WO2010058314 Hydroxyquinolin-2(1H)-ones and derivatives thereof

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Scaffold: hydroxyquinoli-2(1H)-ones

Biological target:

Enzyme D-amino acid oxidase: DAAO

Activity:

Inhibitor

Steps Conditions Reactions
a Ethyl diazoacetate / Diethylamine / EtOH  Cyclisation
b MeOH / LiOH / H2O Decarboxylation
Steps Conditions Reactions
a LiHMDS / Ethyl methoxyacetate / THF Cyclisation
b BBr3 / DCM Methoxy deprotection
Steps Conditions Reactions
a Ethyl methoxyacetate / LDA / THF  Cyclisation
b BBr3 / DCM Methoxy deprotection

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