Development of dansyl based copper(II) complex to detect hydrogen sulfide in hypoxia ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00948E, Paper Jee Young Kim, Swarbhanu Sarkar, Kondapa Naidu Bobba, Phuong Tu Huynh, Abhinav Bhise, Jeongsoo Yoo Hydrogen sulfide (H2S) has been detected by fluorescence imaging in living cells under hypoxia. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of α,β-alkynyl ketones via the nickel catalysed carbonylative Sonogashira reaction using oxalic acid as a sustainable C1 source ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01064E, Paper Shaifali, Shankar Ram, Vandna Thakur, Pralay Das CO gas free nickel catalysed carbonylative Sonogashira coupling of aryl iodides and phenylacetylenes using oxalic acid as the CO source. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Recent advances in catalytic asymmetric intermolecular oxidation of alkynes ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01096C, Review Article Wen-Bo Shen, Xiang-Ting Tang In recent years, gold-metal-catalyzed intermolecular alkyne oxidation by an N-oxide oxidant, which presumably involves a gold carbenoid intermediate, has attracted increasing attention because it circumvents the employment of hazardous and potentially explosive diazocarbonyl compounds as starting materials for carbene generation. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A computational study on the identity of the active catalyst structure for Ru(II) carboxylate assisted C–H activation in acetonitrile ()
Org. Biomol. Chem., 2019, 17,6678-6686 DOI: 10.1039/C9OB01092K, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Claire L. McMullin, Nasir A. Rajabi, James S. Hammerton Density Functional Theory (DFT) calculations using a consistent methodology accounting for solvation, dispersion and thermal effects have been used to study C–H activation of the simple directing group substrate 2-phenylpyridine (a-H). The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of difluoromethylated 2-oxindoles and quinoline-2,4-diones via visible light-induced tandem radical cyclization of N-arylacrylamides ()
Org. Biomol. Chem., 2019, 17,6629-6638 DOI: 10.1039/C9OB01213C, Paper Huan Sun, Yue Jiang, Ying-Sha Yang, Yun-Yun Li, Lin Li, Wen-Xuan Wang, Tao Feng, Zheng-Hui Li, Ji-Kai Liu Visible light-induced difluoromethylation of N-arylacrylamides to afford difluoromethylated 2-oxindoles and quinoline-2,4-diones with difluoromethyl 2-pyridyl sulfones as radical precursors has been disclosed. The content of this RSS Feed (c) The Royal Society of Chemistry
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Exploring the ring-opening reactions of imidazo[1,5-a]quinolines for the synthesis of imides under photochemical conditions ()
Org. Biomol. Chem., 2019, 17,6570-6573 DOI: 10.1039/C9OB01227C, Communication Ya Peng, Cheng-Tao Feng, Yu-Qing Li, Feng-Xiang Chen, Kun Xu The photoredox ring-opening of imidazoquinolines was developed for the first time, which provides a direct route to imides. The content of this RSS Feed (c) The Royal Society of Chemistry
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Regio- and stereoselective [3 + 2] cycloaddition reaction: access to isoxazole-dispirobisoxindoles featuring three contiguous stereocenters ()
Org. Biomol. Chem., 2019, 17,6551-6556 DOI: 10.1039/C9OB01203F, Communication Shuang Chen, Guan-Lian Wang, Sheng-Wen Xu, Min-Yi Tian, Min Zhang, Xiong-Li Liu, Wei-Cheng Yuan A novel methodology toward the diversity-oriented asymmetric construction of densely functionalized isoxazole-dispirobisoxindoles was developed. The content of this RSS Feed (c) The Royal Society of Chemistry
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One-pot synthesis of 1,3,4-oxadiazol-2(3H)-ones with CO2 as a C1 synthon promoted by hypoiodite ()
Org. Biomol. Chem., 2019, 17,6639-6644 DOI: 10.1039/C9OB01200A, Paper Na Yang, Gaoqing Yuan A convenient and efficient route has been developed to synthesize 1,3,4-oxadiazol-2(3H)-ones from CO2, hydrazines and aryl or aliphatic aldehydes. The content of this RSS Feed (c) The Royal Society of Chemistry
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Structures and biological activities of cycloheptamycins A and B ()
Org. Biomol. Chem., 2019, 17,6595-6600 DOI: 10.1039/C9OB01261C, Paper Zhengyi Qian, Janine Antosch, Jutta Wiese, Johannes F. Imhoff, Hans-Peter Fiedler, Alexander Pöthig, Tobias A. M. Gulder The structures, absolute configurations and biological activities, particularly against P. acnes, of the cycloheptamycin family of cycloheptadepsipeptides are presented. The content of this RSS Feed (c) The Royal Society of Chemistry
