Stille coupling

The Stille reaction (aka Stille Coupling) is a chemical reaction coupling an organotin compound with an sp2-hybridized organic halide catalyzed by palladium. The reaction is widely used in organic synthesis.

X is typically a halide, such as Cl, Br, I. Additionally, X can be a pseudohalide such as a triflate, CF3SO3-.

Patents references

Step Conditions Patent
a Pd(PPh3)4 / Xylene WO2010016005 (Pfizer)
Step Conditions Patent
a  Pd(PPh3)4 / Toluene WO2010026110 (Roche)
Step Conditions Patent
a Tris(dibenzylideneacetone)dipalladium(0) / triphenylarsine / DMF WO2010018112 (Roche)
Step Conditions Patent
a

 Pd(PPh3)4 / Toluene

WO2010026075 (Roche)
Step Conditions Patent
a Pd(PPh3)2Cl2 / CuI / ACN WO2010020810 (Astrazeneca)
Step Conditions Patent
a

Pd(PPh3)2Cl2 / dioxane

WO2010014593 (GSK)

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