Organic & Biomolecular Chemistry

Palladium-catalysed stereoselective synthesis of 4-(diarylmethylidene)-3,4-dihydroisoquinolin-1(2H)-ones: expedient access to 4-substituted isoquinolin-1(2H)-ones and isoquinolines ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02788E, Paper Amrita Mondal, Priyanka Kundu, Moumita Jash, Chinmay Chowdhury Palladium-catalysed stereoselective synthesis of 4-(diarylmethylidene)-3,4-dihydroisoquinolin-1(2H)-ones and their straightforward transformations to 4-substituted isoquinolin-1(2H)-ones and isoquinolines are described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Analysis of redox states of protic and aprotic solutions irradiated by low linear energy transfer carbon-ion beams using a 2,2-diphenyl-1-picrylhydrazyl radical ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C7OB02904G, Paper Ikuo Nakanishi, Shinichi Yamashita, Takashi Shimokawa, Masato Kamibayashi, Emiko Sekine-Suzuki, Megumi Ueno, Yukihiro Ogawa, Toshihiko Ozawa, Ken-ichiro Matsumoto The quantitative evaluation of changes in the redox state induced by low linear energy transfer (LET) radiations, such as the plateau region of heavy-ion beams, via formation of reactive oxygen... The content of this RSS Feed (c) The Royal Society of Chemistry
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A red-emitting fluorescence probe for hydrogen sulfide in living cells with a large Stokes shift ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C7OB02641B, Paper Lei Yang, Yuanan Su, Zhankui Sha, Yani Geng, Fengpei Qi, Xiangzhi Song A red-emitting fluorescent probe was developed for sensitive and selective detection of H2S. Upon the treatment with H2S, this probe exhibited a remarkable fluorescence enhancement (10 folds) with a large... The content of this RSS Feed (c) The Royal Society of Chemistry
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t-BuONa-mediated direct C-H halogenation of electron-deficient (hetero)arenes ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB03081A, Communication Xia Liu, Xin Zhao, Fushun Liang, Baoyi Ren An efficient halogenation of electron-deficient (hetero)arenes is described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Multiplexed detection of nucleic acids using 19F NMR chemical shift changes based on DNA photo-cross-linking of 3-vinylcarbazole derivatives ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB03008H, Communication Shigetaka Nakamura, Yasuharu Takashima, Kenzo Fujimoto The 19F NMR identical to trifluorothymidine was large shifted by DNA photo-cross-linking. The shifted signal dispersion was induced by the substituent of 3-vinylcarbazole derivatives. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Rose Bengal catalysed photo-induced selenylation of indoles, imidazoles and arenes: a metal free approach ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB03177G, Communication Sumbal Saba, Jamal Rafique, Marcelo S. Franco, Alex R. Schneider, Leandro Espindola, Dagoberto O. Silva, Antonio L. Braga A photo-induced, metal-free strategy was used for the direct C(sp2)-H bond selenylation of indoles, imidazoles and arenes using Rose Bengal as a photocatalyst. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A highly efficient nucleophilic substitution reaction between R2P(O)H and triarylmethanols to synthesize phosphorus-substituted triarylmethanes ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02970E, Paper Long Chen, Xin-Yue Fang, Yun-Xiang Zou A highly efficient nucleophilic substitution reaction between R2P(O)H and triarylmethanols was reported, which provides phosphorus-substituted triarylmethanes in rich diversity with 40-96% yields. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A novel lysosome-targeted fluorogenic probe based on 5-triazole-quinoline for the rapid detection of hydrogen sulfide in living cells ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02881D, Communication Yandong Dou, Xiaoxu Gu, Shasha Ying, Shen Zhu, Shian Yu, Wei Shen, Qing Zhu A fluorogenic probe based on the novel fluorophore 5-triazole-quinoline was developed for the detection of hydrogen sulfide, an endogenous signaling molecule associated with the development of various diseases. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Total synthesis of five natural eremophilane-type sesquiterpenoids ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02769A, Paper Zhe Meng, Bo Liu The first total synthesis of five eremophilane-type sesquiterpenoids is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Can strand displacement take place in DNA triplexes? ()
Org. Biomol. Chem., 2018, 16,372-375 DOI: 10.1039/C7OB02871G, Communication Qian Li, Cheng Tian, Xiang Li, Chengde Mao Toehold-mediated strand displacement can take place in the context of DNA triplexes, slowly. The content of this RSS Feed (c) The Royal Society of Chemistry
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Iodine(III)-mediated intramolecular sulfeno- and selenofunctionalization of [small beta],[gamma]-unsaturated tosyl hydrazones and oximes ()
Org. Biomol. Chem., 2018, 16,490-498 DOI: 10.1039/C7OB02892J, Paper Jing-Miao Yu, Chun Cai A cascade radical cyclization/sulfenylation or selenylation of [small beta],[gamma]-unsaturated hydrazones and oximes was realized under mild conditions with phenyliodine(III) diacetate (PIDA) as the sole oxidant, leading to the construction of diversely functionalized heteroatom-containing pyrazoline and isoxazoline derivatives. The content of this RSS Feed (c) The Royal Society of Chemistry
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Enhanced structural diversity in terpenoid biosynthesis: enzymes, substrates and cofactors ()
Org. Biomol. Chem., 2018, 16,348-362 DOI: 10.1039/C7OB02040F, Review Article Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Abith Vattekkatte, Stefan Garms, Wolfgang Brandt, Wilhelm Boland Terpenoid structural diversity is enhanced by multiproduct enzymes. Biosynthesis can be altered by switch in substrates, cofactors and pH. The content of this RSS Feed (c) The Royal Society of Chemistry
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Enantioselective synthesis of novel pyrano[3,2-c]chromene derivatives as AChE inhibitors via an organocatalytic domino reaction ()
Org. Biomol. Chem., 2018, 16,472-479 DOI: 10.1039/C7OB02794J, Paper Jie Zheng, Ming He, Baohua Xie, Lu Yang, Zhiye Hu, Hai-Bing Zhou, Chune Dong Novel optically active pyrano[3,2-c]chromenes have been synthesized (up to 94% yield, 99% ee) through an asymmetric catalytic domino reaction and identified as potent acetylcholinesterase inhibitors. In most cases, the S-enantiomers were superior to R-enantiomers. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and characterization of water-soluble macrocyclic peptides stabilizing protein [small alpha]-turn ()
