Strecker reaction

The Strecker amino acid synthesis, devised by Adolph Strecker, is a series of chemical reactions that synthesize an amino acid from an aldehyde (or ketone). The aldehyde is condensed with ammonium chloride in the presence of potassium cyanide to form an α-aminonitrile, which is subsequently hydrolyzed to give the desired amino-acid.


Patents References



Al-MCM-41 catalyzed three-component Strecker-type synthesis of α-aminonitriles
TetrahedronVolume 66, Issue 106 March 2010Pages 1898-1901
Katsuyuki Iwanami, Hana Seo, Jun-Chul Choi, Toshiyasu Sakakura, Hiroyuki Yasuda



A practical synthesis of optically active arylglycines via catalytic asymmetric Strecker reaction
TetrahedronVolume 65, Issues 29-3018 July 2009Pages 5849-5854
Vorawit Banphavichit, Woraluk Mansawat, Worawan Bhanthumnavin, Tirayut Vilaivan



Organocatalyzed Strecker reactions
TetrahedronVolume 65, Issue 714 February 2009Pages 1219-1234
Pedro Merino, Eugenia Marqués-López, Tomás Tejero, Raquel P. Herrera



Chiral Lanthanum(III)-Binaphthyldisulfonate Complexes for Catalytic EnantioselectiveStrecker Reaction

Manabu Hatano, Yasushi Hattori, Yoshiro Furuya and Kazuaki Ishihara

Org. Lett., 200911 (11), pp 2321–2324



Efficient Three-Component StreckerReaction of Aldehydes/Ketones via NHC-Amidate Palladium(II) Complex Catalysis

Jamie Jarusiewicz, Yvonne Choe, Kyung Soo Yoo, Chan Pil Park and Kyung Woon Jung

J. Org. Chem., 200974 (7), pp 2873–2876