WO2010063929 6-cycloamino-3-(1H-pyrrolo[2,3-B]pyridin-4-yl)imidazo[1,2-B]pyridazine derivatives, preparation thereof and therapeutic use thereof

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Biological target:

Casein kinase 1: CK1

Activity:

Inhibitor

Steps Conditions Reactions
a NH3, 120oC, 10 bars, 16h
b n-butanol, 120oC, 18h Imidazopyridazine formation
c ICl in MeOH, CHCl3 Iodation
d PdCl2(dppf), Cs2CO3, THF/H2O (9/1) Suzuki coupling reaction
e NaOH 6N, MeOH, THF Nitrogen deprotection
f Et3N, Pentanol, 150oC, 26h SNAr

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