Organic & Biomolecular Chemistry



Metal-Free Synthesis of Activated Ynesulfonamides and Teritary Enesulfonamides ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00947G, Communication Lucile Andna, Laurence Miesch An operationally simple synthesis of activated ynesulfonamides and enesulfonamides is described. Ynesulfonamides can be obtained through reaction of sulfonylamides with activated bromoalkynes and Triton B in a short time at... The content of this RSS Feed (c) The Royal Society of Chemistry
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Importance of the Main Chain of Lysine for Histone Lysine Methyltransferase Catalysis ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01038F, Communication Abbas H. K. Al Temimi, Ruben Teeuwen, Vu Tran, Arthur Altunc, Danny Lenstra, Wansheng Ren, Ping Qian, Hong Guo, Jasmin Mecinović Histone lysine methyltransferases (KMTs) are biomedicinally important class of epigenetic enzymes that catalyse methylation of lysine residues in histones and other proteins. Enzymatic and computational studies on simplest lysine analogues... The content of this RSS Feed (c) The Royal Society of Chemistry
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Triaminopyrimidine derivatives as transmembrane HCl transporters ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00725C, Paper Istvan Zsolt Kocsis, Petr Motloch, Ana Guerreiro, Carolina Qiu Mexia De Azeredo, Gonçalo J. L. Bernardes, Christopher Alexander Hunter Small synthetic molecules capable of inducing transmembrane anion transport have received a lot of attention as potential anti-cancer agents due to their ability to interfere with intracellular pH homeostasis. A... The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of 2-alkyl-2-boryl-substituted-tetrahydrofurans via copper(I)-catalysed borylative cyclization of aliphatic ketones ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00962K, Communication Koji Kubota, Minami Uesugi, Shun Osaki, Hajime Ito A new method was developed for synthesizing 2-alkyl-2-boryl-tetrahydrofuran derivatives from aliphatic ketones using a copper(I)/N-heterocyclic carbene complex catalyst. This reaction presumably proceeds through the nucleophilic addition of a borylcopper(I) intermediate... The content of this RSS Feed (c) The Royal Society of Chemistry
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A straightforward TBHP-mediated synthesis of 2-amidobenzoic acids from 2 arylindoles and their antimicrobial activity ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00797K, Paper Anil Kumar, Om Prakash Singh Patel, Shiv Dhiman, Shahid Khan, Vikki N Shinde, Sonam Jaiswal, Manu R Srivastha, Prabhat Nath Jha A simple and highly efficient strategy has been developed for the synthesis of 2-amidobenzoic acids through tert-butyl hydroperoxide (TBHP)-mediated oxygenation and sequential ring opening of 2-arylindoles in one-pot fashion under... The content of this RSS Feed (c) The Royal Society of Chemistry
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Borylative Cyclisation of Diynes using BCl3 and Borocations ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00991D, Communication Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Andrew Warner, Kieron M Enright, John M Cole, Kang Yuan, John S McGough, Michael James Ingleson The borylative cyclisation of 1,2-dialkynyl benzenes with BCl3 leads to dibenzopentalenes (via intramolecular SEAr) or benzofulvenes (via chloride addition) depending on substituents, with stabilised vinyl cation intermediates (e.g. with a... The content of this RSS Feed (c) The Royal Society of Chemistry
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Iron-catalyzed domino Knoevenagel-hetero-Diels-Alder reaction: a facile access to oxabicyclo[3.3.1]nonene derivatives ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00836E, Communication Mingchang Wu, Junhang Yang, Fang Luo, Cungui Cheng, Gangguo Zhu Iron-catalyzed; Knoevenagel-hetero-Diels-Alder reaction; oxabicyclo[3.3.1]nonene; chromene The content of this RSS Feed (c) The Royal Society of Chemistry
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Selective recognition of acetylcholine over choline by a fluorescent cage ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00931K, Communication Augustin Long, Nicolas Fantozzi, Sandra Pinet, Emilie Genin, Rémi Pétuya, Didier Bégué, Vincent Robert, Jean-Pierre Dutasta, Isabelle Gosse, Alexandre Martinez A fluorescent hemicryptophane has been synthesized and can be used as a turn on receptor of acetylcholine. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Asymmetric synthesis of spirooxindole-fused spirothiazolones via squaramide-catalysed reaction of 3-chlorooxindoles with 5-alkenyl thiazolones ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00998A, Paper Yong-Xing Song, Da-Ming Du An efficient and practical squaramide-catalysed asymmetric formal [2 + 1] cycloaddition of 3-chlorooxindoles with 5-alkenyl thiazolones afforded spirooxindole-fused spirothiazolones in high yields with excellent stereoselectivities. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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9-Borabicyclo[3.3.l]nonane-induced Friedel–Crafts benzylation of arenes with benzyl fluorides ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00912D, Communication Jing Guo, Karlee L. Bamford, Douglas W. Stephan 9-Borabicyclo[3.3.l]nonane dimer (9-BBN) mediates the Friedel–Crafts benzylation of arenes with benzyl fluorides, affording a series of 1,1-diarylmethanes under mild conditions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A folate-conjugated platinum porphyrin complex as a new cancer-targeting photosensitizer for photodynamic therapy ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00698B, Paper Mengqian Yang, Jingran Deng, Ding Guo, Jie Zhang, Lixia Yang, Fengshou Wu A new folate-conjugated platinum porphyrin complex was synthesized, which displayed high singlet oxygen quantum yield and strong targeting ability. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Platinum-catalyzed reactions between Si–H groups as a new method for cross-linking of silicones ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00791A, Paper Konstantin V. Deriabin, Ekaterina K. Lobanovskaia, Alexander S. Novikov, Regina M. Islamova The platinum-catalyzed self cross-linking of polymethylhydrosiloxane at RT in air was performed for the first time. cis-[PtCl2(BnCN)2] allows creating high-quality silicone rubbers without visible mechanical defects. