Organic & Biomolecular Chemistry



Synthesis of benzoazepine derivatives via Rh(III)-catalyzed inert C(sp2)−H functionalization and [4 + 3] annulation ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01830A, Communication Yuanshuang Xu, Linghua Zhang, Mengyang Liu, Xiaopeng Zhang, Xinying Zhang, Xuesen Fan In this paper, a novel and sustainable synthesis of the hitherto unreported 5H-benzo[c]imidazo[1,2-a]azepine-6-carboxylic acids via the cascade reactions of 2-arylimidazoles (1) with methylene- oxetanones (2) is presented. Mechanistically, the formation... The content of this RSS Feed (c) The Royal Society of Chemistry
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One-pot Synthesis of High Molar Activity 6-[18F]Fluoro-L-DOPA by Cu-Mediated Fluorination of a BPin Precursor ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01758E, Communication Andrew Mossine, Sean S Tanzey, Allen F Brooks, Katarina J Makaravage, Naoko Ichiishi, Jason M Miller, Bradford D Henderson, Marc Skaddan, Melanie S Sanford, Peter J. H. Scott A one-pot two-step synthesis of 6-[18F]fluoro-L-DOPA ([18F]FDOPA) has been developed involving Cu-mediated radiofluorination of a pinacol boronate ester precursor. The method is fully automated, provides [18F]FDOPA in good activity yield... The content of this RSS Feed (c) The Royal Society of Chemistry
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Vinylboronic Acid-Caged Prodrug Activation using Click-to-Release Tetrazine Ligation ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01881F, Communication Lianne Lelieveldt, Selma Eising, Abel Wijen, Kimberly M Bonger Bioorthogonal reactions can be performed selectively in the presence of any biological functional group and are widely used to achieve site-selective chemical modifications of biomolecules. The click-to-release reaction is a... The content of this RSS Feed (c) The Royal Society of Chemistry
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A computational study of regioselectivity in aluminum hydride ring-opening of cis- and trans-4-t-butyl and 3-methylcyclohexene oxides ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01675A, Paper Nipa Deora, Paul R. Carlier Nucleophilic ring opening of cyclohexene oxides is known to proceed preferentially through the trans-diaxial pathway (the Fürst–Plattner rule). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Substrate-product analogue inhibitors of isoleucine 2-epimerase from Lactobacillus buchneri by rational design ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01823A, Paper Noa T. Sorbara, Joshua W. M. MacMillan, Gregory D. McCluskey, Stephen L. Bearne Substrate-product analogues, designed based on partial movement of the sec-butyl side chain during catalysis, inhibit isoleucine 2-epimerase. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Hyperconjomer stereocontrol of cationic polyene cyclisations ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01364D, Paper Robert T. Rodger, Marlowe S. Graham, Christopher S. P. McErlean The stereochemical outcome of cationic polyene cyclisations of geranylbenzene derivatives is affected by the different reactivity of hyperconjomer intermediates. The synthesis of (±)-taiwaniaquinone G by a cationic polyene cyclisation is described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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CO2 activation by electrogenerated divalent samarium for aryl halide carboxylation ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01752F, Communication Sakna Bazzi, Gaëtan Le Duc, Emmanuelle Schulz, Corinne Gosmini, Mohamed Mellah The first combination of samarium and electrochemistry towards the effective reduction of CO2 for the synthesis of benzoic acids from aryl halides. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Effects of nano-confinement and conformational mobility on molecular imprinting of cross-linked micelles ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01440C, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Kaiqian Chen, Yan Zhao Confining molecular imprinting in the nanospace of a micelle yielded highly selective protein-mimicking nanoparticle receptors to distinguish closely related water-soluble guests. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Side-chain deuterated cholesterol as a molecular probe to determine membrane order and cholesterol partitioning ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01342C, Paper Shinya Hanashima, Yuki Ibata, Hirofumi Watanabe, Tomokazu Yasuda, Hiroshi Tsuchikawa, Michio Murata 24dCho, which perfectly retains the cholesterol's membrane properties, was developed to examine cholesterol's interactions and membrane partitions using solid state 2H NMR. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Rapid Construction of Tetrahydropyridine Scaffolds via Formal Imino Diels-Alder Reactions of Schiff Bases and Nazarov Reagents ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01880H, Paper Yen-Ku Wu, Viresh H Rawal Described is a one-flask, two-step method for the synthesis of highly functionalized piperidines. The process involves formal [4+2] cycloadditions of Schiff bases and Nazarov reagents, followed by facile elaborations of... The content of this RSS Feed (c) The Royal Society of Chemistry
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Scaffold stabilization of a G-triplex and study of its interactions with G-quadruplex targeting ligands ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01537J, Paper Laureen Bonnat, Maëlle Dautriche, Taous Saidi, Johanna Revol-Cavalier, Jérôme Dejeu, Eric Defrancq, Thomas Lavergne G-triplex nucleic acid structures (G3) have been conjectured to form in vivo but little is known about their physiological functions. The identification of ligands capable of specific binding to G3... The content of this RSS Feed (c) The Royal Society of Chemistry
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Neurotransmitter selection by monoamine oxidase isoforms, dissected in terms of function groups by mixed double mutant cycles ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01558B, Paper Simon Turega, Caroline F Dalton, Alessandra Princivalle, Lewis Hudspith, Faraj Shmam Double mutant cycles were constructed using neurotransmitters and synthetic substrates that measure their selective binding to one monoamine oxidase (MAO) enzyme isoform over another as a function of structural change.... The content of this RSS Feed (c) The Royal Society of Chemistry