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Predictive chirality sensing via Schiff base formation ()
Org. Biomol. Chem., 2019, 17,6699-6705 DOI: 10.1039/C9OB01265F, Paper Samantha L. Pilicer, Michele Mancinelli, Andrea Mazzanti, Christian Wolf Determination of ee and absolute configuration of chiral amines is achieved with a sterically crowded Schiff base sensor. The content of this RSS Feed (c) The Royal Society of Chemistry
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Gold(I)-promoted α-selective sialylation of glycosyl ortho-hexynylbenzoates for the latent-active synthesis of oligosialic acids ()
Org. Biomol. Chem., 2019, 17,6580-6584 DOI: 10.1039/C9OB00954J, Communication Jiazhe Wang, Qixin Lou, Jingjing Rong, You Yang A gold(I)-promoted α-selective glycosylation approach with sialyl ortho-hexynylbenzoates as donors is developed for the latent-active synthesis of α-(2 → 9)-linked oligosialic acids. The content of this RSS Feed (c) The Royal Society of Chemistry
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Amine-tethered phenylboronic acid-enabling ring-opening strategy for carbon chain elongation from double aldol cyclic hemiacetals ()
Org. Biomol. Chem., 2019, 17,6562-6565 DOI: 10.1039/C9OB01263J, Communication Yamato Kanzaki, Yuki Hirao, Harunobu Mitsunuma, Motomu Kanai A boron reagent for the ring-opening reaction of double aldol cyclic hemiacetals to generate their aldehyde forms is developed. The content of this RSS Feed (c) The Royal Society of Chemistry
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Organocatalytic asymmetric synthesis of dihydrofuran-spirooxindoles from benzylidene malononitriles and dioxindoles ()
Org. Biomol. Chem., 2019, 17,6557-6561 DOI: 10.1039/C9OB01199D, Communication Megha Balha, Buddhadeb Mondal, Subhas Chandra Pan The first organocatalytic asymmetric synthesis of dihydrofuran-spirooxindoles having a linkage at the 2-position of the dihydrofuran motif has been developed from dioxindoles and benzylidene malononitriles. The content of this RSS Feed (c) The Royal Society of Chemistry
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Diastereoselective synthesis of α-dicarbonyl cyclopropanes via a lanthanide amide-catalysed reaction ()
Org. Biomol. Chem., 2019, 17,6620-6628 DOI: 10.1039/C9OB00732F, Paper Wenxi Sun, Cheng Peng, Zhigang Yao, Fan Xu A lanthanide amide-catalyzed one-pot reaction was developed affording α-dicarbonyl cyclopropanes in good yields and with high stereoselectivity. The content of this RSS Feed (c) The Royal Society of Chemistry
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Questioning the γ-gauche effect: stereoassignment of 1,3-disubstituted-tetrahydro-β-carbolines using 1H–1H coupling constants ()
Org. Biomol. Chem., 2019, 17,6687-6698 DOI: 10.1039/C9OB01139K, Paper Kristýna Cagašová, Maryam Ghavami, Zhong-Ke Yao, Paul R. Carlier Are γ-gauche interactions in trans-tetrahydro-β-carbolines responsible for upfield 13C NMR shifts (Δδ) of C1 and C3 relative to their cis-isomers? The content of this RSS Feed (c) The Royal Society of Chemistry
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Thermal and photochemical annulation of vinyl azides to 2-aminoimidazoles ()
Org. Biomol. Chem., 2019, 17,6566-6569 DOI: 10.1039/C9OB01100E, Communication Lucas Man, Royston C. B. Copley, Anthony L. Handlon The rapid and facile generation of diverse 2-aminoimidazoles via thermal or photochemical activation of vinyl azides has been investigated. The content of this RSS Feed (c) The Royal Society of Chemistry
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Organocatalytic [4 + 2] cyclizations of para-quinone methide derivatives with isocyanates ()
Org. Biomol. Chem., 2019, 17,6662-6670 DOI: 10.1039/C9OB00918C, Paper Yu-Chun Cheng, Cong-Shuai Wang, Tian-Zhen Li, Feng Gao, Yinchun Jiao, Feng Shi The first [4 + 2] cyclizations of o-hydroxyphenyl-substituted p-quinone methide derivatives with isocyanates have been established under the catalysis of Brønsted acids or Brønsted bases, which efficiently constructed benzoxazin-2-one frameworks in generally high yields. The content of this RSS Feed (c) The Royal Society of Chemistry
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Visible-light-induced deboronative alkylarylation of acrylamides with organoboronic acids ()
Org. Biomol. Chem., 2019, 17,6612-6619 DOI: 10.1039/C9OB01023H, Paper Xuezhi Li, Man-Yi Han, Bin Wang, Lei Wang, Min Wang A visible-light-induced deboronative alkylarylation of acrylamides with boronic acids was developed via a tandem reaction process. The content of this RSS Feed (c) The Royal Society of Chemistry
