WO2010000353 Sulfonamides with heterocycle and oxadiazolone headgroup, processes for their preparation and their use as pharmaceuticals

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Biological target:

Peroxisome proliferator-activated receptor: PPAR delta and PPAR alpha

Activity:

Agonist

Steps Conditions Reactions
a DIEA / DMC Sulfonamide synthesis
b CuCN / DSMO Cyanide synthesis
c NH2-OH / Et3N / THF / MeOH  
d

1. Phenylchloroformate / Et3N / DCM

2.DBU / ACN

 

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