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Selective synthesis of 3-deoxy-5-hydroxy-1-amino-carbasugars as potential α-glucosidase inhibitors ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00762H, Paper Chunfeng Jiang, Quan Liu, Jiaming Liu, Kaixuan Liu, Liangliang Tian, Mingfei Duan, Ying Wang, Zhufang Shen, Youjun Xu A selective synthesis of 13 and 15, which could be converted to carbasugars as α-glucosidase inhibitors, was developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Structural characteristics requisite for the ligand-based selective detection of i-motif DNA ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01020C, Paper Sagar Satpathi, Subrahmanyam Sappati, Konoya Das, Partha Hazra A new approach has been explored to detect i-motif DNA structures over its complementary GQ DNA based on the hemi-protonated cytosine–cytosine (C+–C) base pairing recognition. This approach also shows its versatility by detecting various i-motif DNA structures with different chain lengths, molecularity and sizes, etc. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Manganese(III) acetate-mediated direct C(sp2)–H-sulfonylation of enamides with sodium and lithium sulfinates ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00825J, Paper Philipp Kramer, Sara-Cathrin Krieg, Harald Kelm, Georg Manolikakes A Mn(OAc)3 mediated oxidative C(sp2)–H sulfonylation of enamides and encarbamates with sodium and lithium sulfinates is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Preparation of 2-Arylquinolines from β-Arylpropionitriles through Iminyl Radical-Mediated Cyclization ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00944B, Paper hideo togo, Hiroki Naruto Treatment of β-arylpropionitriles with aryllithiums, followed by the reaction with water and then NIS under irradiation with a tungsten lamp gave 2-arylquinolines in good to moderate yields. The present reaction... The content of this RSS Feed (c) The Royal Society of Chemistry
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Metal-Free Synthesis of gem-Silylboronate Esters and Their Pd(0)-Catalyzed Cross-Coupling with Aryliodides ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01006H, Paper Chaoqiang Wu, Zhicheng Bao, Xing Xu, Jianbo Wang A transition-metal-free method for the synthesis of gem-silylboronate esters with arylboronic acids and trimethylsilyldiazomethane (TMSCHN2) has been developed. This transformation is a straightforward homologation of arylboronic acids and is featured... The content of this RSS Feed (c) The Royal Society of Chemistry
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Ene reactions of 2-borylated α-methylstyrenes: a practical route to 4-methylenechromanes and derivatives ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00963A, Paper Chaima Boureghda, aurélie Macé, Fabienne Berrée, Thierry Roisnel, Adbelmadjid Debache, Bertrand Carboni 4-Methylenechromanes were prepared via a three-step process from 2-borylated α-methylstyrenes. This sequence is based on a key glyoxylate-ene reaction catalyzed by scandium(III) triflate. The resulting α-hydroxy boronates, which cyclise to... The content of this RSS Feed (c) The Royal Society of Chemistry
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Diversion of the Arbuzov Reaction: Alkylation of C-Cl Instead of Phosphonic Ester Formation on the Fullerene Cage ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00593E, Paper Olga Kraevaya, Alexander S Peregudov, Sergey I. Troyanov, Ivan Godovikov, Natalia E Fedorova, Regina R Klimova, Vasilina Sergeeva, Larisa V. Kameneva, Elizaveta Ershova, Vyacheslav M. Martynenko, Sandra Claes, Alla A Kushch, Svetlana Kostyuk, Dominique Schols, Alexander F. Shestakov, Pavel Troshin We report “inversed” Arbuzov reaction of the fullerene derivatives C60Ar5Cl with trialkyl phosphites P(OR)3 producing alkylated fullerene derivatives C60Ar5R (R=Me, Et, iPr, nBu) with almost quantitative yields. This reaction provides... The content of this RSS Feed (c) The Royal Society of Chemistry
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Stereoselective Synthesis of Unnatural (2S,3S)-6-Hydroxy-4-Sphingenine-Containing Sphingolipids ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00990F, Communication Christine Beemelmanns, Sebastian Pflanze, Daniel Leichnitz 6-Hydroxy-(4E)-sphingenine-containing sphingolipids are found in mammalian and bacterial membranes and have multiple intra- and intercellular functions. Most sphingolipids contain a (2S,3R)-2-amino-1,3-diol core structure, but only limited examples of unnatural (2S,3S)-2-amino-1,3-diol... The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and biophysical properties of carbamate-locked nucleic acid (LNA) oligonucleotides with potential antisense applications ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00691E, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Cameron Thorpe, Sven Epple, Benjamin Woods, Afaf H. El-Sagheer, Tom Brown Carbamate-LNA oligonucleotides have improved biophysical properties for theraputic applications. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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–TiCl4—nBu3N-mediated cascade annulation of ketones with α-ketoesters: a facile synthesis of highly substituted fused γ-alkylidene- butenolides ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00649D, Paper Megha Nandkumar Palange, Rajesh G. Gonnade, Ravindar Kontham A facile protocol for the synthesis of highly substituted fused γ-alkylidene butenolides using direct annulation of ketones with α-ketoesters, which proceeds through TiCl4-n-Bu3N mediated aldol addition followed by intramolecular enol-lactonization/cyclization... The content of this RSS Feed (c) The Royal Society of Chemistry
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Robust Synthesis of C-terminal Cysteine-Containing Peptide Acids through A Peptide Hydrazide-Based Strategy ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01114E, Communication Chao Zuo, Bingjia Yan, Hanying Zhu, Wei-Wei Shi, Tongkuai Xi, Jing Shi, Gemin Fang A new robust strategy was reported for epimerization-free synthesis of C-terminal Cys-containing peptide acids through mercaptoethanol-mediated hydrolysis of peptide thioesters made in situ from peptide hydrazides. This simple-to-operate and highly... The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and in vitro evaluation of naphthalimide–benzimidazole conjugates as potential antitumor agents ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C8OB02973C, Paper Iqubal Singh, Vijay Luxami, Kamaldeep Paul A novel series of benzimidazole-naphthalimide conjugates was synthesized for the first time and screened for in vitro biological activity for 60 human cancer cell lines representing nine different cancer types. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Functionalised Bicyclic Tetramates Derived from Cysteine as Antibacterial Agents ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01076A, Paper Mark G Moloney, Tharindi Panduwawala, Sarosh Iqbal, Amber L Thompson, Miroslav Genov, Alex Pretsch, Dagmar Pretsch, Shuang Liu, Richard H Ebright, Alison Howells, Tony Maxwell Routes to bicyclic tetramates derived from cysteine permitting ready incorporation of functionality at two different points around the periphery of heterocyclic skeleton are reported. This has enabled the identification of... The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of vicinal dideoxy-difluorinated galactoses ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00707E, Paper Julien Malassis, Jean-Baptiste Vendeville, Qui-Hien Nguyen, Marie Boujon, Quentin Gaignard-Gaillard, Mark Light, Bruno Linclau Three novel dideoxydifluorinated galactose derivatives are described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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I2/DMSO mediated multicomponent reaction for the synthesis of 2-arylbenzo[d]imidazo[2,1-b] thiazole derivatives ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00515C, Paper Asim Jana, Prabhas Bhaumick, Anoop Kumar Panday, Richa Mishra, Lokman H. Choudhury A series of 2-arylbenzo[d]imidazo[2,1-b] thiazoles tethered with barbituric acid has been prepared using I2 in DMSO medium under conventional or microwave heating conditions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Lacto-N-tetraose synthesis by wild-type and glycosynthase variants of the β-N-hexosaminidase from Bifidobacterium bifidum ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00424F, Communication Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Katharina Schmölzer, Melanie Weingarten, Kai Baldenius, Bernd Nidetzky Enzymatic lacto-N-biose transfer from lacto-N-biose 1,2-oxazoline to lactose by wild-type and glycosynthase variants of Bifidobacterium bifidum β-N-hexosaminidase yielded lacto-N-tetraose in a single-step, highly regioselective transformation. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Total synthesis and stereochemical revision of Relgro and 10΄-Oxorelgro ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00838A, Paper Debendra K Mohapatra, Janardhan Gaddam, G Sudhakar Reddy , Marumudi Kanakaraju, Ajit C. Kunwar, Jhillu S. Yadav The first asymmetric total synthesis and stereochemical assignment of 10-membered macrolactones relgro and 10-oxorelgro is disclosed. To this end, palladium-catalyzed Stille coupling, Mitsunobu reaction, ring-closing metathesis, EDCI promoted coupling and... The content of this RSS Feed (c) The Royal Society of Chemistry
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Palladium-Catalyzed Carbonylative Synthesis of Substituted Cyclopentenones from Aryl Iodides and Internal Alkynes ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01019J, Communication Xiao-Feng Wu, Jin-Bao Peng, Wei-Feng Wang In this communcation, a palladium-catalyzed carbonylative synthesis of substituted cyclopentenones has been developed. With aryl iodides and internal alkynes as the substrates, via domino process consisted by formal Pauson-Khand reaction,... The content of this RSS Feed (c) The Royal Society of Chemistry
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Selective binding of nucleosides to gapped DNA duplex revealed by orientation and distance dependence of FRET ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00946A, Paper Hiromu Kashida, Yuta Kokubo, Koki Makino, Hiroyuki Asanuma Herein we used orientation and distance dependence of Förster resonance energy transfer (FRET) to analyze the binding of nucleosides to a gapped DNA duplex. Binding isotherms and information on the... The content of this RSS Feed (c) The Royal Society of Chemistry
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Antinociceptive activity of thiazole-containing cyclized DAMGO and Leu-(Met) enkephalin analogs ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00882A, Paper Hannah M. Harris, Shainnel O. Eans, Michelle L. Ganno, Jennifer C. Davis, Colette T. Dooley, Jay P. McLaughlin, Adel Nefzi A newly developed Hantzsch-based macrocyclization strategy provided cyclic DAMGO and enkephalin analogs with improved oral bioavailability while retaining significant agonist activity. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Binding orientation and reactivity of alkyl α,ω-dibromides in water-soluble cavitands ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01018A, Paper Venkatachalam Angamuthu, Manuel Petroselli, Faiz-Ur Rahman, Yang Yu, Julius Rebek Host–guest complexation of α,ω-dibromides showed rabid tumbling conformation on NMR timescales and afforded mono hydroxyl bromides after hydrolysis in D2O. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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NHC-copper-thiophene-2-carboxylate complex for the hydroboration of terminal alkynes ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00839J, Communication Won Jun Jang, Byung-Nam Kang, Ji Hun Lee, Yoon Mi Choi, Chong-Hyeak Kim, Jaesook Yun An air-stable N-heterocyclic carbene–copper thiophene-2-carboxylate (CuTC) complex has been prepared for the stereoselective hydroboration of terminal alkynes using pinacolborane (HBpin) or 1,8-naphthalenediaminatoborane (HBdan). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Identification of crucial bottlenecks in engineered polyketide biosynthesis ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00831D, Paper Marius Grote, Susanna Kushnir, Niclas Pryk, David Möller, Julian Erver, Ahmed Ismail-Ali, Frank Schulz Quo vadis combinatorial biosynthesis: STOP signs through substrate scope limitations lower the yields in engineered polyketide biosynthesis using cis-AT polyketide synthases. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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The Lossen rearrangement from free hydroxamic acids ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00789J, Review Article Mikaël Thomas, Jérôme Alsarraf, Nahla Araji, Isabelle Tranoy-Opalinski, Brigitte Renoux, Sébastien Papot During more than a century, the Lossen rearrangement was supposed to occur exclusively in the presence of stochiometric amount of activating reagents. Very recently, it was demonstrated that the Lossen rearrangement can take place directly from free hydroxamic acids offering a renewal of interest for this reaction. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Solid-phase synthesis of biocompatible N-heterocyclic carbene–Pd catalysts using a sub-monomer approach ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00716D, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Durgadas Cherukaraveedu, Paul T. Cowling, Gavin P. Birch, Mark Bradley, Annamaria Lilienkampf Biocompatible N-heterocyclic carbene (NHC) based Pd ligands were assembled and loaded with Pd via solid-phase synthesis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Chiral palladium pincer complexes for asymmetric catalytic reactions ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00401G, Review Article Jin-Kui Liu, Jun-Fang Gong, Mao-Ping Song This review covers the methods for the preparation of chiral palladium(II) pincer complexes and their applications in asymmetric catalysis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Phosphine-catalyzed dearomative (3 + 2) annulation of 2-nitrobenzofurans and nitrobenzothiophenes with allenoates ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00775J, Paper Jian-Qiang Zhao, Lei Yang, Yong You, Zhen-Hua Wang, Ke-Xin Xie, Xiao-Mei Zhang, Xiao-Ying Xu, Wei-Cheng Yuan An efficient Ph2PMe-catalyzed dearomative (3 + 2) annulation of 2-nitrobenzofurans, 2-nitrobenzothiophenes, and 3-nitrobenzothiophenes with allenoates is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Correction: Trehalose-cored amphiphiles for membrane protein stabilization: importance of the detergent micelle size in GPCR stability ()
Org. Biomol. Chem., 2019, 17,4919-4920 DOI: 10.1039/C9OB90075F, Correction Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Manabendra Das, Yang Du, Jonas S. Mortensen, Manuel Ramos, Lubna Ghani, Ho Jin Lee, Hyoung Eun Bae, Bernadette Byrne, Lan Guan, Claus J. Loland, Brian K. Kobilka, Pil Seok Chae The content of this RSS Feed (c) The Royal Society of Chemistry
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New geldanamycin derivatives with anti Hsp properties by mutasynthesis ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00892F, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Jekaterina Hermane, Simone Eichner, Lena Mancuso, Benjamin Schröder, Florenz Sasse, Carsten Zeilinger, Andreas Kirschning Four new non hydroquinone derivatives of geldanamycin are prepared by mutasynthesis and their antiproliferative as well as inhibitory properties for human as well as bacterial heatshock proteins are evaluated. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Base-promoted regiodivergent allylation of N-acylhydrazones with Morita–Baylis–Hillman carbonates by tuning the catalyst ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00194H, Paper Fang Sun, Tingrui Yin, Anni Feng, Yong Hu, Chenxia Yu, Tuanjie Li, Changsheng Yao A catalyst-controlled regiodivergent allylation reaction of N-acylhydrazones (NAHs) with Morita–Baylis–Hillman (MBH) carbonates has been developed, paving a new avenue for the diversification of NAH. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Modification of oligonucleotides with weak basic residues via the 2′-O-carbamoylethyl linker for improving nuclease resistance without loss of duplex stability and antisense activity ()
Org. Biomol. Chem., 2019, 17,4835-4842 DOI: 10.1039/C9OB00668K, Paper Yoshiaki Masaki, Keishi Yamamoto, Keita Yoshida, Atsuya Maruyama, Takahito Tomori, Yusuke Iriyama, Hiroyuki Nakajima, Tatsuro Kanaki, Kohji Seio For the improvement of nuclease resistance, four kinds of new modifications through a carbamoylethyl linker were designed. The content of this RSS Feed (c) The Royal Society of Chemistry
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New mechanism, new chromophore: investigating the electrophilic behaviour of styrylindolium dyes ()
Org. Biomol. Chem., 2019, 17,4825-4834 DOI: 10.1039/C9OB00641A, Paper Alexis Perry Deconvolution of sensor-analyte interactions in styrylindolium dyes led to the discovery of an unusual dearomatising 1,8-addition of sulfur-centred nucleophiles. The content of this RSS Feed (c) The Royal Society of Chemistry
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Melleolides impact fungal translation via elongation factor 2 ()
Org. Biomol. Chem., 2019, 17,4906-4916 DOI: 10.1039/C9OB00562E, Paper Maximilian Dörfer, Daniel Heine, Stefanie König, Sagar Gore, Oliver Werz, Christian Hertweck, Markus Gressler, Dirk Hoffmeister The fungal translation elongation factor 2 was identified as a molecular target of honey mushroom antifungal natural products. The content of this RSS Feed (c) The Royal Society of Chemistry
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Active site labeling of fatty acid and polyketide acyl-carrier protein transacylases ()
Org. Biomol. Chem., 2019, 17,4720-4724 DOI: 10.1039/C8OB03229G, Communication Tony D. Davis, Jennifer M. Michaud, Michael D. Burkart Fluorescent probe design and site-directed mutagenesis unveil new activity-based chemical reporters for fatty acid and polyketide synthase acyl-carrier protein transacylases. The content of this RSS Feed (c) The Royal Society of Chemistry
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Pd(II)-Catalyzed C8–H alkoxycarbonylmethylation of 1-naphthylamides with α-chloroalkyl esters ()
Org. Biomol. Chem., 2019, 17,4865-4868 DOI: 10.1039/C9OB00648F, Paper Xiaolong Wang, Cancan Feng, Fan Yang, Yangjie Wu An efficient protocol for palladium-catalyzed regioselective C8–H bond alkoxycarbonylmethylation of 1-naphthylamide derivatives with α-chloroalkyl esters has been developed. The content of this RSS Feed (c) The Royal Society of Chemistry
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Correction: Substituent-controlled racemization of dissymmetric coordination capsules ()
Org. Biomol. Chem., 2019, 17,4917-4918 DOI: 10.1039/C9OB90070E, Correction Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Kentaro Harada, Ryo Sekiya, Takeshi Maehara, Takeharu Haino The content of this RSS Feed (c) The Royal Society of Chemistry
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Caspase-3 probes for PET imaging of apoptotic tumor response to anticancer therapy ()
Org. Biomol. Chem., 2019, 17,4801-4824 DOI: 10.1039/C9OB00657E, Paper Filipe Elvas, Tom Vanden Berghe, Yves Adriaenssens, Peter Vandenabeele, Koen Augustyns, Steven Staelens, Sigrid Stroobants, Pieter Van der Veken, Leonie wyffels Apoptosis is a highly regulated process involved in the normal organism development and homeostasis. The content of this RSS Feed (c) The Royal Society of Chemistry
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A rearrangement involving a solid-state melt reaction for the synthesis of multifunctional tetrasubstituted olefins ()
