WO2010022850 Fused pyrrolidino-cyclopropane derivatives as selectives 11-Beta-hydroxystreroid dehydrogenase type 1 inhibitors

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Scaffold: pyrrolidine-cyclopropane

Biological target:

11-beta-hydroxysteroid dehydrogenase type 1: 11beta-HSD-1

Activity:

Inhibitor

Steps Conditions Reactions
a KOH / MeOH / H2O
Steps Conditions Reactions
a (CH3CH2)2Zn / ICH2I / DCM Cyclopropyl synthesis
b HCl 4N /Dioxane Boc deprotection
c HOBt / EDCI / Et3N / DCM / DMF Amide synthesis (EDCI coupling)

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