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Polyquaternium-1 synthesis methods and compositions (Fri, 18 Jan 2013)
The present embodiments relate to a novel method of making quaternary ammonium polymers comprising the steps of: a) mixing 1,4-bis-dimethylamino-2-butene, triethanolamine, water and an acid; and b) introducing a 1,4-dihalo-2-butene to the mixture so as to initiate a reaction resulting in the quaternary ammonium polymer.
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MAGNETIC RESONANCE IMAGING WITH DUAL VELOCITY ENCODED PROJECTION RECONSTRUCTION ACQUISITION (Fri, 14 Apr 2006)
A phase contrast image is produced using a 3D projection reconstruction pulse sequence. A high velocity-to-noise image is produced by using a LOW VENC motion encoding gradient. Phase wrap errors caused by high velocity flow is corrected using phase information in a HIGH VENC image produced from highly undersampled data acquired during the same scan.
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Modular apparatus for magnetic resonance imaging (Fri, 17 Dec 2010)
The present invention discloses a modular MRI imaging system. The imaging system includes MRI radio-frequency antenna arrays separate from the patient support structure. The antenna arrays are affixed to a thin, flexible film such that they may be located next to the anatomical region of interest. In addition, multiple antenna arrays may be configured in various planar or three-dimensional arrangements to optimize the FOV and SNR. Separate patient support structures are provided that enhance ergonomics and patient stabilization. By removing the antenna from the housing, the support structures may be designed without the constraints of supporting the antenna or the associated electronics. The MRI imaging system further employs a preamplifier module. The preamplifier module houses the preamplifier and much of the other associated circuitry for each of the antennae. The preamplifier module operates to combine the signals from the antenna arrays and pass the signals to the MRI system.
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Copolymers of ethylene and selected acrylate esters (Fri, 08 Mar 2002)
In the copolymerization of ethylene and acrylate esters, the use of selected acrylate esters suppresses the formation of acrylate ester homopolymer, and/or allows the rapid analysis by 1H-NMR of the amount of homopolymer byproduct present in the copolymer, both aids in manufacturing high quality copolymers. Useful such acrylates include hexyl acrylate, 3,5,5-trimethylhexyl acrylate, 2-phenoxyethyl acrylate and 2-phenylethyl acrylate. The polymers are useful for films and molding resins.
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Polyglyceryl compounds and compositions (Fri, 02 Dec 2011)
Provided are compositions comprising one or more compounds having a structure comprising a node structure with from four to twelve carbon atoms, one or more (poly)glyceryl groups, and one or more hydrophobic moieties, wherein each of the one or more (poly)glyceryl groups is linked to the node structure by a first primary linking group, the one or more hydrophobic moieties are each independently linked either to the node structure by a primary linking group or to one of the (poly)glyceryl groups by a secondary linking group, and wherein the polyglyceryl thickener has an average degree of glyceryl polymerization of from greater than 3 to less than about I 1 and an average number of hydrophobic groups per primary linking group of about 0.35 or greater. Also provided are polyglyceryl compounds, compositions comprising water, a surfactant, and a polyglyceryl thickener, as well as, methods of making polyglyceryl compounds and compositions of the present invention. (FIGURE 1) DP of Glycerin (H NMR)
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MOLECULAR SWITCHES AND METHODS FOR THEIR USE (Fri, 11 Apr 2008)
The present invention relates to compositions and methods that allow the manipulation of the catalytic activity of multi-component nucleic acid complexes. Further, the invention provides methods which use these compositions and methods to create molecular sensors, molecular switches, and/or modulators or propagators of autocatalytic self-replicating cascades and other iterative processes. More particularly, the invention relates to compositions allowing self-assembly of active and inactive multicomponent nucleic acid complexes, methods of making such compositions, and methods for use.
