WO2010015613 Organic compounds

WO2010015613.pdf
Adobe Acrobat Document 2.9 MB

Biological target:

Interleukin 8 is a chemokine receptor: CXCR2

Activity:

Antagonist

Steps Conditions Reactions
a
Et3N, THF, 0oC, 1h Nucleophilic substitution
b
H2SO4, dioxane
c
Et3N, EtOH, 45oC Nucleophilic substitution
d
Et3N, CH3CN, EtOH, 80oC, overnight SNAr

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