Org. Biomol. Chem., 2019, 17,4767-4773 DOI: 10.1039/C9OB00639G, Paper Manickam Bakthadoss, Selvakumar Raman, Mohammad Mushaf A new catalyst- and solvent-free intramolecular rearrangement sequence leading towards benzimidazole-tethered tetrasubstituted olefins through a solid-state melt reaction (SSMR). The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of cyclic gem-dinitro compounds via radical nitration of 1,6-diynes with Fe(NO3)3·9H2O ()
Org. Biomol. Chem., 2019, 17,4725-4728 DOI: 10.1039/C9OB00431A, Communication Xiaofei Yi, Kai Chen, Wei Chen, Wanzhi Chen, Miaochang Liu, Huayue Wu Cyclic gem-dinitro compounds were obtained via nitration of 1,6-diynes using Fe(NO3)3·9H2O as the nitrating agent. The content of this RSS Feed (c) The Royal Society of Chemistry
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Diversity of mechanisms in Ras–GAP catalysis of guanosine triphosphate hydrolysis revealed by molecular modeling ()
Org. Biomol. Chem., 2019, 17,4879-4891 DOI: 10.1039/C9OB00463G, Paper Bella L. Grigorenko, Ekaterina D. Kots, Alexander V. Nemukhin Different mechanisms of GTP hydrolysis by Ras–GAP are revealed in QM/MM simulations depending on molecular groups at position 61 in Ras. The content of this RSS Feed (c) The Royal Society of Chemistry
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Regioselective and oxidant-free sulfinylation of indoles and pyrroles with sulfinamides ()
Org. Biomol. Chem., 2019, 17,4789-4800 DOI: 10.1039/C9OB00526A, Paper Yuan-Zhao Ji, Jin-Yu Zhang, Hui-Jing Li, Chunguang Han, Yi-Kun Yang, Yan-Chao Wu An unexpected time-controlled highly selective C3- or C2-sulfinylation of pyrroles with sulfinamides is reported here for the first time. The content of this RSS Feed (c) The Royal Society of Chemistry
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Acid catalysed rearrangement of isobenzofurans to angularly fused phthalides ()
Org. Biomol. Chem., 2019, 17,4715-4719 DOI: 10.1039/C9OB00708C, Communication Bhavani Shankar Chinta, Soniya Gandhi, Beeraiah Baire An acid catalysed, cascade process for the construction of angularly fused polycyclic phthalides from isobenzofurans via a simultaneous ring closing–ring opening cascade has been reported. This approach serves as a greener alternative for the angularly fused polycyclic phthalides. The content of this RSS Feed (c) The Royal Society of Chemistry
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β-Glucuronidase triggers extracellular MMAE release from an integrin-targeted conjugate ()
Org. Biomol. Chem., 2019, 17,4705-4710 DOI: 10.1039/C9OB00617F, Communication Paula López Rivas, Christoph Müller, Christian Breunig, Torsten Hechler, Andreas Pahl, Daniela Arosio, Laura Belvisi, Luca Pignataro, Alberto Dal Corso, Cesare Gennari A non-internalizing conjugate targeting αvβ3 integrin inhibits the proliferation of integrin-expressing cancer cells in the presence of β-glucuronidase. The content of this RSS Feed (c) The Royal Society of Chemistry
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Cobalt-catalyzed cyclization with the introduction of cyano, acyl and aminoalkyl groups ()
Org. Biomol. Chem., 2019, 17,4783-4788 DOI: 10.1039/C9OB00637K, Paper Hiroto Hori, Shigeru Arai, Atsushi Nishida An efficient synthesis of carbo- and heterocycles using CC, CO and CN bonds under cobalt catalysis is described. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of pyrazolylvinyl ketones from furan derivatives ()
Org. Biomol. Chem., 2019, 17,4850-4855 DOI: 10.1039/C9OB00701F, Paper Nattawut Sawengngen, Petrakis N. Chalikidi, Sara Araby, Frank Hampel, Peter Gmeiner, Olga V. Serdyuk A new protocol for the synthesis of pyrazol-5-ylvinyl ketones, e.g. pyrazole-chalcones, employing furfuryl ketones as a triketone equivalent, has been described. The content of this RSS Feed (c) The Royal Society of Chemistry
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Total synthesis of (±)-epi-stemodan-13α,17-diol ()
Org. Biomol. Chem., 2019, 17,4711-4714 DOI: 10.1039/C9OB00661C, Communication Song Chen, Ting Chen, Guanggen Liu, Xiao Wang, Guili Zhu, Yongjiang Liu, Shaomin Fu, Bo Liu Stemodan-13α,17-diol is a natural stemodane-type diterpenoid isolated from Stemodia chilensis. The content of this RSS Feed (c) The Royal Society of Chemistry
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Organic photoredox catalysis enabled cross-coupling of arenediazonium and sulfinate salts: synthesis of (un)symmetrical diaryl/alkyl aryl sulfones ()
Org. Biomol. Chem., 2019, 17,4761-4766 DOI: 10.1039/C9OB00864K, Paper Ruchi Chawla, Lal Dhar S. Yadav Transition-metal- and oxidant/reductant-free visible-light-mediated synthesis of (un)symmetrical diaryl/alkyl aryl sulfones from aryl diazonium and sulfinate salts employing eosin Y as an organo-photoredox catalyst is reported. The content of this RSS Feed (c) The Royal Society of Chemistry
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Gold–carbene assisted formation of tetraarylmethane derivatives: double X–H activation by gold ()
Org. Biomol. Chem., 2019, 17,4856-4864 DOI: 10.1039/C9OB00470J, Paper Dalovai Purnachandar, Kanaparthy Suneel, Sridhar Balasubramanian, Galla V. Karunakar An efficient gold–carbene promoted generation of tetraarylmethane derivatives from enynones and indoles was accomplished by the formation of a new C–O bond and two C–C bonds. It is significant that addition of two nucleophiles resulted the desired compounds. The content of this RSS Feed (c) The Royal Society of Chemistry
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Silver-mediated three-component cycloaddition reaction for direct synthesis of 1-N-vinyl-substituted 1,2,3-triazoles ()
Org. Biomol. Chem., 2019, 17,4843-4849 DOI: 10.1039/C9OB00686A, Paper Jinpeng Chen, Taoyuan Liang, He Zhao, Chuyuan Lin, Lu Chen, Min Zhang Direct synthesis of 1-N-vinyl-1,2,3-triazoles via silver-mediated three-component cycloaddition reaction of phenylacetylenes, trimethylsilylazide, and 1,3-dicarbonyl compounds is presented. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of multisubstituted arylsulfones via a one-pot, three-component [3 + 3] benzannulation reaction ()
Org. Biomol. Chem., 2019, 17,4753-4760 DOI: 10.1039/C9OB00394K, Paper Xiang-Zheng Tang, Jie Liang, Xue-Jing Zhang, Raymond Wai-Yin Sun, Ming Yan, Albert S. C. Chan A one-pot, three-component [3 + 3] benzannulation reaction of α,β-unsaturated carbonyl compounds, bromoallylic sulfones, and sodium sulfinates provided multisubstituted arylsulfones with moderate to good yields. The content of this RSS Feed (c) The Royal Society of Chemistry
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1,2,4-Oxadiazole-5-ones as analogues of tamoxifen: synthesis and biological evaluation ()
