WO2010010187 Novel Compounds useful for the treatment of Degenerative and Inflammatory Diseases

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Scaffold: Triazolopyridine

Biological target:

Janus kinase: JAK 

Activity:

Inhibitor

Steps Conditions Reactions
a CH2Cl2, 16h
b DIEA, EtOH/MeOH (1/1) reflux Cyclization (triazolopyridine formation)
c Et3N, CH3CN N-acylation
d tBuOH, 120oC, 16h SNAr
e TFA, CH2Cl2, 16h Acid chloride formation
f DIPEA, CH2Cl2, 16h Sulfonamide formation

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