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Catalytic Asymmetric Synthesis of 2,5-Dihydrofurans Using Synergistic Bifunctional Ag Catalysis ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01903K, Paper Taoda Shi, Shenghan Teng, Gopi Krishna Reddy Alavala, Xin Guo, Yueteng Zhang, Kohlson T. Moore, Thomas Buckley, Damian Mason, Wei Wang, Eli Chapman, Wenhao Hu We report a bifuctional Ag catalyst promoted intramolecular capture of oxonium ylides with alkynes for the enantioselective synthesis of 2,5-dihydrofurans. This represents unprecedented synergistic catalysis of a bifunctional Ag catalyst.... The content of this RSS Feed (c) The Royal Society of Chemistry
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Catalytic Allylic Functionalization via π-Allyl Palladium Chemistry ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01725A, Review Article Rodney Agustinho Fernandes, Jothi L Nallasivam This review highlights the palladium-catalyzed allylic C-H functionalization from early 2014 to present date. The π-allylpalladium chemistry emphasizes the research originated from less appealing stoichiometric Pd(II) based allylic C-H activation... The content of this RSS Feed (c) The Royal Society of Chemistry
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Diastereoselective Multi-Component tandem condensation: Synthesis of 2-amino-4-(2-furanone)-4H-chromene-3-carbonitriles ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01345H, Paper vijay Gupta, Debashish sahu, Shailja Jain, Kumar Vanka, Ravi Prakash Singh A general strategy for one-pot stereoselective synthesis of 2-amino-4-(2-furanone)-4H-chromene-3-carbonitriles by reaction of salicylaldehyde, malononitrile and butenolides via tandem Knoevenagel/Pinner/vinylogous Michael condensation is presented. The β,γ-butenolides gave syn-selective MCR adduct with... The content of this RSS Feed (c) The Royal Society of Chemistry
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Three-component difluoroalkylamination of alkenes mediated by photoredox and iron cooperative catalysis ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01815H, Communication Rui Xu, Chun Cai A new three-component difluoroalkylamination of alkenes mediated by photoredox and iron cooperative catalysis has been developed with a broad substrate scope. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Scalable syntheses of traceable ribosylated NAD+ precursors ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01981B, Communication Mikhail V. Makarov, Nekoda W. Harris, Marcelo Rodrigues Rodrigues, Marie Migaud Nicotinamide adenine dinucleotide, NAD+, is an essential cofactor and substrate for many cellular enzymes. Its sustained intracellular levels have been linked to improved physiological end points in a range of... The content of this RSS Feed (c) The Royal Society of Chemistry
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An Easily Accessible Isospiropyran Switch ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01822K, Communication Jovica D. Badjic, Taylor Neal, Jennifer Neal, Allyson Eippert, Curtis Moore, Heather C Allen In the presence of SiCl4, three molecules of 5′−bromo−2′−hydroxyacetophenone 2 underwent tandem aldol condensation to give isospiropyran 1 in 69% yield. Acid (CH3SO3H), silica and elevated temperature prompted a scission... The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of helical π-conjugated polymers bearing pyridine N-oxide pendants and asymmetric allylation of aldehydes in the helical cavity ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01828J, Communication Tomoyuki Ikai, Takumu Yoshida Asymmetric allylation of aldehydes was conducted inside the helical cavity of a helically folded π-conjugated polymer bearing pyridine N-oxide pendants. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Facile synthesis of stable selenocystine peptides and their solution state NMR studies ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01910C, Communication Ram P. Gokula, Kirti Patel, Shakti K. Maurya, Harkesh B. Singh A facile general route for the synthesis of various selenocystine tripeptides containing acidic, basic and neutral side chain amino acids is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Biocatalytic dynamic kinetic reductive resolution with ketoreductase from Klebsiella pneumoniae: the asymmetric synthesis of functionalized tetrahydropyrans ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01681C, Paper Rasmita Barik, Joydev Halder, Samik Nanda Ketoreductase from growing cells of Klebsiella pneumoniae (NBRC 3319) acts as an efficient reagent for converting racemic α-benzyl/cinnamyl substituted-β-ketoesters to the corresponding β-hydroxy esters with excellent yields and stereoselectivities (ee and de >99%). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Rhodium(III)-catalysed cascade [3 + 2] annulation of N-aryloxyacetamides with 3-(hetero)arylpropiolic acids: synthesis of benzofuran-2(3H)-ones ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01553A, Paper Jin-Long Pan, Tuan-Qing Liu, Chao Chen, Quan-Zhe Li, Wei Jiang, Tong-Mei Ding, Zhi-Qiang Yan, Guo-Dong Zhu We first reported the rhodium(III)-catalyzed cascade [3 + 2] annulation of N-aryloxyacetamides with propiolic acids affording benzofuran-2(3H)-ones. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Application of Isatin-derived Saturated Esters in the Synthesis of 3,3’-Spirooxindole γ-Butyrolactams ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01347D, Paper Ding Du, Jindong Zhu, Shuaishuai Fang, Shiyi Jin, Rui Ma, Tao Lu Stable while reactive isatin-derived saturated esters have been utilized as 3-carbon synthons in a base-promoted formal [3+2] annulation with N-Boc imines. The developed protocol offers a direct pathway for the... The content of this RSS Feed (c) The Royal Society of Chemistry
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Silver-promoted decarboxylative radical addition/annulation of oxamic acids with gem-difluoroolefins: concise access to CF2-containing 3,4-dihydroquinolin-2-ones ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01236B, Communication Guojun Chen, Chenglong Li, Jianfeng Peng, Zeli Yuan, Peijun Liu, Xiaozu Liu Described is a silver-promoted decarboxylative radical addition/annulation of oxamic acids with gem-difluoroalkenes enabling the convenient synthesis of various structurally diverse CF2-containing 3,4-dihydroquinolin-2-ones that might find applications in medical chemistry. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A base-promoted cascade reaction of α,β-unsaturated N-tosylhydrazones with o-hydroxybenzyl alcohols: highly regioselective synthesis of N-sec-alkylpyrazoles ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01780A, Paper Lian-Mei Chen, Juan Zhao, An-Jie Xia, Xiao-Qiang Guo, Ya Gan, Chuang Zhou, Zai-Jun Yang, Jun Yang, Tai-Ran Kang An efficient method for the synthesis of N-sec-alkylpyrazoles via a cascade reaction of α,β-unsaturated N-tosylhydrazones with ortho-hydroxybenzyl alcohols has been developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Melioidosis patient serum-reactive synthetic tetrasaccharides bearing the predominant epitopes of Burkholderia pseudomallei and Burkholderia mallei O-antigens ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01711A, Paper Maude Cloutier, Emmanilo Delar, Kevin Muru, Seynabou Ndong, Robert R. Hoyeck, Taniya Kaewarpai, Narisara Chantratita, Mary N. Burtnick, Paul J. Brett, Charles Gauthier Tetrasaccharides mimicking Burkholderia pseudomallei and Burkholderia mallei lipopolysaccharide O-antigens were synthesized and found to be highly reactive with Thai melioidosis patient serum, highlighting their potential as vaccine candidates. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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P-Chiral, N-Phosphoryl Sulfonamide Brønsted Acids with an Intramolecular Hydrogen Bond Interaction that Modulates Organocatalysis ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01774G, Communication Minglei Yuan, Ifenna Irvin Mbaezue, Zhi Zhou, Filip Topić, Youla S. Tsantrizos Brønsted acids exemplified by OttoPhosa I (5c), were designed and evaluated in the asymmetric transfer hydrogenation of quinolines. Their catalytic properties are modulated by an intramolecular hydrogen bond that rigidifies... The content of this RSS Feed (c) The Royal Society of Chemistry
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Proton-induced fluorescence in modified quino[7,8-h]quinolines: dual sensing for protons and π-donors ()
Org. Biomol. Chem., 2019, 17,8221-8233 DOI: 10.1039/C9OB01391A, Paper Alexander F. Pozharskii, Valery A. Ozeryanskii, Vladimir Y. Mikshiev, Anatoly V. Chernyshev, Anatoly V. Metelitsa, Alexander S. Antonov Expanded quino-quinoline and quinazolino-quinazoline ligands change their emission upon protonation and π-coordination, model proton transfer and work in biphasic solvent systems. The content of this RSS Feed (c) The Royal Society of Chemistry
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Transition metal-free C–F/C–Cl/C–C cleavage of ClCF2COONa for the synthesis of heterocycles ()
Org. Biomol. Chem., 2019, 17,8071-8074 DOI: 10.1039/C9OB01641D, Communication Yizhe Yan, Chang Cui, Jianyong Wang, Shaoqing Li, Lin Tang, Yanqi Liu ClCF2COONa was employed as a C1 synthon for 1,3,5-triazines or quinazolinones in up to 96% yields under transition metal-free and external oxidant-free conditions. The content of this RSS Feed (c) The Royal Society of Chemistry
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Rapid and efficient synthesis of a novel cholinergic muscarinic M1 receptor positive allosteric modulator using flash chemistry ()
Org. Biomol. Chem., 2019, 17,8166-8174 DOI: 10.1039/C9OB01718F, Paper Shotaro Miura, Koichiro Fukuda, Shinichi Masada, Hirotsugu Usutani, Makoto Kanematsu, David G. Cork, Tetsuji Kawamoto Continuous flash synthesis of a 2-bromobenzaldehyde derivative from the corresponding 1-bromo-2-iodobenzene derivative is described for rapid and efficient synthesis of a novel cholinergic muscarinic M1 receptor positive allosteric modulator. The content of this RSS Feed (c) The Royal Society of Chemistry
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The secondary structure of a heptapeptide containing trifluoromethyl-λ6-tetrafluorosulfanyl substituted amino acids ()
Org. Biomol. Chem., 2019, 17,8079-8082 DOI: 10.1039/C9OB01797F, Communication Akari Ikeda, Aimée Capellan, John T. Welch The polar hydrophobic trifluoromethyl-λ6-tetrafluorosulfanyl (CF3SF4) group effectively induces secondary structure in a heptapeptide in both polar and non-polar solvents. The content of this RSS Feed (c) The Royal Society of Chemistry
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Correction: cis or trans with class II diterpene cyclases ()
Org. Biomol. Chem., 2019, 17,8259-8260 DOI: 10.1039/C9OB90139F, Correction Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Meirong Jia, Reuben J. Peters The content of this RSS Feed (c) The Royal Society of Chemistry
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Tandem arylation and regioselective allylic etherification of 2,3-allenol via Pd/B cooperative catalysis ()
Org. Biomol. Chem., 2019, 17,8075-8078 DOI: 10.1039/C9OB01792E, Communication Hongfang Li, Tao Li, Yu Jen Hsueh, Xue Wu, Feng Xu, Yong Jian Zhang An efficient method for the construction of arylated allylic ethers was developed via three-component tandem arylation and allylic etherification of 2,3-allenol with aryl iodides and alcohols. The content of this RSS Feed (c) The Royal Society of Chemistry
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Convergent synthesis of hydrophilic monomethyl dolastatin 10 based drug linkers for antibody–drug conjugation ()
Org. Biomol. Chem., 2019, 17,8115-8124 DOI: 10.1039/C9OB01639B, Paper Kanwen Yang, Bo Chen, Diego A. Gianolio, James E. Stefano, Michelle Busch, Charlene Manning, Kim Alving, Richard C. Gregory, William H. Brondyk, Robert J. Miller, Pradeep K. Dhal A cytotoxic reagent-free fragment coupling methodology was developed to produce hydrophilic drug linkers to prepare aggregation free antibody–drug conjugates. The content of this RSS Feed (c) The Royal Society of Chemistry
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Highly efficient asymmetric bioreduction of 1-aryl-2-(azaaryl)ethanones. Chemoenzymatic synthesis of lanicemine ()
Org. Biomol. Chem., 2019, 17,8214-8220 DOI: 10.1039/C9OB01616C, Paper Ramón Liz, Elisa Liardo, Francisca Rebolledo 1-Aryl-2-(azaaryl)ethanols with ee > 99% have been prepared by KRED-catalyzed reduction of the ketone precursors. A chemoenzymatic synthesis of lanicemine is described. The content of this RSS Feed (c) The Royal Society of Chemistry
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Stabilization of the triple helix in collagen mimicking peptides ()
Org. Biomol. Chem., 2019, 17,8031-8047 DOI: 10.1039/C9OB01646E, Review Article Vladimir Kubyshkin The review classifies existing chemical approaches towards stronger triple helical assemblies in peptides. The content of this RSS Feed (c) The Royal Society of Chemistry
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Compatibility of 5-ethynyl-2′F-ANA UTP with in vitro selection for the generation of base-modified, nuclease resistant aptamers ()
Org. Biomol. Chem., 2019, 17,8083-8087 DOI: 10.1039/C9OB01515A, Communication Fabienne Levi-Acobas, Adam Katolik, Pascal Röthlisberger, Thomas Cokelaer, Ivo Sarac, Masad J. Damha, Christian J. Leumann, Marcel Hollenstein A nucleoside triphosphate bearing modifications at both the sugar and the nucleobase level was shown to be compatible with combinatorial methods of in vitro selection. The content of this RSS Feed (c) The Royal Society of Chemistry