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A facile construction of oxygen heterocycles by the reaction of benzoxepine-4-carboxylates with dihaloalkanes and activated alkynes ()
Org. Biomol. Chem., 2019, 17,6645-6653 DOI: 10.1039/C9OB00769E, Paper Veera Prasad Kasagani, Siva Hariprasad Kurma, China Raju Bhimapaka The manuscript describes the preparation of naphtho[1,3]-dioxoles, [1,4]-dioxines, [1,4]-dioxepines, [1,4]-dioxocines and diethyl 2-(2-ethoxy-2-oxoethyl)naphtho[1,3]dioxoles by the reaction of benzoxepine-4-carboxylates with dihaloalkanes and activated alkynes. The content of this RSS Feed (c) The Royal Society of Chemistry
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Full solid-phase total synthesis of macrocyclic natural peptides using four-dimensionally orthogonal protective groups ()
Org. Biomol. Chem., 2019, 17,6519-6527 DOI: 10.1039/C9OB01130G, Review Article Hiroaki Itoh, Masayuki Inoue This review focuses on four-dimensionally orthogonal protective group strategies for the full solid-phase synthesis of macrocyclic natural peptides. The content of this RSS Feed (c) The Royal Society of Chemistry
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A convenient one-pot nanosynthesis of a C(sp2)–C(sp3)-linked 3D grid via an ‘A2 + B3’ approach ()
Org. Biomol. Chem., 2019, 17,6574-6579 DOI: 10.1039/C9OB00754G, Communication Ying Wei, Mengcheng Luo, Guangwei Zhang, Jiaqi Lei, Ling-Hai Xie, Wei Huang The synthesis of fluorene-based 3D-grid-FTPA, which shows excellent chemical, thermal, and photo-stabilities, has been developed using a one-pot Friedel–Crafts reaction. The content of this RSS Feed (c) The Royal Society of Chemistry
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Visible-light induced decarboxylative alkylation of quinoxalin-2(1H)-ones at the C3-position ()
Org. Biomol. Chem., 2019, 17,6654-6661 DOI: 10.1039/C9OB01169B, Paper Wenxuan Xue, Yingpeng Su, Ke-Hu Wang, Rong Zhang, Yawei Feng, Lindan Cao, Dangfeng Huang, Yulai Hu 3-Alkylquinoxalin-2(1H)-ones are synthesized via direct alkylation of quinoxalin-2(1H)-ones at the C3 position under visible light irradiation. The content of this RSS Feed (c) The Royal Society of Chemistry
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Copper-catalysed borylation of aryl chlorides ()
Org. Biomol. Chem., 2019, 17,6601-6606 DOI: 10.1039/C9OB01244C, Paper Laura Kuehn, Mingming Huang, Udo Radius, Todd B. Marder The first example of a Cu-catalysed borylation of a wide range of aryl chlorides with different electronic and steric properties is mediated by a readily prepared NHC-stabilised Cu catalyst and KOtBu. The aryl chlorides are converted into their corresponding arylboronic esters using B2pin2 or B2neop2 as the boron reagent. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synergistic palladium/enamine catalysis for asymmetric hydrocarbon functionalization of unactivated alkenes with ketones ()
Org. Biomol. Chem., 2019, 17,6607-6611 DOI: 10.1039/C9OB01165J, Paper Chiyu Wei, Xiaohan Ye, Qingyu Xing, Yong Hu, Yan Xie, Xiaodong Shi Synergistic palladium and enamine catalysis was explored to promote ketone addition to unactivated olefins. The content of this RSS Feed (c) The Royal Society of Chemistry
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Regioselective oxidation of indoles to 2-oxindoles ()
Org. Biomol. Chem., 2019, 17,6671-6677 DOI: 10.1039/C9OB00764D, Paper Santosh V. Shelar, Narshinha P. Argade Facile regioselective oxidation of indoles to 2-oxindoles promoted by sulfuric acid adsorbed on silica gel is reported. The content of this RSS Feed (c) The Royal Society of Chemistry
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Reversal of enantioselectivity in chiral metal complex-catalyzed asymmetric reactions ()
Org. Biomol. Chem., 2019, 17,6538-6550 DOI: 10.1039/C9OB01027K, Review Article Weidi Cao, Xiaoming Feng, Xiaohua Liu The achievements of chiral metal complex-catalyzed enantiodivergent reactions during the period from 2008 to present were updated. The content of this RSS Feed (c) The Royal Society of Chemistry
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Introduction to chemical warfare agents, relevant simulants and modern neutralisation methods ()
