Organic & Biomolecular Chemistry

Acceptorless Dehydrogenation and Dehydrogenative Coupling of Alcohols Catalysed by Protic NHC Ruthenium Complexes ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00542C, Paper Weihong Chang, Xue Gong, Shuizhong Wang, Ling-Ping Xiao, Guoyong Song A new family of protic NHC Ru complexes ligated with a phosphine-tethered imidazole moiety were prepared, which can act as excellent catalysts for acceptorless dehydrogenation of secondary alcohols and dehydrogenative... The content of this RSS Feed (c) The Royal Society of Chemistry
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cis or trans with class II diterpene cyclases ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00510E, Communication Meirong Jia, Reuben J. Peters Isoprenoid precursors readily undergo (poly)cyclization in electrophilic reaction cascades, presumably as internal addition of the carbon-carbon double-bonds from neighboring isoprenyl repeats readily forms relatively stable cyclohexyl tertiary carbocation intermediates. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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ipso-Cyclization: an emerging tool for multifunctional spirocyclohexadienones ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00405B, Review Article Chada Raji Reddy, Santosh Kumar Prajapti, Kamalkishor Warudikar, Ravi Ranjan, Billa Bhargava Rao Various ipso-annulation strategies to access diversely substituted spirocyclohexadienones and their applications have been presented. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Stereoselective synthesis of novel adamantane derivatives with high potency against rimantadine-resistant influenza A virus strains ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00331E, Communication Nikolai Yu. Kuznetsov, Rabdan M. Tikhov, Ivan A. Godovikov, Michael G. Medvedev, Konstantin A. Lyssenko, Elena I. Burtseva, Elena S. Kirillova, Yuri N. Bubnov A series of (R)- and (S)-isomers of new adamantane-substituted heterocycles were synthesized and tested for antiviral activity. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Syntheses and kinetic studies of cyclisation-based self-immolative spacers. ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00121E, Paper Steve Huvelle, Ahmed Alouane, Thomas le Saux, Ludovic Jullien, Frederic Schmidt Kinetic analysis of disassembly of self-immolative spacers based on cyclisation processes was performed. Five compounds were synthesized belonging to two different series, and their kinetic constants were determined. Electro-donating substituents... The content of this RSS Feed (c) The Royal Society of Chemistry
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Recent Progress in Transition-Metal-Catalyzed Enantioselective Indole Functionalizations ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00413C, Review Article Yi-Xia Jia, Jing-Biao Chen Numerous efficient synthetic methods for enantioselective indole functionalization emerged in recent years. This review summarizes major achievements in the transition-metal-catalyzed enantioselective indole functionalization reactions since 2010, which focuses on C-C... The content of this RSS Feed (c) The Royal Society of Chemistry
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ZnBr2-Mediated Oxidative Spiro-Bromocyclization of Propiolamide for the Synthesis of 3-Bromo-1-azaspiro[4.5]deca-3,6,9-triene-2,8-dione ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00293A, Paper Yicheng He, Guanyinsheng Qiu A ZnBr2-mediated oxidative spiro-bromocyclization of N-arylpropiolamide is described here for the synthesis of 3-Bromo-1-azaspiro[4.5]deca-3,6,9-triene-2,8-dione with a high efficiency. One equivalent of water is introduced into the final product. The reaction... The content of this RSS Feed (c) The Royal Society of Chemistry
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Tandem SN2[prime or minute] nucleophilic substitution/oxidative radical cyclization of aryl substituted allylic alcohols with 1,3-dicarbonyl compounds ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00620A, Paper Zhen Zhang, Cheng Li, Shao-Hua Wang, Fu-Min Zhang, Xue Han, Yong-Qiang Tu, Xiao-Ming Zhang Herein we present a novel tandem SN2[prime or minute] nucleophilic substitution/oxidative radical cyclization of aryl substituted allylic alcohols with 1,3-dicarbonyl compounds. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Selective synthesis of mono- and bis-butenolides [small alpha]-aminomethyl adducts ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00206H, Paper Arbia Talbi, Acha Arfaoui, Talia Bsaibess, Mohamed Lotfi Efrit, Anne Gaucher, Damien Prim, Hedi M'Rabet The selective installation of [small alpha]-methylamine residues at the butenolide core is described from [small alpha]-bromomethylene--butenolide and primary as well as secondary amines in methanol at 0 [degree]C. The preparation of mono-... The content of this RSS Feed (c) The Royal Society of Chemistry
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Post-translational Modifications Involved in the Biosynthesis of Thiopeptide Antibiotics ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00466D, Review Article Qingfei Zheng, Hui Fang, wen liu Thiopeptide antibiotics are a class of typical ribosomally synthesized and post-translationally modified peptides (RiPPs) with complex chemical structures that are difficult to construct via chemical synthesis. To date, more than... The content of this RSS Feed (c) The Royal Society of Chemistry
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Reverse micelle-based water-soluble nanoparticles for simultaneous bioimaging and drug delivery ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00169J, Paper Ying Chen, Yong Liu, Yongchao Yao, Shiyong Zhang, Zhongwei Gu With special confined water pools, reverse micelles (RMs) have shown potential for a wide range of applications. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A Threonine Turnstile Defines a Dynamic Amphiphilic Binding Motif in the AAA ATPase p97 Allosteric Binding Site ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00526A, Paper Peter Wipf, James Burnett, Chaemin Lim, Brian Daniel Peyser, Lalith P. Samankumara, Marina Kovaliov, Raffaele Colombo, Stacie Bulfer, Matt Laporte, Ann Hermone, Connor McGrath, Michelle Arkin, Rick Gussio, Donna Huryn The turnstile motion of two neighboring threonines sets up a dynamic side chain interplay that can accommodate both polar and apolar ligands in a small molecule allosteric protein binding site.... The content of this RSS Feed (c) The Royal Society of Chemistry