Org. Biomol. Chem., 2018, 16,459-471 DOI: 10.1039/C7OB02852K, Paper Lei Wang, Pascale Coric, Kexin Zhu, Wang-Qing Liu, Michel Vidal, Serge Bouaziz, Sylvain Broussy Macrocyclic peptides mimic tight "non-classical" [small alpha]-turn type II-[small alpha]LS found in proteins, as shown by spectroscopic and computational analysis of their equilibrating conformations. The content of this RSS Feed (c) The Royal Society of Chemistry
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Hydroxyl directed C-arylation: synthesis of 3-hydroxyflavones and 2-phenyl-3-hydroxy pyran-4-ones under transition-metal free conditions ()
Org. Biomol. Chem., 2018, 16,444-451 DOI: 10.1039/C7OB01929G, Paper Sayantan Paul, Asish K. Bhattacharya Hydroxyl assisted, efficient, transition-metal free and direct C-arylation of 3-hydroxychromone and 5-hydroxy pyran-4-one moieties in the presence of a base, air as an oxidant and arylhydrazines as arylating agents to furnish highly biologically active 3-hydroxyflavones and 2-phenyl-3-hydroxy pyran-4-ones has been developed. The content of this RSS Feed (c) The Royal Society of Chemistry
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DABCO-catalyzed silver-promoted direct thiolation of pyrazolones with diaryl disulfides ()
Org. Biomol. Chem., 2018, 16,424-432 DOI: 10.1039/C7OB02860A, Paper Akkharaphong Thupyai, Chaleena Pimpasri, Sirilata Yotphan Efficient direct thiolation of N-substituted pyrazolones with diaryl disulfides was developed using a combination of DABCO and AgOAc to assist C-S bond formation. The content of this RSS Feed (c) The Royal Society of Chemistry
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Convenient synthesis of 2-amino-3-(arylthio)indoles via the Rh-catalyzed reaction of 3-diazoindol-2-imines with thioesters ()
Org. Biomol. Chem., 2018, 16,439-443 DOI: 10.1039/C7OB02597A, Paper Fanghui Ma, Jing Qian, Ping Lu, Yanguang Wang 2-Amino-3-(arylthio)indoles were conveniently synthesized via the Rh(II)-catalyzed C-S/N-C coupling reaction between 3-diazoindol-2-imines and thioesters. The content of this RSS Feed (c) The Royal Society of Chemistry
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A regiospecific rhamnosyltransferase from Epimedium pseudowushanense catalyzes the 3-O-rhamnosylation of prenylflavonols ()
Org. Biomol. Chem., 2018, 16,452-458 DOI: 10.1039/C7OB02763J, Paper Keping Feng, Ridao Chen, Kebo Xie, Dawei Chen, Baolin Guo, Xiao Liu, Jimei Liu, Min Zhang, Jungui Dai A novel rhamnosyltransferase and a UDP-rhamnose synthase were characterized and applied to the biosynthesis of bioactive prenylflavonol rhamnosides. The content of this RSS Feed (c) The Royal Society of Chemistry
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Exploring bis-(amino)cyclopropenylidene as a non-covalent Bronsted base catalyst in conjugate addition reactions ()
Org. Biomol. Chem., 2018, 16,384-388 DOI: 10.1039/C7OB02882B, Communication Gurdeep Singh, Prithwish Goswami, Ramasamy Vijaya Anand The catalytic application of bis-(amino)cyclopropenylidene, as a non-covalent Bronsted base, in the 1,4- and 1,6-conjugate addition of carbon nucleophiles to enones and p-quinone methides, respectively, is described. The content of this RSS Feed (c) The Royal Society of Chemistry
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An intramolecular tryptophan-condensation approach for peptide stapling ()
Org. Biomol. Chem., 2018, 16,389-392 DOI: 10.1039/C7OB02667F, Communication Eunice Y.-L. Hui, Bhimsen Rout, Yaw Sing Tan, Chandra S. Verma, Kok-Ping Chan, Charles W. Johannes Stapled peptides are gaining tremendous interest as next-generation therapeutic agents to target protein-protein interactions. Herein, we report an intramolecular peptide stapling method which links two tryptophan residues at C2 position of the indole moieties via acid-mediated condensation with an aldehyde. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of azulene-substituted benzofurans and isocoumarins via intramolecular cyclization of 1-ethynylazulenes, and their structural and optical properties ()
Org. Biomol. Chem., 2018, 16,480-489 DOI: 10.1039/C7OB02861J, Paper Taku Shoji, Miwa Tanaka, Sho Takagaki, Kota Miura, Akira Ohta, Ryuta Sekiguchi, Shunji Ito, Shigeki Mori, Tetsuo Okujima The preparation of azulene-substituted benzofurans and isocoumarins was established by two types of intramolecular cyclization reaction of 1-ethynylazulenes. The content of this RSS Feed (c) The Royal Society of Chemistry
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Bifunctional catalysis in the stereocontrolled synthesis of tetrahydro-1,2-oxazines ()
Org. Biomol. Chem., 2018, 16,376-379 DOI: 10.1039/C7OB02894F, Communication Marek Moczulski, Piotr Drelich, Lukasz Albrecht The application of bifunctional catalysis for the synthesis of tetrahydro-1,2-oxazines is described. The content of this RSS Feed (c) The Royal Society of Chemistry
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A Bronsted acid-promoted asymmetric intramolecular allylic amination of alcohols ()
Org. Biomol. Chem., 2018, 16,380-383 DOI: 10.1039/C7OB02599H, Communication Jianqiao Zhou, Hexin Xie An asymmetric intramolecular allylic amination reaction catalyzed by a chiral Bronsted acid is disclosed, affording biologically intriguing chiral 2-substituted hydroquinolines in up to 90% yield and with up to 93% ee. The content of this RSS Feed (c) The Royal Society of Chemistry
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Side chain-specific 11/9-helix propensity of [small alpha]/[small beta]-peptides with alternating residue types ()
Org. Biomol. Chem., 2018, 16,433-438 DOI: 10.1039/C7OB02816D, Paper Jaeyeon Lee, Jihyun Shim, Philjae Kang, Moon-Gun Choi, Soo Hyuk Choi The 11/9-helix propensity of [small alpha]/[small beta]-peptides is dependent on a specific side chain group of [small alpha]- or [small beta]3-residue. The content of this RSS Feed (c) The Royal Society of Chemistry
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Contiguous hydrophobic and charged surface patches in short helix-constrained peptides drive cell permeability ()
Org. Biomol. Chem., 2018, 16,367-371 DOI: 10.1039/C7OB02952G, Communication Samuel R. Perry, Timothy A. Hill, Aline D. de Araujo, Huy N. Hoang, David P. Fairlie Different ways to get peptides into cells. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of thiazolidine-thiones, imino-thiazolidines and oxazolidines via the base promoted cyclisation of epoxy-sulfonamides and heterocumulenes ()
