WO2010052625 Pyrrolidines

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Scaffold: pyrrolidine

Biological target:

Prostaglandin E2 receptor: EP2

Activity:

Antagonist

Steps	Conditions	Reactions
a	4-methoxy-benzoyl chloride / Et₃N / THF	Amide synthesis
b	LiHMDS / ethyl chloroformate / THF	Ester synthesis
c	Savinase 16T Type W enzyme / H₃PO₄ / ACN	Carboxylic acid synthesis (Ester hydrolysis)
d	LiBH4 / isopropanol	Ester reduction
e	AcCl / EtOH	Ester synthesis (esterification)
f	4-Toluenesulfonyl chloride / Trimethylamine / Triethylamine / DCM	Tosyl synthesis

Steps	Conditions	Reactions
a	K₂CO₃ / DMSO	Ether synthesis (Nucleophilic substitution)