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Domino reaction of cyclic sulfamidate imines with Morita-Baylis-Hillman acetates promoted by DABCO: a metal-free approach to functionalized nicotinic acid derivatives ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00240H, Paper Debashis Majee, Soumen Biswas, Mobin M Shaikh, Sampak Samanta A facile, green, metal-free based new one-pot synthetic strategy has been developed for the easy access to a wide array of medicinally promising functionalized pyridines having an ester, nitrile or... The content of this RSS Feed (c) The Royal Society of Chemistry
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Metabolism of 2,3-dihydroxypropane-1-sulfonate by marine bacteria ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00357A, Communication Ersin Celik, Michael Maczka, Nils Bergen, Thorsten Brinkhoff, Stefan Schulz, Jeroen S. Dickschat The uptake and conversion of the algal sulfoquinovose catabolite 2,3-dihydroxypropane-1-sulfonate by marine bacteria was studied in isotopic labelling experiments. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Palladium-catalyzed highly regioselective hydroaminocarbonylation of aromatic alkenes to branched amides ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00371D, Communication Jinping Zhu, Bao Gao, Hanmin Huang Pd(t-Bu3P)2 has been successfully identified as an efficient catalyst for the hydroaminocarbonylation of aromatic alkenes to branched amides under relatively mild reaction conditions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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New mechanistic interpretations for nitrone reactivity ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00429J, Review Article Pedro Merino, Tomas Tejero, Ignacio Delso, Rosa Matute The reactivity of nitrones in cycloadditions and related reactions is revisited by introducing a topological perspective. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Direct palladium-mediated on-resin disulfide formation from Allocam protected peptides ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00536A, Communication Thilini D. Kondasinghe, Hasina Y. Saraha, Samantha B. Odeesho, Jennifer L. Stockdill We present a mild, convenient method for direct conversion of Allocam protected peptides to disulfide-containing protected peptides on solid support. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Outstanding Reviewers for Organic & Biomolecular Chemistry in 2016 ()
Org. Biomol. Chem., 2017, 15,2478-2478 DOI: 10.1039/C7OB90045G, Editorial We would like to take this opportunity to highlight the Outstanding Reviewers for Organic & Biomolecular Chemistry in 2016, as selected by the editorial team for their significant contribution to the journal. The content of this RSS Feed (c) The Royal Society of Chemistry
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Comparative pharmacokinetic profile of cyclosporine (CsA) with a decapeptide and a linear analogue ()
Org. Biomol. Chem., 2017, 15,2501-2506 DOI: 10.1039/C7OB00096K, Communication David A. Price, Heather Eng, Kathleen A. Farley, Gilles H. Goetz, Yong Huang, Zhaodong Jiao, Amit S. Kalgutkar, Natasha M. Kablaoui, Bhagyashree Khunte, Spiros Liras, Chris Limberakis, Alan M. Mathiowetz, Roger B. Ruggeri, Jun-Min Quan, Zhen Yang The synthesis and in vivo pharmacokinetic profile of an analogue of cyclosporine is disclosed. The content of this RSS Feed (c) The Royal Society of Chemistry
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Rapid and visual detection of heparin based on the disassembly of polyelectrolyte-induced pyrene excimers ()
Org. Biomol. Chem., 2017, 15,2569-2574 DOI: 10.1039/C7OB00115K, Paper Yadong Qiao, Zhiyi Yao, Wenqi Ge, Li Zhang, Hai-Chen Wu A sensor based on polyelectrolyte-induced pyrene excimers has been developed for the visual detection of heparin with high sensitivity and selectivity. The content of this RSS Feed (c) The Royal Society of Chemistry
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Base-mediated insertion reaction of alkynes into carbon-carbon [sigma]-bonds of ethanones: synthesis of hydroxydienone and chromone derivatives ()
Org. Biomol. Chem., 2017, 15,2497-2500 DOI: 10.1039/C7OB00476A, Communication Fangfang Zhang, Qiyi Yao, Yang Yuan, Murong Xu, Lingkai Kong, Yanzhong Li Base-promoted C-C [sigma]-bond insertion with methylene compounds bearing only one EWG (C-C [sigma]-bond insertion/cyclization). The content of this RSS Feed (c) The Royal Society of Chemistry
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Application of the aza-Diels-Alder reaction in the synthesis of natural products ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C6OB02761J, Review Article Min-Hui Cao, Nicholas J. Green, Sheng-Zhen Xu The Diels-Alder reaction that involves a nitrogen atom in the diene or dienophile is termed the aza-Diels-Alder reaction. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Total synthesis of phenylpropanoid glycoside osmanthuside-B6 facilitated by double isomerisation of glucose-rhamnose orthoesters ()
Org. Biomol. Chem., 2017, 15,2638-2646 DOI: 10.1039/C7OB00198C, Paper Duc Thinh Khong, Zaher M. A. Judeh Osmanthuside-B6 was synthesized in 22% overall yield. The synthesis involved a newly discovered glucose-rhamnose orthoester double isomerization process. The content of this RSS Feed (c) The Royal Society of Chemistry
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Copper-catalyzed TEMPO oxidative cleavage of 1,3-diketones and [small beta]-keto esters for the synthesis of 1,2-diketones and [small alpha]-keto esters ()
Org. Biomol. Chem., 2017, 15,2629-2637 DOI: 10.1039/C7OB00241F, Paper Peng-Jun Zhou, Cheng-Kun Li, Shao-Fang Zhou, Adedamola Shoberu, Jian-Ping Zou Copper-catalyzed, TEMPO oxidized cleavage of [small alpha]-methylene of 1,3-diketones and [small beta]-keto esters to form 1,2-diketones and [small alpha]-keto esters. The content of this RSS Feed (c) The Royal Society of Chemistry
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Enantioselective copper catalysed intramolecular C-H insertion reactions of [small alpha]-diazo-[small beta]-keto sulfones, [small alpha]-diazo-[small beta]-keto phosphine oxides and 2-diazo-1,3-diketones; the influence of the carbene substituent ()
Org. Biomol. Chem., 2017, 15,2609-2628 DOI: 10.1039/C7OB00214A, Paper Amy E. Shiely, Catherine N. Slattery, Alan Ford, Kevin S. Eccles, Simon E. Lawrence, Anita R. Maguire Enantioselective C-H insertion reactions are described. The content of this RSS Feed (c) The Royal Society of Chemistry
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A facile and general acid-catalyzed deuteration at methyl groups of N-heteroarylmethanes ()