Org. Biomol. Chem., 2018, 16,402-413 DOI: 10.1039/C7OB02915B, Paper Mandala Anitha, K. C. Kumara Swamy Epoxy-sulfonamides react with heterocumulenes (CS2/RNCS/RNCO) in the presence of a base to afford ring expansion products in good to high yields with excellent regioselectivity. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of trifluoroalkyl or difluoroalkyl phenanthridine derivatives via cascade reaction using an intramolecular cyano group as a radical acceptor under photoredox catalysis ()
Org. Biomol. Chem., 2018, 16,414-423 DOI: 10.1039/C7OB02804K, Paper Xu Liu, Zhongjie Wu, Zeguo Zhang, Ping Liu, Peipei Sun In the presence of Ru(phen)3Cl2 or fac-Ir(ppy)3 under visible-light irradiation, the addition of fluorinated radicals to N-arylacrylamides followed by an intramolecular cyano group insertion cascade cyclization process produced the target compounds in moderate to good yields. The content of this RSS Feed (c) The Royal Society of Chemistry
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[18F]ODIBO: a prosthetic group for bioorthogonal radiolabeling of macromolecules via strain-promoted alkyne-azide cycloaddition ()
Org. Biomol. Chem., 2018, 16,363-366 DOI: 10.1039/C7OB02532G, Communication Mehdi Boudjemeline, Christopher D. McNitt, Thomas A. Singleton, Vladimir V. Popik, Alexey P. Kostikov [18F]oxadibenzocyclooctyne ([18F]ODIBO) allows for efficient biorthogonal radiolabeling of macromolecules at low concentrations and room temperature via SPAAC. The content of this RSS Feed (c) The Royal Society of Chemistry
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Tricyclanos: conformationally constrained nucleoside analogues with a new heterotricycle obtained from a D-ribofuranose unit ()
Org. Biomol. Chem., 2018, 16,393-401 DOI: 10.1039/C7OB02296D, Paper Mate Kicsak, Attila Mandi, Szabolcs Varga, Mihaly Herczeg, Gyula Batta, Attila Benyei, Aniko Borbas, Pal Herczegh Nucleoside analogues having a new N,O-containing tricycle in place of the ribose unit have been prepared by a diastereoselective cyclocondensation of Tris and dialdehydes obtained from ribofuranosyl nucleosides. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of a novel HER2 targeted aza-BODIPY-antibody conjugate: Synthesis, photophysical characterisation and in vitro evaluation. ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C7OB02957H, Paper Miffy Cheng, Antoine Maruani, Huguette Savoie, Vijay Chudasama, Ross W Boyle We herein report the synthesis and analysis of a novel aza-BODIPY-antibody conjugate, formed by controlled and regioselective bioconjugation methodology. Employing the clinically relevant antibody, which targets HER2 positive cancers, represents... The content of this RSS Feed (c) The Royal Society of Chemistry
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Electrophilic Fluorination of Stereodefined Polysubstituted Silyl Ketene Hemiaminals en route to Tertiary -Fluorinated Carbonyl Derivatives ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB00067K, Communication Ilan Marek, Jian Qiang Huang, Zackaria Nairoukh The highly diastereoselective synthesis of tertiary -fluoro carbonyl compounds is reported in only two chemical steps from a simple alkyne through the reaction of stereodefined fully substituted silyl ketene hemiaminal... The content of this RSS Feed (c) The Royal Society of Chemistry
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Michael addition of carbonyl compounds to nitroolefins under the catalysis of new pyrrolidine-based bifunctional organocatalysts ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02798B, Paper A. Castan, R. Badorrey, J. A. Galvez, P. Lopez-Ram-de-Viu, M. D. Diaz-de-Villegas Novel bifunctional pyrrolidine-based organocatalysts applicable for the asymmetric Michael addition of aldehydes and ketones to nitroolefins have been developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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5[prime or minute]-Vitamin B12 derivatives suitable for bioconjugation via the amide bond ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02898A, Paper A. Jackowska, M. Chrominski, M. Giedyk, D. Gryko Vitamin B12 derivatives bearing either the amino or the carboxylic group at the 5[prime or minute]-position were synthesised hence enabling conjugation of therapeutics to vitamin B12 via the amide bond. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Structural revision of two unusual rhamnofolane diterpenes, curcusones I and J, by means of DFT calculations of NMR shifts and coupling constants ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02916K, Paper Ariel M. Sarotti The structures of two unusual rhamnofolane diterpenes, curcusones I and J, have been revised using quantum calculations of NMR shifts. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Total Synthesis of Pipecolic Acid and 1-C-Alkyl 1,5-Iminopentitol Derivatives by way of Stereoselective Aldol Reactions from (S)-Isoserinal ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C7OB02797D, Paper Sebastian Bas, Rafal Kusy, Monika Pasternak-Suder, Cyril NICOLAS, Jacek Mlynarski, Olivier Martin A short synthesis of iminosugars and pipecolic acid derivatives has been realized through aldol addition of a pyruvate, a range of ketones and (S)-isoserinal, followed by catalytic reductive intramolecular amination.... The content of this RSS Feed (c) The Royal Society of Chemistry
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Computational evidence for a reaction pathway bifurcation in Sasaki-type (4+3)-cycloadditions. ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB00075A, Paper Jed Marcus Burns The current report seeks to validate the existence of a post-transition state bifurcation in the Lewis acid-catalysed (4+3)-cycloaddition of butadiene and [small alpha]-methoxy acrolein. Cycloaddition transition state (TS) structures are shown... The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of branched and linear 1,4-linked galactan oligosaccharides ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C7OB03035E, Paper Mathias C. Franch Andersen, Irene Boos, Christine Kinnaert, Shahid Awan, Henriette Pedersen, Stjepan K Kracun, Gyrithe Lanz, Maja G Rydahl, Louise Kjaerulff, Maria Hakansson, Raymond Kimbung, Derek Logan, Charlotte Gotfredsen, William George Tycho Willats, Mads Hartvig Hartvig Clausen We report the synthesis of linear and branched (1[rightward arrow]4)-D-galactans. Four tetrasaccharides and one pentasaccharide were accessed by adopting a procedure of regioselective ring opening of a 4,6-O-naphthylidene protecting group followed... The content of this RSS Feed (c) The Royal Society of Chemistry