Org. Biomol. Chem., 2019, 17,6528-6537 DOI: 10.1039/C9OB00802K, Review Article Baptiste Picard, Isabelle Chataigner, Jacques Maddaluno, Julien Legros This short review presents the current main chemical warfare agents and their most relevant simulants, and the recent catalytic and selective methods for their soft neutralization, potentially usable in the future as an alternative to “heavy” methods for decontamination. The content of this RSS Feed (c) The Royal Society of Chemistry
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Tumour-targeting photosensitisers for one- and two-photon activated photodynamic therapy ()
Org. Biomol. Chem., 2019, 17,6585-6594 DOI: 10.1039/C9OB00731H, Paper Sébastien Jenni, Angélique Sour, Frédéric Bolze, Barbara Ventura, Valérie Heitz Efficient receptor-mediated delivery of a folate-targeted photosensitiser to kill cancer cells following two-photon excitation in the near-infrared is demonstrated. The content of this RSS Feed (c) The Royal Society of Chemistry
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Total Synthesis of (+)-ar-Macrocarpene ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01373C, Communication Arindam Khatua, Sovan Niyogi, Vishnumaya Bisai This report features first catalytic asymmetric total synthesis of sesquiterpene, (+)-ar-macrocarpene (1a) in 7 steps in 57.9% overall yields from commercially available inexpensive 5,5-dimethylcyclohexane 1,3-dione. The strategy relies on a... The content of this RSS Feed (c) The Royal Society of Chemistry
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Solid-liquid extraction of iodide and bromide from aqueous media by a new water-insoluble phenoxycalix[4]pyrrole-epichlorohydrin polymer ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01306G, Paper Nancy AlHaddad, Ahmad Rifai, Amaury Kasprowiak, Francine Cazier-Dennin, P.-E. Danjou The present study describes the synthesis of the first phenoxycalix[4]pyrrole-epichlorohydrin based polymer. The advantage of this latter resides in its fast-single step synthesis protocol, low cost, water insolubility and its... The content of this RSS Feed (c) The Royal Society of Chemistry
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Squaramide‐Catalyzed Asymmetric Mannich Reactions Between 3‐Fluorooxindoles and Pyrazolinone Ketimines ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01350D, Paper Qing-Da Zhang, Bo-Liang Zhao, Bing-Yu Li, Da-Ming Du An Enantioselective Mannich reaction between 3‐fluorooxindoles and pyrazolinone ketimines has been developed for the construction of amino‐pyrazolone‐oxindoles containing stereogenic C−F units. Depending on this new protocol that allows for the... The content of this RSS Feed (c) The Royal Society of Chemistry
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1,2-Addition versus homoconjugate addition reactions of indoles and electron-rich arenes to α-cyclopropyl N-acyliminium ions: synthetic and computational studies ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01363F, Paper Greg M. Ryder, Uta Wille, Anthony C. Willis, Stephen G. Pyne α-Cyclopropyl-N-acyliminium ions towards reaction with indoles to give 5-(3-indoyl)-5-cyclopropylpyrrolidin-2-ones and, in the case of highly electron deficient indoles and electron rich arenes, spiroheterocycles. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and electrochromic behavior of a multi-electron redox-active N-heteroheptacenequinone ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01323G, Paper Kyosuke Isoda, Mitsuru Matsuzaka, Tomoaki Sugaya, Takeshi Yasuda, Makoto Tadokoro N-Heteropentacenequinone can accept four electrons as well as show electrochromism. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Direct Synthesis of Highly Functionalized Furans from Donor-Acceptor Cyclopropanes via DBU-mediated Ring Expansion Reactions ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01308C, Paper Zhenjie Su, Zengyang Xie, Shan Wang, Naili Luo, Cunde Wang A DBU-mediated, unprecedented formal ring expansion reaction of 2-acyl-3-arylcyclopropane-1,1-dicarbonitriles for the synthesis of multisubstituted furan derivatives is reported. This transformation represents the regioselective ring- opening reaction of cyclopropane-1,1-dicarbonitriles and annulation... The content of this RSS Feed (c) The Royal Society of Chemistry
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Hydantoin analogs inhibit the fully assembled ClpXP protease without affecting the individual peptidase and chaperone domains ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01339C, Communication Christian Fetzer, Vadim Korotkov, Stephan Axel Sieber Proteolysis mediated by ClpXP is a crucial cellular process linked to bacterial pathogenesis. The development of specific inhibitors has largely focused on ClpP. However, this focus was challenged by a... The content of this RSS Feed (c) The Royal Society of Chemistry