Org. Biomol. Chem., 2017, 15,2507-2511 DOI: 10.1039/C7OB00062F, Communication Min Liu, Xue Chen, Tieqiao Chen, Shuang-Feng Yin A general acid-catalyzed deuteration at the methyl group of N-heteroarylmethanes was achieved, which could be conducted at a 500 mmol-scale, showing its good potential for use in large-scale synthesis. The content of this RSS Feed (c) The Royal Society of Chemistry
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Ligand-free Cu(II)-mediated aerobic oxidations of aldehyde hydrazones leading to N,N[prime or minute]-diacylhydrazines and 1,3,4-oxadiazoles ()
Org. Biomol. Chem., 2017, 15,2585-2592 DOI: 10.1039/C7OB00042A, Paper Lei Liu, Suliu Feng These reactions offered advantages including green oxidation by O2 in air, simple workups and wide scope of substrates. The content of this RSS Feed (c) The Royal Society of Chemistry
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In situ formation of pyronin dyes for fluorescence protease sensing ()
Org. Biomol. Chem., 2017, 15,2575-2584 DOI: 10.1039/C7OB00370F, Paper Sylvain Debieu, Anthony Romieu A cutting-edge strategy for fluorogenic sensing of proteases (leucine aminopeptidase for the proof of concept) and based on the "covalent-assembly" principle is reported. Non-fluorescent mixed bis-aryl ethers are readily converted into a fluorescent pyronin through a domino process triggered by the peptide bond cleavage event caused by the targeted enzyme. The content of this RSS Feed (c) The Royal Society of Chemistry
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Metal- and additive-free oxygen-atom transfer reaction: an efficient and chemoselective oxidation of sulfides to sulfoxides with cyclic diacyl peroxides ()
Org. Biomol. Chem., 2017, 15,2647-2654 DOI: 10.1039/C7OB00021A, Paper Shaoyan Gan, Junjie Yin, Yuan Yao, Yang Liu, Denghu Chang, Dan Zhu, Lei Shi Metal- and additive-free sulfoxidation was developed using cyclic diacyl peroxides as oxygen sources and a single two-electron transfer mechanism was suggested. The content of this RSS Feed (c) The Royal Society of Chemistry
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Acid-promoted cyclization of 2,4-diaryl-1,1,1-trifluorobut-3-en-2-oles and their TMS-ethers into CF3-indenes ()
Org. Biomol. Chem., 2017, 15,2541-2550 DOI: 10.1039/C7OB00406K, Paper Matvei Yu. Martynov, Roman O. Iakovenko, Anna N. Kazakova, Irina A. Boyarskaya, Aleksander V. Vasilyev 2,4-Diaryl-1,1,1-trifluorobut-3-en-2-oles and their TMS-ethers in H2SO4 at room temperature in just 2 min are quantitatively cyclized into 1-aryl-3-trifluoromethyl-1H-indenes. The content of this RSS Feed (c) The Royal Society of Chemistry
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Enzymatic cascades for the stereo-complementary epimerisation of in situ generated epoxy alcohols ()
Org. Biomol. Chem., 2017, 15,2562-2568 DOI: 10.1039/C7OB00015D, Paper Yu-Chang Liu, Chao Guo, Yan Liu, Hai-Bo Wang, Zhong-Liu Wu Styrene monooxygenase and each of the two sets of alcohol dehydrogenases work in a tandem concurrent manner for the production of chiral epoxy alcohols using whole-cell catalysts. The content of this RSS Feed (c) The Royal Society of Chemistry
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Isolation and structure elucidation of natural products of three soft corals and a sponge from the coast of Madagascar ()
Org. Biomol. Chem., 2017, 15,2593-2608 DOI: 10.1039/C7OB00191F, Paper Marie Pascaline Rahelivao, Tilo Lubken, Margit Gruner, Olga Kataeva, Rahanira Ralambondrahety, Hanta Andriamanantoanina, Marek P. Checinski, Ingmar Bauer, Hans-Joachim Knolker The Madagascan soft coral Capnella fungiformis provided the two diastereoisomeric ethyl furancarboxylates 1 and 2 and the diepoxyguaiane sesquiterpene oxyfungiformin (3). The content of this RSS Feed (c) The Royal Society of Chemistry
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Photocatalytic N-formylation of amines via a reductive quenching cycle in the presence of air ()
Org. Biomol. Chem., 2017, 15,2536-2540 DOI: 10.1039/C7OB00250E, Paper Tamal Ghosh, Amrita Das, Burkhard Konig Photochemical N-formylation of amines was achieved without any additional formylating agents in the presence of air. Mechanistic investigations suggest a reaction pathway proceeding via the addition of in situ formed radical cations of enamines with photochemically generated superoxide radical anions. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthetic applications of vinyl cyclopropane opening ()
Org. Biomol. Chem., 2017, 15,2479-2490 DOI: 10.1039/C6OB02647H, Review Article Marta Meazza, Hao Guo, Ramon Rios Vinyl cyclopropanes are amongst the most useful building blocks in organic synthesis. In this review we give an overview of their applications, focusing on the present century. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of perfluoroalkylated pentacenes and evaluation of their fundamental physical properties ()
Org. Biomol. Chem., 2017, 15,2522-2535 DOI: 10.1039/C7OB00043J, Paper Shigeyuki Yamada, Keita Kinoshita, Shota Iwama, Takashi Yamazaki, Toshio Kubota, Tomoko Yajima, Kyoko Yamamoto, Shinya Tahara We synthesized new perfluoroalkylated pentacenes and revealed that the fluorine-containing substituents played essential roles in controlling their electron density and the molecular alignment. The content of this RSS Feed (c) The Royal Society of Chemistry
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One-pot synthesis of [small alpha],[small beta]-epoxy ketones through domino reaction between alkenes and aldehydes catalyzed by proline based chiral organocatalysts ()
Org. Biomol. Chem., 2017, 15,2551-2561 DOI: 10.1039/C7OB00031F, Paper Veeramanoharan Ashokkumar, Ayyanar Siva A proline based metal free organocatalysts developed by new approach for the synthesis of epoxide derivatives through domino reaction. This domino reaction allows the direct access to epoxide from various alkene and aldehyde through C-H functionalization and C-C/C-O bond formation. The catalytic efficiencies of organocatalysts were also determined by domino reaction with very good yield (up to 95 %) and ee's (up to 99 %). The content of this RSS Feed (c) The Royal Society of Chemistry
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Peptide Weinreb amide derivatives as thioester precursors for native chemical ligation ()
Org. Biomol. Chem., 2017, 15,2491-2496 DOI: 10.1039/C7OB00103G, Communication Chang Rao, Chuan-Fa Liu Peptide C-ter Weinreb amide derivatives are excellent thioester surrogates for native chemical ligation. The content of this RSS Feed (c) The Royal Society of Chemistry
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Eight at one stroke - a synthetic tetra-disulfide peptide epitope ()
