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For simultaneously determining the analytical NMR spectra of a number of samples placed suitably arranged in the measuring site of an NMR measuring apparatus, spatially and timely varying magnetic fields are used. The resulting signals are spatially resolved by a suited processing, for example Fourier transform. Surprisingly, from these signals, analytical NMRs of high resolution can be obtained for each sample. The method can be applied to two-dimensional arrangements of samples, for example a bundle of capillaries imitating a conventional NMR sample tube or a well plate, or three-dimensional arrangements, for example stacks of well plates. The method allows the determination of NMR spectra for analysis or for comparison with anterior spectra for long time behavior studies and quality assessment with only a fraction of time needed for measuring the samples individually.

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Method for increasing the throughput of NMR spectrometers (Wed, 28 Nov 2001)

For simultaneously determining the analytical NMR spectra of a number of samples placed suitably arranged in the measuring site of an NMR measuring apparatus, spatially and timely varying magnetic fields are used. The resulting signals are spatially resolved by a suited processing, e. g. Fourier transform. Surprisingly, from these signals, analytical NMRs of high resolution may be obtained for each sample. The method can be applied to two-dimensional arrangements of samples, e. g. a bundle of capillaries (1, 10) imitating a conventional NMR sample tube or a well plate (18), and even three-dimensional arrangements, like stacks of well plates (18), may be examined. The method allows the determination of NMR spectra for analysis or for comparison with anterior spectra for long time behaviour studies and quality assessment with only a fraction of time needed for measuring the samples individually.

>> Read More

METHOD FOR INCREASING THE THROUGHPUT OF NMR SPECTROMETERS (Thu, 25 Oct 2001)

For simultaneously determining the analytical NMR spectra of a number of samples placed suitably arranged in the measuring site of an NMR measuring apparatus, spatially and timely varying magnetic fields are used. The resulting signals are spatially resolved by a suited processing, for example Fourier transform. Surprisingly, from these signals, analytical NMRs of high resolution can be obtained for each sample. The method can be applied to two- dimensional arrangements of samples, for example a bundle of capillaries (1, 10) imitating a conventional NMR sample tube or a well plate (18), or three- dimensional arrangements, for example stacks of well plates (18). The method allows the determination of NMR spectra for analysis or for comparison with anterior spectra for long time behavior studies and quality assessment with only a fraction of time needed for measuring the samples individually.

>> Read More

METHOD FOR INCREASING THE THROUGHPUT OF NMR SPECTROMETERS (Thu, 25 Oct 2001)

For simultaneously determining the analytical NMR spectra of a number of samples placed suitably arranged in the measuring site of an NMR measuring apparatus, spatially and timely varying magnetic fields are used. The resulting signals are spatially resolved by a suited processing, for example Fourier transform. Surprisingly, from these signals, analytical NMRs of high resolution can be obtained for each sample. The method can be applied to two-dimensional arrangements of samples, for example a bundle of capillaries (1, 10) imitating a conventional NMR sample tube or a well plate (18), or three-dimensional arrangements, for example stacks of well plates (18). The method allows the determination of NMR spectra for analysis or for comparison with anterior spectra for long time behavior studies and quality assessment with only a fraction of time needed for measuring the samples individually.

>> Read More

A method for detecting a target substance by nuclear magnetic resonance (Wed, 28 Jan 2009)

A method for detecting a known target substance in a sample by means of nuclear magnetic resonance (NMR) of a preselected nuclear species contained in the target substance is described. The method comprises the steps of: a) providing a starting sample known or suspected to contain the target substance; b) adding to the starting sample an amount of isotope-labeled target substance, thus obtaining a composite sample, the isotope-labeled target substance being obtainable from the target substance by replacing at least one nucleus thereof by another isotope thereof, wherein said replacing induces a change in the position or multiplicity of at least one NMR signal of the target substance; c) acquiring NMR signals of the preselected nuclear species from the composite sample; d) determining actual positions of an auxiliary set of NMR signals of the isotope-labeled target substance; e) calculating actual positions of a principal set of NMR signals of the target substance from the actual positions of the auxiliary set of signals and from a predetermined relationship between relative positions of the signals of the isotope-labeled target substance and of the signals of the target substance; f) detecting at least one signal of the target substance located at an actual position calculated by step e).