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MODULAR APPARATUS FOR MAGNETIC RESONANCE IMAGING (Fri, 24 Dec 2010)
The present invention discloses a modular MRI imaging system (10). The imaging system (10) includes MRI radio-frequency antenna arrays (20) separate from the patient support structure (40). The antenna arrays (20) are affixed to a thin, flexible film such that they may be located next to the anatomical region of interest. In addition, multiple antenna arrays (20) may be configured in various planar or three-dimensional arrangements to optimize the FOV and SNR. Separate patient support structures (40) are provided that enhance ergonomics and patient stabilization. By removing the antenna from the housing, the support structures (40) may be designed without the constraints of supporting the antenna or the associated electronics. The MRI imaging system further employs a preamplifier module (60). The preamplifier module (60) houses the preamplifier and much of the other associated circuitry for each of the antennae. The preamplifier module (60) operates to combine the signals from the antenna arrays and pass the signals to the MRI system.
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Polyglyceryl compounds and compositions (Fri, 02 Dec 2011)
Provided are compositions comprising one or more compounds having a structure comprising a node structure with from four to twelve carbon atoms, one or more (poly)glyceryl groups, and one or more hydrophobic moieties, wherein each of the one or more (poly)glyceryl groups is linked to the node structure by a first primary linking group, the one or more hydrophobic moieties are each independently linked either to the node structure by a primary linking group or to one of the (poly)glyceryl groups by a secondary linking group, and wherein the polyglyceryl thickener has an average degree of glyceryl polymerization of from greater than 3 to less than about 11 and an average number of hydrophobic groups per primary linking group of about 0.35 or greater. Also provided are polyglyceryl compounds, compositions comprising water, a surfactant, and a polyglyceryl thickener, as well as, methods of making polyglyceryl compounds and compositions of the present invention. (FIGURE 1) 10 000 - E31 100 10. DP of Glycerin (H NMR)
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Elastomeric Polypropylene (Thu, 09 Apr 1970)
1,187,406. Polypropylene. JOHNSON & JOHNSON. 18 April, 1967 [8 Aug., 1966; 31 March, 1967], No. 17773/67. Heading C3P. Isotactic randiotactic stereoblock polypropylene having a diethyl ether solubility of at least 1% and containing randiotactic blocks linked end to end to intervening isotactic elements, the randiotactic blocks comprising by weight 40 to 60% heterotactic polypropylene, 20 to 30% isotactic polypropylene and 20 to 30% syndiotactic polypropylene, is prepared by reacting isotactic polypropylene at 325‹ to 600‹ F. with a free radical initiator in amount sufficient to provide at least 0À001 weight per cent active oxygen or equivalent and a bromine compound in amount sufficient to provide at least 0À005 weight per cent active bromine, said active bromine and active oxygen being present in a ratio of at least 0À2 to 1 part by weight. Specified free radical initiators are dicumyl peroxide, 2,5-dimethyl-2,5.bis-(t.-butylperoxy) hexane or hexyne-3, and di-t.-butyl peroxide. Specified bromine compounds are tris - (2,3 - dibromopropyl) phosphate, 1,2 - dibromocyclohexane, ,1 - dibromo - p - xylene, 1,1,2,2 - tetrabromoethane, 1 - bromododecane, 2,3 - dibromopropanol, carbon tetrabromide and mixtures thereof. A non-reactive dispersant, e.g. stearic acid, may also be present, and the products may be compounded with conventional pigments and stabilizers and made into filaments, films, sheets, electrical insulation, gaskets, tubes and adhesives. Many examples of the racemization of isotactic polypropylene to the stereoblock polymer of the invention are given.
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THE CITRATE SALT OF 5, 8, 14-TRIAZATETRACYCLO(10.3.1.0?2,11.04.9¿)-HEXADECA-2.(11),3,5,7,9-PENTAENE AND PHARMACEUTICAL COMPOSITIONS THEREOF (Fri, 22 Nov 2002)
The present invetion is directed to the citrate salt of 5, 8, 14-triazatetracyclo[10.3.1.0?2.11.04.9¿]-hexadeca-2(11),3,5,7,9-pentaene, formula 1, and pharmaceutical compositions thereof. The presetn invention is also directed to the various forms fo the citrate salt, particularly its hydrate and its anhydrous/nearly anyhydrous polmorph. The invention is also directed to processes for preparation of these citrate salt forms.