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E-Z isomerization in Suzuki cross-couplings of haloenones: Ligand effects and evidence for a separate catalytic cycle. ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C7OB02925J, Paper Navneet Chehal, Peter H M Budzelaar, Philip Hultin Suzuki cross-coupling of haloalkenes is generally assumed to occur with retention of the alkene stereochemistry. While studying Suzuki cross-couplings on E-1,2-dichlorovinyl phenyl ketone, we were surprised to observe extensive isomerization.... The content of this RSS Feed (c) The Royal Society of Chemistry
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Specific labeling of mitochondria of Chlamydomonas with cationic helicene fluorophores ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02906C, Paper Christoph Bauer, Romain Duwald, Geraldine Maria Labrador, Simon Pascal, Pau Moneva Lorente, Johann Bosson, Jerome Lacour, Jean-David Rochaix Twelve cationic helicenes and one triangulene were tested for the specific labeling of mitochondria from algal cells. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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One-pot cascade synthesis of azabicycles via the nitro-Mannich reaction and N-alkylation ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB03104A, Communication Wannaporn Disadee, Somsak Ruchirawat A cascade of double intramolecular cyclizations via the nitro-Mannich reaction and N-alkylation provides direct access to various ring systems of azabicycles. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Unexpected cleavage of upper rim-bridged calix[4]arenes leading to linear oligophenolic derivatives ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB03101G, Paper P. Slavik, H. Dvorakova, M. Krupicka, P. Lhotak Upper rim-bridged calix[4]arenes possess an unprecedented reactivity as a consequence of their high internal strain imposed by the single bond bridge. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Formal total synthesis of salvianolic acid N ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB03025H, Paper Kong Wu, Zhong Pao Xie, Dong-Mei Cui, Chen Zhang Salvianolic acid N was synthesized starting from 3,4-dimethoxybenzaldehyde in 11 steps and with an overall yield of 11%. The key reaction steps were the Wittig reaction for Z-stereoselectivity, the copper catalyzed intramolecular cyclization for seven membered ring skeleton, and the deprotected allylic group with Pd catalysis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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New mechanism for internal nucleophilic substitution reactions. ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C7OB02994B, Paper Ramon J. Zaragoza, Maria Jose Aurell, Miguel A Gonzalez-Cardenete A new mechanism of the classic internal nucleophilic substitution reactions SNi by means of computational studies in gas-phase, DCM and acetonitrile is reported. Despite the importance of the SNi mechanism,... The content of this RSS Feed (c) The Royal Society of Chemistry
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A semi-rigid isoindoline-derived nitroxide spin label for RNA ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02870A, Paper Dnyaneshwar B. Gophane, Burkhard Endeward, Thomas F. Prisner, Snorri Th. Sigurdsson The new semi-rigid spin label ImUm showed limited motion in RNA duplexes and accurate distances between two spin labels in RNA duplexes were obtained by pulsed EPR spectroscopy. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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The unexpected racemization and hydrogen-deuterium exchange of the hydrogen at the [small alpha]-carbon of proline analogs containing the 5-azoniaspiro[4.4]nonyl-group ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02926H, Paper B. Setner, M. Wierzbicka, L. Jerzykiewicz, M. Lisowski, Z. Szewczuk Herein, we present an unexpected racemization and the hydrogen-deuterium exchange (HDX) at the [small alpha]-C atom of the proline derivative under basic aqueous conditions (1% water solution of triethylamine). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Organocatalytic [3 + 2] cycloaddition of oxindole-based azomethine ylides with 3-nitrochromenes: a facile approach to enantioenriched polycyclic spirooxindole-chromane adducts ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB03051G, Paper Shiqi Wu, Guodong Zhu, Shiqiang Wei, Hongbo Chen, Jingping Qu, Baomin Wang An organocatalytic asymmetric [3 + 2] cycloaddition of oxindole-based azomethine ylides with 3-nitro-2H-chromenes is reported, delivering densely functionalized polycyclic spirooxindole-chromane adducts. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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FeCl3-catalyzed dimerization/elimination of 1,1-diarylalkenes: efficient synthesis of functionalized 4H-chromenes ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02941A, Communication Chao Ma, Yu Zhao An efficient synthesis of valuable poly-substituted 4H-chromenes was developed via a [4 + 2] cycloaddition followed by the elimination of 1,1-diarylalkenes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A Catalyst-Free Intermolecular trans-Iodoalkylation of Alkynes ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C7OB03159A, Communication Jie-Jie Liu, Hong-Yan Huang, Liang Cheng, Qi Liu, Dong Wang, Li Liu We report the first catalyst-free and trans-selective iodoalkylation reaction of alkynes with a series of [small alpha]-carbonyl compounds. This unprecedented three-component iodoalkylation reaction is enabled by using (iodoethynyl)trimethylsilane as a radical... The content of this RSS Feed (c) The Royal Society of Chemistry
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Solvent Incorporated Sequential [3+2] Annulation/Substitution Reaction of Azomethine Imines and Propargyl Sulfur Ylide ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C7OB03012F, Communication Shoujie Shen, Yanli Yang, Jiangyan Duan, Zhenhu Jia, Jinyan Liang A novel solvent incorporated sequential [3+2] cycloaddition /substitution reaction of azomethine imines with propargyl sulfur ylide was developed. In the actual three-component reaction, propargyl sulfur ylide acts as dipole reagent... The content of this RSS Feed (c) The Royal Society of Chemistry