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A METHOD FOR DETECTING A TARGET SUBSTANCE BY NUCLEAR MAGNETIC RESONANCE (Wed, 07 Apr 2010)

A method for detecting a known target substance in a sample by means of nuclear magnetic resonance (NMR) of a preselected nuclear species contained in the target substance is described. The method comprises the steps of: a) providing a starting sample known or suspected to contain the target substance; b) adding to the starting sample an amount of isotope-labeled target substance, thus obtaining a composite sample, the isotope-labeled target substance being obtainable from the target substance by replacing at least one nucleus thereof by another isotope thereof, wherein said replacing induces a change in the position or multiplicity of at least one NMR signal of the target substance; c) acquiring NMR signals of the preselected nuclear species from the composite sample; d) determining actual positions of an auxiliary set of NMR signals of the isotope-labeled target substance; e) calculating actual positions of a principal set of NMR signals of the target substance from the actual positions of the auxiliary set of signals and from a predetermined relationship between relative positions of the signals of the isotope-labeled target substance and of the signals of the target substance; f) detecting at least one signal of the target substance located at an actual position calculated by step e).

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A METHOD FOR DETECTING A TARGET SUBSTANCE BY NUCLEAR MAGNETIC RESONANCE (Thu, 29 Jan 2009)

A method for detecting a known target substance in a sample by means of nuclear magnetic resonance (NMR) of a preselected nuclear species contained in the target substance is described. The method comprises the steps of: a) providing a starting sample known or suspected to contain the target substance; b) adding to the starting sample an amount of isotope-labeled target substance, thus obtaining a composite sample, the isotope-labeled target substance being obtainable from the target substance by replacing at least one nucleus thereof by another isotope thereof, wherein said replacing induces a change in the position or multiplicity of at least one NMR signal of the target substance; c) acquiring NMR signals of the preselected nuclear species from the composite sample; d) determining actual positions of an auxiliary set of NMR signals of the isotope-labeled target substance; e) calculating actual positions of a principal set of NMR signals of the target substance from the actual positions of the auxiliary set of signals and from a predetermined relationship between relative positions of the signals of the isotope-labeled target substance and of the signals of the target substance; f) detecting at least one signal of the target substance located at an actual position calculated by step e).

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Method for estimating the number of nuclei of a preselected isotope in a molecular species from an NMR spectrum (Wed, 11 May 2005)

A method for estimating the number of nuclei of a preselected isotope in a molecular species starts with an NMR spectrum of a sample containing said molecular species as a predominant substance, said NMR spectrum comprising a plurality of signal peaks corresponding to said nuclei. By applying inclusion and ordering criteria one obtains a set of ordered signal peaks, the integration of which leads to a set of ordered integrals. Nested outer and inner iteration cycles are carried out, wherein for each cycle a trial number of nuclei is assigned to one of said ordered integrals whilst the other ordered integrals are rescaled accordingly and rounded to the next integer value, so as to yield a candidate total number of nuclei. An estimated total number of nuclei is obtained by taking the lowest one from the plurality of candidate total numbers of nuclei that have the highest number of occurrences.

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Method for estimating the number of nuclei of a preselected isotope in a molecular species from an NMR spectrum (Wed, 11 May 2005)

A method for estimating the number of nuclei of a preselected isotope in a molecular species starts with an NMR spectrum of a sample containing said molecular species as a predominant substance, said NMR spectrum comprising a plurality of signal peaks corresponding to said nuclei. By applying inclusion and ordering criteria one obtains a set of ordered signal peaks, the integration of which leads to a set of ordered integrals. Nested outer and inner iteration cycles are carried out, wherein for each cycle a trial number of nuclei is assigned to one of said ordered integrals whilst the other ordered integrals are rescaled accordingly and rounded to the next integer value, so as to yield a candidate total number of nuclei. An estimated total number of nuclei is obtained by taking the lowest one from the plurality of candidate total numbers of nuclei that have the highest number of occurrences.