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MULTICOMPONENT NUCLEIC ACID ENZYMES AND METHODS FOR THEIR USE (Fri, 20 Apr 2007)
The present invention relates to Multicomponent Nucleic Acid Enzymes (MNAzymes) and methods for their use. MNAzymes comprise two or more oligonucleotide components which self-assemble in the presence of one or more MNAzyme assembly facilitator molecules to form a catalytically active structure. Compositions for making MNAzymes, and collections of MNAzymes are provided. Also provided are methods for using MNAzymes for the detection, identification and/or quantification of one or more targets. The methods can be practiced in solution-based assays or in assays where one or more reaction components are attached to a support structure. The methods allow for multiplexing the MNAzyme detection to detect multiple targets in a single reaction. Also provided are kits for making the compositions, and for practicing the methods provided herein.
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COPOLYMERS OF ETHYLENE AND SELECTED ACRYLATE ESTERS (Fri, 07 Dec 2001)
In the copolymerization of ethylene and acrylate esters, the use of selected acrylate esters suppresses the formation of acrylate ester homopolymer, and/or allows the rapid analysis by 1H-NMR of the amount of homopolymer by product present in the copolymer, both aids in manufacturing high quality copolymers. Useful such acrylates include hexyl acrylate, 3,5,5-trimethylhexyl acrylate, 2-phenoxyethyl acrylate and 2-phenylethyl acrylate. The polymers are useful for films and molding resins.
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MOLECULAR SWITCHES AND METHODS FOR THEIR USE (Fri, 11 Apr 2008)
The present invention relates to compositions and methods that allow the manipulation of the catalytic activity of multi-component nucleic acid complexes. Further, the invention provides methods which use these compositions and methods to create molecular sensors, molecular switches, and/or modulators or propagators of autocatalytic self-replicating cascades and other iterative processes. More particularly, the invention relates to compositions allowing self-assembly of active and inactive multicomponent nucleic acid complexes, methods of making such compositions, and methods for use.
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POLYETHYLENE STRETCH FILM (Sat, 12 Sep 2009)
A film comprising greater than 70 wt %, based on the weight of the film, of a core layer comprising a core composition comprising: (a) within the range of from 50 to 99 wt% linear low density polyethylene based on the weight of the core composition; and (b) within the range of from 1 to 50 wt% propylene-alpha-olefin copolymer based on the weight of the core composition, wherein the propylene-alpha-olefin copolymer possesses: (i) a melting temperature (Tm) of less than 105°C, and (ii) a heat of fusion (Hf) of less than 75 J/g; wherein the film is a cast or blown film. The films have excellent strength and elasticity and are ideal for such applications as stretch wrap.
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Modified cyanoacrylate monomers and methods of preparation (Wed, 10 Aug 1977)
Difunctional monomers of the formula, ##STR1## where R is an organic linking group derived from a diol or a dihalide of the formula X-R-X, where X is either chlorine, bromine, iodine, or hydroxy, are prepared by reacting a conjugated diene, exemplified by anthracene, with an ester of 2-cyanoacrylic acid to form the Diels-Alder adduct of the ester. The ester adduct is hydrolyzed to ultimately obtain either the Diels-Alder adduct of either 2-cyanoacrylic acid--alkali metal salt or 2-cyanoacryloyl halide. These latter intermediates are respectively reacted with either the dihalide or the diol to afford the bis-Diels-Alder adduct of the R substituted bis (2-cyanoacrylate) monomer. The protective diene group may then be removed, for example, by reaction with excess maleic anhydride and the resulting difunctional monomer isolated. PAL The difunctional monomers thus prepared can be utilized as crosslinking agents in blends comprising one or more of these difunctional monomers and at least one monofunctional monomer, exemplified by an ester of 2-cyanoacrylic acid. Alternately, one or more difunctional monomers can be homopolymerized or copolymerized to a highly crosslinked polymer. The copolymerized compositions of the monomer blends are particularly useful as adhesives, especially in dental applications for coating or sealing enamel surfaces of teeth to allay decay, or for the bonding of brackets to teeth in orthodontics the bond being substantially more resistant to moisture than where the monofunctional monomer is used alone.