Org. Biomol. Chem., 2017, 15,2512-2521 DOI: 10.1039/C6OB02746F, Paper Andreas Schrimpf, Uwe Linne, Armin Geyer A tetra-disulfide peptide dimer, representing an antiparallel hinge, is synthesised without the need for orthogonal cysteine protecting groups. The content of this RSS Feed (c) The Royal Society of Chemistry
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Highly Enantioselective Friedel-Crafts Reaction of 3,5-Dimethoxylphenol with Nitroolefins Mediated by Bifunctional Quinine Derived Thiourea Catalyst ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00372B, Communication Xiaoyu Han, Can Ye, Fenfen Chen, Qu Chen, Yongjiang Wang, Xiaofei Zeng An useful enantioselective Friedel-Crafts reaction of 3,5-dimethoxylphenol with nitroolefins catalyzed by a bifunctional quinine derived thiourea catalyst 9 was developed. The Michael addition products could be obtained in good to... The content of this RSS Feed (c) The Royal Society of Chemistry
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Thiolysis of NBD-based dyes for colorimetric and fluorescent detection of H2S and biothiols: design and biological applications ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00332C, Review Article Long Yi, Zhen Xi Hydrogen sulfide (H2S) is an important endogenous signaling molecule with multiple biological functions. Development of colorimetric and fluorescent probes for visualization of H2S is useful for studying H2S biology. This... The content of this RSS Feed (c) The Royal Society of Chemistry
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Towards the biodegradation pathway of fosfomycin ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00546F, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Katharina Pallitsch, Alexander Roller, Friedrich Hammerschmidt Three functionalised propylphosphonic acids were synthesised to study C-P bond cleavage in R. huakuii PMY 1. (R)-1-Hydroxy-2-oxopropylphosphonic acid [(R)-5] was prepared by chiral resolution of (+/-)-dimethyl 1-hydroxy-2-methylallyllphosphonate [(+/-)-12], followed by... The content of this RSS Feed (c) The Royal Society of Chemistry
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Direct Csp2-H Enolization: An Allenoate Alkylation Cascade Toward the Assembly of Multi-substituted Furans ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00248C, Communication Anand Singh, Debanjan Bakshi A new disconnection toward tri- and tetrasubstituted furans has been conceptualized and demonstrated. A mild, base mediated reaction of allenoate pronucleophile with [small alpha]-haloketones/dicarbonyl compounds results in a Csp2-alkylation/enolization/O-vinylation sequence to... The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis, SAR and biological studies of sugar amino acid based almiramide analogues: N-methylation leads the way ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C6OB02610A, Paper Dipendu Das, Hina P.A. Khan, Rahul Shivahare, Suman Gupta, Jayanta Sarkar, Imran Siddiqi, RAVI SANKAR AMPAPATHI, Tushar Kanti Chakraborty Leishmaniasis, caused by the protozoan parasites of the genus Leishmania, is one of the most neglected diseases endemic in many continents posing enormous global health threats and therefore, the discovery... The content of this RSS Feed (c) The Royal Society of Chemistry
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Cyclic dipeptide based cell-penetrating peptidomimetics for effective DNA delivery ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00167C, Communication Govindaraju T, Chilakapati Madhu, Chandrashekhar Voshavar, K Rajasekhar Unnatural CDP-amino acid (kd) is used in the design and synthesis of novel cell penetrating peptidomimetic (Kkd-5). The balanced cationic nature and structural rigidity of Kkd-5 resulted in serum stability,... The content of this RSS Feed (c) The Royal Society of Chemistry
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Efficient synthesis of polymethoxyselenoflavones via regioselective direct C-H arylation of selenochromones ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00118E, Paper Woo-Ram Yang, Yong-Sung Choi, Jin-Hyun Jeong A simple direct C-H arylation of two difficult coupling partners, selenochromones and electron-rich aryl bromide, has been developed, affording diverse polymethoxyselenoflavones with great efficiency and high selectivity. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of pyrrolo[1,2-a]naphthyridines by Lewis acid mediated cycloisomerization ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00343A, Paper Anika Flader, Silvio Parpart, Peter Ehlers, Peter Langer Functionalized pyrrolo[1,2-a]naphthyridines were synthesized by application of PtCl2 and Bi(OTf)3 as simple Lewis acids in a cycloisomerization reaction. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Structurally diverse arene-fused ten-membered lactams accessed via hydrolytic imidazoline ring expansion ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00535K, Communication Alexander Sapegin, Angelina Osipyan, Mikhail Krasavin A facile approach to hitherto unknown ten-membered ring systems via a hydrolytic imidazoline ring expansion (HIRE) is described. Medium-sized rings are scarce in the contemporary medicinal chemistry toolbox. The new HIRE strategy broadens the arsenal of synthetic methods to obtain such scaffolds. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Multidrug resistance regulators (MDRs) as scaffolds for the design of artificial metalloenzymes ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00390K, Paper Manuela Bersellini, Gerard Roelfes Artificial metalloenzymes were created from multidrug resistance regulator proteins by in vivo incorporation of an unnatural metal binding amino acid. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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New photoheterolysis precursors to study oxenium ions: combining experiment and theory ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00180K, Perspective Yunfan Qiu, Arthur H. Winter The combination of theoretical calculations and laser flash photolysis experiments has aided in understanding the reactivity and properties of oxenium ions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Asymmetric Synthesis of Vinylogous [small beta]-Amino Acids and Their Incorporation Into Mixed Backbone Oligomers ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00333A, Paper Hao Wu, Hongchan An, Shuting Mo, Thomas Kodadek Chiral vinylogous [small beta]-amino acids (VBAA) were synthesized using enantioselective Mannich reactions of aldehydes with in situ generated N-carbamoyl imines followed by a Horner-Wadsworth-Emmons reaction. The efficiency with which these units... The content of this RSS Feed (c) The Royal Society of Chemistry
