Passerini reaction

The Passerini reaction is a chemical reaction involving an isocyanide, an aldehyde (or ketone), and a carboxylic acid to form a α-acyloxy amide.



Passerini Three-Component Reaction of Alcohols under Catalytic Aerobic Oxidative Conditions

Julien Brioche, Geraldine Masson and Jieping Zhu

Org. Lett., 2010, 12 (7), pp 1432–1435



Passerini Reaction−Amine Deprotection−Acyl Migration Peptide Assembly: Efficient Formal Synthesis of Cyclotheonamide C

Sophie Faure, Thomas Hjelmgaard, Stéphane P. Roche and David J. Aitken

Org. Lett.200911 (5), pp 1167–1170



New efficient synthesis of 4-aminocarbonyl substituted 4H-3,1-benzoxazines by a Passerini 3CC/Staudinger/aza-Wittig sequence
TetrahedronVolume 65, Issue 4110 October 2009Pages 8563-8570
Ping He, Jing Wu, Yi-Bo Nie, Ming-Wu Ding



Studies on the application of the Passerini reaction and enzymatic procedures to the synthesis of tripeptide mimetics
TetrahedronVolume 63, Issue 326 August 2007Pages 7647-7653
Wiktor Szymanski, Magdalena Zwolinska, Ryszard Ostaszewski