Org. Biomol. Chem., 2019, 17,4892-4905 DOI: 10.1039/C9OB00651F, Paper Maria A. Chiacchio, Laura Legnani, Agata Campisi, Bottino Paola, Lanza Giuseppe, Daniela Iannazzo, Lucia Veltri, Salvatore Giofrè, Roberto Romeo 2,3,4-Triaryl-substituted 1,2,4-oxadiazole-5-ones have been prepared as fixed-ring analogues of tamoxifen by 1,3-dipolar cycloaddition of nitrones to isocyanates. The content of this RSS Feed (c) The Royal Society of Chemistry
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Copper-catalyzed oxidative amination of methanol to access quinazolines ()
Org. Biomol. Chem., 2019, 17,4774-4782 DOI: 10.1039/C9OB00392D, Paper Gandhesiri Satish, Ashok Polu, Laxman Kota, Andivelu Ilangovan A novel method for the copper-catalyzed oxidative amination of 2′-aminoarylketones with methanol as a C1 carbon source and ammonium acetate as an amine source to construct quinazolines was established in a one-pot manner. The content of this RSS Feed (c) The Royal Society of Chemistry
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Metal-catalysed reactions enabled by guanidine-type ligands ()
Org. Biomol. Chem., 2019, 17,4689-4699 DOI: 10.1039/C8OB02240B, Review Article Xi-Yang Cui, Choon-Hong Tan, Dasheng Leow A review of metal–guanidine complexes, which are selective and powerful catalysts for organic transformations, asymmetric synthesis, and polymerisation. The content of this RSS Feed (c) The Royal Society of Chemistry
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Chemical composition of DNA-encoded libraries, past present and future ()
Org. Biomol. Chem., 2019, 17,4676-4688 DOI: 10.1039/C9OB00581A, Review Article Paige Dickson, Thomas Kodadek We discuss here the chemical composition of DNA-encoded libraries likely to be made in the near future. The content of this RSS Feed (c) The Royal Society of Chemistry
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Oxidative sulfonamidomethylation of imidazopyridines utilizing methanol as the main C1 source ()
Org. Biomol. Chem., 2019, 17,4869-4878 DOI: 10.1039/C9OB00596J, Paper Xue-Mei Zhao, En-Ling Huang, Yu-Shen Zhu, Jing Li, Bing Song, Xinju Zhu, Xin-Qi Hao An efficient one pot, three component synthesis of C3 sulfonamidomethylated imidazopyridines has been disclosed utilizing methanol and DTBP as the major and minor methylene source, respectively. The content of this RSS Feed (c) The Royal Society of Chemistry
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N-Heterocyclic carbene-catalyzed diastereoselective synthesis of sulfenylated indanes via sulfa-Michael–Michael (aldol) cascade reactions ()
Org. Biomol. Chem., 2019, 17,4700-4704 DOI: 10.1039/C9OB00210C, Communication Ze-Nan Feng, Jin-Yun Luo, Yang Zhang, Guang-Fen Du, Lin He N-Heterocyclic carbene (NHC)-catalyzed diastereoselective synthesis of multisubstituted sulfenylated indanes has been developed. The content of this RSS Feed (c) The Royal Society of Chemistry
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Evaluating aryl esters as bench-stable C(1)-ammonium enolate precursors in catalytic, enantioselective Michael addition–lactonisations ()
Org. Biomol. Chem., 2019, 17,4747-4752 DOI: 10.1039/C9OB00703B, Paper Claire M. Young, James E. Taylor, Andrew D. Smith An evaluation of a range of aryl, alkyl and vinyl esters as prospective C(1)-ammonium enolate precursors in enantioselective Michael addition–lactonisation processes with (E)-trifluoromethylenones using isothiourea catalysis is reported. The content of this RSS Feed (c) The Royal Society of Chemistry
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Substituent-controlled racemization of dissymmetric coordination capsules ()
Org. Biomol. Chem., 2019, 17,4729-4735 DOI: 10.1039/C9OB00388F, Paper Kentaro Harada, Ryo Sekiya, Takeshi Maehara, Takeharu Haino We report the effect of substituents (methyl, isopropyl, methoxy, and methoxyphenyl) at the 6′-position of the 2,2′-bipyridyl arms on the racemization of dissymmetric coordination capsules 1a–d. The content of this RSS Feed (c) The Royal Society of Chemistry
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Late-stage C–H amination of abietane diterpenoids ()
Org. Biomol. Chem., 2019, 17,4736-4746 DOI: 10.1039/C9OB00272C, Paper María Ivana Lapuh, Alejandro Dana, Pablo H. Di Chenna, Benjamin Darses, Fernando J. Durán, Philippe Dauban Application of Rh(II)-catalyzed C–H amination reactions allows the selective late-stage diversification of abietane diterpenoids. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and characterization of pentaerythritol derived glycoconjugates as supramolecular gelators ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00475K, Paper Anji Chen, Dan Wang , Jonathan Bietsch , Guijun Wang Carbohydrate based self-assembling supramolecular systems are important classes of new materials with many potential applications. In this study, a series of branched 1,2,3-triazole based glycoconjugates were synthesized and characterized in... The content of this RSS Feed (c) The Royal Society of Chemistry
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Planarized B,N-Phenylated Dibenzoazaborine with a Carbazole Substructure: Electronic Impact of the Structural Constraint ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00934E, Communication Mikinori Ando, Mika Sakai, Naoki Ando, Masato Hirai, Shigehiro Yamaguchi A B,N-diphenyl-5,10-dihydro-dibenzo-1,4-azaborine, in which both phenyl groups on the boron and nitrogen atoms are planarized to generate a carbazole substructure, was synthesized. The structral constraint around the boron and nitrogen... The content of this RSS Feed (c) The Royal Society of Chemistry
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Gold-catalyzed facile intramolecular rearrangement and cyclization sequence for synthesis of 2,5-dihydrofurans ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00756C, Paper Galla venkata karunakar, Komalla Sunil, Yadagiri Thummala, Purnachander Dalovai, Sridhar Balasubramanian An efficient gold-catalyzed intramolecular rearrangement and cyclization protocol was developed for synthesis of 2,5-dihydrofuran derivatives from O-propargyl β-enaminones. In this organic transformation new C-C and C-O bonds are formed under... The content of this RSS Feed (c) The Royal Society of Chemistry
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Triazole Functionalized Acyclic Cucurbit[n]uril-Type Receptors: Host•Guest Recognition Properties ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00906J, Paper Weijian Xue, Peter Y Zavalij, Lyle D. Isaacs We report the synthesis of three new triazole functionalized acyclic CB[n]-type receptors (2 – 4) by click chemistry. The compounds have good solubility in water (≥ 8 mM) and do... The content of this RSS Feed (c) The Royal Society of Chemistry
