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Solid-state NMR spectrometer, sample holder therefor, and method of solid-state NMR spectroscopy (Thu, 11 Apr 2013)
A high-resolution solid-state NMR spectrometer which can measure a disklike sample. The spectrometer includes: a stator having an air bearing disposed within the static magnetic field, the rotor being disposed in the stator; and an engaging mechanism mounted in a one-end portion of the rotor and detachably holding a sample holder that holds the disklike sample.
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ANTIBIOTIC TAN-749, PRODUCTION AND USE THEREOF (Tue, 30 Dec 1986)
Antibiotic TAN-749 or its salts produced by a microorganism belonging to the genus Pseudomonas possess antibacterial activities against gram-positive and gram-negative bacteria including drug-resistant ones, and therefore can be useful as a chemotherapeutic drug for bacterial infections in mammals.
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POLYMORPHS OF 1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C][1,5]NAPHTHYRIDIN-4-AMINE ETHANESULFONATE (Thu, 06 Jul 2006)
The invention provides various crystalline forms of 1-(2-methylpropyl)-1H- imidazo[4,5-c][1,5]naphthyridin-4-amine ethanesulfonate, pharmaceutical compositions, methods of making, and methods of use.
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Polymorphs of 1-(2-Methylpropyl)-1H-Imidazo[4,5-C][1,5]Naphthyridin-4-Amine Ethane-Sulfonate (Thu, 14 May 2009)
The invention provides various crystalline forms of 1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine ethanesulfonate, pharmaceutical compositions, methods of making, and methods of use.
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METHOD FOR PRODUCING CEPHAM COMPOUNDS (Wed, 18 Nov 1981)

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ANTIBIOTIC TAN-950A, ITS PRODUCTION AND USE (Wed, 02 Nov 1988)
The novle antibiotic TAN-950A and salt thereof having the following physico-chemical properties (as the monosodium salt), or a salt thereof : 1) Appearance : White solid 2) Molecular formula : C6H7N2O4Na 3) Ultraviolet (UV) absorption spectrum : in water lambda max 253+/-3nm (E @@@ = 380+/-50) is characterized by cultivating a microbe belonging to the genus Streptomyces capable of producing the antibiotic TAN-950A in the culture medium to produce and accumulate the antibiotic TAN-950A. Shows antimicrobial action against fungi, they can be used in the therapeutics of fungal infections, in human and other animals etc: by oral, parenteral or external administration.
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Antibiotic TAN-950A, its production and use (Tue, 23 Jan 1990)
As the novel antibiotic TAN-950A having the structural formula ##STR1## and salt thereof of the present invention show antimicrobial action against fungi, they can be used in the therapeutics of fungal infections, in human and other animals etc. by oral, parenteral or external administration.
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Glutamate receptor inhibitor (Tue, 21 Sep 1993)
A compound having glutamate receptor inhibitor activity represented by the formula: ##STR1## where R represents a hydrogen atom or a group of the formula: ##STR2## m and n each represents an integer of 3 or 4 and p represents an integer of 0 or 1, or a salt thereof is provided. The compounds are useful for an insecticide.
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2-CHLOROPROPIONIC ACID AND ITS DERIVATIVES (Fri, 30 Dec 1977)
1496156 3-Aryl-2-halo-propionic acid derivatives TAKEDA YAKUHIN KOGYO KK 11 Dec 1974 [19 April 1974 9 Oct 1974] 53566/74 Heading C2C Novel compounds I (in which R1 is H, 1-5C alkyl, halo, OH, CF 3 or 1-4C alkoxy; R2 and R3 are H or 1-5C alkyl; X is halo; Y is -O-, 1-6C alkylenethio, 1-6C alkyleneoxy, or 1-6C alkylenedioxy; Z is COOH or a group convertible thereto (e.g. ester, nitrile, amide or aldehyde groups) and n is 1 or 2) and pharmaceutically acceptable salts thereof are prepared by reaction of a compound II (in which R4 is as R1 or is -N 2 +X-) with a compound III Intermediates isolated are 4-(2-phenoxyethyl)- acetanilide; 4-(2-phenoxyethyl)aniline hydrochloride; 4- (1 -phenyl-2-methylpropyloxy)- aniline hydrochloride; 4-acetamidophenoxy-4- chlorophenyl methane; 4-(4-chlorobenzyloxy)- aniline; 4 - (4 - chlorophenoxymethyl)aniline; 4 - (3 - trifluoromethylphenoxy)nitrobenzene and 4 - (3 - trifluoromethylphenoxy)aniline, all of which are prepared by known methods. Pharmaceutical compositions having hypolipidemic, hypoglycemic and other activities comprise a compound I or a suitable salt together with a carrier or diluent.
