WO2010029119 Novel Imidazoline Compounds as Androgen Receptor Modulators

WO2010029119.pdf
Adobe Acrobat Document 9.3 MB

Biological target:

Androgen Receptor

Activity:

modulator

Steps Conditions Reactions
a HCOONa, EtOH.H2O, microwave irradiations 150oC, 11 bar, 5 min Suzuki cross coupling reaction
b Ag2O, CaSO4, 3h Saponification
c KCN, (NH4)2CO3.H2O, EtOH.H2O, 55-60oC Amide bond formation
d Cu2O, DMAC, 160oC, 3h Sandmeyer reaction
e K2CO3, MeI, DMF Buchwald-Hartwig cross coupling reaction
f BF3Me2S, CH2Cl2, 7h Allyl deprotection

Site Search