WO2010052625 Pyrrolidines
Scaffold: pyrrolidine
| Steps | Conditions | Reactions |
| a | 4-methoxy-benzoyl chloride / Et3N / THF | Amide synthesis |
| b | LiHMDS / ethyl chloroformate / THF | Ester synthesis |
| c | Savinase 16T Type W enzyme / H3PO4 / ACN | Carboxylic acid synthesis (Ester hydrolysis) |
| d | LiBH4 / isopropanol | Ester reduction |
| e | AcCl / EtOH | Ester synthesis (esterification) |
| f | 4-Toluenesulfonyl chloride / Trimethylamine / Triethylamine / DCM | Tosyl synthesis |
| Steps | Conditions | Reactions |
| a | K2CO3 / DMSO | Ether synthesis (Nucleophilic substitution) |