WO2010018113 Bi-aryl aminotetralines

WO2010018113.pdf
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Scaffold: aminotetraline

Biological target:

Prostaglandin D2 receptors: CRTH2

Activity:

Antagonist

Steps Conditions Reactions
a DIEA / THF Sulfonamide synthesis
b NaH / DMF Ether synthesis (Aromatic substitution)                  
Steps Conditions Reactions
a NaH / DMF Ether synthesis (Aromatic substitution)
Steps Conditions Reactions
a Pd(PPh3)4 / K2CO3 / Dioxane
Suzuki reaction

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