WO2010062415 Nitrooxy cycloalkane derivatives

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Scaffold: Cycloalkane

Steps Conditions Reactions
a
mCPBA, CH2Cl2, overnight Oxidation (Epoxide formation)
Chiral separation 100-gram Biotage SNAP cartridge Chiral separation
b
conc. H2SO4, MeOH, 4h
c
Ac2O, conc. HNO3, CH2Cl2, 0oC Nitrooxidation
Chiral separation OD Column Chiral separation
d
4N KOH, MeOH 0 to 10oC, 3h Saponification

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