Tuberculosis

ノノムラエ種からの環状ペプチド、その生産プロセス、およびそれを含むマイコバクテリア関連疾病の治療または予防のための薬学的組成物 (Fri, 23 May 2014)
<p num=""> ノノムラエ種MJM5123(Nonomuraea sp. MJM5123)からの新規な抗結核環状ペプチド(anti−TB cylic peptides)、その生産プロセス、およびそれを含むマイコバクテリア感染の治療または予防のための薬学的組成物を提供する。本発明の組成物は、MDRおよびXDRを含む複製/非複製M.結核(M.tuberculosis)に対抗して非常に活動的なので、結核治療剤として効果的に使用できる。</p>
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(6,7-dihydro-2-nitro-5H-imidazol[2,1-b][1,3]oxazin-6-yl) amide compounds, preparation methods and uses thereof (Fri, 07 Jun 2013)
<p id="p-0001" num="0000">(6,7-Dihydro-2-nitro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)amide compounds of formula (I), and their pharmaceutically acceptable salts, preparation methods and pharmaceutical compositions thereof are disclosed, wherein m and R are defined as in the description. The uses of the compounds in preparing medicaments for treating infectious diseases caused by <i>Mycobacterium tuberculosis</i>, especially infectious diseases caused by multi-drug resistance <i>Mycobacterium tuberculosi </i>are also disclosed.</p>
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(6,7-DIHYDRO-2-NITRO-5H-IMIDAZOL[2,1-B][1,3]OXAZIN-6-YL) AMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF (Thu, 28 Mar 2013)
(6,7-Dihydro-2-nitro-5H-imidazo [2,1-b][1,3]oxazin-6-yl)amide compounds of formula (I), and their pharmaceutically acceptable salts, preparation methods and pharmaceutical compositions thereof are disclosed, wherein m and R are defined as in the description. The uses of said compounds in preparing medicaments for treating infectious diseases caused by Mycobacterium tuberculosis, especially infectious diseases caused by multi-drug resistance Mycobacterium tuberculosi are also disclosed.
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신규 항균제 (Thu, 18 Aug 2011)
본 발명은 화학식 I의 신규한 페닐 옥사졸리디논 화합물, 그것의 약제학적으로 허용가능한 유사체, 호변체 형태, 입체이성질체, 다형체, 프로드러그, 대사물, 그것의 염 또는 용매화합물에 관한 것이다. 본 발명은 또한 화학식 I의 신규한 화합물 또는 그것의 약제학적으로 허용가능한 유사체, 호변체 형태, 입체이성질체, 다형체, 프로드러그, 대사물, 그것의 염 또는 용매화합물의 합성 방법에 관한 것이다. 또한 본 발명은 화학식 I의 신규한 화합물을 포함하는 약제학적 조성물 및 그것을 사용하는 방법을 제공한다. 본 발명의 화합물은 다수의 호기성 및/또는 혐기성 그램 양성 및/또는 그램 음성 병원체, 예컨대, 스타필로코쿠스(), 스트렙토코쿠스(), 엔테로코쿠스(), 박테리오이데스(), 클로스트리디아(), 헤모필루스 인플루엔자(), 모락셀라(), 미코박테리움 투버쿨러시스(Mycobacterium tuberculosis)와 같은 항산성 균의 다양한 약물 내성 종뿐만 아니라 스타필로코쿠스() 및 엔테로코쿠스()의 리네졸리드 내성 종에 대해 효과적인 항균제로서 유용하다. (화학식 I) Staphylococcus Streptococcus Enterococcus Bacterioides Clostridia H. influenza Moraxella Staphylococcus Enterococcus JPEG pct00088.jpg 29 74
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ベンズイミダゾール及びその医薬組成物 (Fri, 23 Jul 2010)
<p num=""> 本発明は、新規のベンズイミダゾール誘導体及びその薬学的に許容可能な塩に関する。本発明の別の態様は、マイコバクテリウム・ツベクローシス(Mycobacterium tuberculosis)又はフランシセラ・ツラレンシス(Francisella tulerensis)に感染した患者を、ベンズイミダゾール誘導体又はその薬学的に許容可能な塩の患者への投与により治療する方法に関する。</p>
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2,3-DIHYDRO-6-NITROIMIDAZO[2,1-b]OXAZOL DERIVATIVES FOR TREATMENT OF TUBERCULOSIS (Fri, 28 Aug 2009)
FIELD: chemistry. SUBSTANCE: invention relates to derivatives of 2,3-dihydro-6-nitroimidazo[2,1-b]oxazol of general formula (1), as well as to their optically active forms and pharmacologically acceptable salts: where values of R1, R2 and n are given in i.1 of invention formula. EFFECT: development of compounds, which have bactericidal action against Mycobacterium tuberculosis, polyresistant Mycobacterium tuberculosis and can be applied as antituberculosis medication. 3 cl, 16 ex, 183 tbl, 1515 ex
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PEPTIDES ANTAGONISTS FOR INHIBITING HEAT SHOCK PROTEIN (HSP 16.3) OF MYCOBACTERIUM TUBERCULOSIS (Thu, 08 Mar 2007)
The present invention provides peptide antagonists of Hsp16.3, a chaperon protein 5 necessary for the survival of <i>Mycobacterium tuberculosis </i>in the dormant phase is described.
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ビシクロ[3.1.0]ヘキサン含有オキサゾリジノン抗生物質及びその誘導体 (Fri, 04 Feb 2005)
<p num="">ビシクロ[3.1.0]ヘキサン含有部分を有する新規なオキサゾリジノンであって、それは、多種耐性ブドウ状球菌、連鎖状球菌およびエンテロコッカスの如き好気性および嫌気性病原体、バクテロイデスssp.、クロストリジウムssp.並びにミクロバクテリウム ツベルクロシス(Mycobacterium tuberculosis)の如き抗酸微生物およびその他のミクロバクテリウムの種に対して有効である。この化合物は、構造式I、その光学的対掌体、ジアステレオマー、又は調薬的に受容可能な塩またはそのエステルで表され、種々のR<sub>1</sub>、R<sub>2</sub>、R<sub>3</sub>、R<sub>4a</sub>、A、Ar、HAr、n、rおよびsが定義されている。</p>
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Sulfoglycolipid antigens, their extraction from mycobacterieum tuberculosis, and their use against tuberculosis (Thu, 21 Oct 2004)
The present invention relates to compounds of the following general formula: <CHEM> wherein R1 and R2 are fatty acyl groups, a process to extract them from Mycobacterium tuberculosis, and their use in the treatment or the prophylaxis of tuberculosis.
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CARBOHYDRATE COMPLEX EXTRACTED FROM MYCOBACTERIUM TUBERCULOSIS AND PROCESS FOR THE PREPARATION THEREOF (Thu, 13 Apr 2000)
A carbohydrate complex, which is a mixture of low molecular-weight polysaccharides of an arabinomannan structure extracted from $i(Mycobacterium tuberculosis), is highly effective in treating various cancer patients without incurring any adverse side effects.
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