WO2010010186 Novel Compounds useful for the treatment of Degenerative and Inflammatory Diseases

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Scaffold: Triazolopyridine

Biological target:

Janus kinase: JAK 

Activity:

Inhibitor

Steps Conditions Reactions
a CH2Cl2, 16h
b DIEA, EtOH/MeOH (1/1) reflux Cyclization (triazolopyridine formation)
c Et3N, CH3CN N-acylation
d Pd(dppf)Cl2, K2CO3, dioxane/H2O, microwave irradiations Suzuki cross coupling reaction
e Oxalyl chloride, cat DMF, CH2Cl2, 2h Acid chloride formation
f Et3N, CH2Cl2 Amide bond formation

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