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Merrifield resin supported Rose Bengal ammonium salt: An efficient catalyst for synthesis of vinyl sulfones through a visible-light-induced decarboxylative sulfonylation of cinnamic acids with sodium sulfinates ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00790C, Paper Pinhua Li, Guan-Wu Wang A visible-light-induced decarboxylative sulfonylation of cinnamic acids with sodium sulfinates for the synthesis of vinyl sulfones were developed. The reaction underwent smoothly in the presence of Merrifield resin supported Rose... The content of this RSS Feed (c) The Royal Society of Chemistry
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pH-Regulated anion transport activities of bis(iminourea) derivatives across the cell and vesicle membrane ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00650H, Paper Abhishek Saha, Nasim Akhtar, Vishnu Kumar, Suresh Kumar, Hemant Kumar Srivastava, Sachin Kumar, Debasis Manna Recently synthetic anion transporters have gained considerable attention because of their aptitude to disrupt cellular anion homeostasis and promote cell death. Herein, we report the development of bis(iminourea) derivatives as... The content of this RSS Feed (c) The Royal Society of Chemistry
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Mono-selective β-C–H arylation of N-methylated amino acids and peptides promoted by 2-(methylthio)aniline directing group ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00966C, Paper Thorsten Kinsinger, Uli Kazmaier 2-(Methylthio)aniline (MTA) directed C(sp3)–H functionalisations are efficient and straightforward protocols for the selective β-modification of N-methylated amino acids. The decreased reactivity of MTA in comparison to the 8-amino¬quinoline (AQ) directing... The content of this RSS Feed (c) The Royal Society of Chemistry
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Bianthryl-based organocatalysts for the asymmetric Henry reaction of fluoroketones ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00884E, Communication Jan Otevrel, David Svestka, Pavel Bobal An efficient organocatalyzed asymmetric Henry reaction between α-fluoroketones and nitroalkanes has been developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Recent progress in photochemical radical di- and mono-fluoromethylation ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00734B, Review Article Takashi Koike, Munetaka Akita Di- and mono-fluoromethyl radicals can be easily accessed by photochemical protocols. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Fe-Catalyzed decarbonylative cascade reaction of N-aryl cinnamamides with aliphatic aldehydes to construct 3,4-dihydroquinolin-2(1H)-ones ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00492K, Paper Ru-Xin Gao, Xin-Qi Luan, Zi-Yi Xie, Luo Yang, Yong Pei A practical Fe-catalyzed decarbonylative cascade reaction of N-aryl cinnamamides with aliphatic aldehydes to provide C3 alkylated 3,4-dihydroquinolin-2(1H)-ones is developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Post-genomic approach based discovery of alkylresorcinols from a cricket-associated fungus, Penicillium soppi ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00807A, Communication Akiho Kaneko, Yohei Morishita, Kento Tsukada, Tohru Taniguchi, Teigo Asai A highly reducing polyketide synthase (HR-PKS) collaborates with a type III PKS to produce alkylresorcinols via unusual biosynthetic machinery. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Chemical ADP-ribosylation: mono-ADPr-peptides and oligo-ADP-ribose ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00501C, Review Article Qiang Liu, Gijsbert A. van der Marel, Dmitri Viktorovitsj Filippov ADP-ribosylation is an important post-translational modification that plays a pivotal role in many cellular processes, including cell signaling, DNA repair, gene regulation and apoptosis. Although synthetic mono- or poly-ADP-ribosylated biomolecules... The content of this RSS Feed (c) The Royal Society of Chemistry
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Chloroform as a CO surrogate: applications and recent developments ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00886A, Review Article Krishanu Mondal, Pallabi Halder, Greeshma Gopalan, P. Sasikumar, K. V. Radhakrishnan, Parthasarathi Das Transition-metal-catalyzed carbonylation reaction using chloroform as CO surrogate to synthesize carbonylated heterocyclic moieties. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Chemo-Divergent Reaction of Azomethine Imines and 2H-Azirines for the Synthesis of Nitrogen-Containing Scaffolds ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00740G, Communication Yufeng Wu, Bing Tian, Chao Hu, Kohei Sekine, Matthias Rudolph, Frank - Rominger, Stephen Hashmi The metal-free reactions of 2H-azirines with C,N-cyclic azomethine imines were investigated. N-bridged strained ring-fused triazole derivatives or 1,2,4-triazine derivatives are obtained, the chemo-selectivity is dependent on the protecting group on... The content of this RSS Feed (c) The Royal Society of Chemistry
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Visible Light-Mediated Organophotocatalyzed C-H Bond Functionalization Reactions ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00834A, Review Article Mustafa Uygur, Olga García Mancheño Over the last decade, a variety of methodologies for the direct functionalization of C-H bonds habe been developed. Among others, visible light photoredox has recently emerged as one of the... The content of this RSS Feed (c) The Royal Society of Chemistry
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Highly functionalised (γ-azido/γ-fluoro-β-iodo/)vinyl derivatives from phosphorus based allenes or allenoates: I•••O halogen bonding interactions ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00715F, Paper K. C. Kumara Swamy, Mandala Anitha Multifunctional γ-azido/γ-fluoro- β-iodo-vinyl phosphine oxides/ phosphonates/ esters/ sulfone were synthesised by iodination followed by azidation/fluorination of phosphorus-based allenes or allenoates (allenyl esters) or a sulphur based allene. Surprisingly, the reaction... The content of this RSS Feed (c) The Royal Society of Chemistry