>> Read More

Method for processing a set of spectra, particularly NMR spectra (Thu, 28 Sep 2006)

A method for processing a set of spectra, particularly NMR spectra, by selecting a principle spectral range, recording a plurality of principle spectra in the principal spectral range, obtaining a reference principal spectrum in the principal spectral range, carrying out, for each one of the principal spectra, a bin-wise division of the principal spectrum by the reference principal spectrum to obtain a corresponding set of spectral quotients; calculating, for at least one of the principal spectra, an associated set of statistical measures derived from the corresponding set of spectral quotients, and carrying out, for at least one of the sets of statistical measures, an outlier detection test.

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Method for estimating the number of nuclei of a preselected isotope in a molecular species from and NMR spectrum (Thu, 26 May 2005)

A method for estimating the number of nuclei of a preselected isotope in a molecular species starts with an NMR spectrum of a sample containing said molecular species as a predominant substance, said NMR spectrum comprising a plurality of signal peaks corresponding to said nuclei. By applying inclusion and ordering criteria one obtains a set of ordered signal peaks, the integration of which leads to a set of ordered integrals. Nested outer and inner iteration cycles are carried out, wherein for each cycle a trial number of nuclei is assigned to one of said ordered integrals whilst the other ordered integrals are rescaled accordingly and rounded to the next integer value, so as to yield a candidate total number of nuclei. An estimated total number of nuclei is obtained by taking the lowest one from the plurality of candidate total numbers of nuclei that have the highest number of occurrences.

>> Read More

METHOD FOR ESTIMATING THE NUMBER OF NUCLEI OF A PRESELECTED ISOTOPE IN A MOLECULAR SPECIES FROM AN NMR SPECTRUM (Sat, 07 May 2005)

A method for estimating the number of nuclei of a preselected isotope in a molecular species starts with an NMR spectrum of a sample containing said molecular species as a predominant substance, said NMR spectrum comprising a plurality of signal peaks corresponding to said nuclei. By applying inclusion and ordering criteria one obtains a set of ordered signal peaks, the integration of which leads to a set of ordered integrals. Nested outer and inner iteration cycles are carried out, wherein for each cycle a trial number of nuclei is assigned to one of said ordered integrals whilst the other ordered integrals are resealed accordingly and rounded to the next integer value, so as to yield a candidate total number of nuclei. An estimated total number of nuclei is obtained by taking the lowest one from the plurality of candidate total numbers of nuclei that have the highest number of occurrences.

>> Read More

Method for processing a set of spectra, particularly NMR spectra (Wed, 27 Sep 2006)

A method for processing a set of spectra, particularly NMR spectra, comprising the steps of: a) selecting a principal spectral range; b) recording a plurality of principal spectra in said principal spectral range; c) obtaining a reference principal spectrum in said principal spectral range; d) carrying out, for each one of said principal spectra, a bin-wise division of the principal spectrum by said reference principal spectrum to obtain a corresponding set of spectral quotients; e) calculating, for at least one of said principal spectra, an associated set of statistical measures derived from the corresponding set of spectral quotients; and f) carrying out, for at least one of said sets of statistical measures, an outlier detection test.

>> Read More

Method for processing a set of spectra, particularly NMR spectra (Wed, 27 Sep 2006)

A method for processing a set of spectra, particularly NMR spectra, comprising the steps of: a) selecting a principal spectral range; a) recording a plurality of principal spectra in said principal spectral range; c) obtaining a reference principal spectrum in said principal spectral range; d) carrying out, for each one of said principal spectra, a bin-wise division of the principal spectrum by said reference principal spectrum to obtain a corresponding set of spectral quotients; e) calculating, for at least one of said principal spectra, an associated set of statistical measures derived from the corresponding set of spectral quotients; and f) carrying out, for at least one of said sets of statistical measures, an outlier detection test.

>> Read More

METHOD FOR PROCESSING A SET OF SPECTRA, PARTICULARLY NMR SPECTRA (Sun, 24 Sep 2006)

A method for processing a set of spectra, particularly NMR spectra, comprises the steps of: a) selecting a principal spectral range; b) recording a plurality of principal spectra in said principal spectral range; c) obtaining a reference principal spectrum in said principal spectral range; d) carrying out, for each one of said principal spectra, a bin-wise division of the principal spectrum by said reference principal spectrum to obtain a corresponding set of spectral quotients; e) calculating, for at least one of said principal spectra, an associated set of statistical measures derived from the corresponding set of spectral quotients; and f) carrying out, for at least one of said sets of statistical measures, an outlier detection test.