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A Nano-Catalytic Approach for C-B Bond Formation Reactions ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C7OB02958F, Review Article Piyush Kumar Verma, Mahadev L. Shegavi, Shubhankar Kumar Bose, Geetharani K A chronological survey of the metal/metal oxide nanoparticles catalysed borylation reactions is presented. The transition-metal-catalysed borylation is considered as one of the most efficient methods for the synthesis of organoboron... The content of this RSS Feed (c) The Royal Society of Chemistry
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DBU-Promoted Carbonylative Synthesis of 1,3-Oxathiolan-2-ones from Propargylic Alcohols with TFBen as the CO source ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C7OB03145A, Communication Xiao-Feng Wu, jun ying, chao zhou A DBU-promoted carbonylative cyclization of propargylic alcohols with sulfur has been developed. Various 1,3-oxathiolan-2-ones were produced in 61-98% yields under mild conditions in the absence of metal catalysts. TFBen (benzene-1,3,5-triyl... The content of this RSS Feed (c) The Royal Society of Chemistry
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Theoretical insight into the regioselective ring-expansions of bicyclic aziridinium ions ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02253K, Paper Esma B. Boydas, Gamze Tanriver, Matthias D'hooghe, Hyun-Joon Ha, Veronique Van Speybroeck, Saron Catak Unraveling the factors affecting the regioselectivity in the ring-expansions of bicyclic aziridiniums. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of aryl a,a-difluoroethyl thioethers a novel structure motif in organic chemistry, and extending to aryl a,a-difluoro oxyethers ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C7OB02987J, Paper Ren Tomita, Nawaf Al-Maharik, Andrea Rodil, Michael Buehl, David O'Hagan A method for the preparation of aryl a,a--difluoroethyl thioethers (ArSCF2CH3) is reported and the synthesis approach is extended to aryl a,a--difluoroethyl oxygen ethers. Selected building blocks are further elaborated in... The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthetic and Immunological Studies on Trimeric MUC1 Immunodominant Motif Antigens-based Anti-cancer Vaccine Candidates ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C7OB02976D, Paper Mingjing Li, Fan Yu, Chao Yao, Peng George Wang, Yonghui Liu, Wei Zhao Therapeutic vaccines have been regarded as a very promising treatment modality against cancer. Tumor-associated MUC1 is a promising antigen for the design of antitumor vaccines. However, body's immune tolerance and... The content of this RSS Feed (c) The Royal Society of Chemistry
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The Thiolation of Pentafluorobenzene with Disulfides by C-H, C-F Bonds Activation and C-S Bond Formation ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C7OB02836A, Paper Zijian Liu, Kunbing Ouyang, Nianfa Yang A metal-free thiolation reaction between pentafluorobenzene and disulfides through C-H, C-F bond activation and C-S bond formation is reported. Bisthiolated tetrafluorobenzene derivatives would be prepared in moderate to good yield... The content of this RSS Feed (c) The Royal Society of Chemistry
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The Piancatelli Reaction and its Variants: Recent Applications to High Added-Value Chemicals and Biomass Valorization ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C7OB02962D, Review Article Charlie Verrier, Sylvie Moebs-Sanchez, Yves Queneau, Florence Popowycz The Piancatelli reaction, also called Piancatelli rearrangement, consists in the direct conversion of furfuryl alcohols in cyclopentenone derivatives through a furan ring opening-electrocyclization process. Following its discovery in the late... The content of this RSS Feed (c) The Royal Society of Chemistry
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Conformational stabilization of a [small beta]-hairpin through a triazole-tryptophan interaction ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02815F, Paper Donatella Diana, Claudia Di Salvo, Veronica Celentano, Lucia De Rosa, Alessandra Romanelli, Roberto Fattorusso, Luca D. D'Andrea Triazole and indole rings stabilize a [small beta]-hairpin conformation through an aromatic-aromatic interaction. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Highly chemoselective intermolecular cross-benzoin reactions using an ad hoc designed novel N-heterocyclic carbene catalyst ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB03005C, Paper Eoghan G. Delany, Stephen J. Connon A new N-heterocyclic carbene catalyst incorporating a bulky yet electron-deficient N-aryl substituent promotes highly chemoselective intermolecular crossed benzoin condensations. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Structural elucidation of major selective androgen receptor modulator (SARM) metabolites for doping control ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB03030D, Communication Neeraj Garg, Annelie Hansson, Heather K. Knych, Scott D. Stanley, Mario Thevis, Ulf Bondesson, Mikael Hedeland, Daniel Globisch Elucidated and validated structure of the major SARM doping drug metabolites. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Asymmetric synthesis of (-)-sedacryptine through a diastereoselective Mannich reaction of N,O-acetals with ketones ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02989F, Paper Yi-Wen Liu, Rui-Jun Ma, Jia-Hang Yan, Zhu Zhou, Bang-Guo Wei An approach to access the 3-hydroxyl-2,6-disubstituted piperidine scaffold has been developed through the Mannich process involving N,O-acetals and ketones, and the process is demonstrated by the asymmetric synthesis of (-)-sedacryptine. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and Characterization of a Photocleavable Collagen-Like Peptide ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C7OB02198D, Paper Alfredo Ornelas, Kaitlyn N Williams, Kevin Hatch, Aurelio Paez, Angela C Aguilar, Cameron C Ellis, Nishat Tasnim, Supriyo Ray, Carl Dirk, Thomas Boland, Binata Joddar, Chunqiang Li, Katja Michael A 34 amino acid long collagen-like peptide rich in proline, hydroxyproline, and glycine, and with four photoreactive N-acyl-7-nitroindoline units incorporated into the peptide backbone was synthesized by on-resin fragment condensation.... The content of this RSS Feed (c) The Royal Society of Chemistry