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Highly regioselective α-formylation and α-acylation of BODIPY dyes via tandem cross-dehydrogenative coupling with in situ deprotection ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00927B, Paper Fan Lv, Yang Yu, Erhong Hao, Changjiang Yu, Hua Wang, Noёl Boens, Lijuan Jiao An efficient protocol for the regioselective C–H α-formylation and α-acylation of BODIPY dyes using dioxolane derivatives as aldehyde equivalents is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A novel codrug made of the combination of ethionamide and its potentiating booster: synthesis, self-assembly into nanoparticles and antimycobacterial evaluation ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00680J, Paper Alexandra Pastor, Arnaud Machelart, Xue Li, Nicolas Willand, Alain Baulard, Priscille Brodin, Ruxandra Gref, Didier Desmaële A self-assembling codrug of ethionamide with its booster induced reduction of the bacterial load in mycobacterium-infected mice upon intranasal administration. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of amino acid derivatives of 5-alkoxy-3,4-dihalo-2(5H)-furanones and their preliminary bioactivity investigation as linkers ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00736A, Paper Shi-He Luo, Kai Yang, Jian-Yun Lin, Juan-Juan Gao, Xin-Yan Wu, Zhao-Yang Wang MTT tests of 2(5H)-furanone derivatives obtained via metal-free C–N coupling show that amino acids as linkers have no toxic effect. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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The base-free van Leusen reaction of cyclic imines on water: synthesis of N-fused imidazo 6,11-dihydro β-carboline derivatives ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00660E, Communication Killari Satyam, V. Murugesh, Surisetti Suresh Construction of imidazoles on dihydro β-carboline imines has been disclosed using the van Leusen reaction under base-free conditions on water. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A phototunable anion receptor for C–H⋯X interactions with benzoate anions ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00781D, Paper Sk. Atiur Rahaman, Munshi Sahid Hossain, Sruthy Baburaj, Ankita Biswas, Arijit Bag, Subhajit Bandyopadhyay A phototunable receptor binds to anions in one of its photoisomeric forms via CH⋯X interaction. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Selective synthesis of (1H-benzo[d]imidazol-2-yl)(phenyl)methanone and quinoxaline from aromatic aldehyde and o-phenylenediamine ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00531E, Paper Zhenzhen Zhan, Haojie Ma, Xinfeng Cui, Pengbo Jiang, Jinghong Pu, Yixin Zhang, Guosheng Huang We have designed a general, inexpensive, and versatile method for the synthesis of (1H-benzo[d]imidazol-2-yl)(phenyl)methanone and the formation of C–N bonds via an aromatic aldehyde and o-phenylenediamine. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Development of a Carbon-11 PET Radiotracer for Imaging TRPC5 in the Brain ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00893D, Paper Yanbo Yu, Qianwa Liang, Hui Liu, Zonghua Luo, Hongzhen Hu, Joel S Perlmutter, Zhude Tu The transient receptor potential channels subfamily member 5 (TRPC5) is a calcium permeable cation channel widely expressed in the brain. Accumulating evidence indicates that it plays a crucial role in... The content of this RSS Feed (c) The Royal Society of Chemistry
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The Catalytic Asymmetric Synthesis of CF3-Containing Spiro- Oxindole-Pyrrolidine-Pyrazolone Compounds through Squaramide-Catalyzed 1,3-Dipolar Cycloaddition ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00720B, Communication Cui Wang, Dongwa Wen, Hui Chen, Yabo Deng, xueting liu, xin liu, li wang, Fengyun Gao, Yifei Guo, Mengmeng Sun, Kairong Wang, Wenjin Yan The pharmaceutically important compounds were synthesized through the organocatalytic 1,3-dipolar cycloaddition reaction. In the presence of cinchonine-derived squaramide catalyst, the cycloaddition of N-2,2,2-trifluoroethylisatin ketimines with α,β-unsaturated pyrazolones gave a spiro-pyrrolidine-linked... The content of this RSS Feed (c) The Royal Society of Chemistry
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4′‑C‑Trifluoromethyl Modified Oligodeoxynucleotides: Synthesis, Biochemical Studies, and Cellular Uptake Properties ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00765B, Paper Yifei Zhou, Chuanlong Zang, Huawei Wang, Jiajun Li, Zenghui Cui, Qiang Li, Fengmin Guo, Zhiguo Yan, Xin Wen, Zhen Xi, Chuanzheng Zhou Herein, we report the synthesis of 4′-C-trifluoromethyl (4′-CF3) thymidine (T4′-CF3) and its incorporation into oligodeoxynucleotides (ODNs) through solid-supported DNA synthesis. The 4′-CF3 modification leads to a marginal effect on the... The content of this RSS Feed (c) The Royal Society of Chemistry
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H2O2-responsive polymeric micelle with a benzil moiety for efficient DOX delivery and AIE Imaging ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00859D, Paper Yan-Dong Dai, Xue-Yi Sun, Wan Sun, Jing-Bo Yang, Rui Liu, Yi Luo, Tao Zhang, Yu Tian, Zhong-Lin Lu, Lan He Nano drug delivery is a promising domain in biomedical theranostic and has aroused more and more attention in recent years. We report here an amphiphilic polymer TPG1, bearing H2O2-sensitive benzil... The content of this RSS Feed (c) The Royal Society of Chemistry
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DFT studies on metal-catalyzed cycloisomerization of trans-1,5-enynes to cyclopropane sesquiterpenoids ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00890J, Paper Lia Sotorríos, Vera P. Demertzidou, Alexandros L. Zografos, Enrique Gómez-Bengoa DFT studies reveal the distinct fates of 1,2- and 1,3-acetate migration in the cycloisomerization reaction of 1,5-enynes and the significant differences between platinum(II) and gold(I) catalysis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and in vitro evaluation of fluorine-18 benzimidazole sulfones as CB2 PET-radioligands ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00656G, Paper Annukka Kallinen, Rochelle Boyd, Samuel Lane, Rajiv Bhalla, Karine Mardon, Damion H. R. Stimson, Eryn L. Werry, Roger Fulton, Mark Connor, Michael Kassiou New 18F-fluorinated benzimidazole 5-sulfones with low nanomolar binding affinity were synthesised as PET-radioligand candidates for the CB2 receptor. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Enantioselective synthesis of tunable chiral pyridine–aminophosphine ligands and their applications in asymmetric hydrogenation ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB00770A, Paper Youran Liu, Fei Chen, Yan-Mei He, Chenghao Li, Qing-Hua Fan A small library of tunable chiral pyridine–aminophosphine ligands were synthesized based on tetrahydroquinoline scaffolds obtained via Ru-catalyzed asymmetric hydrogenation. The ligands were applied in the Ir-catalyzed asymmetric hydrogenation of olefins and imines. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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