>> Read More

A method for detecting a target substance by nuclear magnetic resonance (Wed, 09 Jun 2010)

A method for detecting a known target substance in a sample by means of nuclear magnetic resonance (NMR) of a preselected nuclear species contained in the target substance is described. The method comprises the steps of: a) providing a starting sample known or suspected to contain the target substance; b) adding to the starting sample an amount of isotope-labeled target substance, thus obtaining a composite sample, the isotope-labeled target substance being obtainable from the target substance by replacing at least one nucleus thereof by another isotope thereof, wherein said replacing induces a change in the position or multiplicity of at least one NMR signal of the target substance; c) acquiring NMR signals of the preselected nuclear species from the composite sample; d) determining actual positions of an auxiliary set of NMR signals of the isotope-labeled target substance; e) calculating actual positions of a principal set of NMR signals of the target substance from the actual positions of the auxiliary set of signals and from a predetermined relationship between relative positions of the signals of the isotope-labeled target substance and of the signals of the target substance; f) detecting at least one signal of the target substance located at an actual position calculated by step e).

>> Read More

A METHOD FOR DETECTING A TARGET SUBSTANCE BY NUCLEAR MAGNETIC RESONANCE (Thu, 29 Jan 2009)

A method for detecting a known target substance in a sample by means of nuclear magnetic resonance (NMR) of a preselected nuclear species contained in the target substance is described. The method comprises the steps of: a) providing a starting sample known or suspected to contain the target substance; b) adding to the starting sample an amount of isotope-labeled target substance, thus obtaining a composite sample, the isotope-labeled target substance being obtainable from the target substance by replacing at least one nucleus thereof by another isotope thereof, wherein said replacing induces a change in the position or multiplicity of at least one NMR signal of the target substance; c) acquiring NMR signals of the preselected nuclear species from the composite sample; d) determining actual positions of an auxiliary set of NMR signals of the isotope-labeled target substance; e) calculating actual positions of a principal set of NMR signals of the target substance from the actual positions of the auxiliary set of signals and from a predetermined relationship between relative positions of the signals of the isotope-labeled target substance and of the signals of the target substance; f) detecting at least one signal of the target substance located at an actual position calculated by step e).

>> Read More

METHOD FOR INCREASING THE THROUGHPUT OF NMR SPECTROMETERS (Wed, 15 Jan 2003)

For simultaneously determining the analytical NMR spectra of a number of samples placed suitably arranged in the measuring site of an NMR measuring apparatus, spatially and timely varying magnetic fields are used. The resulting signals are spatially resolved by a suited processing, for example Fourier transform. Surprisingly, from these signals, analytical NMRs of high resolution can be obtained for each sample. The method can be applied to two-dimensional arrangements of samples, for example a bundle of capillaries (1, 10) imitating a conventional NMR sample tube or a well plate (18), or three-dimensional arrangements, for example stacks of well plates (18). The method allows the determination of NMR spectra for analysis or for comparison with anterior spectra for long time behavior studies and quality assessment with only a fraction of time needed for measuring the samples individually.

>> Read More

Method for increasing the throughput of nmr spectrometers (Thu, 11 Oct 2001)

For simultaneously determining the analytical NMR spectra of a number of samples placed suitably arranged in the measuring site of an NMR measuring apparatus, spatially and timely varying magnetic fields are used. The resulting signals are spatially resolved by a suited processing, for example Fourier transform. Surprisingly, from these signals, analytical NMRs of high resolution can be obtained for each sample. The method can be applied to two-dimensional arrangements of samples, for example a bundle of capillaries (1, 10) imitating a conventional NMR sample tube or a well plate (18), or three-dimensional arrangements, for example stacks of well plates (18). The method allows the determination of NMR spectra for analysis or for comparison with anterior spectra for long time behavior studies and quality assessment with only a fraction of time needed for measuring the samples individually.

>> Read More

Caledothricins used in the treatment mycotic diseases (Tue, 24 Jun 1997)

Physiologically active caledothricins A-I and their salts, which are useful for the treatment of mycotic diseases. Also strains belonging to the genus Pseudomonas capable of producing the caledothricins upon cultivation.

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