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Blocked bis 2-cyanoacrylate monomers (Wed, 19 Jan 1977)
Difunctional monomers of the formula, ##STR1## where R is an organic linking group derived from a diol or a dihalide of the formula X--R--X, where X is either chlorine, bromine, iodine, or hydroxy, are prepared by reacting a conjugated diene, exemplified by anthracene, with an ester of 2-cyanoacrylic acid to form the Diels-Alder adduct of the ester. The ester adduct is hydrolyzed to ultimately obtain either the Diels-Adler adduct of either 2-cyanoacrylic acid--alkali metal salt or 2-cyanoacryloyl halide. These latter intermediates are respectively reacted with either the dihalide or the diol to afford the bis-Diels-Alder adduct of the R substituted bis (2-cyanoacrylate) monomer. The protective diene group may then be removed, for example, by reaction with excess maleic anhydride and the resulting difunctional monomer isolated. PAL The difunctional monomers thus prepared can be utilized as crosslinking agents in blends comprising one or more of these difunctional monomers and at least one monofunctional monomer, exemplified by an ester of 2-cyanoacrylic acid. Alternately, one or more difunctional monomers can be homopolymerized or copolymerized to a highly crosslinked polymer. The copolymerized compositions of the monomer blends are particularly useful as adhesives, especially in dental applications for coating or sealing enamel surfaces of teeth to allay decay, or for the bonding of brackets to teeth in orthodontics and bond being substantially more resistant to moisture than where the monofunctional monomer is used alone.
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Cyanoacrylic acid adducts (Wed, 23 Mar 1977)
Difunctional monomers of the formula, ##STR1## where R is an organic linking group derived from a diol or a dihalide of the formula X-R-X, where X is either chlorine, bromine, iodine, or hydroxy, are prepared by reacting a conjugated diene, exemplified by anthracene, with an ester of 2-cyanoacrylic acid to form the Diels-Alder adduct of the ester. The ester adduct is hydrolyzed to ultimately obtain either the Diels-Alder adduct of either 2-cyanoacrylic acid--alkali metal salt or 2-cyanoacryloyl halide. These later intermediates are respectively reacted with either the dihalide or the diol to afford the bis-Diels-Alder adduct of the R substituted bis (2-cyanoacrylate) monomer. The protective diene group may then be removed, for example, by reaction with excess maleic anhydride and the resulting difunctional monomer isolated. PAL The difunctional monomers thus prepared can be utilized as crosslinking agents in blends comprising one or more of these difunctional monomers and at least one monofunctional monomer, exemplified by an ester of 2-cyanoacrylic acid. Alternately, one or more difunctional monomers can be homopolymerized or copolymerized to a highly crosslinked polymer. The copolymerized compositions of the monomer blends are particularly useful as adhesives, especially in dental applications for coating or sealing enamel surfaces of teeth to allay decay, or for the bonding of brackets to teeth in orthodontics the bond being substantially more resistant to moisture than where the monofunctional monomer is used alone.