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Catalyst-free facile synthesis of polycyclic indole/pyrrole substituted-1,2,3-triazoles ()
Org. Biomol. Chem., 2019, 17,8153-8165 DOI: 10.1039/C9OB01560D, Paper Jitendra Gour, Srikanth Gatadi, Ravikumar Akunuri, Madhavi Venkata Yaddanapudi, Mushtaq Ahmad Nengroo, Dipak Datta, Sidharth Chopra, Srinivas Nanduri A general and catalyst-free access to the fused polycyclic N-heterocycles via an intramolecular azide–alkene cascade reaction under mild reaction conditions has been developed. The content of this RSS Feed (c) The Royal Society of Chemistry
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Transition metal-free synthesis of quinazolinones using dimethyl sulfoxide as a synthon ()
Org. Biomol. Chem., 2019, 17,8067-8070 DOI: 10.1039/C9OB01629E, Communication Seohoo Lee, Jaeuk Sim, Hyeju Jo, Mayavan Viji, Lanka Srinu, Kiho Lee, Heesoon Lee, Vishwanath Manjunatha, Jae-Kyung Jung Biologically important quinazolinones have been synthesized from 2-aminobenzamides and DMSO. The content of this RSS Feed (c) The Royal Society of Chemistry
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Fine structural tuning of styryl-based dyes for fluorescence and CD-based sensing of various ds-DNA/RNA sequences ()
Org. Biomol. Chem., 2019, 17,8243-8258 DOI: 10.1039/C9OB01186B, Paper Valentina Botti, Alessio Cesaretti, Željka Ban, Ivo Crnolatac, Giuseppe Consiglio, Fausto Elisei, Ivo Piantanida A strong impact of fluorophores’ charge and length on the binding mode, intracellular distribution and antiproliferative activity; intriguing theragnostic potential. The content of this RSS Feed (c) The Royal Society of Chemistry
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Copper-catalyzed synthesis of spiro-indolofurobenzopyrans: tandem reactions of diazoamides and O-propargyl salicylaldehydes ()
Org. Biomol. Chem., 2019, 17,8088-8093 DOI: 10.1039/C9OB01275C, Communication Sengodagounder Muthusamy, Ammasi Prabu, Eringathodi Suresh An atom-economical synthesis of spiro-indolofurobenzopyrans was developed from diazoamides and O-propargyl salicylaldehydes in the presence of copper(I) thiophene-2-carboxylate in a diastereoselective manner. The content of this RSS Feed (c) The Royal Society of Chemistry
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Przewalcyrones A–F, epoxychromene-containing polycyclic polyprenylated acylphloroglucinols with immunosuppressive activity from Hypericum przewalskii Maxim. ()
Org. Biomol. Chem., 2019, 17,8234-8242 DOI: 10.1039/C9OB01500K, Paper Yulin Duan, Shuangshuang Xie, Yi Guo, Yuben Qiao, Zhengyi Shi, Li Tao, Mengyi Deng, Yunfang Cao, Yongbo Xue, Changxing Qi, Yonghui Zhang Chemical investigation of Hypericum przewalskii Maxim. resulted in the identification of six new epoxychromene-containing polycyclic polyprenylated acylphloroglucinols with potential immunosuppressive activity. The content of this RSS Feed (c) The Royal Society of Chemistry
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Exploitation of donor–acceptor cyclopropanes and N-sulfonyl 1-azadienes towards the synthesis of spiro-cyclopentane benzofuran derivatives ()
Org. Biomol. Chem., 2019, 17,8149-8152 DOI: 10.1039/C9OB01369E, Paper Kamal Verma, Irshad Maajid Taily, Prabal Banerjee An efficient method for the synthesis of spiro-cyclopentane benzofuran derivatives via a MgI2-catalyzed formal [3 + 2] cycloaddition reaction between donor–acceptor cyclopropanes and N-sulfonyl 1-azadienes in good yield has been developed. The content of this RSS Feed (c) The Royal Society of Chemistry
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Are one-step aromatic nucleophilic substitutions of non-activated benzenes concerted processes? ()
Org. Biomol. Chem., 2019, 17,8185-8193 DOI: 10.1039/C9OB01589B, Paper Luis R. Domingo, Mar Ríos-Gutiérrez, Eduardo Chamorro, Patricia Pérez Analysis of the mechanism of one-step SNAr reactions of non-activated benzenes shows the presence of structures similar to those of Meisenheimer intermediates, thus accounting for the non-concerted nature of these reactions. The content of this RSS Feed (c) The Royal Society of Chemistry
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Ep7GT, a glycosyltransferase with sugar donor flexibility from Epimedium pseudowushanense, catalyzes the 7-O-glycosylation of baohuoside ()
Org. Biomol. Chem., 2019, 17,8106-8114 DOI: 10.1039/C9OB01352K, Paper Keping Feng, Ridao Chen, Kebo Xie, Dawei Chen, Jimei Liu, Wenyu Du, Lin Yang, Jungui Dai A novel glycosyltransferase from Epimedium pseudowushanense, Ep7GT, regiospecifically catalyzes the 7-O-glucosylation of baohuoside to form icariin and shows sugar donor/acceptor promiscuity to yield different flavonoid glycosides. The content of this RSS Feed (c) The Royal Society of Chemistry
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Z-isomerization of retinoids through combination of monochromatic photoisomerization and metal catalysis ()
Org. Biomol. Chem., 2019, 17,8125-8139 DOI: 10.1039/C9OB01645G, Paper Shirin Kahremany, Christopher Lane Sander, Gregory P. Tochtrop, Adam Kubas, Krzysztof Palczewski Photoisomerization of therapeutic cis-retinoids using monochromatic UV light-tunable via photocatalysts and explained by DFT calculations. The content of this RSS Feed (c) The Royal Society of Chemistry
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Retro-biosynthetic construction of corynanthe alkaloid skeletons from rhynchophylline alkaloids ()
Org. Biomol. Chem., 2019, 17,8062-8066 DOI: 10.1039/C9OB01740B, Communication Xiaogang Tong, Bingfei Shi, Qian Liu, Yanman Huo, Chengfeng Xia Corynanthe alkaloids could be generated from rhynchophylline alkaloids in a retro-biosynthetic manner via a Wagner–Meerwein rearrangement. The content of this RSS Feed (c) The Royal Society of Chemistry
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Mechanistic insights into ring cleavage of hydroquinone by PnpCD from quantum mechanical/molecular mechanical calculations ()
Org. Biomol. Chem., 2019, 17,8194-8205 DOI: 10.1039/C9OB01084J, Paper Senzhi Li, Jiarui Lu, Wenzhen Lai QM/MM calculations for ring cleavage of hydroquinone by PnpCD show that Asn258 loses coordination to the iron when the reaction begins. The first-sphere Glu262 can act as an acid–base catalyst to lower the rate-limiting barrier. The content of this RSS Feed (c) The Royal Society of Chemistry
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Regioselective radical arylation: silver-mediated synthesis of 3-phosphorylated coumarins, quinolin-2(1H)-one and benzophosphole oxides ()
