Sonogashira reaction

In organic chemistry, a Sonogashira coupling is a coupling reaction of terminal alkynes with aryl or vinyl halides. 

Patents references

Step Conditions Patent
a trans-Dichlorobis(triphenylphosphine)palldium (II) / CuI / Et3N WO2010026075 (Roche)
Step Conditions Patent
a Pd(PPh3)2Cl2 / CuI / DIEA / DMF WO2010016005 (Pfizer)


The Sonogashira Reaction: A Booming Methodology in Synthetic Organic Chemistry 

Chem. Rev., 2007, 107 (3), pp 874–922