PATENTSCOPE: EN_ALL:nmr AND PA:allergan

3,4-DISUBSTITUTED 3-CYCLOBUTENE-1,2-DIONES AND USE THEREOF (Fri, 22 Feb 2019)
Described herein are compounds, or pharmaceutically acceptable salts thereof, of the following formula (I). The compounds are useful for treating inflammatory and autoimmune diseases.
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PHENYL UREA DERIVATIVES AS N-FORMYL PEPTIDE RECEPTOR MODULATORS (Fri, 20 Oct 2017)
The present invention relates to phenyl urea derivatives useful for the treatment of inflammatory diseases, pharmaceutical compositions containing them and their use as tools or as pharmaceuticals as modulators of the N-formyl peptide receptor (FPR), including FPR1 and FPR2, or as selective agonists of the FPR1 receptor.
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PHENYL UREA DERIVATIVES AS N-FORMYL PEPTIDE RECEPTOR MODULATORS (Fri, 06 Oct 2017)
The present disclosure relates to phenyl urea derivatives useful for the treatment of inflammatory diseases, pharmaceutical compositions containing them and their use as modulators of the N-formyl peptide receptor (FPR), including FPRl and FPR2, or as selective agonists of the FPRl receptor.
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PHENYL UREA ANALOGS AS FORMYL PEPTIDE REPCEPTOR 1 (FPR1) SELECTIVE AGONISTS (Fri, 10 Feb 2017)
The present disclosure relates to phenyl urea derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor (FPR), such as agonism of the FPR1 and/or FPR2 receptor, or selective agonism of the FPR1 receptor relative to the FPR2 receptor.
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CYCLOSPORINS MODIFIED ON THE MEBMT SIDECHAIN BY HETEROCYCLIC RINGS (Fri, 07 Oct 2016)
The present invention relates to novel cyclosporin analogs, processes for preparing them, pharmaceutical compositions containing them, and methods for using these analogs and the compositions containing them for the treatment of medical conditions, including but not limited to ocular conditions such as dry eye.
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CYCLOSPORIN DERIVATIVES WHEREIN THE MEBMT SIDECHAIN HAS BEEN CYCLIZED (Fri, 15 Jul 2016)
The present invention relates to cyclosporin analogs that are potent inhibitors of cyclophilin D and have low immunosuppressive activity; processes for preparing them; pharmaceutical compositions containing them; and methods for using these analogs and compositions containing them for the treatment of medical conditions, including but not limited to ischemic conditions, such as ischemia-reperfusion (I/R) injury, including myocardial I/R injury, cerebral I/R injury, and ocular or retinal I/R injury.
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TROMETHAMINE SALT OF BIMATOPROST ACID IN CRYSTALLINE FORM 1, METHODS FOR PREPARATION, AND METHODS FOR USE THEREOF (Thu, 31 Dec 2015)
The present invention provides tromethamine salt of (Z)-7-[3,5-Dihydroxy-2-((E)-3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid in crystalline Form 1 and amorphous form. This compound is may also be referred to as "tromethamine salt of bimatoprost acid." The invention crystalline form is useful for solid ocular implant or topical formulations, utilized in the treatment of various ocular conditions, such as, for example, ocular hypertension.
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NOVEL EP4 AGONISTS AS THERAPEUTIC COMPOUNDS (Fri, 11 Dec 2015)
Described herein are compounds that are EP4 agonists and antagonists which are useful for treating a variety of pathological conditions associated with activity of EP4 receptors.
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IMIDAZOLE DERIVATIVES AS FORMYL PEPTIDE RECEPTOR MODULATORS (Fri, 27 Nov 2015)
The present invention relates to imidazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor.
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BICYCLIC DERIVATIVES AS SPHINGOSINE-1 -PHOSPHATE RECEPTORS MODULATORS (Fri, 30 Oct 2015)
The present invention relates to novel bicyclic derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
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COMPLEMENT FACTOR Bb ANTIBODIES (Fri, 04 Sep 2015)
The present disclosure relates to antibodies and polynucleotides encoding the same, which may be used to prevent, control, or reduce the activity of the complement pathway. In addition, the disclosure is directed to compositions and methods for diagnosing and treating diseases mediated by or involving complement Factor Bb. Specifically, the disclosure is related to anti-complement Factor Bb antibodies.
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COMPLEMENT COMPONENT C5 ANTIBODIES (Fri, 28 Aug 2015)
The present disclosure relates to antibodies and polynucleotides encoding the same, that may be used to prevent, control, or reduce the activity of the complement pathway. In addition, the disclosure is directed to compositions and methods for diagnosing and treating diseases mediated by or involving complement C5. Specifically, the disclosure is related to C5 antibodies.
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UREA HYDANTOIN DERIVATIVES AS FORMYL PEPTIDE MODULATORS (Fri, 07 Aug 2015)
The present invention relates to urea hydantoin compounds, processes for preparing them, pharmaceutical compositions containing them, and their use as pharmaceuticals as modulators of the FPR2 receptor, and to methods of treating inflammatory diseases or conditions in a subject in need thereof by administering the compound(s) or pharmaceutical composition to the subject.
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2,5-DIOXOIMIDAZOLIDIN-1-YL-3-UREA DERIVATIVES AS FORMYL PEPTIDE MODULATORS (Fri, 07 Aug 2015)
The present invention relates to l-(2,5-dioxoimidazolidin-l-y)-3- substituted urea compounds of formula I, processes for preparing them, pharmaceutical compositions containing them, their use as pharmaceuticals as modulators of the FPR2 receptor, and to methods of treating inflammatory diseases or conditions in a subject in need thereof by administering the compound(s) or pharmaceutical composition to the subject.
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SPHERICAL FORMS OF CROSS-LINKED HYALURONIC ACID AND METHODS OF USE THEREOF (Fri, 31 Jul 2015)
This disclosure relates generally to spherical forms comprising cross-linked hyaluronic acid, methods of making such spherical forms and using thereof, for example, in aesthetic applications (e.g., facial contouring, soft tissue augmentation products) and the like.
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ANTAGONISTS ACTING AT MULTIPLE PROSTAGLANDIN RECEPTORS FOR THE TREATMENT OF INFLAMMATION (Fri, 31 Jul 2015)
Compounds (I), processes for their preparation, pharmaceutical compositions containing such compounds and their use in treating therapeutic conditions, in particular conditions mediated by the action of ligands on the FP, DP, EP1, EP4, IP, DP and TP prostaglandin (PG) receptors thereby providing a general anti-inflammatory response. ( I )
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DIPHENYL UREA DERIVATIVES AS FORMYL PEPTIDE RECEPTOR MODULATORS (Fri, 24 Jul 2015)
The present invention relates to 1,3,4-oxadiazole derivatives of formulae I and II, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-l-phosphate receptors.
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SUBSTITUTED DIALKYL(OXIDO)-Λ4-SULFANYLIDENE NICOTINAMIDE DERIVATIVES AS KINASE INHIBITORS (Fri, 19 Jun 2015)
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
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SUBSTITUTED NICOTINAMIDE DERIVATIVES AS KINASE INHIBITORS (Fri, 19 Jun 2015)
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
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BENZOTHIOPHENE SULFONAMIDES DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS (Fri, 12 Jun 2015)
The present invention relates to benzothiophene sulfonamide derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.
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