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Metal-Free Synthesis of 2-Aminonaphthalenes by Intramolecular Transannulation of 1-Sulfonyl-4-(2-alkenylphenyl)-1,2,3-triazoles ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00637C, Communication Ze-Feng Xu, Xing Yu, Dongdong Yang, Chuan-Ying Li A facile metal-free synthesis of naphthalenes by intramolecular transannulation of 1-sulfonyl-4-(2-alkenylphenyl)-1,2,3-triazoles was realized. The in situ formed ketenimine was proposed as the key intermediate, and the desired 2-aminonaphthalenes were generated... The content of this RSS Feed (c) The Royal Society of Chemistry
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Post-Synthetic Modification of Tryptophan Containing Peptides via NIS Mediation ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00329C, Communication Zili Chen, Cheng-Xue Gu, Qing-Wei Bi, Chu-Kun Gao, Jian Wen, Zhi-Gang Zhao An efficient new method was developed to provide modified tryptophan peptides through NIS mediated N2-selective coupling of Trp unit with 1,2,3-triazoles, of which, the preliminary spectral properties were also studied. The content of this RSS Feed (c) The Royal Society of Chemistry
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Rational design, synthesis, and biological evaluation of Pan-Raf inhibitors to overcome resistance ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00518K, Paper Lu Wang, Gaoyuan Zhu, Qing Zhang, Chunqi Duan, Yanmin Zhang, Zhimin Zhang, Yujun Zhou, Tao Lu, Weifang Tang Selective BRafV600E inhibitors with DFG-in conformation have been proven effective against a subset of melanoma. However, representative inhibitor vemurafenib rapidly acquire resistance in the BRafWT cells through a CRaf or... The content of this RSS Feed (c) The Royal Society of Chemistry
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Metal-free phosphonation of heteroarene N-oxides with trialkyl phosphite at room temperature ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00402H, Communication Ming-Tao Chen, Xia You, Li-Gang Bai, Qun-Li Luo A new protocol is described for the conversion of heteroarene N-oxides to heteroarylphosphonates through in situ activation with bromotrichloromethane. The N-oxides of isoquinoline, quinoline, quinoxaline and 1,10-phenanthroline were fast transformed... The content of this RSS Feed (c) The Royal Society of Chemistry
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Metal-free oxidative ring contraction of benzodiazepinones: an entry to quinoxalinones ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00205J, Paper Hasan Mtiraoui, Kevin Renault, Morgane Sanselme, Moncef Msaddek, Pierre-Yves Renard, Cyrille Sabot Herein is reported a practical method for the construction of 3-benzoylquinoxalinones from benzodiazepinones in the presence of DMSO which serves both as a solvent and an oxidant. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthetic glycoconjugates characterize the fine specificity of Brucella A and M monoclonal antibodies ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00445A, Paper Satadru Sekhar Mandal, N. Vijaya Ganesh, Joanna M. Sadowska, David R. Bundle Synthetic oligosaccharide glycoconjugates representing A and M epitopes of Brucella bacteria define the fine specificity of five monoclonal antibodies. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Small molecule Hedgehog pathway antagonists ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C6OB01959E, Paper Trieu N. Trinh, Eileen A. McLaughlin, Christopher P. Gordon, Ilana R. Bernstein, Victoria J. Pye, Kate A. Redgrove, Adam McCluskey Leveraging our quinolone-1-(2H)-one based Hedgehog signalling pathway (HSP) inhibitors we have developed two new classes of HSP inhibitors based on: L-tryptophan and benzo[1,3]dioxol-5-ylmethyl-[2-(1H-indol-3-yl)-ethyl]-amine. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Tunable Copper-Catalyzed Multicomponent Reaction Towards Alkaloid-Inspired Indole/Lactam Polycycles ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00532F, Paper Laurent Commeiras, Jean-Luc PARRAIN, Muhammad Idham Darussalam MARDJAN, Sandy Perie A versatile copper(I)-catalyzed cascade multicomponent reaction strategy between readily available (Z)-3-iodoacrylic acids, terminal alkynes, and primary amines is reported, leading to a great diversity of complex heterocyclic backbone based on... The content of this RSS Feed (c) The Royal Society of Chemistry
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Azobenzene-Benzoylphenylureas as Photoswitchable Chitin Synthesis Inhibitors ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C6OB02813F, Paper Xue Tian, Chao Zhang, Qi Xu, Z. Li, Xusheng Shao Benzoylphenylureas (BPUs) are used as synthetic insect growth regulators for inhibiting the chitin synthesis. Merging insecticidal BPUs with photoswitchable azobenzene generated the photoresponsive chitin synthesis inhibitors. One prepared azobenzene-benzoylphenylurea can... The content of this RSS Feed (c) The Royal Society of Chemistry
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Correction and removal of expression of concern: A unifying mechanism for the rearrangement of vinyl allene oxide geometric isomers to cyclopentenones ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB90046E, Correction Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Richard Kelly To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Structural diversification of the aminobicyclo[4.3.0]nonane skeleton using alkynylsilyl-derived allylic trichloroacetimidates ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00456G, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Mohamed A. B. Mostafa, Angus E. McMillan, Andrew Sutherland The late-stage synthesis of aminobicyclo[4.3.0]nonane analogues has been achieved from a key vinylsilane intermediate, prepared in turn by a one-pot multi-step process using an alkynylsilyl-derived allylic trichloroacetimidate. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Phenacyl azides as efficient intermediates: one-pot synthesis of pyrrolidines and imidazoles ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00299H, Communication Chada Narsimha Reddy, Manda Sathish, Susanta Adhikary, Jagadeesh Babu Nanubolu, Abdullah Alarifi, Ram Awatar Maurya, Ahmed Kamal Phenacyl azides: versatile substrates to produce various diastereoselective pyrrolidines and imidazoles in a one-pot manner through azomethine ylide formation with excellent yields. