Scaffold: pyrrolidine
Steps | Conditions | Reactions |
a | 4-methoxy-benzoyl chloride / Et3N / THF | Amide synthesis |
b | LiHMDS / ethyl chloroformate / THF | Ester synthesis |
c | Savinase 16T Type W enzyme / H3PO4 / ACN | Carboxylic acid synthesis (Ester hydrolysis) |
d | LiBH4 / isopropanol | Ester reduction |
e | AcCl / EtOH | Ester synthesis (esterification) |
f | 4-Toluenesulfonyl chloride / Trimethylamine / Triethylamine / DCM | Tosyl synthesis |
Steps | Conditions | Reactions |
a | K2CO3 / DMSO | Ether synthesis (Nucleophilic substitution) |