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Highly efficient Baby Spinach-based minimal modified sensor (BSMS) for nucleic acid analysis ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01414D, Paper Rashi Soni, Deepti Sharma, A Murali Krishna, Jagadeesh Sathiri, Ashwani Sharma Molecular recognition between nucleic acids has proven to be a powerful tool for designing hybridization probes for detection of DNA and RNA sequences. Most of the detection probes rely on... The content of this RSS Feed (c) The Royal Society of Chemistry
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Thermal rearrangement of optically active tetradeuterated 2-methoxymethyl-methylenecyclopropane and the bent bond/antiperiplanar hypothesis ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01030K, Paper Ghislain Deslongchamps, Pierre Deslongchamps The bent bond/antiperiplanar hypothesis (BBAH) provides, for the first time, a mechanistic model that rationalizes methylenecyclopropane rearrangements. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Controllable synthesis of 3-chloro- and 3,3-dichloro-2-oxindoles via hypervalent iodine-mediated chlorooxidation ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01173K, Paper Xinpeng Jiang, Liechao Yang, Wenlong Yang, Yu Zhu, Liyun Fang, Chuanming Yu Controllable synthesis of 3-chloro- and 3,3-dichloro-2-oxindoles via chlorooxidation of indoles has been developed in up to 99% yields. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Recent advances in synthesis of oxaspirolactones and their application in the total synthesis of related natural products ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01212E, Review Article Sagar Sudam Thorat, Ravindar Kontham Oxa-spirolactones are ubiquitous structural motifs found in natural products and synthetic molecules with diverse biochemical and physicochemical profile, and represent a valuable target in natural products chemistry andmedicinal chemistry. Since... The content of this RSS Feed (c) The Royal Society of Chemistry
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Thermodynamically driven self-assembly of pyridinearene to hexameric capsules ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01383K, Communication Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Anniina Kiesilä, Ngong Kodiah Beyeh, Jani O. Moilanen, Rakesh Puttreddy, Sven Götz, Kari Rissanen, Perdita Barran, Arne Lützen, Elina Kalenius For the first time the formation of hexameric pyridine[4]arene capsule has been observed in gas phase, in solution and in solid state. A thermodynamic balance between capsule formation was observed, showing favour to hexamer. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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The disruption of verM activates the production of gliocladiosin A and B in Clonostachys rogersoniana ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01102A, Communication Ying Wang, Jinwei Ren, Honghua Li, Yuanyuan Pan, Xingzhong Liu, Yongsheng Che, Gang Liu Two dipeptides (Gliocladiosin A and B) conjugated with a macrolide were identified in the verM disruption mutant of Clonostachys rogersoniana. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Membrane-specific spin trap, 5-dodecylcarbamoyl-5-N- dodecylacetamide-1-pyroline-N-oxide (diC12PO): Theoretical, bioorthogonal fluorescence imaging and EPR studies ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01334B, Paper Frederick A. Villamena, Colwyn A. Headley, Claire N. Hoffman, Juliana Freisen, Yongbin Han, Joseph M. Macklin, Jay L Zweier, Antal Rockenbauer, Jeff Kuret Membranous organelles are major endogenous sources of reactive oxygen and nitrogen species. When present at high levels, these species can cause macromolecular damage and disease. To better detect and scavenge... The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and characterization of bent fluorine-containing donor–π-acceptor molecules as intense luminophores with large Stokes shifts ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01300H, Paper Shigeyuki Yamada, Akito Nishizawa, Masato Morita, Takuya Hosokai, Yusuke Okabayashi, Tomohiro Agou, Takaaki Hosoya, Toshio Kubota, Tsutomu Konno Bent fluorine-containing D–π-A molecules showed intense photoluminescence with large Stokes shifts stem from their twisted and bent molecular geometries. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Stereoselective deconjugation of macrocyclic α,β-unsaturated esters by sequential amidation and olefin transposition: application to enantioselective phase-transfer catalysis ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01355E, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Alexandre Homberg, Radim Hrdina, Mahesh Vishe, Laure Guénée, Jérôme Lacour The stereoselective synthesis of chiral macrocycles bearing two aliphatic amide functional groups is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Cu(I) catalysed annulation of isothiocyanates/isocyanates with 2-iodo-sulfonamides: synthesis of benzodithiazines, benzothiadiazinones, benzothiazinylidene-anilines and benzothiazolylidene-anilines ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00994A, Paper K. Sandeep, Alla Siva Reddy, K. C. Kumara Swamy Cu(I)-catalysed reaction of 2-iodobenzene sulfonamides with aryl isothiocyanates leads to benzodithiazines but the corresponding reaction with aryl isocyanates affords benzothiadiazinones. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A styryl based fluorogenic probe with high affinity for a cyclodextrin derivative ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01349K, Paper Goutam Chakraborty, Alok K. Ray, Prabhat K. Singh, Haridas Pal A styryl-based fluorogenic near-IR probe registers a very high association constant with sulfobutylether substituted β-cyclodextrin host, having prospects as biological marker and improved pH and temperature sensor. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Aromatic-Fused Diketophosphanyl-Cored Organic Functional Materials: Phosphorus Mimics of Imides or Beyond? ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01328H, Review Article Youhei Takeda, Satoshi Minakata Recently, a missing piecies of organophosphorus compounds, i.e., aromatic-fused diketophosphanyl compounds, has attracted much attention as promising scaffold as builiding blocks for functional organic materials. In this review, the brief... The content of this RSS Feed (c) The Royal Society of Chemistry
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Traceless point-to-axial chirality exchange in the atropselective synthesis of biaryls/heterobiaryls ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01304K, Review Article Thien T. Nguyen A strategy for establishing a chiral axis from stereogenic centers via elimination or oxidative aromatization with a high level of chirality transfer was developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Hantzsch esters: an emerging versatile class of reagents in photoredox catalyzed organic synthesis ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01289C, Review Article Peng-Zi Wang, Jia-Rong Chen, Wen-Jing Xiao This minireview highlights the recent advances in the chemistry of Hantzsch esters in photoredox catalyzed organic synthesis, with particular emphasis placed on reaction mechanisms. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and evaluation of photo-activatable β-diarylsydnone-L-alanines for fluorogenic photo-click cyclization of peptides ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00898E, Communication Zhuojun Yao, Xueting Wu, Xiaocui Zhang, Qin Xiong, Shichao Jiang, Zhipeng Yu β-Diarylsydnone-L-alanines were designed and introduced into peptides allowing photo-cyclization only in phosphate containing buffer with concomitant fluorescence generation in live cells. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Improved synthesis of the bifunctional chelator p-SCN-Bn-HOPO ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01068H, Paper N. V. S. Dinesh K. Bhupathiraju, Ali Younes, Minhua Cao, Jafar Ali, Huseyin T. Cicek, Kathryn M. Tully, Shashikanth Ponnala, John W. Babich, Melissa A. Deri, Jason S. Lewis, Lynn C. Francesconi, Charles Michael Drain An improved high yield synthesis of bifunctional HOPO ligand that enables diverse applications in biomedicine including 89Zr PET imaging. