WO2010043513 New benzimidazole derivatives

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Scaffold: benzimidazole

Biological target:

Farnesoid-X-receptor: FXR

Activity:

Agonist

Steps Conditions Reactions
a Boc2O / I2 / EtOH Boc protection
b

1. MeOH

2. HCl 4N / Dioxane

Ugi reaction / Boc deprotection
Steps Conditions Reactions
1 NaNO2 / AcOH / Ac2O
2 LiOH / H2O2 / THF:H2O (3:1)
Steps Conditions Reactions
1 Boc2O / DMAP / ACN
2 LiOH / H2O

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