Org. Biomol. Chem., 2019, 17,8175-8184 DOI: 10.1039/C9OB01585J, Paper Hong Hou, Yue Xu, Haibo Yang, Chaoguo Yan, Yaocheng Shi, Shaoqun Zhu A silver-mediated domino radical addition/cyclization reaction of diaryl- or dialkyl-phosphine oxides with propynoic acid derivatives delivering 3-phosphorylated coumarins, quinolin-2(1H)-one and benzophosphole oxides is presented. The content of this RSS Feed (c) The Royal Society of Chemistry
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Total synthesis of wikstrol A and wikstrol B ()
Org. Biomol. Chem., 2019, 17,8206-8213 DOI: 10.1039/C9OB01219B, Paper Kui Lu, Ming Li, Yuna Huang, Yuanyuan Sun, Zhi Gong, Qijun Wei, Xia Zhao, Yongmin Zhang, Peng Yu The first total synthesis of wikstrol A and wikstrol B was achieved via Sharpless asymmetric dihydroxylation, Sonogashira and rhodium-catalyzed oxidative coupling as key steps. The content of this RSS Feed (c) The Royal Society of Chemistry
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Palladium-catalyzed multicomponent reactions: an overview ()
Org. Biomol. Chem., 2019, 17,8048-8061 DOI: 10.1039/C9OB01538H, Review Article Salim Saranya, K. R. Rohit, Sankaran Radhika, Gopinathan Anilkumar This first review on this topic focuses on the developments in the chemistry of Pd-catalyzed multi-component reactions (MCRs). The content of this RSS Feed (c) The Royal Society of Chemistry
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The one pot asymmetric synthesis of 3,3′-pyrrolidonyl spiroxindoles via a regio- and stereoselective domino reaction ()
Org. Biomol. Chem., 2019, 17,8140-8148 DOI: 10.1039/C9OB01570A, Paper Saumen Hajra, Suhas Shivajirao Bhosale, Atanu Hazra, Nikhil Kanaujia The asymmetric synthesis of 4-aryl-3,3′-spiropyrrolidonyl oxindoles with excellent stereoselectivity (dr >99 : 1 and an ee up to >99%) was achieved via a domino reaction. The content of this RSS Feed (c) The Royal Society of Chemistry
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A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A ()
Org. Biomol. Chem., 2019, 17,8094-8105 DOI: 10.1039/C9OB01133A, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. William Doherty, Eva-Maria Dürr, Hannah T. Baddock, Sook Y. Lee, Peter J. McHugh, Tom Brown, Mathias O. Senge, Eoin M. Scanlan, Joanna F. McGouran Modified thymidine incorporating zinc-binding pharmacophores offers a novel approach for inhibitor development of SNM1A using rationally designed nucleoside derived inhibitors. The content of this RSS Feed (c) The Royal Society of Chemistry
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Controllable Construction of Isoquinolinedione and Isocoumarin Scaffolds via RhIII-Catalyzed C-H Annulation of N-tosylbenzamides with Diazo Compounds ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01789E, Paper Yanfei Liu, Jiaping Wu, Baiyang Qian, Yongjia Shang A highly efficient protocol for synthesis of isoquinolinediones by RhIII-catalyzed C-H activation/annulation/decarboxylation of N-tosylbenzamides with diazo compounds is reported. The switchable synthesis of isocoumarins was also achieved successfully via C-H... The content of this RSS Feed (c) The Royal Society of Chemistry
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Clickable Styryl Dyes for Fluorescence Labeling of Pyrrolidinyl PNA Probes for the Detection of Base Mutations in DNA ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01492F, Paper Boonsong Ditmangklo, Jaru Taechalertpaisarn, Khatcharin Siriwong, Tirayut Vilaivan Fluorescence hybridization probes are important tools for rapid, specific and sensitive analysis of genetic mutations. In this work, we synthesized novel alkyne-modified styryl dyes for conjugation with pyrrolidinyl peptide nucleic... The content of this RSS Feed (c) The Royal Society of Chemistry
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Nickel-Catalyzed C3-Acylation of 2H‑Indazoles with Aldehydes ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01749F, Paper Yanling Liu, You-lu Pan, Gangjian Li, Haifeng Xu, Jianzhong Chen A direct coupling of 2H‑Indazoles’ C3 position and acyl groups has been achieved to produce 3-acyl-2H-Indazoles. The Ni(II)-catalyzed acylation might proceed through a radical pathway for the reaction of 2H‑Indazoles... The content of this RSS Feed (c) The Royal Society of Chemistry
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Azines: synthesis, structure, electronic structure and their applications ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01272A, Review Article Sumit S. Chourasiya, Deepika Kathuria, Aabid Abdullah Wani, Prasad V. Bharatam Azines (2,3-diaza-1,3-butadienes): structure, electronic structure, tautomerism, and their applications in organic synthesis, medicinal chemistry and materials chemistry. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Photo- and dioxygen-enabled radical C(sp3)―N(sp2) cross-coupling between guanidines and perfluoroalkyl iodides ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01520E, Communication Shulin Liu, Rui Wang, Bo Zhu, Wei Guan, Fushun Liang A photo- and dioxygen-enabled intermolecular radical Csp3—Nsp2 cross-coupling between guanidines and perfluoroalkyl iodides has been developed. N2-perfluoroalkacylguanidines, which are of biological importance, were obtained under mild conditions via Nsp2-perfluoroalkylation and... The content of this RSS Feed (c) The Royal Society of Chemistry
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Palladium(II) ligated with selenated NHC based (Se, CNHC, N−) type pincer: An efficient catalyst for Mizoroki-Heck and Suzuki Miyaura coupling in water ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01674K, Communication Kamal Nayan Sharma, Naveen Satrawala, Avinash Kumar Srivastava, Munsaf Ali, Raj Kumar Joshi A new 1-[N-benzylacetamido]-3-[1-(2-phenylselenylethyl)] benzimidazolium chloride (L), the precursor of a novel (Se,CNHC,N−) type first pincer ligand (L) has been synthesized in high yield through a sequence of consecutive reactions of... The content of this RSS Feed (c) The Royal Society of Chemistry
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Chemoenzymatic Reduction of Citreorosein and its Implications for Aloe-Emodin and Rugulosin C (Bio)synthesis ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01690B, Communication Amit Mondal, Nirmal Saha, Anshul Rajput, Shailesh Kumar Singh, Brindaban Roy, Syed Masood Husain A chemoenzymatic reduction of citreorosein by the NADPH-dependent polyhydroxyanthracene reductase from Cochliobolus lunatus or by MdpC from Aspergillus nidulans in presence of Na2S2O4, gave access to putative biosynthetic intermediates, (R)-3,8,9,10-tetrahydroxy-6-(hydroxymethyl)-3,4-dihydroanthracene-1(2H)-one... The content of this RSS Feed (c) The Royal Society of Chemistry