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Manganese(III) acetate catalyzed oxidative amination of benzylic C(sp3)-H bonds with nitriles ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00512A, Communication Yaxing Zhang, Jianyu Dong, Lixin Liu, Long Liu, Yongbo Zhou, Shuang-Feng Yin Mn-Catalyzed oxidative amination of benzylic C(sp3)-H bonds with nitriles towards secondary amides in moderate to excellent yields. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Access to [small pi]-conjugated azaindole derivatives via rhodium(III)-catalyzed cascade reaction of azaindoles and diazo compounds ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00059F, Communication Chen-Fei Liu, Guo-Tai Zhang, Jun-Shu Sun, Lin Dong Diazo compounds play an important role as a coupling partner to access unique [small pi]-conjugated 7-azaindole derivatives via rhodium(III)-catalyzed double C-H activation/cyclization. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Cyclopropanation of [60]fullerobenzofurans via electrosynthesis ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00463J, Paper Guan-Wu Wang, Junjie Wang, Hao-Sheng Lin, Chuang Niu The electrochemical cyclopropanation of [60]fullerobenzofurans with diethyl dibromomalonate has been investigated. Controlled by steric effect, the sterically favored e bisadducts are obtained as the major products along with two trans-3... The content of this RSS Feed (c) The Royal Society of Chemistry
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Expedient Synthesis of Phenanthro-Imidazo-Pyridine Fused Heteropolynuclear Framework via CDC coupling: A New Class of Luminophores ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00564D, Paper Biswadip Banerji, Satadru Chatterjee, K Chandrasekhar, Suvankar Bera, Leena Mazumder, Chandraday Prodhan, Keya Chaudhuri We here in report, design and synthesis of a group of fused phenthro-imidazo[1,2-a]pyridine derivatives, as a new class of luminescent materials through Pd(II) catalyzed intramolecular CDC (cross dehydrogenative coupling) reaction.... The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of phenanthiridine spiropyrans and studies of their effects on G-quadruplex DNA ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00300E, Paper Madeleine Livendahl, Jan Jamroskovic, Mattias Hedenstrom, Tim Gorlich, Nasim Sabouri, Erik Chorell G-quadruplex (G4) DNA structures are involved in many important biological processses and can be linked to several human diseases. Drug-like low molecular weight compounds that target G4 structures are therefore... The content of this RSS Feed (c) The Royal Society of Chemistry
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SQUARE SUGARS: CHALLENGES AND SYNTHETIC STRATEGIES ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB00386B, Review Article Damien Hazelard, Philippe Compain Square sugars (4-membered ring carbohydrate mimetics) are at the intersection between several important topics in connection with the recent emergence in medicinal chemistry of glycomimetic drugs and small ring systems.... The content of this RSS Feed (c) The Royal Society of Chemistry
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Thiyl radical-mediated cyclization of [small omega]-alkynyl O-tert-butyldiphenylsilyloximes ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00279C, Paper Nina Shibata, Takahisa Tsuchiya, Yoshimitsu Hashimoto, Nobuyoshi Morita, Shintaro Ban, Osamu Tamura Treatment of [small omega]-alkynyl O-tert-butyldiphenylsilyloximes with odorless thiol and AIBN gave cyclic O-silylhydroxylamines via a radical process in good yields. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Enantioselective Diels-Alder-Lactamization Organocascades Employing a Furan-Based Diene ()
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C6OB02738E, Communication Mikail E Abbasov, Brandi Hudson, Weixu Kong, Dean J Tantillo, Daniel Romo Alpha,beta-Unsaturated acylammonium salts are useful dienophiles enabling highly enantioselective and stereodivergent Diels-Alder-initiated organocascades with furan-based dienes. Complex polycyclic systems can thus be obtained from readily prepared dienes, commodity acid chlorides,... The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of chiral cyclic amines via Ir-catalyzed enantioselective hydrogenation of cyclic imines ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00442G, Paper Ying Zhang, Duanyang Kong, Rui Wang, Guohua Hou A highly enantioselective hydrogenation of cyclic imines has been successfully realized providing chiral cyclic amines with excellent enantioselectivities in the absence of any additive. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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The design and synthesis of an [small alpha]-Gal trisaccharide epitope that provides a highly specific anti-Gal immune response ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00448F, Paper Kensaku Anraku, Shun Sato, Nicholas T. Jacob, Lisa M. Eubanks, Beverly A. Ellis, Kim D. Janda The anti-[small alpha]Gal antibody response induced by a happen-conjugate can discriminate between closely related [small alpha]Gal epitopes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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[small beta]-Amyrin biosynthesis: catalytic mechanism and substrate recognition ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00238F, Review Article Tsutomu Hoshino In the past five years, there have been remarkable advances in the study of [small beta]-amyrin synthase. This review outlines the catalytic mechanism and substrate recognition in [small beta]-amyrin biosynthesis, which have been attained by the site-directed mutagenesis and substrate analog experiments. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Cyclic peptide unguisin A is an anion receptor with high affinity for phosphate and pyrophosphate ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00316A, Paper A. Daryl Ariawan, James E. A. Webb, Ethan N. W. Howe, Philip A. Gale, Pall Thordarson, Luke Hunter Unguisin A (1) is a marine-derived, GABA-containing cyclic heptapeptide with a high binding affinity for phosphates. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Asymmetric organocatalytic synthesis of tertiary azomethyl alcohols: key intermediates towards azoxy compounds and [small alpha]-hydroxy-[small beta]-amino esters ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00308K, Paper Jose A. Carmona, Gonzalo de Gonzalo, Inmaculada Serrano, Ana M. Crespo-Pena, Michal Simek, David Monge, Rosario Fernandez, Jose M. Lassaletta New carbohydrate based organocatalysts have been developed for the asymmetric nucleophilic addition of formaldehyde tert-butylhydrazone to [small alpha]-keto esters. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Betti's base for crystallization-induced deracemization of substituted aldehydes: synthesis of enantiopure amorolfine and fenpropimorph ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C6OB02765B, Paper Andrea Carella, Gabriel Ramos Ferronatto, Emanuela Marotta, Andrea Mazzanti, Paolo Righi, Claudio Paolucci Betti's base was used to deracemize substituted aldehydes via a CIDT process. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Novel fluorescent anthracene-bodipy dyads displaying sensitivity to pH and turn-on behaviour towards Cu(II) ions ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00274B, Paper A. Vanessa Saura, M. Isabel Burguete, Francisco Galindo, Santiago V. Luis The effect of the nature of the spacer in three new bichromophoric compounds showing intramolecular PET and EET processes has been studied. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Intramolecular macrolactonization, photophysical and biological studies of new class of polycyclic pyrrole derivatives ()