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CRYSTALLINE FORMS OF 2-[(2S)-1-AZABICYCLO[2.2.2]OCT-2-YL]-6-(3-METHYL-1H- PYRAZOL-4-YL)THIENO[3,2-D]PYRIMIDIN-4(3H)-ONE HEMIHYDRATE (Thu, 05 Oct 2017)
The present disclosure relates to crystalline forms of 2-[(2S)-1-azabicyclo[2.2.2]oct-2-yl]-6-(3-methyl-1H-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3H)-one hemihydrate (Compound 1) and/or tautomers thereof, wherein Compound 1 has the structure: (I) ⋅ 0.5 H2O; processes for preparing crystalline forms of Compound 1 and/or tautomers thereof; pharmaceutical compositions comprising the crystalline forms; methods of inhibiting a cell division cycle 7 in a mammal comprising administering the crystalline forms; and methods of treating a cell division cycle 7 mediated cancer in a mammal comprising administering the crystalline forms or a pharmaceutical composition comprising the crystalline forms.
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PROCESS FOR PREPARING CEPHALOSPORINS (Wed, 13 Jul 1977)
1479802 Production of 7-amino-3-cephem compounds TAKEDA YAKUHIN KOGYO KK 16 July 1975 [16 July 1974] 29899/75 Heading C2C A cephem compound of the Formula (I) wherein R2 denotes a nitrogen-containing heterocyclic group, or a salt or ester thereof, is obtained by reacting a compound of the Formula (II) wherein R1 denotes H, C 1 -C 8 alkylthio group or a nitrogen-containing heterocyclic-thio group, or a salt or ester thereof, with an amino compound of the formula NH 2 R3, wherein R3 denotes OH or an amino group which may be substituted by an alkyl or aryl group, or a salt thereof. The reaction may be conducted in the presence of a solvent, e.g. water, an alcohol, an ether, an alkyl cyanide, a haloform or an alkylene halide, and in the presence of an inorganic or organic acid or using (III) in the form of a salt with an inorganic or organic acid.
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INTERMEDIATES FOR USE IN PREPARATION OF CEPHALOSPORIN DERIVATIVES (Wed, 27 Sep 1978)
1526176 Cephalosporins TAKEDA YAKUHIN KOGYO KK 1 March 1977 08597/77 Addition to 1491019 Heading C2C Novel compounds (I) where W is halogen and R3 is an optionally substituted nitrogen-containing heterocyclic group, are made by acylating corresponding 7-amino compounds.
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INTERMEDIATES FOR USE IN PREPARATION OF CEPHALOSPORIN DERIVATIVES (Wed, 09 Nov 1977)
1491019 Cephalosporin derivatives TAKEDA YAKUHIN KOGYO KK 20 Dec 1974 [25 Dec 1973 20 Feb 1974 15 April 1974 17 July 1974 13 Nov 1974] 01777/77 Divided out of 1491018 Heading C2C The novel compounds I (W is halo; Y is acetoxy or -SR 3 ; R 3 is a N- containing heterocyclic group) and esters or pharmaceutically acceptable salts thereof are prepared by reaction of a compound II with a compound WCH 2 COCH 2 COW.
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Sorbitol/dexlansoprazole co-crystals and method for making same (Tue, 27 Nov 2012)
A crystal of dexlansoprazole and sorbitol. The crystal is a co-crystal or a salt thereof of dexlansoprazole and sorbitol. There is also a method for making the co-crystal or salt thereof.
