WO2010043584 Salicyclic acid derivatives being farnesyl pyrophosphate synthase activity inhibitors

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Biological target:

Farnesyl pyrophosphate synthase: FPPS

Activity:

Inhibitor

Steps Conditions Reactions
a
K2CO3, KI, DMF, 65oC, 7h O-alkylation
b Pd(PPh3)4, 2M Na2CO3, THF 80oC, 2h Suzuki coupling reaction
c
LiOH.H2O, THF/MeOH 1/1, 60oC, 1h Saponification
d
Pd(OAc)2, BINAP, Cs2CO3, dioxane, microwaves, 115oC, 50min Buchwald-Hartwig reaction
e
LiOH.H2O, THF/MeOH 1/1, microwaves 120oC, 12min Saponification

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