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Heterogeneous Amberlyst-15-catalyzed synthesis of complex hybrid heterocycles containing [1,6]-naphthyridine under metal-free green conditions ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01256G, Paper Isravel Muthukrishnan, B. S. Vachan, Muthu Karuppasamy, A. Eniyaval, C. Uma Maheswari, Subbiah Nagarajan, J. Carlos Menéndez, Vellaisamy Sridharan Synthesis of complex hybrid heterocycles containing [1,6]-naphthyridine under metal-free green conditions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Design and application of diimine-based copper(I) complexes in photoredox catalysis ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01331H, Communication Tamás Földesi, Gellért Sipos, Réka Adamik, Bálint Nagy, Balázs L. Tóth, Attila Bényei, Krisztina J. Szekeres, Győző G. Láng, Attila Demeter, Timothy J. Peelen, Zoltán Novák Novel copper catalysts were designed, synthesized and utilized in visible light-driven photocatalytic ATRA reactions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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PdII catalyzed ligand controlled synthesis of bis(3-furanyl)methanones and methyl 3-furancarboxylates ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01189G, Paper Taichi Kusakabe, Tomoyuki Mochida, Tomohiro Ariyama, Dong Lee, Shin Ohkubo, Keisuke Takahashi, Keisuke Kato Polysubstituted furans 2 and 3 were selectively synthesized from the same allenyl ketone substrate. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Correction: Ring closing metathesis (RCM) approach to the synthesis of conduramine B-2, ent-conduramine F-2, aminocyclopentitol and trihydroxyazepane ()
Org. Biomol. Chem., 2019, 17,6506-6506 DOI: 10.1039/C9OB90109D, Correction Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Vimal Kant Harit, Namakkal G. Ramesh The content of this RSS Feed (c) The Royal Society of Chemistry
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Dehydrogenative C(sp3)–H bond functionalization of tetrahydroisoquinolines mediated by organic oxidants under mild conditions ()
Org. Biomol. Chem., 2019, 17,6420-6425 DOI: 10.1039/C9OB01090D, Paper Zdravko Džambaski, Bojan P. Bondžić DDQ and IBX are effective SET oxidants of N-aryl-protected and unprotected THIQs. Mannich and Strecker type functionalizations ensued in an overall CDC reaction. The content of this RSS Feed (c) The Royal Society of Chemistry
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Iridium-catalyzed intramolecular enantioselective allylation of quinazolin-4(3H)-one derivatives ()
Org. Biomol. Chem., 2019, 17,6461-6464 DOI: 10.1039/C9OB01057B, Paper Fei Peng, Hua Tian, Pengxiang Zhang, Haijun Yang, Hua Fu An efficient chiral cyclic phosphoramidite ligand-enabled iridium-catalyzed intramolecular allylation of quinazolin-4(3H)-one derivatives has been developed with high reactivity and high to excellent enantioselectivity. The content of this RSS Feed (c) The Royal Society of Chemistry
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Structural flexibility versus rigidity of the aromatic unit of DNA ligands: binding of aza- and azoniastilbene derivatives to duplex and quadruplex DNA ()
Org. Biomol. Chem., 2019, 17,6404-6413 DOI: 10.1039/C9OB00809H, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. H. Ihmels, M. Karbasiyoun, K. Löhl, C. Stremmel The increased flexibility of a quadruplex-DNA ligand does not necessarily lead to stronger interactions with the quadruplex DNA as compared with rigid ligands that have essentially the same size and extent of π system. The content of this RSS Feed (c) The Royal Society of Chemistry
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Catalytic direct amidations in tert-butyl acetate using B(OCH2CF3)3 ()
Org. Biomol. Chem., 2019, 17,6465-6469 DOI: 10.1039/C9OB01012B, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Charlotte E. Coomber, Victor Laserna, Liam T. Martin, Peter D. Smith, Helen C. Hailes, Michael J. Porter, Tom D. Sheppard B(OCH2CF3)3-catalysed direct amidations of challenging substrates (polar heteroycles, poorly nucleophilic anilines) work well in tBuOAc under Dean–Stark conditions. The content of this RSS Feed (c) The Royal Society of Chemistry
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Metal-free regioselective direct thiolation of 2-pyridones ()
Org. Biomol. Chem., 2019, 17,6432-6440 DOI: 10.1039/C9OB01061K, Paper Kunita Phakdeeyothin, Sirilata Yotphan A metal-free site-selective approach for direct C–H thiolation of 2-pyridones was developed. The content of this RSS Feed (c) The Royal Society of Chemistry
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Aryne insertion into the PO bond: one-pot synthesis of quaternary phosphonium triflates ()
Org. Biomol. Chem., 2019, 17,6450-6460 DOI: 10.1039/C9OB01157A, Paper Kashmiri Neog, Dhiraj Dutta, Babulal Das, Pranjal Gogoi A novel transition-metal free synthetic strategy for the direct synthesis of quaternary phosphonium triflates via insertion of aryne into phosphine oxide. The content of this RSS Feed (c) The Royal Society of Chemistry