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Thioarylmaleimides: accessible, tunable, and strongly emissive building blocks ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01741K, Communication Jayden Price, Emily Albright, Andreas Decken, Sara Eisler Thioarylmaleimides (TAMS) with a wide range of photophysical properties were realized. The photophysical properties of the TAMS are varied, and can be controlled via strategic choice of the thioaryl moiety. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Emerones A–C: three novel merosesquiterpenoids with unprecedented skeletons from Emericella sp. XL029 ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01788G, Paper Heng-Ye Chen, Ting-Kai Liu, Jian Yang, Xiao-Long Yang Three novel merosesquiterpenoids (1–3) from Emericella sp. XL029. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A targeted approach for the synthesis of multi-phosphorylated peptides: a tool for studying the role of phosphorylation patterns in proteins ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01874C, Paper Mamidi Samarasimhareddy, Daniel Mayer, Norman Metanis, Dmitry Veprintsev, Mattan Hurevich, Assaf Friedler An efficient strategy for the synthesis of multiphosphorylated peptides is described. Such peptides are essential in elucidating the biological roles of the phosphorylation patterns and barcodes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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α-Halogenoacetamides: versatile and efficient tools for the synthesis of complex aza-heterocycles ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01683J, Review Article Abderrahman El Bouakher, Arnaud Martel, Sébastien Comesse This review presents the use of α-alkyl- and α-alkoxy-halogenoacetamides as powerful partners for domino and 1,3-dipolar cycloaddition reactions resulting in a ring closure. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Rhodium-catalyzed C–H activation/annulation of amidines with 4-diazoisochroman-3-imines toward isochromeno[3,4-c]isoquinolines ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01612K, Paper Shengbo Xu, Shanshan Qiao, Song Sun, Jin-Tao Yu, Jiang Cheng Rhodium-catalyzed C–H activation/annulation of amidines with 4-diazoisochroman-3-imines toward 8-amino-5H-isochromeno[3,4-c]isoquinolines with good functional group tolerance. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Recent advances in the synthesis of carbazoles from indoles ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01381D, Review Article Trapti Aggarwal, Sushmita, Akhilesh K. Verma Synthesis of carbazoles using indoles as precursors through CH activation/annulation. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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The effect of MR1 ligand glyco-analogues on mucosal-associated invariant T (MAIT) cell activation ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01436E, Paper Chriselle D. Braganza, Kensuke Shibata, Aisa Fujiwara, Chihiro Motozono, Koh-Hei Sonoda, Sho Yamasaki, Bridget L. Stocker, Mattie S. M. Timmer Glyco-analogues of MR1 ligands can bind MR1 and activate MAIT cells at levels similar to 5-OP-RU. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Triflic acid-mediated synthesis of thioglycosides ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01610D, Communication Samira Escopy, Yashapal Singh, Alexei V. Demchenko Examples include all common hexoses, aminosugars, sialic acids, and disaccharides. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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An asymmetric iminium ion catalysis-enabled cascade cycloaddition reaction of chromone-oxindole synthons with enals: construction of a spirooxindole–hexahydroxanthone framework ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01670H, Communication Wen-Hui Zhang, Yan-you Zhou, Xue-Wen He, Yi Gong, Xiong-Li Liu, Ying Zhou We report the first asymmetric iminium ion catalysis-enabled cascade cycloaddition reaction of bifunctional chromone-oxindole synthons and α,β-unsaturated aldehydes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Enantioselective construction of 3-substituted 3-amino-2-oxindoles containing an N,N-ketal skeleton via organocatalyzed aza-addition of isatin imines ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01870K, Communication Chen Zhang, Xinye Shang, Yuyu Cheng, Fushuai Li, Hanhui Zhao, Pengfei Li, Wenjun Li The first example of organocatalytic chemo-, regio- and enantioselective aza-Mannich reactions of triazoles and arylamines, respectively, with isatin-derived imines has been achieved. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Endoplasmic reticulum targeted fluorescent probe for the detection of hydrogen sulfide based on twist-blockage strategy ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01750J, Paper Yongru Zhang, Beibei Zhang, zipeng li, Lanbang Wang, xueling ren, Yong Ye Hydrogen sulfide (H2S) is pretty important for humans and it is involved in many physiological regulations. In our experiment, we planned and reported a new naked-eyes colorimetric fluorescent sensing element... The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis of imidazo[1,2-c]thiazoles through Pd-catalyzed bicyclization of tert-butyl isonitrile with thioamides ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01664C, Paper Xiangjun Peng, Feng Qin, Mengyue Xu, Shaojie Zhu, Yingming Pan, Haitao Tang, Xiujin Meng, Hengshan Wang We report herein the synthesis of imidazo[1,2-c]thiazoles through a Pd-catalyzed insertion reaction of three isonitrile molecules and cascade bicyclization in a one-pot, two-step process. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and environment-dependent fluorescence behavior of a biaryl-conjugated (diphenylmethylene)imidazolinone ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01727E, Paper Masahiro Ikejiri, Ryouta Nishiguchi, Chikoto Kubota, Aki Fujisaka, Kazuyuki Miyashita A GFP chromophore analog, bar-DAIN, which equips 2-biaryl and 5-diphenylmethylene moieties, shows environment-dependent fluorescence behavior for viscous and aggregative conditions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Natural diterpene pyrones: chemistry and biology ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01501A, Review Article Amjad Ayad Qatran Al-Khdhairawi, Geoffrey A. Cordell, Noel F. Thomas, Narendra Babu Shivanagere Nagojappa, Jean-Frédéric F. Weber Diterpene pyrones (DTPs) are a group of well-known, mainly fungal, natural products, first isolated in 1966. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Preparation of isoquinazolines via metal-free [4 + 2] cycloaddition of ynamides with nitriles ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01395D, Paper Hao Wu, Yu Liu, Ming-xing He, Hao Wen, Wei Cao, Ping Chen, Yu Tang TfOH-mediated [4 + 2] cycloaddition of ynamides with nitriles to construct 1,2-dihydroquinazolines is realized by a direct reaction in moderate to excellent yields (up to 93%) in a stereospecific manner. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Advances in Asymmetric Visible-light Photocatalysis, 2015-2019 ()