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Modified cyanoacrylate monomers and methods for preparation (Wed, 16 Mar 1977)
Difunctional monomers of the formula, ##STR1## where R is an organic linking group derived from a diol or a dihalide of the formula X-R-X, where X is either chlorine, bromine, iodine, or hydroxy, are prepared by reacting a conjugated diene, exemplified by anthracene, with an ester of 2-cyanoacrylic acid to form the Diels-Alder adduct of the ester. The ester adduct is hydrolyzed to ultimately obtain either the Diels-Alder adduct of either 2-cyanoacrylic acid--alkali metal salt of 2-cyanoacryloyl halide. These latter intermediates are respectively reacted with either the dihalide or the diol to afford the bis-Diels-Alder adduct of the R substituted bis (2-cyanoacrylate) monomer. The protective diene group may then be removed, for example, by reaction with excess maleic anhydride and the resulting difunctional monomer isolated. PAL The difunctional monomers thus prepared can be utilized as crosslinking agents in blends comprising one or more of these difunctional monomers and at least one monofunctional monomer, exemplified by an ester of 2-cyanoacrylic acid. Alternately, one or more difunctional monomers can be homopolymerized or copolymerized to a highly crosslinked polymer. The copolymerized compositions of the monomer blends are particularly useful as adhesives, especially in dental applications for coating or sealing enamel surfaces of teeth to allay decay, or for the bonding of brackets to teeth in orthodontics the bond being substantially more resistant to moisture than where the monofunctional monomer is used alone.
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Preparation of bis (2-cyanoacrylate)monomers (Wed, 18 Aug 1976)
Difunctional monomers of the formula, ##EQU1## where R is an organic linking group derived from a diol or a dihalide of the formula X-R-X, where X is either chlorine, bromine, iodine, or hydroxy, are prepared by reacting a conjugated diene, exemplified by anthracene, with an ester of 2-cyanoacrylic acid to form the Diels-Alder adduct of the ester. The ester adduct is hydrolyzed to ultimately obtain either the Diels-Alder adduct of either 2-cyanoacrylic acid--alkali metal salt or 2-cyanoacryloyl halide. These latter intermediates are respectively reacted with either the dihalide or the diol to afford the bis-Diels-Alder adduct of the R substituted bis (2-cyanoacrylate) monomer. The protective diene group may then be removed, for example, by reaction with excess maleic anhydride and the resulting difunctional monomer isolated. PAL The difunctional monomers thus prepared can be utilized as crosslinking agents in blends comprising one or more of these difunctional monomers and at least one monofunctional monomer, exemplified by an ester of 2-cyanoacrylic acid. Alternately, one or more difunctional monomers can be homopolymerized or copolymerized to a highly crosslinked polymer. The copolymerized compositions of the monomer blends are particularly useful as adhesives, especially in dental applications for coating or sealing enamel surfaces of teeth to allay decay, or for the bonding of brackets to teeth in orthodontics the bond being substantially more resistant to moisture than where the monofunctional monomer is used alone.
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Modified cyanoacrylate monomers and methods of preparation (Wed, 10 Aug 1977)
Difunctional monomers of the formula, ##STR1## where R is an organic linking group derived from a diol or a dihalide of the formula X--R--X, where X is either chlorine, bromine, iodine, or hydroxy, are prepared by reacting a conjugated diene, exemplified by anthracene, with an ester of 2-cyanoacrylic acid to form the Diels-Alder adduct of the ester. The ester adduct is hydrolyzed to ultimately obtain either the Diels-Alder adduct of either 2-cyanoacrylic acid--alkali metal salt or 2-cyanoacryloyl halide. These latter intermediates are respectively reacted with either the dihalide or the diol to afford the bis-Diels-Alder adduct of the R substituted bis (2-cyanoacrylate) monomer. The protective diene group may then be removed, for example, by reaction with excess maleic anhydride and the resulting difunctional monomer isolated. PAL The difunctional monomers thus prepared can be utilized as crosslinking agents in blends comprising one or more of these difunctional monomers and at least one monofunctional monomer, exemplified by an ester of2-cyanoacrylic acid. Alternately, one or more difunctional monomers can be homopolymerized or copolymerized to a highly crosslinked polymer. The copolymerized compositions of the monomer blends are particularly useful as adhesives, especially in dental applications for coating or sealing enamel surfaces of teeth to allay decay, or for the bonding of brackets to teeth in orthodontics the bond being substantially more resistant to moisture than where the monofunctional monomer is used alone.
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