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NMR measuring method and measuring apparatus for tissue of a living body (Wed, 03 Feb 1993)
There is carried out an NMR measurement in which a receiver coil (7) for receiving an NMR free induction signal comes in contact with or in close vicinity to one side of tissue of a living body (1) immersed in a perfusion solution (4), while a portion or whole body of the receiver coil (7) is so held as not to come in contact with the perfusion solution (4). According to this measuring method, since a portion or whole body of the receiver coil (7) does not come in contact with the perfusion solution (4), the receiver coil (7) is hardly subject to the electromagnetic influence of changes in the perfusion solution (4). This prevents the free induction signal from being embedded in noise, assuring measurement with high sensitivity. Even for a large-size internal organ, only a signal from an area presenting a uniform magnetic field may be acquired, since the measurement is carried out with the receiver coil (7) coming in contact with or in close vicinity to one side of the internal organ. Thus, a high-resolution free induction signal may be acquired.
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IRON-CONTAINING PREPARATION FOR USE AS NMR CONTRAST MEDIUM (Thu, 13 Dec 1990)
Iron-contg. prepn used as an NMR contrast medium contains as essential components (1) an iron cmpd (01. - 10% wt, (0.5-5%) (as Fe)); (2) sodium and/or bi-carbonate (8 - 60%, (20-45%), and esp. 22-26% sodium carbonate or 20-45% sodium bicarbonate); (3) a neutralising agent (10 -70% (20-50%) and esp. 30-40%). Potassium carbonate may also be present as a preservative (0.2-12% wt, (0.3-3%) and esp. 0.4-1%). The prepn. is pref. an aq soln of pH 3- 5.5 (3.5 -4.6) but may be made up as dispersion for dilution or as tablets for dissolution before use.
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Nuclear magnetic resonance measuring method for solid samples (Thu, 25 Mar 2010)
In a nuclear magnetic resonance measuring method for solid samples, there are provided the steps of exciting a nuclear spin of a solid sample placed in a static magnetic field by allowing exciting pulses to pass through a receiver coil. A FID signal (Free Induction Decay signal) is received from the excited nuclear spin by applying reading pulses after a lapse of time Ä after applying the exciting pulses is finished. An Inversion Recovery IR - Nuclear Magnetic Resonance NMR spectrum is obtained by subjecting the FID signal to a frequency conversion process. The estimation of a constituent ratio of constituent substances of the solid sample is achieved by acquiring a plurality of FID signals while changing the period of time Ä, by calculating IR-NMR spectra based on these FID signals, by obtaining a longitudinal relaxation curve by plotting spectrum strength with respect to time Ä in a specific frequency of the TR-NMR spectrum, and by making a regression analysis while regarding the longitudinal relaxation curve as a total sum of a plurality of longitudinal relaxation curves differing in longitudinal relaxation time.
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Method of using iron containing preparation for NMR imaging (Wed, 30 Dec 1992)
There is described an iron containing preparation for NMR imaging comprising, as necessary ingredients, the prescribed amounts of an iron containing compound, sodium carbonate or sodium hydrogencarbonate and a neutralizing agent. This preparation is safe, easy to drink, and when taking, provides clear and accurate contrast imaging of inner organs. Further, addition of potassium carbonate to this preparation gives excellent preservation stability.
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Low hygroscopic aripiprazole drug substance and processes for the preparation thereof (Fri, 14 Sep 2007)
The present invention provides low hygroscopic forms of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for an extended period.
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2-SUBSTITUTED-CYCLOPENTANONE DERIVATIVES (Thu, 16 Oct 1980)

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Low hygroscopic aripiprazole drug substance and processes for the preparation thereof (Fri, 14 Sep 2007)
The present invention provides low hygroscopic forms of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the anhydrous aripiprazole crystals is stored for an extended period.
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NOVEL PYRAZINOXIDE COMPOUND OF NF-1616-904 AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND A PROCESS FOR ITS PREPARATION (Thu, 16 Feb 1989)
A novel pyrazinoxide compound of NF-1616-904 having the formula (1), and a process for its preparation by hydrolyzing the intermediate compound of NF-1616-902 which is separated from a culture broth of a microorganism belonging to the genus Thielavia. The pyrazinoxide compound of NF-1616-904 possesses biological and pharmacological activities, and is a useful pharmaceutical for preventing and treating diseases caused by superoxide radicals (O2<-> ), and nephritis.
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OA-7653 Substance (Wed, 30 Mar 1983)
The antibiotic of the invention is produced from a novel strain belonging to Streptomyces hygroscopicus, acts against various bacteria and is useful, for example, as active components of antibacterial compositions.
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Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same (Fri, 27 Mar 2015)
An object of the present invention is to provide a compound that can be used as a more superior therapeutic agent for central nervous system diseases. The present invention provides a dihydrate of 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one or of a salt thereof, and a process for producing the same.