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01609K, Review Article Chunhui Jiang, Wei Chen, Wen-hua Zheng, Hongfei Lu In this review, the recent advances of visible-light-triggered enantioselective reactions classified by different catalytic strategies are summarized. The progress achieved in this area would inspire us to develop new strategies,... The content of this RSS Feed (c) The Royal Society of Chemistry
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Benzannulated spiroketal natural products: isolation, biological activity, biosynthesis, and total synthesis ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01598A, Review Article Rachel M. Gillard, Margaret A. Brimble A review discussing the isolation, biological activity, biosynthesis, and total synthesis of naturally occurring benzannulated spiroketals. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Direct methyl C(sp3)–H azolation of thioanisoles via oxidative radical coupling ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01530B, Communication Xin Wang, Changhao Li, Yixiao Zhang, Bing Zhang, Kai Sun A mild organocatalyst-enabled methyl C(sp3)–H bond azolation of thioanisoles has been developed, affording a facile route for the construction of nitrogen-functionalized thioanisoles. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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B(C6F5)3-catalyzed divergent cyanosilylations of chromones dependent on temperature ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01710K, Communication Qiaotian Wang, Xiangqing Feng, Wei Meng, Haifeng Du A B(C6F5)3-catalyzed divergent cyanosilylation of chromones dependent on temperature has been realized to afford the corresponding products in good to high yields. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and application of light-switchable arylazopyrazole rapamycin analogs ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01719D, Communication Taylor M. Courtney, Trevor J. Horst, Chasity P. Hankinson, Alexander Deiters The first photoswitchable rapamycin analogs were synthesized and evaluated in split-enzyme assays using FKBP/FRB fusion, revealing configurational specificity of the system. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Optically active Ag(I): o-OPE helicates using a single homochiral sulfoxide as chiral inducer ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01573F, Paper Sandra Resa, Pablo Reiné, Luis Álvarez de Cienfuegos, Santiago Guisán-Ceinos, María Ribagorda, Giovanna Longhi, Giuseppe Mazzeo, Sergio Abbate, Antonio J. Mota, Delia Miguel, Juan M. Cuerva Preferred-handed helical folding of OPEs achieved by just one chiral motif: changes in CD spectra after Ag(I) complexation. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Modifications of amino acids using arenediazonium salts ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01471C, Review Article Saumitra Sengupta, Srinivasan Chandrasekaran Aryl transfer reactions from arenediazonium salts have started to make their impact in chemical biology with initial forays in the arena of arylative modifications and bio-conjugations of amino acids, peptides and proteins. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Synthesis and identification of heteroaromatic N-benzyl sulfonamides as potential anticancer agents ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01694E, Paper Megan D. Hopkins, Felagot A. Abebe, Kristina A. Scott, Garett L. Ozmer, Alec A. Sheir, Lucas J. Schroeder, Robert J. Sheaff, Angus A. Lamar The regioselective incorporation of a sulfonamide unit to a broad range of heteroarene scaffolds has been developed. Synthesized N-benzyl sulfonamides have been screened against a variety of cancer cell lines for cytotoxicity effects. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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A route to access imidazol[1,5-a]indole-1,3-diones and pyrrolo[1,2-c]imidazole-1,3-diones ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01462D, Paper Ramana Sreenivasa Rao, Femil Joseph Shajan, D. Srinivasa Reddy A simple and practical method for synthesizing imidazol[1,5-a]indoles and pyrrolo[1,2-c]imidazoles has been developed. The present method uses microwave conditions and is free from the need for work-up and column chromatography. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Recognition of mixed-sequence DNA targets using spermine-modified Invader probes ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01686D, Communication Shiva P. Adhikari, Raymond G. Emehiser, Saswata Karmakar, Patrick J. Hrdlicka Invader probes are additionally activated for recognition of mixed-sequence DNA targets upon incorporation of spermine bulges. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Palladium-catalyzed cascade reactions of alkene-tethered carbamoyl chlorides with N-tosyl hydrazones: synthesis of alkene-functionalized oxindoles ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01672D, Communication Wan Sun, Chen Chen, Yuan Qi, Jinghui Zhao, Yinwei Bao, Bolin Zhu An efficient approach for the construction of alkene-functionalized oxindoles was developed via palladium-catalyzed cascade reactions of alkene-tethered carbamoyl chlorides with N-tosyl hydrazones. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Dual-quenching NBD-based fluorescent probes for separate detection of H2S and Cys/Hcy in living cells ()
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01535C, Paper Yaqing Jiang, Xiuru Ji, Changyu Zhang, Zhen Xi, Lu Sun, Long Yi Dual-quenching fluorescent probes based on thiolysis of NBD thioether/ether/amine for fast and separate detection of H2S and Cys/Hcy in living cells were rationally constructed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Optimised approach to albumin–drug conjugates using monobromomaleimide-C-2 linkers ()
Org. Biomol. Chem., 2019, 17,7870-7873 DOI: 10.1039/C9OB00721K, Communication Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Archie Wall, Karl Nicholls, Mikael B. Caspersen, Stig Skrivergaard, Kenneth A. Howard, Kersti Karu, Vijay Chudasama, James R. Baker Monobromomaleimides with C-2-PEG linkers offer an optimised platform for site-selective albumin conjugation, offering efficient conjugation and accelerated stabilising hydrolysis which prevents loss of drug during construction. The content of this RSS Feed (c) The Royal Society of Chemistry
