WO2010065571 Treatment for glomerulonephritis with 2-[4-(-7ethyl-5H-pyrrolo[2,3-B]-pyrazin-6-yl)propan-2-ol

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Biological target:

Spleen tyrosine kinase: Syk

 Activity:

Inhibitor

Steps Conditions Reactions
a Sodium bis(trimethylsilyl)amide, THF, 40oC azaindole formation
b CH3MgCl, THF, 0oC Grignard reaction

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