WO2010011912 TRPV4 Antagonist

WO2010011912.pdf
Adobe Acrobat Document 1.4 MB

Biological target:

TRPV4

Activity:

Antagonist

Steps Conditions Reactions
a EDCI / HOBt / NMM / DCM  Amide synthesis (EDCI Coupling)
b H2 / Pd-C / MeOH  CBz deprotection
c

EDCI / HOBt / NMM / DCM

Amide synthesis (EDCI Coupling)
d

TFA / DCM

Boc deprotection
e

EDCI / HOBt / NMM / DCM

Amide synthesis (EDCI Coupling)

Site Search