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Triflic anhydride mediated synthesis of 3,4-dihydroquinazolines: a three-component one-pot tandem procedure ()
Org. Biomol. Chem., 2019, 17,7995-8000 DOI: 10.1039/C9OB01596E, Paper Christina L. Magyar, Tyler J. Wall, Steven B. Davies, Molly V. Campbell, Haven A. Barna, Sydney R. Smith, Christopher J. Savich, R. Adam Mosey A triflic anhydride mediated one-pot tandem reaction involving a Pictet–Spengler-like annulation step has been developed for the synthesis of 3,4-dihydroquinazolines. The content of this RSS Feed (c) The Royal Society of Chemistry
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Three-state switching in a double-pole change-over nanoswitch controlled by redox-dependent self-sorting ()
Org. Biomol. Chem., 2019, 17,7956-7963 DOI: 10.1039/C9OB01456J, Paper Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Sudhakar Gaikwad, Merve Sinem Özer, Susnata Pramanik, Michael Schmittel Entangled toggling leads to a rare case of a double-pole change-over switching. Since two connections are cleaved in a correlated manner, it represents an intriguing modus operandi of molecular nanoswitching. The content of this RSS Feed (c) The Royal Society of Chemistry
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Distortion of mannoimidazole supports a B2,5 boat transition state for the family GH125 α-1,6-mannosidase from Clostridium perfringens ()
Org. Biomol. Chem., 2019, 17,7863-7869 DOI: 10.1039/C9OB01161G, Communication Open Access Open Access Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Alexandra Males, Gaetano Speciale, Spencer J. Williams, Gideon J. Davies Enzyme transition-state mimics can act as powerful inhibitors and allow structural studies that report on the conformation of the transition-state. The content of this RSS Feed (c) The Royal Society of Chemistry
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Copper-catalysed C–H functionalisation gives access to 2-aminobenzimidazoles ()
Org. Biomol. Chem., 2019, 17,7943-7955 DOI: 10.1039/C9OB01651A, Paper Peter R. Clark, Glynn D. Williams, Nicholas C. O. Tomkinson This paper describes the development, optimisation and exemplification of a copper-catalysed C–H functionalisation to form pharmaceutically relevant 2-aminobenzimidazoles from aryl-guanidines. The content of this RSS Feed (c) The Royal Society of Chemistry
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Enantioselective photooxygenation of β-dicarbonyl compounds in batch and flow photomicroreactors ()
Org. Biomol. Chem., 2019, 17,7938-7942 DOI: 10.1039/C9OB01379B, Paper Xiao-Fei Tang, Jing-Nan Zhao, Yu-Feng Wu, Ze-Hao Zheng, Shi-Hao Feng, Zong-Yi Yu, Guang-Zhi Liu, Qing-Wei Meng A series of C-2′ modified cinchonine-derived phase-transfer catalysts were synthesized and applied to the photo-organocatalytic aerobic oxidation of β-dicarbonyl compounds in batch and flow photomicroreactors. The content of this RSS Feed (c) The Royal Society of Chemistry
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Solvent interception, heterocyclization and desilylation upon NBS-induced sulfamidation of trimethyl(vinyl)silane ()
Org. Biomol. Chem., 2019, 17,7927-7937 DOI: 10.1039/C9OB01689A, Paper Vera V. Astakhova, Mikhail Yu. Moskalik, Bagrat A. Shainyan NBS-induced oxidative sulfamidation of trimethyl(vinyl)silane is strongly solvent and reagent dependent leading to various heterocycles in up to quantitative yield. The content of this RSS Feed (c) The Royal Society of Chemistry
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Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry ()
Org. Biomol. Chem., 2019, 17,8014-8018 DOI: 10.1039/C9OB01745C, Paper Krishna Sharma, Alexander V. Strizhak, Elaine Fowler, Xuelu Wang, Wenshu Xu, Claus Hatt Jensen, Yuteng Wu, Hannah F. Sore, Yu Heng Lau, Marko Hyvönen, Laura S. Itzhaki, David R. Spring The Sondheimer dialkyne is extensively used in double strain-promoted azide–alkyne cycloadditions. The content of this RSS Feed (c) The Royal Society of Chemistry
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Facile synthesis of substituted quinolines by iron(III)-catalyzed cascade reaction between anilines, aldehydes and nitroalkanes ()
Org. Biomol. Chem., 2019, 17,7907-7917 DOI: 10.1039/C9OB01294J, Paper Sachinta Mahato, Anindita Mukherjee, Sougata Santra, Grigory V. Zyryanov, Adinath Majee A library of substituted quinolines has been synthesized by the reaction of aldehydes, anilines and nitroalkanes using a catalytic amount of Fe(III) chloride. The content of this RSS Feed (c) The Royal Society of Chemistry
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Direct thiocarbamation of imidazoheterocycles via dual C–H sulfurization ()
Org. Biomol. Chem., 2019, 17,7854-7857 DOI: 10.1039/C9OB01403A, Communication Jian-Chao Deng, Jun-Rong Zhang, Ming-Hua Li, Jie-Cheng Huang, Zhi-Sheng Lai, Xin-Yu Tong, Zi-Ning Cui, Ri-Yuan Tang Direct thiocarbamation via dual C–H sulfurization. The content of this RSS Feed (c) The Royal Society of Chemistry
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Curtachalasins, immunosuppressive agents from the endophytic fungus Xylaria cf. curta ()
Org. Biomol. Chem., 2019, 17,7985-7994 DOI: 10.1039/C9OB01552C, Paper Wen-Xuan Wang, Gui-Guang Cheng, Zheng-Hui Li, Hong-Lian Ai, Juan He, Jing Li, Tao Feng, Ji-Kai Liu Eleven new cytochalasins were isolated from Xylaria cf. curta. Their selective immunosuppressive properties provide new clues for drug development of immunosuppressants. The content of this RSS Feed (c) The Royal Society of Chemistry
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Diastereoselective synthesis of spirocyclic isoxazolo[5,4-c]pyrrolo[2,1-a]isoquinolines via cascade double [3 + 2]cycloadditions ()
Org. Biomol. Chem., 2019, 17,8008-8013 DOI: 10.1039/C9OB01474H, Paper Dan Liu, Jing Sun, Yu Zhang, Chao-Guo Yan Novel polycyclic spiro compounds were conveniently synthesized in good yields and with high diastereoselectivity from cascade double [3 + 2] cycloaddition reactions. The content of this RSS Feed (c) The Royal Society of Chemistry
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First α-deuterium nitroxides; synthesis and EPR study ()
Org. Biomol. Chem., 2019, 17,7900-7906 DOI: 10.1039/C9OB01127G, Paper Hila Toledo, Boris Tumanskii, Denis Sh. Sabirov, Alexander Kaushansky, Natalia Fridman, Alex M. Szpilman Herein is reported the first preparation of stable α-deuterium nitroxides of the IAPNO family. The content of this RSS Feed (c) The Royal Society of Chemistry
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