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CEPHALOSPORIN COMPOUNDS (Wed, 19 Mar 1975)
1387656 Sulphocephalosporin compounds TAKEDA YAKUHIN KOGYO KK 17 July 1972 [17 July 1971 22 Oct 1971] 33395/72 Addition to 1300692 Heading C2C Novel cephalosporin compounds having the general formula (I) and salts thereof, wherein R is hydrogen, an alkyl or cycloalkyl group, or a substituted or unsubstituted mono- or poly-cyclic aryl or thienyl group, and R1 together with the N atom forms a substituted or unsubstituted mono- or poly-cyclic heterocyclic ring having at least one double bond (indicated by the dotted line) and 1 or 2 nitrogen atoms and optionally a sulphur atom, are prepared by N-acylating a 7-aminocephalosporanic acid derivative of Formula (IV) or a salt or ester thereof, with a sulphocarboxylic acid of Formula (V) or N-acylating functional derivative thereof, or reacting a sulphocephalosporanic acid of Formula (II) with a nitrogen-containing heterocyclic compound of Formula (III) preferably in the presence of an isocyanate, a thiocyanate or a thiol, to replace the acetoxy group by the heterocyclic radical in the 3- position, in which formulae R and R1 have the aforesaid meanings, and if necessary removing an ester group and/or converting the product into a salt. - Sulpho - - (p - nitrophenyl) acetyl chloride and -sulpho-3-thienylacetyl chloride are prepared by reacting the correspondingly substituted acetic acids with thionyl chloride. The compounds (I) and their pharmaceutically acceptable salts are admixed with a pharmaceutical carrier or diluent to provide antibiotically active pharmaceutical compositions.
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THIAZOLO (5,4-B) AZEPINE COMPOUNDS (Mon, 24 Feb 1997)
Compounds of the formula I. are claimed, wherein R1 is a hydrogen atom, an aliphatic group which may be substituted, a carboxylic acyl group which may be substituted or a sulphonic acyl group which may be substituted; R2 is a hydrogen atom, an aromatic group which may be substituted or an aliphatic group which may be substituted. Processes for the preparation of compounds of formula I are also claimed.
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CONDENSED THIAZOLE COMPOUNDS, THEIR PRODUCTION AND USE (Wed, 28 Oct 1992)
The derivatives are of the formula: wherein A is a single bond or CH2; R1 is hydrogen atom, or an optionally substituted aliphatic, carboxylic acyl or sulphonic acyl group; and R2 is hydrogen atom, or an optionally substituted aromatic cyclic or aliphatic group, and the salts thereof.
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CRYSTALLINE FORMS OF HISTONE DEACETYLASE INHIBITORS (Thu, 24 Jul 2008)
The application is related to polymorphs and salts of compounds having the formulae: Compound (I) N-(2-Aminophenyl)-4-((5,6-dimethoxy-2H-indazol-2-yl)methyl)benzamide Compound (II) 4-((6-Acetamido-2H-indazol-2-yl)methyl)-N-(2-aminophenyl)benzamide Compound (III) 1-(4-(2-Aminophenylcarbamoyl)benzyl)-N-ethyl-1H-pyrazole-4-carboxamide Also provided are novel methods for the preparation of the polymorphs of Compound (I), and kits and articles of manufacture of the compositions, and methods of using the compositions to treat various diseases.
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PROCESS FOR PRODUCING ANTIBIOTICS (Wed, 16 Jul 1975)

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Condensed heterocyclic compounds, their production and use (Thu, 22 Dec 1994)
These compounds have the general formula where each of rings A, B and C represents an optionally substituted benzene ring; X is O, S or NR where R is H or an optionally substituted hydrocarbon group; Y is -(CH2)n- where n is 1 or 2 or -NH-; and Ra is H or an optionally substituted hydrocarbon group, provided that when ring C is unsubstituted or substituted only in the para-position ring B is substituted at least at the ortho-position. Salts of such compounds are included. Intermediate carboxylic and carbamic acid and 2-amino- and 2-aminomethyl derivatives are also claimed.
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