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Rhodium-catalyzed C7-alkylation of indolines with maleimides ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB03039H, Communication Changduo Pan, Yun Wang, Chao Wu, Jin-Tao Yu A rhodium(III)-catalyzed direct cross-coupling reaction of indolines with maleimides via C-H bond activation was developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A mild method for synthesizing carboxylic acids by oxidation of aldoximes using hypervalent iodine reagents ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02858J, Communication Akira Nakamura, Hodaka Kanou, Junki Tanaka, Akira Imamiya, Tomohiro Maegawa, Yasuyoshi Miki A variety of aldoximes can be efficiently converted into the corresponding carboxylic acids with hypervalent iodine reagent. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Nickel-catalyzed cross-coupling of [small beta]-carbonyl alkenyl pivalates with arylzinc chlorides ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C7OB02947K, Paper Wen-Jing Pan, Zhong-Xia Wang The nickel-catalyzed cross-coupling reaction of [small beta]-carbonyl alkenyl pivalates with arylzinc reagents generates 3-aryl-substituted [small alpha],[small beta]-unsaturated carbonyl compounds via C-O bond cleavage. The reaction features mild reaction conditions, a wide scope of... The content of this RSS Feed (c) The Royal Society of Chemistry
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Decarboxylation-promoted Pd-catalyzed asymmetric propargylic [3 + 2] annulation for the enantioselective construction of a quaternary stereocenter in 2,3-dihydrofurans ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02778H, Paper Kun Li, Fu-Lin Zhu, Zhen-Ting Liu, Jing Tong, Xiang-Ping Hu A Pd-catalyzed asymmetric [3 + 2] cycloaddition of tertiary propargylic carbonates with [small beta]-ketoesters has been developed, in which a quaternary stereocenter was formed in high enantioselectivity. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Convenient, functional group-tolerant, transition metal-free synthesis of aryl and heteroaryl trifluoromethyl ketones with the use of methyl trifluoroacetate ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02862H, Paper Kazumasa Funabiki, Ayaka Hayakawa, Toshiyasu Inuzuka A new convenient, functional group-tolerant, transition metal-free route to aryl trifluoromethyl ketones under mild conditions is described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A BF3[middle dot]Et2O catalyzed atom-economical approach to highly substituted indole-3-carbinols from nitrosobenzenes and propargylic alcohols ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02559A, Paper Sengodagounder Muthusamy, Alagesan Balasubramani, Eringathodi Suresh The BF3[middle dot]Et2O catalyzed tandem reaction of nitrosobenzenes and propargylic alcohols for the formation of highly substituted indole-3-carbinols. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Kinetic basis for the activation of human cyclooxygenase-2 rather than cyclooxygenase-1 by nitric oxide ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02992F, Paper Jie Qiao, Lixin Ma, Justine Roth, Yamin Li, Yi Liu Kinetic basis for the activation of human cyclooxygenase-2 by nitric oxide. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Eosin Y photoredox catalyzed net redox neutral reaction for regiospecific annulation to 3-sulfonylindoles via anion oxidation of sodium sulfinate salts ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02977B, Communication Rajendra S. Rohokale, Shrikant D. Tambe, Umesh A. Kshirsagar An eosin Y photoredox catalyzed net redox neutral process for 3-sulfonylindoles via the anionic oxidation of sodium sulfinate salts and its radical cascade cyclization with 2-alkynyl-azidoarenes was developed with visible light as a mediator. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Glycosylation of a model proto-RNA nucleobase with non-ribose sugars: implications for the prebiotic synthesis of nucleosides ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB03017G, Paper David M. Fialho, Kimberly C. Clarke, Megan K. Moore, Gary B. Schuster, Ramanarayanan Krishnamurthy, Nicholas V. Hud The emergence of the earliest nucleosides is an important, but unresolved, element of the origins of life that may have been facilitated by heterocycle reactivity and self-assembly. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Neutral glycoconjugated amide-based calix[4]arenes: complexation of alkali metal cations in water ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02955A, Paper Nikola Cindro, Josip Pozar, Dajana Barisic, Nikola Bregovic, Katarina Piculjan, Renato Tomas, Leo Frkanec, Vladislav Tomisic Novel water-soluble calix[4]arene glycoconjugates with efficient cation-binding sites were synthesized and their complexation reactions in methanol and aqueous solutions were studied. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Bioinspired total synthesis of tetrahydrofuran lignans by tandem nucleophilic addition/redox isomerization/oxidative coupling and cycloetherification reactions as key steps ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02848B, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Pratap R. Jagtap, Ivana Cisarova, Ullrich Jahn Three steps suffice to complete a bioinspired total synthesis of tetrahydrofuran lignans using tandem addition/isomerization/dimerization and cycloetherification reactions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Tailoring the properties of a hypoxia-responsive 1,8-naphthalimide for imaging applications ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB03164E, Paper Kylie Yang, Kathryn G. Leslie, Sally Y. Kim, Bill Kalionis, Wojciech Chrzanowski, Katrina A. Jolliffe, Elizabeth J. New A series of bioreductive fluorescent sensors based on nitro-naphthalimide enables matching of probe properties to biological application. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Catalytic enantioselective synthesis of carboxy-substituted 2-isoxazolines by cascade oxa-Michael-cyclization ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02722B, Paper Hyo-Jun Lee, Bora Eun, Eonseon Sung, Gil Tae Hwang, Young Kwan Ko, Chang-Woo Cho Enantioselective phase-transfer-catalyzed cascade synthesis of chiral carboxy-substituted 2-isoxazolines was achieved. The cascade reaction was applied to synthesis of herbicide (S)-methiozolin. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A domino reaction of 3-chlorochromones with aminoheterocycles. Synthesis of pyrazolopyridines and benzofuropyridines and their optical and ecto-5[prime or minute]-nucleotidase inhibitory effects ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02729J, Paper Mariia Miliutina, Julia Janke, Sidra Hassan, Sumera Zaib, Jamshed Iqbal, Joanna Lecka, Jean Sevigny, Alexander Villinger, Aleksej Friedrich, Stefan Lochbrunner, Peter Langer Biologically active fused pyridines were prepared by a new domino reaction. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Inexpensive multigram-scale synthesis of cyclic enamines and 3-N spirocyclopropyl systems ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02659E, Paper Pratik Kumar, Omar Zainul, Scott T. Laughlin Cyclic enamines are important synthons for many synthetic and pharmacological targets. We report a method for the synthesis of cyclic enamines with exocyclic double bonds and four- to seven-membered rings that permits usage of common N-protecting groups and tolerates functionality round the ring system. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of spiro-tetrahydrothiopyran-oxindoles by Michael-aldol cascade reactions: discovery of potential P53-MDM2 inhibitors with good antitumor activity ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02726E, Paper Shengzheng Wang, Shuqiang Chen, Zhongjie Guo, Shipeng He, Fan Zhang, Xueying Liu, Weiping Chen, Shengyong Zhang, Chunquan Sheng Novel one-pot Michael-aldol cascade reactions were used to efficiently construct spiro-tetrahydrothiopyran-oxindoles with good in vitro antitumor activity. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Transition-metal-catalyst-free synthesis of anthranilic acid derivatives by transfer hydrogenative coupling of 2-nitroaryl methanols with alcohols/amines ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02919E, Communication Shudi Zhang, Zhenda Tan, Biao Xiong, Huan Feng Jiang, Min Zhang A transition metal catalyst-free synthesis of anthranilic acid derivatives, featuring operational simplicity, broad substrate scope, good functional tolerance, high step efficiency, is presented. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Bioluminescent probe for detecting endogenous hypochlorite in living mice ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02842C, Paper Chunchao Tang, Yuqi Gao, Tingting Liu, Yuxing Lin, Xiaomeng Zhang, Chaochao Zhang, Xiang Li, Tianchao Zhang, Lupei Du, Minyong Li As a kind of biologically important reactive oxygen species (ROS), hypochlorite (ClO-) plays a crucial role in many physiological processes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Iodine mediated oxidative cross-coupling of unprotected anilines and heteroarylation of benzothiazoles with 2-methylquinoline ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02241G, Paper Abdul Rahim, Siddiq Pasha Shaik, Mirza Feroz Baig, Abdullah Alarifi, Ahmed Kamal Iodine mediated dual C-H activation of Csp3-H of 2-methylquinoline and Csp2-H of anilines for the construction of C-C and C-O bonds and the oxidative insertion of 2-methylquinoline to the benzothiazole under metal and peroxide free condition. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Catalytic asymmetric enamine protonation reaction ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02615C, Review Article Niankai Fu, Long Zhang, Sanzhong Luo Recent advances in catalytic enantioselective enamine protonation for the synthesis of optically active carbonyl compounds are summarized in this review. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Teaching an old scaffold new recognition tricks: oligopyrrolamide antagonists of IAPP aggregation ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02910A, Paper Sunil Kumar, Maria C. Vogel, Andrew D. Hamilton An oligopyrrolamide was identified as a potent antagonist of the aggregation of IAPP, a process associated with type 2 diabetes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Design of a substrate-tailored peptiligase variant for the efficient synthesis of thymosin-[small alpha]1 ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02812A, Paper Marcel Schmidt, Ana Toplak, Henriette J. Rozeboom, Hein J. Wijma, Peter J. L. M. Quaedflieg, Jan H. van Maarseveen, Dick B. Janssen, Timo Nuijens A substrate-tailored peptide ligase for the chemo-enzymatic peptide synthesis (CEPS) of thymosin-[small alpha]1. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Direct access to spirobiisoxazoline via double 1,3-dipolar cycloaddition of nitrile oxide with allenoate ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C7OB03040A, Communication Wenjun Li, Xinye Shang, Kun Liu, Zhongyin Zhang, Xianhong Xu, Pengfei Li The double [3+2]-cycloadditions between nitrile oxides and allenoates have been achieved. In the presence of DABCO combined with Et3N, 2-substitutedbuta-2,3-dienoates reacted with oxime chlorides to afford spirobiisoxazolines in 55-90% yields... The content of this RSS Feed (c) The Royal Society of Chemistry
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Introduction of Axial Chirality at a Spiro Carbon Atom in Synthesis of a Pentaerythritol - Imine Macrocycles ()
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C7OB02672B, Paper Jakub Grajewski, Kamila Piotrowska, Mikolaj Zgorzelak, Agnieszka Janiak, Katarzyna Biniek, Urszula Rychlewska, Jacek Gawronski Novel chiral macrocyclic polyimines with spiro carbon atoms are described. The key feature of the synthesis is the formation of an axially chiral quaternary carbon atom having four constitutionally identical... The content of this RSS Feed (c) The Royal Society of Chemistry
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Dess-Martin periodinane oxidative rearrangement for preparation of [small alpha]-keto thioesters ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02959D, Paper Randy Sanichar, Ciaran Carroll, Ryan Kimmis, Bela Reiz, John C. Vederas Facile preparation of [small alpha]-keto thioesters via a new rearrangement reaction mediated by the Dess-Martin Periodinane reagent. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Correction: Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety ()
Org. Biomol. Chem., 2018, 16,336-336 DOI: 10.1039/C7OB90195J, Correction Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Supojjanee Sansook, Cory A. Ocasio, Iain J. Day, Graham J. Tizzard, Simon J. Coles, Oleg Fedorov, James M. Bennett, Jonathan M. Elkins, John Spencer The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of unnatural [small alpha]-amino acid derivatives via selective o-C-H functionalization ()
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C7OB02921G, Paper Wanting Zeng, Moldir Nukeyeva, Qiumei Wang, Chao Jiang Selective o-C-H functionalization of aryl based amino acids including arylation, alkylation, alkynylation, halogenation, alkoxylation, and acyloxylation were developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A fluorescent activatable probe for imaging intracellular Mg2+ ()