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Substituted carbostyril derivatives as 5-HT 1A receptor subtype agonists (Fri, 04 May 2007)
The present invention relates to use of a compound for the production of a medicament for treating a patient suffering from a disorder of the central nervous system associated with 5-HTA receptor subtype, which the medicament comprising as an active ingredient a carbostyril derivative or a salt thereof represented by the formula (1): wherein the carbon-carbon bond between 3- and 4 positions in the carbostyril skeleton is a single or a double bond; and a pharmaceutically acceptable salt or solvate thereof.
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Low hygroscopic aripiprazole (crystal D) drug substance and processes for the preparation thereof (Thu, 05 Jun 2008)
The present invention provides an improved low hygroscopic form, form D, of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for an extended period.
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Low hygroscopic aripiprazole drug substance and processes for the preparation thereof (Thu, 20 May 2004)
The present invention provides low-hygroscopic forms of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for an extended period.
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Substituted carbostyril derivatives as 5-HT 1A receptor subtype agonists for the treatment of bipolar disorder (Thu, 19 Oct 2006)
According to the invention there is provided the use of a carbostyril compound of the formula (1): wherein the dotted line represents a single or a double bond, or a pharmaceutically acceptable salt or solvate thereof, for the production of a medicament, effective in the treatment of disorders of the central nervous system associated with 5-HT 1A receptor subtype, selected from (i) treatment-resistant schizophrenia, inveterate schizophrenia, or chronic schizophrenia, each with or without cognitive impairment, (ii) bipolar I disorder with most recent hypomanic, manic, mixed, depressed or unspecific episode, and (iii) bipolar II disorder with recurrent major depressive episodes with hypomanic episodes, and cyclothymic disorder. Preferably, the compound of formula (1) is 7-{4-[4-(2,3-dichlorophenyl)-1-piperaziny]butoxyl}-3,4-dihydrocarbostyril.
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5-SUBSTITUTED ALKANOYL-8-HYDROXYCARBOSTYRIL DERIVATIVES AND PRODUCTION THEREOF (Fri, 06 Jan 1978)
1496875 Carbostyril derivatives OTSUKA PHARMACEUTICAL CO Ltd 27 Dec 1974 13 June 1974 11 Nov 1974 (5) 4 Dec 1974] 28864/77 Divided out of 1496767 Heading C2C Novel compounds II (R1 is 1-4 C alkyl; R2 and R3 are H, 1-4 C alkyl, 4-6 C cycloalkyl, or aryl-1-4 C alkyl or -NR2R3 is a 5- or 6-membered, substituted or unsubstituted heterocyclic ring containing 1 or 2 N, O or S atoms as heteroatoms and R4 is H or 1-4 C alkyl) and acid addition salts thereof are prepared by reaction of a compound IV (X is halo) with ammonia or an amine HNR2R3 or by dealkylation of a compound II where R4 is alkyl to give one where R4 is H. Compounds IV are prepared by reaction of a compound VI with an -haloalkanoyl halide.
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Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same (Fri, 31 Oct 2014)
An object of the present invention is to provide a compound that can be used as a more superior therapeutic agent for central nervous system diseases. The present invention provides a dihydrate of 7-[4-(4-benzo[b]thiophen-4-y1-piperazin-1-y1)butoxy]-1H-quinolin-2-one or of a salt thereof, and a process for producing the same.
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DIHYDRATE OF BENZOTHIOPHENE COMPOUND AND PROCESS FOR PRODUCING THE SAME (Thu, 05 Mar 2015)
An object of the present invention is to provide a compound that can be used as a more superior therapeutic agent for central nervous system diseases. The present invention provides a dihydrate of 7-[4-(4-benzo[b]thiophen-4-y1-piperazin-1-y1)butoxy]-1H-quinolin-2-one or of a salt thereof, and a process for producing the same.
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Remedy for dermatopathy and metallothionein inducer (Wed, 11 Dec 1996)
Zinc salts, zinc complexes or salts thereof of a compound selected from the group consisting of nicotinamides, picolinamides, 3,4-dihydroxybenzoic acids, amino acids, peptides, hinokitiols and pyridine carboxylic acids represented by formula (1): ##STR1## possess a metallothionein inducing effect, effect of suppressing the production of sunburn cells, and therefore, useful as cosmetics and as drugs which are for ameliorating sunburn, preventing sunburn, ameliorating skin diseases, relieving irradiation disorders, and the like.
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Aqueous olanexidine solution, method of preparing the same, and disinfectant (Fri, 09 Dec 2005)
A disinfectant which contains olanexidine in such a concentration that the disinfectant shows an effective bactericidal activity and which is reduced in side effects such as skin irritation. The disinfectant comprises an aqueous solution which contains olanexidine and gluconic acid, the amount of the latter being at least equimolar with the former, and contains substantially none of acids other than gluconic acid and of salts of the acids (other than gluconic acid).
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DIHYDRATE OF BENZOTHIOPHENE COMPOUND OR OF A SALT THEREOF, AND PROCESS FOR PRODUCING THE SAME (Fri, 10 Mar 2017)
An object of the present invention is to provide a compound that can be used as a more superior therapeutic agent for central nervous system diseases. The present invention provides a dihydrate of 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one or of a salt thereof, and a process for producing the same.
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