Org. Biomol. Chem., 2017, 15,2411-2421 DOI: 10.1039/C7OB00160F, Paper Suresh Kumar Mondal, Arabinda Mandal, Susanta Kumar Manna, Sk Asraf Ali, Maidul Hossain, Vangala Venugopal, Avijit Jana, Shubhankar Samanta Herein, we report an efficient synthesis of N-substituted pyrrole derivatives and their application to construct macrocyclic oxazocinone. The content of this RSS Feed (c) The Royal Society of Chemistry
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Palladium-catalyzed intermolecular tandem cyclization reaction: a highly regioselective synthesis of functionalized 3H-spiro[isobenzofuran-1,3[prime or minute]-isochroman] scaffolds ()
Org. Biomol. Chem., 2017, 15,2403-2410 DOI: 10.1039/C6OB02802K, Paper Liang Wang, Xuehu Li, Hua Tao, Xiang Zhou, Xihong Lu, Wenyue Du, Tingting Jiang, Zhijun Xin, Jianping Liang A highly regioselective synthesis of functionalized 3H-spiro[isobenzofuran-1,3[prime or minute]-isochroman] scaffolds via palladium-catalyzed tandem cyclization. The content of this RSS Feed (c) The Royal Society of Chemistry
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Isoafricanol synthase from Streptomyces malaysiensis ()
Org. Biomol. Chem., 2017, 15,2353-2358 DOI: 10.1039/C7OB00234C, Communication Patrick Rabe, Markiyan Samborskyy, Peter F. Leadlay, Jeroen S. Dickschat A terpene cyclases from Streptomyces malaysiensis was characterised as (+)-isoafricanol synthase and its mechanism was investigated using isotopically labelled substrates. The content of this RSS Feed (c) The Royal Society of Chemistry
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Palladium-catalyzed synthesis of monofluoroalkenes from 3,3-difluoropropenes using dimethylmalonate and derivatives as nucleophiles ()
Org. Biomol. Chem., 2017, 15,2376-2384 DOI: 10.1039/C7OB00376E, Paper Myriam Drouin, Sebastien Tremblay, Jean-Francois Paquin The catalytic synthesis of monofluoroalkenes bearing a malonate or its derivatives at the [small beta] position from various 3,3-difluoropropenes is presented. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of N,N-disubstituted 2-aminothiophenes by the cyclization of gem-difluoroalkenes with [small beta]-keto thioamides ()
Org. Biomol. Chem., 2017, 15,2436-2442 DOI: 10.1039/C7OB00368D, Paper Xuxue Zhang, Mingsheng Wu, Juan Zhang, Song Cao A novel and effective method for the construction of highly functionalized aminothiophenes via the cyclization of gem-difluoroalkenes with [small beta]-keto tertiary thioamides is described. The content of this RSS Feed (c) The Royal Society of Chemistry
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A formal homo-Nazarov cyclization of enantioenriched donor-acceptor cyclopropanes and following transformations: asymmetric synthesis of multi-substituted dihydronaphthalenes ()
Org. Biomol. Chem., 2017, 15,2443-2449 DOI: 10.1039/C7OB00278E, Paper Seijiro Takada, Naoya Takaki, Kenta Yamada, Yoshinori Nishii Multi-substituted trans-dihydronaphthalenes were obtained in high ee from a TiCl4-mediated cyclization of enantioenriched D-A cyclopropanes, followed by a triflation of OH. The content of this RSS Feed (c) The Royal Society of Chemistry
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Palladium/zinc co-catalyzed asymmetric transfer hydrogenation of oxabenzonorbornadienes with alcohols as hydrogen sources ()
Org. Biomol. Chem., 2017, 15,2359-2362 DOI: 10.1039/C7OB00175D, Communication Fujie Ma, Jingchao Chen, Fan Yang, Madhuri Vikas Shinde, Yongyun Zhou, Baomin Fan Asymmetric transfer hydrogenation of oxabenzonorbornadienes was realized by using alcohols as hydrogen sources under a co-catalytic system of palladium and zinc. The content of this RSS Feed (c) The Royal Society of Chemistry
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Diversity-oriented synthesis and cytotoxic activity evaluation of biaryl-containing macrocycles ()
Org. Biomol. Chem., 2017, 15,2450-2458 DOI: 10.1039/C6OB02726A, Paper Karell Perez-Labrada, Marco A. Cruz-Mendoza, Alejandra Chavez-Riveros, Eduardo Hernandez-Vazquez, Tomas Torroba, Luis D. Miranda Synthesis of biaryl-containing macrocycles has been carried out through a four-step approach comprising two Ugi four component reactions and a Suzuki-Miyaura macrocyclization. The content of this RSS Feed (c) The Royal Society of Chemistry
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Mechanistic investigations of the asymmetric hydrosilylation of ketimines with trichlorosilane reveals a dual activation model and an organocatalyst with enhanced efficiency ()
Org. Biomol. Chem., 2017, 15,2422-2435 DOI: 10.1039/C6OB02537D, Paper X. Li, A. T. Reeder, F. Torri, H. Adams, S. Jones Mechanistic investigations of a catalyst used for the asymmetric hydrosilylation have revealed a 'dual activation' model and catalyst that maintains its performance at 0.01 mol% loading. The content of this RSS Feed (c) The Royal Society of Chemistry
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Ratiometric electrochemical detection of hydrogen peroxide and glucose ()
Org. Biomol. Chem., 2017, 15,2459-2466 DOI: 10.1039/C7OB00211D, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Sean Goggins, Ellen A. Apsey, Mary F. Mahon, Christopher G. Frost Ferrocene-derived probes equipped with self-immolative linkers and boronic ester trigger moieties enable selective electrochemical detection of hydrogen peroxide, and glucose. The content of this RSS Feed (c) The Royal Society of Chemistry
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Transition-metal-free synthesis of 3-(1-pyrrolidinyl)quinolines and 3-(1-pyrrolidinyl)quinoline 1-oxides via a one-pot reaction of 3-(1-pyrrolidinyl)crotonates with nitrobenzenes ()