Org. Biomol. Chem., 2018, 16,239-244 DOI: 10.1039/C7OB02965A, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Ryan Treadwell, Fabio de Moliner, Ramon Subiros-Funosas, Toby Hurd, Kirsten Knox, Marc Vendrell An BODIPY probe for detection and imaging of Mg2+ without interference from Ca2+ is described. The content of this RSS Feed (c) The Royal Society of Chemistry
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Genetically-encoded fragment-based discovery (GE-FBD) of glycopeptide ligands with differential selectivity for antibodies related to mycobacterial infections ()
Org. Biomol. Chem., 2018, 16,223-227 DOI: 10.1039/C7OB02783D, Paper Ying Chou, Elena N. Kitova, Maju Joe, Richard Brunton, Todd L. Lowary, John S. Klassen, Ratmir Derda GE-FBD discovered discriminatory antigens for antibodies (Abs) associated with Mycobacterial infections; the accurate detection of such Abs is critical for global management of tuberculosis. The content of this RSS Feed (c) The Royal Society of Chemistry
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The role of catalytic residue pKa on the hydrolysis/transglycosylation partition in family 3 [small beta]-glucosidases ()
Org. Biomol. Chem., 2018, 16,316-324 DOI: 10.1039/C7OB02558K, Paper Inacrist Geronimo, Christina M. Payne, Mats Sandgren The catalytic acid/base residue (E441) pKa, as modulated by its electrostatic environment, has potential impact on the hydrolysis/transglycosylation partition in [small beta]-glucosidases. The content of this RSS Feed (c) The Royal Society of Chemistry
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Palladium-catalyzed synthesis of fluoreones from bis(2-bromophenyl)methanols ()
Org. Biomol. Chem., 2018, 16,208-212 DOI: 10.1039/C7OB02895D, Communication Qian Gao, Senmiao Xu Palladium plays a dual role in synthesizing fluorenones from bis(2-bromophenyl)methanols. The content of this RSS Feed (c) The Royal Society of Chemistry
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The renascence of continuous-flow peptide synthesis - an abridged account of solid and solution-based approaches ()
Org. Biomol. Chem., 2018, 16,180-196 DOI: 10.1039/C7OB02759A, Review Article Christopher P. Gordon Within a decade of Merrifield's seminal description of solid-phase peptide synthesis, the synergies between solid-phase approaches and flow synthesis were noted by a number of groups. The content of this RSS Feed (c) The Royal Society of Chemistry
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Stereocontrolled glycoside synthesis by activation of glycosyl sulfone donors with scandium(III) triflate ()
Org. Biomol. Chem., 2018, 16,325-335 DOI: 10.1039/C7OB02792C, Paper Amandine Xolin, Romain Losa, Aicha Kaid, Cedric Tresse, Jean-Marie Beau, Francois-Didier Boyer, Stephanie Norsikian Activation of armed glycosyl sulfone donors, using scandium(III) triflate under microwave irradiation, provides a selective preparation of [small alpha]-mannosides. The content of this RSS Feed (c) The Royal Society of Chemistry
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Gold catalyzed Heck-coupling of arenediazonium o-benzenedisulfonimides ()
Org. Biomol. Chem., 2018, 16,295-301 DOI: 10.1039/C7OB02624B, Paper Margherita Barbero, Stefano Dughera An efficient gold catalyzed Heck coupling of arenediazonium o-benzenedisulfonimides is proposed. An o-benzenedisulfonimide anion enables a radical pathway that does not require the presence of photocatalysts or external oxidants. The content of this RSS Feed (c) The Royal Society of Chemistry
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Concise total synthesis of (+)-asperazine A and (+)-pestalazine B ()
Org. Biomol. Chem., 2018, 16,202-207 DOI: 10.1039/C7OB02985C, Communication Brandon M. Nelson, Richard P. Loach, Stefan Schiesser, Mohammad Movassaghi The highly convergent total synthesis of dimeric diketopiperazine alkaloids (+)-asperazine A and (+)-pestalazine B is described. The content of this RSS Feed (c) The Royal Society of Chemistry
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Intramolecular nucleophilic addition of carbanions generated from N-benzylamides to cyclopropenes ()
Org. Biomol. Chem., 2018, 16,285-294 DOI: 10.1039/C7OB02068F, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Vladimir Maslivetc, Colby Barrett, Nicolai A. Aksenov, Marina Rubina, Michael Rubin An unusual reaction is described, involving a formal intramolecular nucleophilic substitution of bromocyclopropanes with nitrogen ylides generated in situ from N-benzyl carboxamides. This reaction involves cyclopropene intermediates and allows for the facile preparation of 3-azabicyclo[3.1.0]hexan-2-ones. The content of this RSS Feed (c) The Royal Society of Chemistry
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A nickel catalyzed acceptorless dehydrogenative approach to quinolines ()
Org. Biomol. Chem., 2018, 16,274-284 DOI: 10.1039/C7OB02670F, Paper Seuli Parua, Rina Sikari, Suman Sinha, Siuli Das, Gargi Chakraborty, Nanda D. Paul A general, efficient and environmentally benign, one-step synthesis of substituted quinoline derivatives was achieved by acceptorless dehydrogenative coupling of o-aminobenzylalcohols with ketones and secondary alcohols catalyzed by a cheap, earth abundant and easy to prepare macrocyclic nickel catalyst [Ni(MeTAA)]. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and structural investigation of a series of mannose-containing oligosaccharides using mass spectrometry ()
Org. Biomol. Chem., 2018, 16,228-238 DOI: 10.1039/C7OB02723K, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. S. Daikoku, R. Pendrill, Y. Kanie, Y. Ito, G. Widmalm, O. Kanie Gas-phase collision-induced dissociation and acid hydrolysis of mannose-containing oligosaccharides were performed, which revealed the reactivity order of linkage isomers. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of spirocyclic orthoesters by 'anomalous' rhodium(II)-catalysed intramolecular C-H insertions ()
Org. Biomol. Chem., 2018, 16,256-261 DOI: 10.1039/C7OB02123B, Paper Fanny J. Lombard, Romain J. Lepage, Brett D. Schwartz, Ryne C. Johnston, Peter C. Healy, Elizabeth H. Krenske, Mark J. Coster Spirocyclic orthoesters are synthesised by 'anomalous' Rh(II)-catalysed intramolecular C-H insertion reactions. The content of this RSS Feed (c) The Royal Society of Chemistry
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