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The role of olefin geometry in the activity of hydrocarbon stapled peptides targeting eukaryotic translation initiation factor 4E (eIF4E) ()
Org. Biomol. Chem., 2019, 17,6414-6419 DOI: 10.1039/C9OB01041F, Paper James M. Song, Erin E. Gallagher, Arya Menon, Lauren D. Mishra, Amanda L. Garner Ring-closing metathesis of monosubstituted alkenyl amino acids leads to stapled peptides with differing olefin geometry and biological activity. The content of this RSS Feed (c) The Royal Society of Chemistry
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The first radiosynthesis of 2-amino-5-[18F]fluoropyridines via a “minimalist” radiofluorination/palladium-catalyzed amination sequence from anisyl(2-bromopyridinyl)iodonium triflate ()
Org. Biomol. Chem., 2019, 17,6359-6363 DOI: 10.1039/C9OB01187K, Communication Mathilde Pauton, Raphaël Gillet, Catherine Aubert, Guillaume Bluet, Florence Gruss-Leleu, Sébastien Roy, Cécile Perrio Radiofluorination of anisyl(2-bromopyridinyl)iodonium triflate under “minimalist” conditions: an entry to 2-amino-5-[18F]fluoropyridines via Buchwald–Hartwig amination. The content of this RSS Feed (c) The Royal Society of Chemistry
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Facile synthesis of chiral ε-sultams via an organocatalytic aza-Friedel–Crafts reaction ()
Org. Biomol. Chem., 2019, 17,6364-6368 DOI: 10.1039/C9OB01158G, Communication Zi-Biao Zhao, Lei Shi, Yaming Li, Fan-Jie Meng, Yong-Gui Zhou A facile enantioselective aza-Friedel–Crafts reaction has been developed for the synthesis of chiral ε-sultams with an enantiomeric excess of up to 92%. The content of this RSS Feed (c) The Royal Society of Chemistry
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Transition-metal free oxidative C–H etherification of acylanilines with alcohols through a radical pathway ()
Org. Biomol. Chem., 2019, 17,6346-6350 DOI: 10.1039/C9OB01224A, Communication Xiaobo Xu, Zhengzhou Chu, Chengcai Xia Synthesis of methyl/ethyl aryl ether via oxidative C–H etherification of acylanilines with alcohols under transition-metal-free conditions. The content of this RSS Feed (c) The Royal Society of Chemistry
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Total syntheses of the bilirubin oxidation end product Z-BOX C and its isomeric form Z-BOX D ()
Org. Biomol. Chem., 2019, 17,6489-6496 DOI: 10.1039/C9OB01117J, Paper Daniel Schulze, Juliane Traber, Marcel Ritter, Helmar Görls, Georg Pohnert, Matthias Westerhausen The bilirubin degradation product BOX C has been detected in human bile. The total synthesis of this biomolecule allows an extensive characterization including elucidation of its X-ray structure. The content of this RSS Feed (c) The Royal Society of Chemistry
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Copper-mediated cascade radical cyclization of olefins with naphthalenyl iododifluoromethyl ketones ()
Org. Biomol. Chem., 2019, 17,6426-6431 DOI: 10.1039/C9OB00916G, Paper Peng Peng, Guo-zhi Huang, Ying-xin Sun, Xing Wang, Jing-jing Wu, Fan-hong Wu Copper-mediated radical cyclization of naphthalenyl iododifluoromethyl ketones with olefins was developed to generate a series of unprecedented gem-difluorodihydrophenanthrenones with excellent regioselectivity. The content of this RSS Feed (c) The Royal Society of Chemistry
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A NIR fluorescent probe for detection of viscosity and lysosome imaging in live cells ()
Org. Biomol. Chem., 2019, 17,6398-6403 DOI: 10.1039/C9OB01222B, Paper Tong Chen, Zikang Chen, Ruiyuan Liu, Shaobing Zheng A D–π-A structure near-infrared fluorescent probe (Lyso-BTC) is explored for its fluorescence visualization and detection of lysosomes in view of a large Stokes shift (∼190 nm), NIR emission (685 nm), excellent photostability, fluorescence response to viscosity, and lysosome-targeted property. The content of this RSS Feed (c) The Royal Society of Chemistry
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Asymmetric kinetic resolution of sulfides for the construction of unsymmetric sulfides and chiral 3,3-disubstituted oxindoles ()
Org. Biomol. Chem., 2019, 17,6351-6354 DOI: 10.1039/C9OB01065C, Communication Kaiye Wang, Yanan Xiang, Zhujun Shi, Hongyu Wang, Na Li, Bo Tang An efficient method for preparing unsymmetric disulfides using para-quinone methides derived from isatins was developed. In addition, chiral 3,3-disubstituted oxindoles were also obtained with high selectivities via asymmetric kinetic resolution. The content of this RSS Feed (c) The Royal Society of Chemistry
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