Org. Biomol. Chem., 2017, 15,2397-2402 DOI: 10.1039/C6OB02658C, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Robert Bujok, Piotr Cmoch, Zbigniew Wrobel, Krzysztof Wojciechowski 20 examples of tert-butyl 3-(1-pyrrolidinyl)-quinoline-2-carboxylate/quinoline 1-oxides including optically pure derivatives. The content of this RSS Feed (c) The Royal Society of Chemistry
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An efficient Sn(II)-catalyzed one-pot synthesis of a 3-substituted azetidine-2,4-dione framework ()
Org. Biomol. Chem., 2017, 15,2385-2391 DOI: 10.1039/C7OB00294G, Paper Santosh S. Chavan, Mrudul V. Supekar, Pralhad A. Burate, Bapurao D. Rupanwar, Anil M. Shelke, Gurunath Suryavanshi A novel Sn(II)-catalyzed tandem cyclization reaction of aromatic aldehydes with ethyl cyanoacetate has been achieved to afford a series of 3-substituted azetidine-2,4-diones in good to excellent yields. The content of this RSS Feed (c) The Royal Society of Chemistry
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Iridium catalyzed acceptor/acceptor carbene insertion into N-H bonds in water ()
Org. Biomol. Chem., 2017, 15,2392-2396 DOI: 10.1039/C7OB00177K, Paper Kankanala Ramakrishna, Chinnappan Sivasankar Carbenes from highly stable acceptor/acceptor diazo compounds can be inserted into the N-H bonds of aromatic amines using an Ir(I) catalyst in an aqueous medium. The content of this RSS Feed (c) The Royal Society of Chemistry
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Gold/silver-catalyzed controllable regioselective vinylcarbene insertion into O-H bonds ()
Org. Biomol. Chem., 2017, 15,2345-2348 DOI: 10.1039/C7OB00338B, Communication Guangyang Xu, Kai Liu, Zhenya Dai, Jiangtao Sun The controllable regioselective vinylcarbene insertion into O-H bonds of 2-pyridones/benzyl alcohols has been realized. The content of this RSS Feed (c) The Royal Society of Chemistry
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Rapid chemoenzymatic route to glutamate transporter inhibitor L-TFB-TBOA and related amino acids ()
Org. Biomol. Chem., 2017, 15,2341-2344 DOI: 10.1039/C7OB00305F, Communication Haigen Fu, Sabry H. H. Younes, Mohammad Saifuddin, Pieter G. Tepper, Jielin Zhang, Erik Keller, Andre Heeres, Wiktor Szymanski, Gerrit J. Poelarends Rapid route to L-TFB-TBOA: Using only nine chemical transformations, we have managed to construct the complex amino acid L-TFB-TBOA starting from commercially available dimethyl acetylenedicarboxylate. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of 2-aryloxy butenoates by copper-catalysed allylic C-H carboxylation of allyl aryl ethers with carbon dioxide ()
Org. Biomol. Chem., 2017, 15,2370-2375 DOI: 10.1039/C7OB00341B, Paper Atsushi Ueno, Masanori Takimoto, Zhaomin Hou 2-Aryloxy butenoates were efficiently synthesized by deprotonative alumination of ally aryl ethers and subsequent Cu-catalysed carboxylation with CO2. The content of this RSS Feed (c) The Royal Society of Chemistry
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Structure-activity relationships of the ATP cofactor in ligase-catalysed oligonucleotide polymerisations ()
Org. Biomol. Chem., 2017, 15,2349-2352 DOI: 10.1039/C6OB02792J, Communication Yi Lei, Ryan Hili Modified ATP cofactors were used to increase the fidelity of T4 DNA ligase-catalysed oligonucleotide polymerisation of modified oligonucleotides. The content of this RSS Feed (c) The Royal Society of Chemistry
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Recent advances in organocatalytic enantioselective transfer hydrogenation ()
Org. Biomol. Chem., 2017, 15,2307-2340 DOI: 10.1039/C7OB00113D, Review Article Ana Maria Faisca Phillips, Armando J. L. Pombeiro Robust, environmentally friendly reductants enable highly enantioselective reactions in the presence of chiral catalysts. The content of this RSS Feed (c) The Royal Society of Chemistry
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Recent advances in chiral imino-containing ligands for metal-catalyzed asymmetric transformations ()
Org. Biomol. Chem., 2017, 15,2280-2306 DOI: 10.1039/C6OB02817A, Review Article Xu Chen, Zhan Lu In this review, the recent applications of a variety of chiral imino-containing ligands classified by different types of metal-catalyzed asymmetric reactions are summarized. The progress made in this area would encourage us to design and synthesize more novel chiral imino-containing ligands, and explore their applications in metal-catalyzed asymmetric transformations. The content of this RSS Feed (c) The Royal Society of Chemistry
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An efficient Ugi-3CR/aza Diels-Alder/Pomeranz-Fritsch protocol towards novel aza-analogues of (+/-)-nuevamine, (+/-)-lennoxamine and magallanesine: a diversity oriented synthesis approach ()
Org. Biomol. Chem., 2017, 15,2363-2369 DOI: 10.1039/C6OB02572B, Paper Oscar Vazquez-Vera, Jorge S. Sanchez-Badillo, Alejandro Islas-Jacome, Manuel A. Renteria-Gomez, Shrikant G. Pharande, Carlos J. Cortes-Garcia, Monica A. Rincon-Guevara, Ilich A. Ibarra, Rocio Gamez-Montano, Eduardo Gonzalez-Zamora Diversity oriented synthesis of (+/-)-nuevamine, (+/-)-lennoxamine and magallanesine aza-analogues by MCR. The content of this RSS Feed (c) The Royal Society of Chemistry
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Enantioselective synthesis of an octahydroindolizine (indolizidine) alcohol using an enzymatic resolution ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00192D, Paper Jing Zhang, Rao Kolluri, Salvador G. Alvarez, Mark M. Irving, Rajinder Singh, Matthew A. J. Duncton A homo-chiral synthesis of (7R,8aS)-octahydro-5,5-dimethylindolizin-7-amine 8 and (7S,8aS)-octahydro-5,5-dimethylindolizin-7-ol 9, amine building blocks which have found applications within the pharmaceutical industry, is presented. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00220C, Paper Mauricio Morais, Joao P. M. Nunes, Kersti Karu, Nafsika Forte, Irene Benni, Mark E. B. Smith, Stephen Caddick, Vijay Chudasama, James R. Baker Dibromomaleimide (DBM) reagents are described which hydrolyse rapidly post-conjugation, representing an optimised platform for homogeneous and stable antibody conjugation. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Ruthenium-catalyzed regioselective allylic amination of 2,3,3-trifluoroallylic carbonates ()
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00514H, Paper Shin-ichi Isobe, Shou Terasaki, Taisyun Hanakawa, Shota Mizuno, Motoi Kawatsura Synthesis of trifluorinated terminal alkenes possessing allylic amines by ruthenium-catalyzed branch selective allylic amination. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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